Breast cancer(BC)is the most prevalent cancer in women globally.Anti-cancer advancements have enabled the killing of BC cells through various therapies;however,cancer relapse is still a major limitation and decreases ...Breast cancer(BC)is the most prevalent cancer in women globally.Anti-cancer advancements have enabled the killing of BC cells through various therapies;however,cancer relapse is still a major limitation and decreases patient survival and quality of life.Epithelial-to-mesenchymal transition(EMT)is responsible for tumor relapse in several cancers,This highly regulated event causes phenotypic,genetic,and epigenetic changes in the tumor microenvironment(TME).This review summarizes the recent advancements regarding EMT using dedifferentiation and partial EMT theories.We extensively review the mechanistic pathways,TME components,and various anti-cancer adjuvant and neo-adjuvant therapies responsible for triggering EMT in BC tumors.展开更多
文摘Breast cancer(BC)is the most prevalent cancer in women globally.Anti-cancer advancements have enabled the killing of BC cells through various therapies;however,cancer relapse is still a major limitation and decreases patient survival and quality of life.Epithelial-to-mesenchymal transition(EMT)is responsible for tumor relapse in several cancers,This highly regulated event causes phenotypic,genetic,and epigenetic changes in the tumor microenvironment(TME).This review summarizes the recent advancements regarding EMT using dedifferentiation and partial EMT theories.We extensively review the mechanistic pathways,TME components,and various anti-cancer adjuvant and neo-adjuvant therapies responsible for triggering EMT in BC tumors.
