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会阴切开术是经阴道分娩时重度会阴裂伤的危险因素还是保护因素(德国) 被引量:1
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作者 david m Pachaly J +1 位作者 Vetter K 柳蕴 《世界核心医学期刊文摘(妇产科学分册)》 2005年第10期60-61,共2页
Purpose: Is an episiotomy a protective or a risk factor for severe perineal lacerations; which other obstetric influencing factors exist? Patients and Methods: Retrospective analysis of the perinatal data from Berlin ... Purpose: Is an episiotomy a protective or a risk factor for severe perineal lacerations; which other obstetric influencing factors exist? Patients and Methods: Retrospective analysis of the perinatal data from Berlin from 1993 to 1999. Study inclusion criteria: vaginal delivery in singleton pregnancies. Setting up of two study subgroups: vaginal delivery of singletons, cephalic presentation >34/0 gestational weeks, birth weight 2500 to 4000 g. Separate analysis of the primi- (subgroup 1) and multiparae (subgroup 2). Multivariate analysis with stepwise logistic regression. Identification of factors which correlate with severe perineal lacerations. Results: 74.7% of all vaginal deliveries of singletons (n = 128 745) fulfilled the inclusion criteria. In spontaneous deliveries, the frequency of episiotomy was 60.8% , in vacuum extraction and forceps delivery 95.3 and 98.6% respectively. Severe perineal lacerations were significantly more frequent in vaginal- operative deliveries than in spontaneous vaginal delivery. If no episiotomy was incised, perineal lacerations stage 3/4 were less frequent in spontaneous and vacuum extraction deliveries. Following regression analysis, severe perineal- lacerations were less frequent in primipara if the active period of labour is ≤ 10 minutes, if no episiotomy is incised, in vacuum than in forceps extraction, if fetal head circumference is < 36 cm, and if no further traumas of the birth canal occur. Results were similar for multiparae: severe perineal lacerations were less frequent if the active period of labour is < 10 minutes, if no episiotomy is incised, and if no vaginal operative delivery occurs. Conclusions: Episiotomies seem to carry one of the highest risks for a severe perineal laceration among the avoidable risk factors. Therefore, use of an episiotomy must be restricted to well- justified cases. When considering perineal protection, vacuum extraction should be preferred to forceps extraction. 展开更多
关键词 会阴切开术 会阴裂伤 阴道分娩 时重 产钳助娩 头先露 单胎妊娠 阴道助娩 胎头吸引术 经产妇
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一种抗原递呈细胞的调节阀——维生素A 被引量:1
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作者 david m Duriancik +2 位作者 Denise E Lackey Kathleen A H 《饲料博览》 2010年第9期50-50,共1页
维生素A与免疫系统的反应能力有关,维生素A缺乏症是众所周知的,其是调节先天性和适应性免疫反应的中间物。维生素A合成和代谢的研究进展已经将抗原递呈细胞(APC)视为其新陈代谢的的中心免疫细胞。目前已知抗原递呈细胞可以表达视黄醛脱... 维生素A与免疫系统的反应能力有关,维生素A缺乏症是众所周知的,其是调节先天性和适应性免疫反应的中间物。维生素A合成和代谢的研究进展已经将抗原递呈细胞(APC)视为其新陈代谢的的中心免疫细胞。目前已知抗原递呈细胞可以表达视黄醛脱氢酶和分泌视黄酸。产生的视黄酸有自分泌和旁分泌作用。自分泌作用包括非经典的CD1d分子主要组织相容性Ⅰ类样分子和基质金属蛋白-9。旁分泌作用影响多淋巴细胞普西细胞群。具体来说,维甲酸类增加了IgA的同型转换的B淋巴细胞,增强了调节性T细胞分化,并指导淋巴细胞归附到黏膜。CD1d分子脂质抗原递呈扩展了自然杀伤T细胞群体。在此之前,维生素主要是对适应性免疫淋巴细胞起作用,但最近研究表明,抗原递呈细胞可能是维生素A免疫系统功能的中枢驱动器。 展开更多
关键词 维生素A 抗原递呈细胞 免疫淋巴细胞 自分泌 旁分泌
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