Objective:To investigate the hypolipidaemic and antioxidant effects of aqueous leaf extract of Enicoslemma littorale(E.littorale)Blume(Ens)against ethanol induced hepatic injury in albino rats.Methods:Male albino rats...Objective:To investigate the hypolipidaemic and antioxidant effects of aqueous leaf extract of Enicoslemma littorale(E.littorale)Blume(Ens)against ethanol induced hepatic injury in albino rats.Methods:Male albino rats of six numbers in each group were undertaken for study.Hypolipidaemic and antioxidant effect of E.littorale Blume(Ens)aqueous leaf extract at a dosage of 250 mg/kg bw was evaluated.Results:Levels of serum and tissue cholesterol,triglycerides and free fatty acids were elevated and levels of tissue thiobarbituric acid reactive substances(TBARS)and lipid hydroperoxide were increased in ethanol treated rats.The activity levels of liver antioxidant enzymes such as superoxide dismutase(SOD),catalase(CAT),glutathione peroxidase(GPX)and glutathione-s-transferase(GST)were decreased.After adiminstration of extract of E,littorale Blume,levels of cholesterol,triglycerides and free fatty acids were decreased in serum and liver tissue,levels of TBARS and lipid hydroperoxide were decreased,and Ever antioxidant enzymes were increased in liver tissue;Conclusions:It can be concluded that the aqueous leaf extract of E,littorale Blume(Ens)has potent restorative effect on hyperlipidaemic and oxidative stress.展开更多
Objective:To evaluate the effect of aqueous seed extract of Solarium suratlense(S.suraltense)on the oxidative potential of cauda cpididymal spermatozoa.Methods:S.surattense seed extract was orally administered at the ...Objective:To evaluate the effect of aqueous seed extract of Solarium suratlense(S.suraltense)on the oxidative potential of cauda cpididymal spermatozoa.Methods:S.surattense seed extract was orally administered at the dosage of 10 mg/kg b.w.for 15 days,after which aspartate transferase(AST),alanine transferase(ALT),glutamate dehydrogenase(GDH),citric acid and isocitrate dehydrogenase(ICDH)were assayed.Results:The activity levels of the enzymes AST and ALT,which are considered to be the androgenicity in the sperm suspension,were depleted in the extract fed rats.The activity level of the enzyme ICDH,was reduced significantly in the treated group(P<0.00l).Conclusions:It can be concluded that the oral administration of the aqueous seed extract of S.surattense can deplete the oxidative stress of cauda epididymal spermatozoa in albino rats.展开更多
WHO（2007）中枢神经系统肿瘤分类中列出WHOⅡ级的弥漫性星形细胞瘤（A Ⅱ WHO 2007）和WHOⅢ级的间变性星形细胞瘤（ AA Ⅲ WHO 2007）之间的区别。 A Ⅱ WHO （2007）的患者与AA Ⅲ WHO （2007）的患者相比显著年轻、生存期明显较长...WHO（2007）中枢神经系统肿瘤分类中列出WHOⅡ级的弥漫性星形细胞瘤（A Ⅱ WHO 2007）和WHOⅢ级的间变性星形细胞瘤（ AA Ⅲ WHO 2007）之间的区别。 A Ⅱ WHO （2007）的患者与AA Ⅲ WHO （2007）的患者相比显著年轻、生存期明显较长。迄今为主,分级和分类仅仅依靠形态学而未考虑IDH这一预后相关分子标记的状态。作者发现,对于IDH突变的星形细胞瘤而言,WHO（2007）的分级系统对预后的提示意义较差。检测来自3个独立的病例系列共1360例成人弥漫性星形细胞肿瘤的年龄分布和生存时间,其中包括683例Ⅱ级IDH突变型星形细胞瘤（ A Ⅱ IDHmut）、562例IDH突变型的间变性星形细胞瘤（ AA Ⅲ IDHmut）和115例IDH 突变的胶质母细胞瘤（ GBM IDHmut ）。 A ⅡIDHmut和 AA Ⅲ IDHmut的患者显示具有相同的发病年龄（36～37岁）,而两级别之间的生存时间差异小于 WHO （2007）的报道（A Ⅱ IDHmut 中位生存时间为10.9年,AAⅢIDHmut为9.3年）。作者分析提示AⅡWHO2007与AAⅢ WHO2007年龄分布和生存时间的差异主要取决于 IDH非突变型肿瘤所占的比例。这些数据结果对目前实行的星形细胞瘤分级和危险分层提出了重大挑战,并可能对 IDH突变型星形细胞瘤的治疗管理产生深远的影响。展开更多
文摘Objective:To investigate the hypolipidaemic and antioxidant effects of aqueous leaf extract of Enicoslemma littorale(E.littorale)Blume(Ens)against ethanol induced hepatic injury in albino rats.Methods:Male albino rats of six numbers in each group were undertaken for study.Hypolipidaemic and antioxidant effect of E.littorale Blume(Ens)aqueous leaf extract at a dosage of 250 mg/kg bw was evaluated.Results:Levels of serum and tissue cholesterol,triglycerides and free fatty acids were elevated and levels of tissue thiobarbituric acid reactive substances(TBARS)and lipid hydroperoxide were increased in ethanol treated rats.The activity levels of liver antioxidant enzymes such as superoxide dismutase(SOD),catalase(CAT),glutathione peroxidase(GPX)and glutathione-s-transferase(GST)were decreased.After adiminstration of extract of E,littorale Blume,levels of cholesterol,triglycerides and free fatty acids were decreased in serum and liver tissue,levels of TBARS and lipid hydroperoxide were decreased,and Ever antioxidant enzymes were increased in liver tissue;Conclusions:It can be concluded that the aqueous leaf extract of E,littorale Blume(Ens)has potent restorative effect on hyperlipidaemic and oxidative stress.
基金Supported by postgraduate Department of Zoology,Voorhees College
文摘Objective:To evaluate the effect of aqueous seed extract of Solarium suratlense(S.suraltense)on the oxidative potential of cauda cpididymal spermatozoa.Methods:S.surattense seed extract was orally administered at the dosage of 10 mg/kg b.w.for 15 days,after which aspartate transferase(AST),alanine transferase(ALT),glutamate dehydrogenase(GDH),citric acid and isocitrate dehydrogenase(ICDH)were assayed.Results:The activity levels of the enzymes AST and ALT,which are considered to be the androgenicity in the sperm suspension,were depleted in the extract fed rats.The activity level of the enzyme ICDH,was reduced significantly in the treated group(P<0.00l).Conclusions:It can be concluded that the oral administration of the aqueous seed extract of S.surattense can deplete the oxidative stress of cauda epididymal spermatozoa in albino rats.
文摘WHO（2007）中枢神经系统肿瘤分类中列出WHOⅡ级的弥漫性星形细胞瘤（A Ⅱ WHO 2007）和WHOⅢ级的间变性星形细胞瘤（ AA Ⅲ WHO 2007）之间的区别。 A Ⅱ WHO （2007）的患者与AA Ⅲ WHO （2007）的患者相比显著年轻、生存期明显较长。迄今为主,分级和分类仅仅依靠形态学而未考虑IDH这一预后相关分子标记的状态。作者发现,对于IDH突变的星形细胞瘤而言,WHO（2007）的分级系统对预后的提示意义较差。检测来自3个独立的病例系列共1360例成人弥漫性星形细胞肿瘤的年龄分布和生存时间,其中包括683例Ⅱ级IDH突变型星形细胞瘤（ A Ⅱ IDHmut）、562例IDH突变型的间变性星形细胞瘤（ AA Ⅲ IDHmut）和115例IDH 突变的胶质母细胞瘤（ GBM IDHmut ）。 A ⅡIDHmut和 AA Ⅲ IDHmut的患者显示具有相同的发病年龄（36～37岁）,而两级别之间的生存时间差异小于 WHO （2007）的报道（A Ⅱ IDHmut 中位生存时间为10.9年,AAⅢIDHmut为9.3年）。作者分析提示AⅡWHO2007与AAⅢ WHO2007年龄分布和生存时间的差异主要取决于 IDH非突变型肿瘤所占的比例。这些数据结果对目前实行的星形细胞瘤分级和危险分层提出了重大挑战,并可能对 IDH突变型星形细胞瘤的治疗管理产生深远的影响。
