Syzygium cumini Linn.,commonly known as Jamun,is a member of the Myrtaceae family and is also referred to by synonyms such as Eugenia djouant Perr.,Eugenia cumini,Eugenia jambolana Lam.,Syzygium jambolana Lam.,and Myr...Syzygium cumini Linn.,commonly known as Jamun,is a member of the Myrtaceae family and is also referred to by synonyms such as Eugenia djouant Perr.,Eugenia cumini,Eugenia jambolana Lam.,Syzygium jambolana Lam.,and Myrtus cumini Linn.This review provides an overview of its medicinal value,including taxonomical classification,geographic distribution,cultivation techniques,pharmacognostical aspects,phytochemical constituents,traditional uses,and pharmacological applications.In India,‘Ram Jamun’or‘Raja Jamun’is cultivated in the north,while the‘Paras’variety is grown in central regions.Various components of S.cumini fruits are utilized to enhance the nutritional quality of wines,jellies,jams,and fermented products.Rich in essential nutrients like vitamins,carbohydrates,minerals,antioxidants,and anthocyanins,S.cumini also contains bioactive phytoconstituents such as gallic acid,tannins,and polyphenols,which contribute to its pharmacological properties.Traditionally,black plums have been used as carminatives,diuretics,and remedies for stomach ailments,spleen enlargement,diarrhea,and urinary retention.Additionally,S.cumini has been historically administered to women post-abortion and is recognized for its role in managing diabetes and dysentery.Polyphenolic compounds in Jamun exhibit potential therapeutic benefits against diabetes,arthritis,cancer,asthma,and cardiovascular diseases.Given its promising ethnopharmacological profile,extensive research has been conducted on various plant parts,highlighting their antioxidant,antifungal,antibacterial,antidiabetic,and anticancer properties.This review aims to provide a comprehensive understanding of Syzygium cumini’s traditional and therapeutic significance,serving as a valuable resource for future research.展开更多
A series of 3-ethoxy-4-hydroxybenzylidene/4-nitrobenzylidene hydrazides（1-20） was synthesized and tested for in vitro antimicrobial activity.The results of antimicrobial studies indicated that the compounds having d...A series of 3-ethoxy-4-hydroxybenzylidene/4-nitrobenzylidene hydrazides（1-20） was synthesized and tested for in vitro antimicrobial activity.The results of antimicrobial studies indicated that the compounds having dinitro,methoxy,hydroxy and nitro substituents on phenyl ring of the aromatic acids were most active ones.The QSAR investigation indicated the importance of the topological parameter,third order molecular connectivity index（~3x） in describing the antimicrobial activity of synthesized hydrazides.展开更多
Herbal medicine is safe and effective in treating various diseases.Traditional herbal medicine plays a tremendous role in treatment of various diseases and accompanying complications,hence herbal medicine requires rem...Herbal medicine is safe and effective in treating various diseases.Traditional herbal medicine plays a tremendous role in treatment of various diseases and accompanying complications,hence herbal medicine requires remarkable attention in further research for the development of numerous active formulations for treatment of health troubles.The plant needs special consideration for development and research of unidentified compound and characterization of novel active molecules that overcome multiple pathological abnormalities.The genus Manilkara contains 135 plants around the world.This overview discusses all the virtues of most important and commonly used plant Manilkara zapota(L.)P.Royen(M.zapota),also known as Sapodilla.M.zapota has various traditional beneficial effects in treatment of various diseases and disorders dating back to prehistoric times and used in ancient traditional system of herbal medicine.展开更多
Discovering potent drug candidates requires new antimalarial targets.For this reason,antimalarial drug researchers focus on developing new drug candidates on promising targets.In the identification of these targets,a ...Discovering potent drug candidates requires new antimalarial targets.For this reason,antimalarial drug researchers focus on developing new drug candidates on promising targets.In the identification of these targets,a basic understanding of the metabolism and biochemical processes of malaria parasites such as Plasmodium falciparum can prove invaluable.However,malarial resistant parasites are becoming more and more significant issues as antimalarial medications progress.Antimalarial drugs are becoming increasingly resistant,thus the search for new molecules is very important task.Artemisinin based combination therapies are becoming more popular for treating malaria.This will ultimately lead to the selection of resistance due to their extensive and indiscriminate deployment.Alternative artemisinin-based combination therapies are therefore required.There is an interest in finding suitable antimalarial compounds based on their potential effectiveness against malaria.The potential activity of 1,3,4 oxadiazole analogues against malarial infections is a major draw of the search for suitable antimalarial compounds.This review identifies existing antimalarial drugs that have own therapeutic effects and evaluating their feasibility for developing novel synthetic antimalarial derivatives.展开更多
Albizia lebbeck Benth,commonly referred to as Indian Siris,is a therapeutically potential plant drug and a financially significant plant with mechanical,therapeutic uses.The leaves of the plant are a rich source of pr...Albizia lebbeck Benth,commonly referred to as Indian Siris,is a therapeutically potential plant drug and a financially significant plant with mechanical,therapeutic uses.The leaves of the plant are a rich source of protein and are said to have significant efficacy against cancer cells.The plant contains a variety of secondary metabolites such as alkaloids,flavonoids,saponins,anthraquinones,phenols and essential oils.Pharmacological reports of the extract of A.lebbek show the diverse pharmacological effects such as anti-inflammatory,antibacterial,anti-fertility,antifungal,anthelmintic,antiulcer etc.The present review paper contains the literature on the scientific reports on the pharmacological and phytochemical importance of A.lebbek,which could be a good source of information for researchers,scientists and industry for future reference.展开更多
Background:Alzheimer’s disease affects millions of people worldwide,and one of its major characteristics is the accumulation of extracellular Aβpeptides in the human brain,leading to neuronal death and resulting in ...Background:Alzheimer’s disease affects millions of people worldwide,and one of its major characteristics is the accumulation of extracellular Aβpeptides in the human brain,leading to neuronal death and resulting in memory deficits,disorientation,and inappropriate behaviour.Objective and Methodology:This review study aims to develop new molecular targets for major depression-associated cognitive dysfunction and determine the mechanisms of action of 1,3,4-oxadiazole-based drug candidates.It encourages scientists to develop and synthesize drugs with low side effects to treat Alzheimer’s disease.Furthermore,the drug has shown significant improvement in memory function among dementia patients,which is due to the increased production of acetylcholine in the brain.These derivatives show a high affinity to amyloid plaques,which are thought to cause cognitive damage in patients with Alzheimer’s disease.This review study emphasizes newly developed inhibitors of amyloid deposition using the enzymeα-secretase,which cleaves amyloid precursor protein into smaller fragments that are toxic to neurons.1,3,4-Oxadiazole compounds have demonstrated no significant toxicity to the central nervous system.The antioxidant properties of 1,3,4-oxadiazoles can reduce free radicals,which play an active role in cell damage and disease.Conclusion:This review aims to provide readers with an overview of the current state of knowledge about oxadiazole-related drugs,emphasizing their biological importance.Key aspects related to the discovery and development of these drug candidates are discussed in detail,including information on their structure,biological activity,chemistry,and pharmacological properties.In addition,different derivatives discovered for Alzheimer’s disease to enhance the therapeutic efficiency of oxadiazole drugs have been comprehensively discussed in this review.展开更多
Malaria is a ubiquitous tropical disease which occurs by the bite of malaria parasite of genus Plasmodium spp.The procurement and treatment of malaria depend on the cost and emergence of drug resistance,chemical compo...Malaria is a ubiquitous tropical disease which occurs by the bite of malaria parasite of genus Plasmodium spp.The procurement and treatment of malaria depend on the cost and emergence of drug resistance,chemical compositions of drug molecules,and different complications and toxic effects associated with them.The antimalarials are classified as gametocidal,prophylaxis,blood schizonticides,tissue schizonticides and sporontocides.In addition,new antimalarial drugs have been discussed in the present review that offers the advantage singly or in combination with other drugs.The ridiculous vector control methods,appearance of drug-resistant parasites,and deficiency of effective vaccines against malaria are the main aspects responsible for the expansion of malaria.Hence,the development of a new drug is the need of hour to conquer the clinical failures of traditional chemotherapy.Though,the discovery and development of a new drug is a costly and lengthy process,hence different nanotechnological techniques may recommend hopeful approaches for the procurement of malaria amid minimum side effects.Delivery of traditional anti-malarial drugs in nanoform offers an opportunity to improve their therapeutic efficacy,reduced side-effects by targeted delivery and improved patient's compliance.This review article will critically highlight the different traditional,hybrid and new anti-malarial drugs.Moreover,different nanocarriers discovered for the site specific liberation of antimalarials to enhance the therapeutic efficiency of these drugs have been comprehensively discussed in this review.展开更多
Women are more likely than men to develop cancer of the breast.Most breast cancer drugs are highly toxic,and treatment can cause side effects.It is imperative to find safe alternative medicines in the pursuit of a cur...Women are more likely than men to develop cancer of the breast.Most breast cancer drugs are highly toxic,and treatment can cause side effects.It is imperative to find safe alternative medicines in the pursuit of a cure for breast cancer.An extract of pineapple contains cysteine proteases known as bromelains.In general,pineapples are regarded as safe foods.From the fruit,stem,and of pineapples,bromelain is produced by multiple endopeptidases.As well as reducing the growth of tumors locally,bromelain severely impaired the cytotoxicity of monocytes in the immune system in the fight against cancer.Specifically,we investigated pineapple’s possible mechanisms of action and its bioactive compounds in breast cancer.展开更多
A large number of people worldwide suffer from pulmonary disorders,and their prevalence is on the rise.Although we have gained a greater understanding of the basis of respiratory airway disorders,the treatments and th...A large number of people worldwide suffer from pulmonary disorders,and their prevalence is on the rise.Although we have gained a greater understanding of the basis of respiratory airway disorders,the treatments and therapies available for those disorders have not progressed historically.Supplements to existing therapies are made from traditional natural derivatives and herbal medicines.Natural compounds such as these are capable of acting as the basis for developing new drugs and related treatments.Plants possess bioactive compounds that have distinct advantages over allopathic medicines because chemotherapy roots severe adverse effects rather than providing limited benefits.As a result of better effects and fewer adverse effects,herbal bioactive is a promising approach for treating respiratory disorders,resulting in a better quality of life and longer life expectancy for patients.Asthma,pulmonary fibrosis,lung cancer,and chronic obstructive pulmonary disease are among the pulmonary disorders addressed in the present article and approaches based on clinical trials.展开更多
Currently,cancer is the most rapidly growing life-threatening disease after cardiovascular in the world,posing a major threat to human life.Telomerase promotes tumorigenesis and development in most cancers and dyskeri...Currently,cancer is the most rapidly growing life-threatening disease after cardiovascular in the world,posing a major threat to human life.Telomerase promotes tumorigenesis and development in most cancers and dyskerin plays a crucial role in telomere maintenance.Cancer molecules are being developed continuously as a result of continuous research.A series of novel anticancer agents have been developed using telomerase inhibitors with improved specificity and pharmacokinetics.As medicinal chemistry advances,heterocyclic-based drugs find increasing applications,including anticancer agents.These properties have led to the development of five-membered aromatic rings of oxadiazoles.In order to enhance their anticancer activity,oxadiazole scaffolds can be modified.In this review,we discuss the functions and mechanism of action of the telomerase enzyme.The paper also summarizes the interaction between 1,3,4-oxadiazole inhibitors and telomerase enzymes.展开更多
文摘Syzygium cumini Linn.,commonly known as Jamun,is a member of the Myrtaceae family and is also referred to by synonyms such as Eugenia djouant Perr.,Eugenia cumini,Eugenia jambolana Lam.,Syzygium jambolana Lam.,and Myrtus cumini Linn.This review provides an overview of its medicinal value,including taxonomical classification,geographic distribution,cultivation techniques,pharmacognostical aspects,phytochemical constituents,traditional uses,and pharmacological applications.In India,‘Ram Jamun’or‘Raja Jamun’is cultivated in the north,while the‘Paras’variety is grown in central regions.Various components of S.cumini fruits are utilized to enhance the nutritional quality of wines,jellies,jams,and fermented products.Rich in essential nutrients like vitamins,carbohydrates,minerals,antioxidants,and anthocyanins,S.cumini also contains bioactive phytoconstituents such as gallic acid,tannins,and polyphenols,which contribute to its pharmacological properties.Traditionally,black plums have been used as carminatives,diuretics,and remedies for stomach ailments,spleen enlargement,diarrhea,and urinary retention.Additionally,S.cumini has been historically administered to women post-abortion and is recognized for its role in managing diabetes and dysentery.Polyphenolic compounds in Jamun exhibit potential therapeutic benefits against diabetes,arthritis,cancer,asthma,and cardiovascular diseases.Given its promising ethnopharmacological profile,extensive research has been conducted on various plant parts,highlighting their antioxidant,antifungal,antibacterial,antidiabetic,and anticancer properties.This review aims to provide a comprehensive understanding of Syzygium cumini’s traditional and therapeutic significance,serving as a valuable resource for future research.
文摘A series of 3-ethoxy-4-hydroxybenzylidene/4-nitrobenzylidene hydrazides（1-20） was synthesized and tested for in vitro antimicrobial activity.The results of antimicrobial studies indicated that the compounds having dinitro,methoxy,hydroxy and nitro substituents on phenyl ring of the aromatic acids were most active ones.The QSAR investigation indicated the importance of the topological parameter,third order molecular connectivity index（~3x） in describing the antimicrobial activity of synthesized hydrazides.
文摘Herbal medicine is safe and effective in treating various diseases.Traditional herbal medicine plays a tremendous role in treatment of various diseases and accompanying complications,hence herbal medicine requires remarkable attention in further research for the development of numerous active formulations for treatment of health troubles.The plant needs special consideration for development and research of unidentified compound and characterization of novel active molecules that overcome multiple pathological abnormalities.The genus Manilkara contains 135 plants around the world.This overview discusses all the virtues of most important and commonly used plant Manilkara zapota(L.)P.Royen(M.zapota),also known as Sapodilla.M.zapota has various traditional beneficial effects in treatment of various diseases and disorders dating back to prehistoric times and used in ancient traditional system of herbal medicine.
文摘Discovering potent drug candidates requires new antimalarial targets.For this reason,antimalarial drug researchers focus on developing new drug candidates on promising targets.In the identification of these targets,a basic understanding of the metabolism and biochemical processes of malaria parasites such as Plasmodium falciparum can prove invaluable.However,malarial resistant parasites are becoming more and more significant issues as antimalarial medications progress.Antimalarial drugs are becoming increasingly resistant,thus the search for new molecules is very important task.Artemisinin based combination therapies are becoming more popular for treating malaria.This will ultimately lead to the selection of resistance due to their extensive and indiscriminate deployment.Alternative artemisinin-based combination therapies are therefore required.There is an interest in finding suitable antimalarial compounds based on their potential effectiveness against malaria.The potential activity of 1,3,4 oxadiazole analogues against malarial infections is a major draw of the search for suitable antimalarial compounds.This review identifies existing antimalarial drugs that have own therapeutic effects and evaluating their feasibility for developing novel synthetic antimalarial derivatives.
文摘Albizia lebbeck Benth,commonly referred to as Indian Siris,is a therapeutically potential plant drug and a financially significant plant with mechanical,therapeutic uses.The leaves of the plant are a rich source of protein and are said to have significant efficacy against cancer cells.The plant contains a variety of secondary metabolites such as alkaloids,flavonoids,saponins,anthraquinones,phenols and essential oils.Pharmacological reports of the extract of A.lebbek show the diverse pharmacological effects such as anti-inflammatory,antibacterial,anti-fertility,antifungal,anthelmintic,antiulcer etc.The present review paper contains the literature on the scientific reports on the pharmacological and phytochemical importance of A.lebbek,which could be a good source of information for researchers,scientists and industry for future reference.
文摘Background:Alzheimer’s disease affects millions of people worldwide,and one of its major characteristics is the accumulation of extracellular Aβpeptides in the human brain,leading to neuronal death and resulting in memory deficits,disorientation,and inappropriate behaviour.Objective and Methodology:This review study aims to develop new molecular targets for major depression-associated cognitive dysfunction and determine the mechanisms of action of 1,3,4-oxadiazole-based drug candidates.It encourages scientists to develop and synthesize drugs with low side effects to treat Alzheimer’s disease.Furthermore,the drug has shown significant improvement in memory function among dementia patients,which is due to the increased production of acetylcholine in the brain.These derivatives show a high affinity to amyloid plaques,which are thought to cause cognitive damage in patients with Alzheimer’s disease.This review study emphasizes newly developed inhibitors of amyloid deposition using the enzymeα-secretase,which cleaves amyloid precursor protein into smaller fragments that are toxic to neurons.1,3,4-Oxadiazole compounds have demonstrated no significant toxicity to the central nervous system.The antioxidant properties of 1,3,4-oxadiazoles can reduce free radicals,which play an active role in cell damage and disease.Conclusion:This review aims to provide readers with an overview of the current state of knowledge about oxadiazole-related drugs,emphasizing their biological importance.Key aspects related to the discovery and development of these drug candidates are discussed in detail,including information on their structure,biological activity,chemistry,and pharmacological properties.In addition,different derivatives discovered for Alzheimer’s disease to enhance the therapeutic efficiency of oxadiazole drugs have been comprehensively discussed in this review.
文摘Malaria is a ubiquitous tropical disease which occurs by the bite of malaria parasite of genus Plasmodium spp.The procurement and treatment of malaria depend on the cost and emergence of drug resistance,chemical compositions of drug molecules,and different complications and toxic effects associated with them.The antimalarials are classified as gametocidal,prophylaxis,blood schizonticides,tissue schizonticides and sporontocides.In addition,new antimalarial drugs have been discussed in the present review that offers the advantage singly or in combination with other drugs.The ridiculous vector control methods,appearance of drug-resistant parasites,and deficiency of effective vaccines against malaria are the main aspects responsible for the expansion of malaria.Hence,the development of a new drug is the need of hour to conquer the clinical failures of traditional chemotherapy.Though,the discovery and development of a new drug is a costly and lengthy process,hence different nanotechnological techniques may recommend hopeful approaches for the procurement of malaria amid minimum side effects.Delivery of traditional anti-malarial drugs in nanoform offers an opportunity to improve their therapeutic efficacy,reduced side-effects by targeted delivery and improved patient's compliance.This review article will critically highlight the different traditional,hybrid and new anti-malarial drugs.Moreover,different nanocarriers discovered for the site specific liberation of antimalarials to enhance the therapeutic efficiency of these drugs have been comprehensively discussed in this review.
文摘Women are more likely than men to develop cancer of the breast.Most breast cancer drugs are highly toxic,and treatment can cause side effects.It is imperative to find safe alternative medicines in the pursuit of a cure for breast cancer.An extract of pineapple contains cysteine proteases known as bromelains.In general,pineapples are regarded as safe foods.From the fruit,stem,and of pineapples,bromelain is produced by multiple endopeptidases.As well as reducing the growth of tumors locally,bromelain severely impaired the cytotoxicity of monocytes in the immune system in the fight against cancer.Specifically,we investigated pineapple’s possible mechanisms of action and its bioactive compounds in breast cancer.
文摘A large number of people worldwide suffer from pulmonary disorders,and their prevalence is on the rise.Although we have gained a greater understanding of the basis of respiratory airway disorders,the treatments and therapies available for those disorders have not progressed historically.Supplements to existing therapies are made from traditional natural derivatives and herbal medicines.Natural compounds such as these are capable of acting as the basis for developing new drugs and related treatments.Plants possess bioactive compounds that have distinct advantages over allopathic medicines because chemotherapy roots severe adverse effects rather than providing limited benefits.As a result of better effects and fewer adverse effects,herbal bioactive is a promising approach for treating respiratory disorders,resulting in a better quality of life and longer life expectancy for patients.Asthma,pulmonary fibrosis,lung cancer,and chronic obstructive pulmonary disease are among the pulmonary disorders addressed in the present article and approaches based on clinical trials.
文摘Currently,cancer is the most rapidly growing life-threatening disease after cardiovascular in the world,posing a major threat to human life.Telomerase promotes tumorigenesis and development in most cancers and dyskerin plays a crucial role in telomere maintenance.Cancer molecules are being developed continuously as a result of continuous research.A series of novel anticancer agents have been developed using telomerase inhibitors with improved specificity and pharmacokinetics.As medicinal chemistry advances,heterocyclic-based drugs find increasing applications,including anticancer agents.These properties have led to the development of five-membered aromatic rings of oxadiazoles.In order to enhance their anticancer activity,oxadiazole scaffolds can be modified.In this review,we discuss the functions and mechanism of action of the telomerase enzyme.The paper also summarizes the interaction between 1,3,4-oxadiazole inhibitors and telomerase enzymes.
