Patients with inflammatory bowel disease(IBD)have an increased risk of deve-loping colorectal cancer,which may ultimately result in peritoneal metastases(PM).PM in patients with IBD is by nature difficult to treat due...Patients with inflammatory bowel disease(IBD)have an increased risk of deve-loping colorectal cancer,which may ultimately result in peritoneal metastases(PM).PM in patients with IBD is by nature difficult to treat due to the chronic inflammation and immunosuppression inherent in IBD.This minireview com-piled existing evidence on management approaches to PM in patients with IBD,including surgical procedures,systemic treatment,and novel therapies.A li-terature review was conducted by searching PubMed and Scopus through June 2025 for studies addressing PM in IBD-associated colorectal or small bowel cancer.Literature specific to PM in IBD is sparse,comprising primarily two small retrospective cohort series comparing outcomes of cytoreductive surgery with hyperthermic intraperitoneal chemotherapy(CRS/HIPEC)in patients with and without IBD.These studies indicated that in high-volume centers with careful preoperative optimization perioperative morbidity and mortality rates for patients with IBD undergoing CRS/HIPEC were similar to those without IBD.However,median overall survival(approximately 19.6-24.0 months)and disease-free survival were consistently shorter and rates of early peritoneal recurrence were higher in patients with IBD.Although CRS/HIPEC can be performed safely in selected patients with IBD and PM,long-term oncologic outcomes appear inferior compared to populations without IBD,likely reflecting later-stage pre-sentation,distinct tumor biology,and IBD-related factors.展开更多
In this article,we discussed the article by Zeng et al,published in a recent issue of the World Journal of Gastroenterology.The publication represents a significant advancement in the prognostic evaluation of rectal n...In this article,we discussed the article by Zeng et al,published in a recent issue of the World Journal of Gastroenterology.The publication represents a significant advancement in the prognostic evaluation of rectal neuroendocrine neoplasms.The GATIS score is a single nomogram model that incorporates five key progno-stic factors:Tumor grade;T stage;tumor size;age;and the prognostic nutritional index.This innovation optimizes the prognostic process,delivering more accurate predictions of overall survival and progression-free survival compared to tradi-tional TNM staging and World Health Organization classification systems.The findings of the study were based on a retrospective analysis spanning 12 years and involving 1408 patients from 17 reference centers in China.In this editorial,we specifically examined the strengths and limitations of the study,the clinical implications of the GATIS score,and the questions arising from its conclusions.展开更多
In this article,we discussed the article by Sohail et al,published in a recent issue of the World Journal of Gastrointestinal Endoscopy.This study highlights the benefits of performing cholecystectomy(CCY)during the s...In this article,we discussed the article by Sohail et al,published in a recent issue of the World Journal of Gastrointestinal Endoscopy.This study highlights the benefits of performing cholecystectomy(CCY)during the same hospitalization for patients with acute cholangitis(AC)associated with gallstones.Specifically,same-admission CCY is associated with significantly lower 30-day readmission rates compared with interval CCY.Furthermore,it has been associated with reduced mortality rates and reduced recurrence of biliary symptoms.Despite these advantages,the procedure is chosen in only a minority of eligible patients.This gap between evidence and practice highlights the need for updated clinical guidelines and further research to optimize the timing of CCY in the management of AC.展开更多
Solitary fibrous tumor(SFT) is a mesenchymal tumor typically located in the pleura,but can also be found as an asymptomatic mass in other areas,including the liver,peritoneum,kidney and salivary glands.However,SFT rar...Solitary fibrous tumor(SFT) is a mesenchymal tumor typically located in the pleura,but can also be found as an asymptomatic mass in other areas,including the liver,peritoneum,kidney and salivary glands.However,SFT rarely locates in the pancreas.We present such a case of pancreatic SFT,along with a review of all reported cases.A 55-year-old man was treated surgically for an asymptomatic pancreatic mass after a rigorous preoperative control.Histologic examination of the resected specimen showed characteristics of an SFT.As only 15 cases of pancreatic SFT have been reported so far,an attempt to compare the cases was considered intriguing.We found that patients with pancreatic SFT were mainly women(81.25%),with a median age of 54 years at the time of diagnosis and a median tumor size of 5.83 cm.Pancreatic SFTs were revealed incidentally in 50% of cases,and all of them showed an enhancement through arterial computed tomography.All tumors were positive for CD34,ten were positive for Bcl-2,and twelve were negative for S100.The diagnosis of this pancreatic tumor is established by a combination of clinical suspicion,imaging procedures and histological findings,and is confirmed by immunohistochemical staining.Although the behavior of SFTs is rather benign,close clinical follow-up is recommended due to a potentially malignant nature.展开更多
BACKGROUND Retrorectal hamartomas or tailgut cysts(TCs)are rare.In most cases,they are asymptomatic and benign;however,rarely,they undergo malignant transformation,mainly in the form of adenocarcinoma.CASE SUMMARY A 5...BACKGROUND Retrorectal hamartomas or tailgut cysts(TCs)are rare.In most cases,they are asymptomatic and benign;however,rarely,they undergo malignant transformation,mainly in the form of adenocarcinoma.CASE SUMMARY A 55-year-old woman presented to our hospital with lower back pain.On magnetic resonance imaging,a large pelvic mass was found,which was located on the right of the ischiorectal fossa,extending to the minor pelvis.The patient underwent extensive surgical resection of the lesion through the right buttock.Histological examination confirmed the diagnosis of a retrorectal mucinous adenocarcinoma originating from a TC.Surgical resection of the tumour was complete,and the patient recovered without complications.The pilonidal sinus was then excised.One year later,semi-annual positron emission tomographycomputed tomography and magnetic resonance imaging scans did not reveal any evidence of local recurrence or metastatic disease.CONCLUSION Preoperative recognition,histological diagnosis,and treatment of TCs pose significant challenges.In addition,the possibility of developing invasive mucinous adenocarcinoma,although rare,should be considered.展开更多
文摘Patients with inflammatory bowel disease(IBD)have an increased risk of deve-loping colorectal cancer,which may ultimately result in peritoneal metastases(PM).PM in patients with IBD is by nature difficult to treat due to the chronic inflammation and immunosuppression inherent in IBD.This minireview com-piled existing evidence on management approaches to PM in patients with IBD,including surgical procedures,systemic treatment,and novel therapies.A li-terature review was conducted by searching PubMed and Scopus through June 2025 for studies addressing PM in IBD-associated colorectal or small bowel cancer.Literature specific to PM in IBD is sparse,comprising primarily two small retrospective cohort series comparing outcomes of cytoreductive surgery with hyperthermic intraperitoneal chemotherapy(CRS/HIPEC)in patients with and without IBD.These studies indicated that in high-volume centers with careful preoperative optimization perioperative morbidity and mortality rates for patients with IBD undergoing CRS/HIPEC were similar to those without IBD.However,median overall survival(approximately 19.6-24.0 months)and disease-free survival were consistently shorter and rates of early peritoneal recurrence were higher in patients with IBD.Although CRS/HIPEC can be performed safely in selected patients with IBD and PM,long-term oncologic outcomes appear inferior compared to populations without IBD,likely reflecting later-stage pre-sentation,distinct tumor biology,and IBD-related factors.
文摘In this article,we discussed the article by Zeng et al,published in a recent issue of the World Journal of Gastroenterology.The publication represents a significant advancement in the prognostic evaluation of rectal neuroendocrine neoplasms.The GATIS score is a single nomogram model that incorporates five key progno-stic factors:Tumor grade;T stage;tumor size;age;and the prognostic nutritional index.This innovation optimizes the prognostic process,delivering more accurate predictions of overall survival and progression-free survival compared to tradi-tional TNM staging and World Health Organization classification systems.The findings of the study were based on a retrospective analysis spanning 12 years and involving 1408 patients from 17 reference centers in China.In this editorial,we specifically examined the strengths and limitations of the study,the clinical implications of the GATIS score,and the questions arising from its conclusions.
文摘In this article,we discussed the article by Sohail et al,published in a recent issue of the World Journal of Gastrointestinal Endoscopy.This study highlights the benefits of performing cholecystectomy(CCY)during the same hospitalization for patients with acute cholangitis(AC)associated with gallstones.Specifically,same-admission CCY is associated with significantly lower 30-day readmission rates compared with interval CCY.Furthermore,it has been associated with reduced mortality rates and reduced recurrence of biliary symptoms.Despite these advantages,the procedure is chosen in only a minority of eligible patients.This gap between evidence and practice highlights the need for updated clinical guidelines and further research to optimize the timing of CCY in the management of AC.
文摘Solitary fibrous tumor(SFT) is a mesenchymal tumor typically located in the pleura,but can also be found as an asymptomatic mass in other areas,including the liver,peritoneum,kidney and salivary glands.However,SFT rarely locates in the pancreas.We present such a case of pancreatic SFT,along with a review of all reported cases.A 55-year-old man was treated surgically for an asymptomatic pancreatic mass after a rigorous preoperative control.Histologic examination of the resected specimen showed characteristics of an SFT.As only 15 cases of pancreatic SFT have been reported so far,an attempt to compare the cases was considered intriguing.We found that patients with pancreatic SFT were mainly women(81.25%),with a median age of 54 years at the time of diagnosis and a median tumor size of 5.83 cm.Pancreatic SFTs were revealed incidentally in 50% of cases,and all of them showed an enhancement through arterial computed tomography.All tumors were positive for CD34,ten were positive for Bcl-2,and twelve were negative for S100.The diagnosis of this pancreatic tumor is established by a combination of clinical suspicion,imaging procedures and histological findings,and is confirmed by immunohistochemical staining.Although the behavior of SFTs is rather benign,close clinical follow-up is recommended due to a potentially malignant nature.
文摘BACKGROUND Retrorectal hamartomas or tailgut cysts(TCs)are rare.In most cases,they are asymptomatic and benign;however,rarely,they undergo malignant transformation,mainly in the form of adenocarcinoma.CASE SUMMARY A 55-year-old woman presented to our hospital with lower back pain.On magnetic resonance imaging,a large pelvic mass was found,which was located on the right of the ischiorectal fossa,extending to the minor pelvis.The patient underwent extensive surgical resection of the lesion through the right buttock.Histological examination confirmed the diagnosis of a retrorectal mucinous adenocarcinoma originating from a TC.Surgical resection of the tumour was complete,and the patient recovered without complications.The pilonidal sinus was then excised.One year later,semi-annual positron emission tomographycomputed tomography and magnetic resonance imaging scans did not reveal any evidence of local recurrence or metastatic disease.CONCLUSION Preoperative recognition,histological diagnosis,and treatment of TCs pose significant challenges.In addition,the possibility of developing invasive mucinous adenocarcinoma,although rare,should be considered.
