Monocytes are effector immune cells but a precise anal-ysis of their role in immune response has been preclud-ed by their heterogeneity. Indeed, human monocytesare composed of at least three different subsets withdiff...Monocytes are effector immune cells but a precise anal-ysis of their role in immune response has been preclud-ed by their heterogeneity. Indeed, human monocytesare composed of at least three different subsets withdifferent phenotypic characteristics and functional prop-erties, the so-called classical, intermediate and non-classical monocytes. A review of the literature showsthat these monocyte subsets are differently affectedduring viral, bacterial, parasitic and fungal infections.The expansion of the CD16＋ compartment （intermedi-ate and non-classical monocytes） is typically observedin the majority of infectious diseases and the increasedproportion of CD16＋ monocytes is likely related totheir activation through their direct interaction with thepathogen or the infammatory context. In contrast, thenumber of non-classical and intermediate monocytesis decreased in Q fever endocarditis, suggesting thatcomplex mechanisms govern the equilibrium among monocyte subsets. The measurement of monocyte sub-sets would be useful in better understanding of the role of monocyte activation in the pathophysiology of infec-tious diseases.展开更多
Ectopic lymphoid structures found within the tumor stroma,such as tertiary lymphoid structures(TLSs),are predictive markers of immune checkpoint blockade(ICB)in solid tumors.In a recent study in Cancer Cell,Duraiswamy...Ectopic lymphoid structures found within the tumor stroma,such as tertiary lymphoid structures(TLSs),are predictive markers of immune checkpoint blockade(ICB)in solid tumors.In a recent study in Cancer Cell,Duraiswamy et al.highlighted other immune structures,such as myeloid antigen-presenting cell(APC)niches,in the context of high-grade serous ovarian cancers(HGSOCs)[1].In these structures,programmed cell death receptor 1(PD-1)^(+)tumor-infiltrating T lymphocytes(TILs)undergo a full activation program(a license to kill)via the CD28 costimulatory molecule during PD-1 blockade in HGSOC.展开更多
文摘Monocytes are effector immune cells but a precise anal-ysis of their role in immune response has been preclud-ed by their heterogeneity. Indeed, human monocytesare composed of at least three different subsets withdifferent phenotypic characteristics and functional prop-erties, the so-called classical, intermediate and non-classical monocytes. A review of the literature showsthat these monocyte subsets are differently affectedduring viral, bacterial, parasitic and fungal infections.The expansion of the CD16＋ compartment （intermedi-ate and non-classical monocytes） is typically observedin the majority of infectious diseases and the increasedproportion of CD16＋ monocytes is likely related totheir activation through their direct interaction with thepathogen or the infammatory context. In contrast, thenumber of non-classical and intermediate monocytesis decreased in Q fever endocarditis, suggesting thatcomplex mechanisms govern the equilibrium among monocyte subsets. The measurement of monocyte sub-sets would be useful in better understanding of the role of monocyte activation in the pathophysiology of infec-tious diseases.
基金The team“Immunity and Cancer”was labeled by the Fondation pour la Recherche Médicale“Equipe FRM DEQ20180339209”.DO is Senior Scholar of the Institut Universitaire de France.
文摘Ectopic lymphoid structures found within the tumor stroma,such as tertiary lymphoid structures(TLSs),are predictive markers of immune checkpoint blockade(ICB)in solid tumors.In a recent study in Cancer Cell,Duraiswamy et al.highlighted other immune structures,such as myeloid antigen-presenting cell(APC)niches,in the context of high-grade serous ovarian cancers(HGSOCs)[1].In these structures,programmed cell death receptor 1(PD-1)^(+)tumor-infiltrating T lymphocytes(TILs)undergo a full activation program(a license to kill)via the CD28 costimulatory molecule during PD-1 blockade in HGSOC.
