With the rapid increase in the aging population comes a rise in the incidence and prevalence of neurodegenerative diseases.Therefore,it is critical to understand the molecular changes that occur,which can either cause...With the rapid increase in the aging population comes a rise in the incidence and prevalence of neurodegenerative diseases.Therefore,it is critical to understand the molecular changes that occur,which can either cause disease or make brains resilient.Epigenetic changes are a common suspect and target,not only because they are among the hallmarks of aging,but also because they are flexible and could potentially be reversed.展开更多
With the increase of life expectancy and population growth,neurodegenerative diseases have risen too and are projected to be a major health public concern by 2050.Neurodegenerative diseases are characterized by the pr...With the increase of life expectancy and population growth,neurodegenerative diseases have risen too and are projected to be a major health public concern by 2050.Neurodegenerative diseases are characterized by the progressive decline of cognitive function leading to the subsequent loss of autonomy.Although the underlying causes of neurodegeneration are not well understood,aging is the main risk factor.展开更多
Neurodegenerative diseases are caused by the loss of neuro- nal cells. As neurons deteriorate, a patient may experience relatively mild symptoms such as failing to name objects and people. However, with the progressio...Neurodegenerative diseases are caused by the loss of neuro- nal cells. As neurons deteriorate, a patient may experience relatively mild symptoms such as failing to name objects and people. However, with the progression of the disease, symp- toms worsen resulting in loss of independence and a sense of＂loss of oneself＂. Finally, the patient dies from a variety of complications.展开更多
基金David and Inez Myers Foundation,the Israeli Ministry of Science and Technology(MOST)The Israel Science Foundation(No.422/23)(to DT).
文摘With the rapid increase in the aging population comes a rise in the incidence and prevalence of neurodegenerative diseases.Therefore,it is critical to understand the molecular changes that occur,which can either cause disease or make brains resilient.Epigenetic changes are a common suspect and target,not only because they are among the hallmarks of aging,but also because they are flexible and could potentially be reversed.
基金supported by The David and Inez Myers Foundation,Beachwood,OH,USA(to DT)。
文摘With the increase of life expectancy and population growth,neurodegenerative diseases have risen too and are projected to be a major health public concern by 2050.Neurodegenerative diseases are characterized by the progressive decline of cognitive function leading to the subsequent loss of autonomy.Although the underlying causes of neurodegeneration are not well understood,aging is the main risk factor.
文摘Neurodegenerative diseases are caused by the loss of neuro- nal cells. As neurons deteriorate, a patient may experience relatively mild symptoms such as failing to name objects and people. However, with the progression of the disease, symp- toms worsen resulting in loss of independence and a sense of＂loss of oneself＂. Finally, the patient dies from a variety of complications.
