Lipoxidation is formed during the oxidation of lipids and specific proteins,causing an alteration in proteins function.Although this occurs under physiological conditions,in many cases,it has been associated with path...Lipoxidation is formed during the oxidation of lipids and specific proteins,causing an alteration in proteins function.Although this occurs under physiological conditions,in many cases,it has been associated with pathological processes,including cancer.Oxidative DNA damage is a significant contributor to cancer development,and lipoxidation products such as malondialdehyde(MDA)and 4-hydroxy-2-nonenal(4-HNE)play a role in the induction of mutations responsible for DNA modifications.Elevations of reactive aldehydes can be seen in patients with metastatic disease in comparison to those without metastatic disease.Lipoxidation adducts can modify the immune response,consequently causing either positive or negative alterations in cancer progression.When reactive aldehydes are added to tumor cells,they exert similar effects to chemotherapeutic drugs by forming DNA adducts and consequently steer the tumor cells toward apoptosis.This article highlights the role of botanical compounds in lipid metabolism,lipid peroxidation,and cell cycle arrest and discusses the potential role they may have in oncology treatments.展开更多
Layered honeycomb intermetallic phases have attracted considerable research interest due to the wide array of exciting physical properties inherent in these materials.Here,we follow the evolution in structure and elec...Layered honeycomb intermetallic phases have attracted considerable research interest due to the wide array of exciting physical properties inherent in these materials.Here,we follow the evolution in structure and electronic properties of a relatively unexplored material system,Sr_(1−x)Ca_(x)PdAs,as the hexagonal PdAs honeycomb layer in SrPdAs distorts into the orthorhombic CaPdAs structure.The Sr-rich compounds(x=0 to 1/3)form symmetric,hexagonal honeycomb PdAs layers,whereas in the Ca-rich region(x=1/2 to 1)the PdAs layers distort into an orthorhombic structure featuring long and short Pd–Pd distances.This dis tortion occurs when the average Pd–Pd distance falls below 4.21Å.All compounds are observed to exhibit metallic temperature-dependent resistivity trends.There are no apparent discontinuities indicative of metal-to-insulator transitions and the room temperature resistivity values range from 18 to 180 mΩcm.In total,this work maps out the structural and electronic phase diagram of Sr_(1−x)Cax PdAs compounds.展开更多
Hydrogen has emerged as a promising energy source for low-carbon and sustainable mobility purposes.However,its applications are still limited by modest conversion efficiency in the electrocatalytic oxygen reduction re...Hydrogen has emerged as a promising energy source for low-carbon and sustainable mobility purposes.However,its applications are still limited by modest conversion efficiency in the electrocatalytic oxygen reduction reaction(ORR)within fuel cells.The complex nature of the ORR and the presence of strong electronic correlations present challenges to atomistic modelling using classical computers.This scenario opens new avenues for the implementation of novel quantum computing workflows.Here,we present a state-of-the-art study that combines classical and quantum computational approaches to investigate ORR on platinum-based surfaces.Our research demonstrates,for the first time,the feasibility of implementing this workflow on the H1-series trappedion quantumcomputer and identify the challenges of the quantum chemistry modelling of this reaction.The results highlight the great potentiality of quantum computers in solving notoriously difficult systems with strongly correlated electronic structures and suggest platinum/cobalt as ideal candidate for showcasing quantum advantage in future applications.展开更多
The use of alternative medicine（AM） in Australia dates back to its earliest times,with the indigenous medicine of the aboriginal peoples and the folk medicine of the early English settlers.AM has until recently exis...The use of alternative medicine（AM） in Australia dates back to its earliest times,with the indigenous medicine of the aboriginal peoples and the folk medicine of the early English settlers.AM has until recently existed quite separately from Western biomedicine（WB） and there has been little integration of the two systems.Now,referred to as complementary medicine（CM）,there has been a movement over the last 20 years to include CM in WB mainstream practices.Varying degrees of success have been reported but for the discipline of oncology.Medical oncology（MO） in Australia is demanding CM provide high levels of evidence for any inclusion in cancer protocols.There are just now the beginnings of this integration, particularly as CM is now being taught in the public university system to a PhD level as well as the public demand for their medical doctors to communicate with their CM practitioners.MO specialists are now open to a dialogue with their CM counterparts.展开更多
文摘Lipoxidation is formed during the oxidation of lipids and specific proteins,causing an alteration in proteins function.Although this occurs under physiological conditions,in many cases,it has been associated with pathological processes,including cancer.Oxidative DNA damage is a significant contributor to cancer development,and lipoxidation products such as malondialdehyde(MDA)and 4-hydroxy-2-nonenal(4-HNE)play a role in the induction of mutations responsible for DNA modifications.Elevations of reactive aldehydes can be seen in patients with metastatic disease in comparison to those without metastatic disease.Lipoxidation adducts can modify the immune response,consequently causing either positive or negative alterations in cancer progression.When reactive aldehydes are added to tumor cells,they exert similar effects to chemotherapeutic drugs by forming DNA adducts and consequently steer the tumor cells toward apoptosis.This article highlights the role of botanical compounds in lipid metabolism,lipid peroxidation,and cell cycle arrest and discusses the potential role they may have in oncology treatments.
基金supported by the Center for Emergent Materials,an NSF-funded MRSEC under award no.DMR-1420451Partial support for transport measurements by M.R.S.was provided by AFOSR project no.FA9550-18-1-0335+1 种基金J.E.G.acknowledges the Camille and Henry Dreyfus Foundation for partial support.D.W.gratefully acknowledges the financial support by the German Science Foundation DFG Research Fellowship(WE6480/1)Y.W.and W.W.thank the Ohio Supercomputer Center for computer time under grant PAS0072.
文摘Layered honeycomb intermetallic phases have attracted considerable research interest due to the wide array of exciting physical properties inherent in these materials.Here,we follow the evolution in structure and electronic properties of a relatively unexplored material system,Sr_(1−x)Ca_(x)PdAs,as the hexagonal PdAs honeycomb layer in SrPdAs distorts into the orthorhombic CaPdAs structure.The Sr-rich compounds(x=0 to 1/3)form symmetric,hexagonal honeycomb PdAs layers,whereas in the Ca-rich region(x=1/2 to 1)the PdAs layers distort into an orthorhombic structure featuring long and short Pd–Pd distances.This dis tortion occurs when the average Pd–Pd distance falls below 4.21Å.All compounds are observed to exhibit metallic temperature-dependent resistivity trends.There are no apparent discontinuities indicative of metal-to-insulator transitions and the room temperature resistivity values range from 18 to 180 mΩcm.In total,this work maps out the structural and electronic phase diagram of Sr_(1−x)Cax PdAs compounds.
文摘Hydrogen has emerged as a promising energy source for low-carbon and sustainable mobility purposes.However,its applications are still limited by modest conversion efficiency in the electrocatalytic oxygen reduction reaction(ORR)within fuel cells.The complex nature of the ORR and the presence of strong electronic correlations present challenges to atomistic modelling using classical computers.This scenario opens new avenues for the implementation of novel quantum computing workflows.Here,we present a state-of-the-art study that combines classical and quantum computational approaches to investigate ORR on platinum-based surfaces.Our research demonstrates,for the first time,the feasibility of implementing this workflow on the H1-series trappedion quantumcomputer and identify the challenges of the quantum chemistry modelling of this reaction.The results highlight the great potentiality of quantum computers in solving notoriously difficult systems with strongly correlated electronic structures and suggest platinum/cobalt as ideal candidate for showcasing quantum advantage in future applications.
文摘The use of alternative medicine（AM） in Australia dates back to its earliest times,with the indigenous medicine of the aboriginal peoples and the folk medicine of the early English settlers.AM has until recently existed quite separately from Western biomedicine（WB） and there has been little integration of the two systems.Now,referred to as complementary medicine（CM）,there has been a movement over the last 20 years to include CM in WB mainstream practices.Varying degrees of success have been reported but for the discipline of oncology.Medical oncology（MO） in Australia is demanding CM provide high levels of evidence for any inclusion in cancer protocols.There are just now the beginnings of this integration, particularly as CM is now being taught in the public university system to a PhD level as well as the public demand for their medical doctors to communicate with their CM practitioners.MO specialists are now open to a dialogue with their CM counterparts.
