Background Electrocardiogram(ECG)analysis has emerged as a promising tool for detecting physiological changes linked to non-cardiac disorders.Given the close connection between cardiovascular and neurocognitive health...Background Electrocardiogram(ECG)analysis has emerged as a promising tool for detecting physiological changes linked to non-cardiac disorders.Given the close connection between cardiovascular and neurocognitive health,ECG abnormalities may be present in individuals with co-occurring neurocognitive conditions.This highlights the potential of ECG as a biomarker to improve detection,therapy monitoring and risk stratification in patients with neurocognitive disorders,an area that remains underexplored.Aims We aimed to demonstrate the feasibility of predicting neurocognitive disorders from ECG features across diverse patient populations.Methods ECG features and demographic data were used to predict neurocognitive disorders,as defined by the International Classification of Diseases 10th revision,focusing on dementia,delirium and Parkinson's disease.Internal and external validations were performed using the Medical Information Mart for Intensive CareⅣand ECG-View datasets.Predictive performance was assessed by the area under the receiver operating characteristic curve(AUROC)scores,and Shapley values were used to interpret feature contributions.Results Significant predictive performance was observed for several neurocognitive disorders.The highest predictive performance was observed for F03:dementia,with an internal AUROC of 0.848(95%confidence interval(CI)0.848 to 0.848)and an external AUROC of 0.865(95%CI 0.864 to 0.965),followed by G30:Alzheimer's disease,with an internal AUROC of 0.809(95%CI 0.808 to 0.810)and an external AUROC of 0.863(95%CI 0.863 to 0.864).Feature importance analysis revealed both established and novel ECG correlates.Conclusions These findings suggest that ECG holds promise as a non-invasive,explainable biomarker for selected neurocognitive disorders.This study demonstrates robust performance across cohorts and lays the groundwork for future clinical applications,including early detection and personalised monitoring.展开更多
Protecting,managing,and restoring freshwater ecosystems in the Anthropocene is essential to tackling the triple planetary crises of biodiversity loss,pollution,and climate change.However,conventional restoration frame...Protecting,managing,and restoring freshwater ecosystems in the Anthropocene is essential to tackling the triple planetary crises of biodiversity loss,pollution,and climate change.However,conventional restoration frameworks often struggle to account for the rapid and nonlinear dynamics that characterize ecological transitions today.In this review,we synthesize emerging insights from freshwater restoration research and propose a novel bivariate framework that integrates both the rate and magnitude of change from a long-term,evolutionary perspective.By examining multidecadal to centennial trajectories and dynamics using paleoenvironmental records,our framework offers a more nuanced classification of ecosystem status along a degradation continuum.Specifically,we categorize four ecosystem types based on their state(from minimally disturbed to highly degraded)and their rate of change(from slow to fast).Each type is associated with distinct system dynamics,restoration potentials,and strategic considerations.To demonstrate practical utility,we apply the framework to a representative Anthropocene lake undergoing severe ecological degradation.While centered on freshwater systems,the framework offers broader relevance for understanding and guiding restoration in other ecosystem types.We conclude by identifying key knowledge gaps and future research directions needed to enhance ecosystem resilience and inform adaptive management in a rapidly changing world.展开更多
品牌转换策略的速度是不是太快了？＂之前有报道说英国电信公司O2发起了自己的传播活动＂Be More Dog＂,这则视频讲述一只不甘平凡的喵星人故事,它羡慕起可以自由奔跑玩耍的汪星人,希望自己变成一只狗……于是它欢乐地奔跑、刨地、接球...品牌转换策略的速度是不是太快了？＂之前有报道说英国电信公司O2发起了自己的传播活动＂Be More Dog＂,这则视频讲述一只不甘平凡的喵星人故事,它羡慕起可以自由奔跑玩耍的汪星人,希望自己变成一只狗……于是它欢乐地奔跑、刨地、接球、跳水,最终成为了一只外表像猫的狗。但随后的一场调查活动对企业频繁转换策略的决定表示质疑。展开更多
很高兴能看到全球战略咨询公司Bain一篇关于发展核心业务的文章，让整个企业能聚焦于现有的“英雄产品”，保持良好的形象并致力将之转变为“超级英雄”。本文列举了一些好案例，能够驱动品牌的核心力增长，该文章摘自《核心增长：如何...很高兴能看到全球战略咨询公司Bain一篇关于发展核心业务的文章，让整个企业能聚焦于现有的“英雄产品”，保持良好的形象并致力将之转变为“超级英雄”。本文列举了一些好案例，能够驱动品牌的核心力增长，该文章摘自《核心增长：如何聚焦于让品牌成功的核心业务》 （Grow the Core： How to focus on your core business for brand success） 一书。展开更多
博客主人/ David Taylor http：//wheresthesausage.typepad：com.汽车品牌路虎推出了路虎咖啡品牌（LandRoverCoffee），在其网站上路虎宣称自己的咖啡“非常吸引人，是国际公认的咖啡品牌．以其高品质闻名，风味区别于其他咖啡品牌”...博客主人/ David Taylor http：//wheresthesausage.typepad：com.汽车品牌路虎推出了路虎咖啡品牌（LandRoverCoffee），在其网站上路虎宣称自己的咖啡“非常吸引人，是国际公认的咖啡品牌．以其高品质闻名，风味区别于其他咖啡品牌”。对于路虎而言，这种品牌扩张方式是否合理呢？展开更多
文摘Background Electrocardiogram(ECG)analysis has emerged as a promising tool for detecting physiological changes linked to non-cardiac disorders.Given the close connection between cardiovascular and neurocognitive health,ECG abnormalities may be present in individuals with co-occurring neurocognitive conditions.This highlights the potential of ECG as a biomarker to improve detection,therapy monitoring and risk stratification in patients with neurocognitive disorders,an area that remains underexplored.Aims We aimed to demonstrate the feasibility of predicting neurocognitive disorders from ECG features across diverse patient populations.Methods ECG features and demographic data were used to predict neurocognitive disorders,as defined by the International Classification of Diseases 10th revision,focusing on dementia,delirium and Parkinson's disease.Internal and external validations were performed using the Medical Information Mart for Intensive CareⅣand ECG-View datasets.Predictive performance was assessed by the area under the receiver operating characteristic curve(AUROC)scores,and Shapley values were used to interpret feature contributions.Results Significant predictive performance was observed for several neurocognitive disorders.The highest predictive performance was observed for F03:dementia,with an internal AUROC of 0.848(95%confidence interval(CI)0.848 to 0.848)and an external AUROC of 0.865(95%CI 0.864 to 0.965),followed by G30:Alzheimer's disease,with an internal AUROC of 0.809(95%CI 0.808 to 0.810)and an external AUROC of 0.863(95%CI 0.863 to 0.864).Feature importance analysis revealed both established and novel ECG correlates.Conclusions These findings suggest that ECG holds promise as a non-invasive,explainable biomarker for selected neurocognitive disorders.This study demonstrates robust performance across cohorts and lays the groundwork for future clinical applications,including early detection and personalised monitoring.
基金supported by the Excellent Research Group Program for Tibetan Plateau Earth System(42588201)the National Key Research and Development Program of China(2022YFF0801101)+1 种基金the National Natural Science Foundation of China(42361144717 and 42471176)the Science and Technology Planning Project(NIGLAS2022GS02)in Nanjing Institute of Geography and Limnology,Chinese Academy of Sciences.
文摘Protecting,managing,and restoring freshwater ecosystems in the Anthropocene is essential to tackling the triple planetary crises of biodiversity loss,pollution,and climate change.However,conventional restoration frameworks often struggle to account for the rapid and nonlinear dynamics that characterize ecological transitions today.In this review,we synthesize emerging insights from freshwater restoration research and propose a novel bivariate framework that integrates both the rate and magnitude of change from a long-term,evolutionary perspective.By examining multidecadal to centennial trajectories and dynamics using paleoenvironmental records,our framework offers a more nuanced classification of ecosystem status along a degradation continuum.Specifically,we categorize four ecosystem types based on their state(from minimally disturbed to highly degraded)and their rate of change(from slow to fast).Each type is associated with distinct system dynamics,restoration potentials,and strategic considerations.To demonstrate practical utility,we apply the framework to a representative Anthropocene lake undergoing severe ecological degradation.While centered on freshwater systems,the framework offers broader relevance for understanding and guiding restoration in other ecosystem types.We conclude by identifying key knowledge gaps and future research directions needed to enhance ecosystem resilience and inform adaptive management in a rapidly changing world.
文摘品牌转换策略的速度是不是太快了？＂之前有报道说英国电信公司O2发起了自己的传播活动＂Be More Dog＂,这则视频讲述一只不甘平凡的喵星人故事,它羡慕起可以自由奔跑玩耍的汪星人,希望自己变成一只狗……于是它欢乐地奔跑、刨地、接球、跳水,最终成为了一只外表像猫的狗。但随后的一场调查活动对企业频繁转换策略的决定表示质疑。
文摘很高兴能看到全球战略咨询公司Bain一篇关于发展核心业务的文章，让整个企业能聚焦于现有的“英雄产品”，保持良好的形象并致力将之转变为“超级英雄”。本文列举了一些好案例，能够驱动品牌的核心力增长，该文章摘自《核心增长：如何聚焦于让品牌成功的核心业务》 （Grow the Core： How to focus on your core business for brand success） 一书。
文摘博客主人/ David Taylor http：//wheresthesausage.typepad：com.汽车品牌路虎推出了路虎咖啡品牌（LandRoverCoffee），在其网站上路虎宣称自己的咖啡“非常吸引人，是国际公认的咖啡品牌．以其高品质闻名，风味区别于其他咖啡品牌”。对于路虎而言，这种品牌扩张方式是否合理呢？
