The incidence of diabetes mellitus,a pressing global health concern that is rapidly increasing,has prompted the exploration of medicinal plants for potential remedies,particularly those within the Rubus genus.This com...The incidence of diabetes mellitus,a pressing global health concern that is rapidly increasing,has prompted the exploration of medicinal plants for potential remedies,particularly those within the Rubus genus.This comprehen-sive review aims to connect traditional knowledge with scientific insights,shedding light on the antidiabetic proper-ties of various Rubus species.An exhaustive exploration of the literature revealed that Rubus chingii Hu,Rubus idaeus,Rubus ulmifolius,Rubus fruticosus,Rubus amabilis,and some other Rubus species exhibited noteworthy antidiabetic effects,each operating via distinct mechanisms.Furthermore,Rubus species serve as abundant reservoirs of bio-active compounds,including flavonoids,phenolic acids,tannins,alkaloids,glycosides,antioxidants,triterpenoids,and sterols.As indicated by various in vivo and in vitro studies,these compounds notably improve insulin secretion,increase hepatic glycogen synthesis,inhibit key digestive enzymes,enhance the functions of β-cells in the pancreas,and effectively reduce blood glucose levels.This review,which describes the antidiabetic potential of Rubus species in terms of both pharmacological effects and traditional uses,offers valuable insights for future scientific initiatives in the development of innovative antidiabetic therapies.展开更多
文摘The incidence of diabetes mellitus,a pressing global health concern that is rapidly increasing,has prompted the exploration of medicinal plants for potential remedies,particularly those within the Rubus genus.This comprehen-sive review aims to connect traditional knowledge with scientific insights,shedding light on the antidiabetic proper-ties of various Rubus species.An exhaustive exploration of the literature revealed that Rubus chingii Hu,Rubus idaeus,Rubus ulmifolius,Rubus fruticosus,Rubus amabilis,and some other Rubus species exhibited noteworthy antidiabetic effects,each operating via distinct mechanisms.Furthermore,Rubus species serve as abundant reservoirs of bio-active compounds,including flavonoids,phenolic acids,tannins,alkaloids,glycosides,antioxidants,triterpenoids,and sterols.As indicated by various in vivo and in vitro studies,these compounds notably improve insulin secretion,increase hepatic glycogen synthesis,inhibit key digestive enzymes,enhance the functions of β-cells in the pancreas,and effectively reduce blood glucose levels.This review,which describes the antidiabetic potential of Rubus species in terms of both pharmacological effects and traditional uses,offers valuable insights for future scientific initiatives in the development of innovative antidiabetic therapies.
