Background:The prevalence of irritable bowel syndrome(IBS)-like symptoms is high in untreated patients with microscopic colitis(MC),but there is uncertainty of the prevalence of IBS-like symptoms in treated patients.W...Background:The prevalence of irritable bowel syndrome(IBS)-like symptoms is high in untreated patients with microscopic colitis(MC),but there is uncertainty of the prevalence of IBS-like symptoms in treated patients.We assessed the degree of IBS-like symptoms in patients with MC in comparison to control subjects,and investigated the association between IBS-like symptoms and faecal calprotectin(FC)in MC patients.Methods:Patients with an established MC diagnosis(n=57)were compared to sex-and age-matched controls(n=138)for scores in the GSRS-IBS(Gastrointestinal Symptom Rating Scale for Irritable Bowel Syndrome)and HADS(Hospital Anxiety Depression Scale).In MC patients,an FC level was simultaneously analysed.Results:The median interval from MC diagnoses to the time the subjects participated in the study was 5.5 years(25th-75th percentiles;4.5-9.5 years).The total GSRS-IBS score,subscores for abdominal pain,bloating,and diarrhoea were significantly higher in MC patients compared to controls(all P<0.001).There was a significant correlation between FC levels and reported bowel frequency(P=0.023),but there was no correlation between FC levels and GSRS-IBS scores.Patients with MC had significantly higher scores on anxiety(HADS-A)(P<0.001)and used more selective serotonin-reuptake-inhibitor drugs(P=0.016)than the control subjects.However,only the control subjects(not the patients with MC)showed significant correlations between GSRS-IBS scores and HADS scores.Conclusions:Patients with MC reported more IBS-like symptoms and anxiety than control subjects but neither FC levels nor symptoms of affectivity were significantly correlated with IBS-like symptoms.展开更多
文摘Background:The prevalence of irritable bowel syndrome(IBS)-like symptoms is high in untreated patients with microscopic colitis(MC),but there is uncertainty of the prevalence of IBS-like symptoms in treated patients.We assessed the degree of IBS-like symptoms in patients with MC in comparison to control subjects,and investigated the association between IBS-like symptoms and faecal calprotectin(FC)in MC patients.Methods:Patients with an established MC diagnosis(n=57)were compared to sex-and age-matched controls(n=138)for scores in the GSRS-IBS(Gastrointestinal Symptom Rating Scale for Irritable Bowel Syndrome)and HADS(Hospital Anxiety Depression Scale).In MC patients,an FC level was simultaneously analysed.Results:The median interval from MC diagnoses to the time the subjects participated in the study was 5.5 years(25th-75th percentiles;4.5-9.5 years).The total GSRS-IBS score,subscores for abdominal pain,bloating,and diarrhoea were significantly higher in MC patients compared to controls(all P<0.001).There was a significant correlation between FC levels and reported bowel frequency(P=0.023),but there was no correlation between FC levels and GSRS-IBS scores.Patients with MC had significantly higher scores on anxiety(HADS-A)(P<0.001)and used more selective serotonin-reuptake-inhibitor drugs(P=0.016)than the control subjects.However,only the control subjects(not the patients with MC)showed significant correlations between GSRS-IBS scores and HADS scores.Conclusions:Patients with MC reported more IBS-like symptoms and anxiety than control subjects but neither FC levels nor symptoms of affectivity were significantly correlated with IBS-like symptoms.
