Adrenocortical carcinoma(ACC)is a rare malignancy with no widely available biomarkers and commonly presents at later stages with a bleak prognosis[1].Dysregulation of signaling pathways involved in the organogenesis a...Adrenocortical carcinoma(ACC)is a rare malignancy with no widely available biomarkers and commonly presents at later stages with a bleak prognosis[1].Dysregulation of signaling pathways involved in the organogenesis and homeostasis of the adrenal cortex is implicated in its pathogenesis[2].The paternally expressed,cleavable protein delta-like non-canonical Notch ligand 1(DLK1)is expressed in rat adrenocortical progenitor cells[3]and in clusters of relatively undifferentiated cells in the human adrenal gland[4].Its expression is rare in most adult human tissues but has been reported across various cancers,often associated with worse survival[5].Here we define the role of DLK1 in adrenocortical development,self-renewal,and the development and progression of ACC.展开更多
基金supported by the MRC(MR/X021017/1,MR/S022155/1)BBSRC(BB/V007246/1)+3 种基金Barts Charity(MGU0436)Rosetrees Trust(M355-F1)The Medical College of Saint Bartholomew’s Hospital Trust,the German Research Foundation(Deutsche Forschungsgemeinschaft,314061271)the National Institutes of Health Physician-Scientist Career Development Award(R01DK123694).
文摘Adrenocortical carcinoma(ACC)is a rare malignancy with no widely available biomarkers and commonly presents at later stages with a bleak prognosis[1].Dysregulation of signaling pathways involved in the organogenesis and homeostasis of the adrenal cortex is implicated in its pathogenesis[2].The paternally expressed,cleavable protein delta-like non-canonical Notch ligand 1(DLK1)is expressed in rat adrenocortical progenitor cells[3]and in clusters of relatively undifferentiated cells in the human adrenal gland[4].Its expression is rare in most adult human tissues but has been reported across various cancers,often associated with worse survival[5].Here we define the role of DLK1 in adrenocortical development,self-renewal,and the development and progression of ACC.
