Objective:To study the effect of Xueshuantong combined with antioxidant drugs on nerve conduction function and oxidative stress in patients with diabetic peripheral neuropathy. Methods: 138 cases of patients with diab...Objective:To study the effect of Xueshuantong combined with antioxidant drugs on nerve conduction function and oxidative stress in patients with diabetic peripheral neuropathy. Methods: 138 cases of patients with diabetic peripheral neuropathy who were treated in endocrinology department of our hospital between June 2014 and October 2016 were enrolled and randomly divided into two groups. The combination group received Xueshuantong combined with antioxidant drug therapy, and the control group received antioxidant drug therapy. Before and after treatment, the nerve conduction velocity as well as serum content of oxidative stress indexes and nerve cytokines was measured.Results: 4 weeks and 8 weeks after treatment, common peroneal nerve and median nerve MNCV and SNCV as well as serum SOD, GSH-Px, HO-1, CAT, CNTF, BDNF and SDF-1 levels of both groups were significantly higher than those before treatment while serum MDA, AOPP and 8-OHdG levels were significantly lower than those before treatment, and common peroneal nerve and median nerve MNCV and SNCV as well as serum SOD, GSH-Px, HO-1, CAT, CNTF, BDNF and SDF-1 levels of combination group were significantly higher than those of control group while serum MDA, AOPP and 8-OHdG levels were significantly lower than those of control group.Conclusion:Xueshuantong combined with antioxidant drugs can improve the nerve conduction function, inhibit oxidative stress response and improve neurotrophy status in patients with diabetic peripheral neuropathy.展开更多
BACKGROUND Malignant tumors are one of the leading causes of death worldwide,imposing a substantial economic and social burden.Early detection is the key to improving cure rates and reducing mortality rates,which requ...BACKGROUND Malignant tumors are one of the leading causes of death worldwide,imposing a substantial economic and social burden.Early detection is the key to improving cure rates and reducing mortality rates,which requires the development of sensitive early detection technologies.Signal amplification techniques play a crucial role in aptamer-based early detection of tumors and are increasingly garnering attention from researchers.AIM To investigate the current research status,developmental trajectories,and hotspots in signal amplification for aptamer-based tumor detection through bibliometric analysis.METHODS English publications pertaining to signal amplification in aptamer-based tumor detection were retrieved from the Web of Science Core Collection database.VOSviewer and CiteSpace software were employed to analyze various information within this field,including countries,institutions,authors,co-cited authors,journals,co-cited journals,cited references,and keywords.RESULTS A total of 757 publications were included in this study.China accounted for 85.47%of all publications,with Nanjing University(China)emerging as the institution with the highest publication output.The most influential authors and journals were Hasanzadeh M.from Iran and"Biosensors and Bioelectronics",respectively.Exosomes and carcinoembryonic antigen(CEA)stood out as the most researched tumor-related molecules.Currently,the predominant signal amplification technique,nanomaterial,and signal transduction method were identified as hybridization chain reactions,gold nanoparticles,and electrochemical methods,respectively.Over the past 3 years,exosomes,CEA,electrochemical biosensors,and nanosheets have emerged as research hotspots,exhibiting a robust burst of intensity.CONCLUSION This study is the first bibliometric analysis of literature on signal amplification in aptamer-based tumor detection and elucidates the current status,hotspots,and prospective research directions within this realm.Additionally,it provides an important reference for researchers.展开更多
<abstract>Aim: To evaluate the efficacy of biofeedback therapy in patients with chronic pelvic pain syndrome (CPPS). Methods: From November 2001 to April 2002, patients visiting the Urological Outpatient Clinic ...<abstract>Aim: To evaluate the efficacy of biofeedback therapy in patients with chronic pelvic pain syndrome (CPPS). Methods: From November 2001 to April 2002, patients visiting the Urological Outpatient Clinic of this Hospital were evaluated by means of the National Institute of Health Chronic Prostatitis Symptom Index (NIH-CPSI) and classified by the NIH classification standard. Sixty-two patients of CPPS category Ⅲwere involved in this study. All patients had been treated by conventional approaches such as antibiotics and alpha-blockers for more than half a year without any improvement. The expressed prostatic secretion results were as follows: WBC 5 to 9/high power field, lipid +-+++and bacterial culture negative. Their NIH-CPSI were 12-40. All the 62 cases complained of micturitional irritation (frequency, urgency, splitted stream and sense of residual urine), 32 cases, of pain or discomfort at the testicular, penile, scrotal, pelvic or rectal region and 13 cases, of white secretion-dripping. The patients were treated by the Urostym Biofeedback equipment (Laborie Co., Canada) 5 times a week for 2 weeks with a stimulus intensity of 15 mA-23 mA and duration of 20 minutes. Results: Sixty patients were significantly improved or cured, while no significant improvement in the remaining 2. No apparent side effect was observed. The NIH-CPSI dropped to 6 to 14 with an average reduction of 21 (P<0.01). In the 60 improved cases, pain was relieved after 2-3 treatment courses and other symptoms disappeared after 4-5 courses. Conclusion: Biofeedback therapy is a safe and effective treatment for CPPS. Large randomized clinical trials are needed to confirm its efficacy and to explore the mechanism of action.展开更多
Nitrogen-doped porous carbon materials（NPCs） have been successfully fabricated by a simple one-step pyrolysis of diethylenetriaminepentaacetic acid（DTPA） in the presence of KOH. The as-synthesized NPCs displayed a...Nitrogen-doped porous carbon materials（NPCs） have been successfully fabricated by a simple one-step pyrolysis of diethylenetriaminepentaacetic acid（DTPA） in the presence of KOH. The as-synthesized NPCs displayed a high specific surface area(3214 m;g;) and a well-defined porous structure when the annealing temperature reached 800 ℃, which showed superior electrochemical performance as supercapacitor electrode materials. Electrochemical tests showed that the NPCs achieved an impressive specific capacitance of 323 F g;at a current density of 0.5 A g;in 6 M KOH aqueous solution and an outstanding cycle stability, negligible specific capacitance decay after 5000 cycles at 10 A g;. This strategy offered a new insight into the preparation of novel carbon materials for the advanced energy storage devices, such as supercapacitors, fuel cells and lithium ion batteries.展开更多
The exploration of computer vision applications for fabric defect detection has immense potential value.However,current relevant research in this area has primarily focused on detection models that aim for high detect...The exploration of computer vision applications for fabric defect detection has immense potential value.However,current relevant research in this area has primarily focused on detection models that aim for high detection accuracy and algorithmic efficiency,while neglecting the practical industrial production requirements.Therefore,we propose a fabric defect detection and post-processing system that integrates an optimized region with convolutional neural network(CNN)features(i.e.,Faster R-CNN)for defect detection,defect localization and detection model evaluation.In addition,the proposed intelligent system incorporates novel approaches,such as a rearranged fabric dataset,anomaly detection,recommended clipping region division,and a replenishment device.This study illustrates an example of artificial intelligence(AI)-driven automated technology in fabric manufacturing.The accuracy and detection speed of different detection models under identical hardware conditions are evaluated and compared with related work.Experimental results demonstrate that the proposed approach achieves comparable performance to other models,while significantly reducing computational resource requirements.The potential efficiency of using two-stage networks on hardware systems for fabric defect detection tasks is highlighted,which is likely to have relevant implications for the textile industry.展开更多
Objective:The present study aimed to document the economic profiles of inactivated COVID-19 vaccines in Hong Kong SAR,Indonesia,China's Mainland,Philippines,Singapore,and Thailand,the evidence on which is currentl...Objective:The present study aimed to document the economic profiles of inactivated COVID-19 vaccines in Hong Kong SAR,Indonesia,China's Mainland,Philippines,Singapore,and Thailand,the evidence on which is currently absent.Methods:Decision tree models were developed to assess the cost-effectiveness of two doses of inactivated COVID-19 vaccines at a population vaccination rate of 50%in the base case,which was an estimate of feasible vaccination coverage according to previous studies.Epidemiological,mortality,cost,and health state utility information were sourced from the literature.Vaccine efficacy against COVID-19 cases by severity were estimated using metaanalyses of publicly accessible phase 3 trial results of inactivated vaccines.The health outcomes were quantified as quality-adjusted life years(QALYs)and compared across the vaccination and no vaccination strategies.In scenario analyses,incidence and vaccination rates were changed semi-continuously over spectrums,the results of which were presented as contour lines informing the efficiency frontiers of vaccination strategies.Oneway and probabilistic sensitivity analyses were also conducted.Results:The vaccination strategy was dominant in all jurisdictions in the base case by producing 105.18,98.15,99.70,60.48,112.00,and 103.47 QALYs while saving US$40.26 million,US$5.26 million,US$7.60 million,US$5.91 million,US$21.33 million,and US$7.18 million in Hong Kong SAR,Indonesia,China's Mainland,Philippines,Singapore,and Thailand per every 100,000 vaccinated individuals,respectively.Results were robust in alternative model specifications.Conclusions:Inactivated COVID-19 vaccines may be cost-saving options in Hong Kong SAR,Indonesia,China's Mainland,Philippines,Singapore,and Thailand.Mass vaccination programs using inactivated COVID-19 vaccines should be considered in these jurisdictions.展开更多
Summary What is already known about this topic?The coronavirus disease 2019(COVID-19)pandemic has caused severe health consequences.Though most COVID-19 deaths occurred among very old people,their life-year loss might...Summary What is already known about this topic?The coronavirus disease 2019(COVID-19)pandemic has caused severe health consequences.Though most COVID-19 deaths occurred among very old people,their life-year loss might be very large because of their life expectancy at that age.展开更多
文摘Objective:To study the effect of Xueshuantong combined with antioxidant drugs on nerve conduction function and oxidative stress in patients with diabetic peripheral neuropathy. Methods: 138 cases of patients with diabetic peripheral neuropathy who were treated in endocrinology department of our hospital between June 2014 and October 2016 were enrolled and randomly divided into two groups. The combination group received Xueshuantong combined with antioxidant drug therapy, and the control group received antioxidant drug therapy. Before and after treatment, the nerve conduction velocity as well as serum content of oxidative stress indexes and nerve cytokines was measured.Results: 4 weeks and 8 weeks after treatment, common peroneal nerve and median nerve MNCV and SNCV as well as serum SOD, GSH-Px, HO-1, CAT, CNTF, BDNF and SDF-1 levels of both groups were significantly higher than those before treatment while serum MDA, AOPP and 8-OHdG levels were significantly lower than those before treatment, and common peroneal nerve and median nerve MNCV and SNCV as well as serum SOD, GSH-Px, HO-1, CAT, CNTF, BDNF and SDF-1 levels of combination group were significantly higher than those of control group while serum MDA, AOPP and 8-OHdG levels were significantly lower than those of control group.Conclusion:Xueshuantong combined with antioxidant drugs can improve the nerve conduction function, inhibit oxidative stress response and improve neurotrophy status in patients with diabetic peripheral neuropathy.
基金National Natural Science Foundation of China,No.82160494 and No.82160444.
文摘BACKGROUND Malignant tumors are one of the leading causes of death worldwide,imposing a substantial economic and social burden.Early detection is the key to improving cure rates and reducing mortality rates,which requires the development of sensitive early detection technologies.Signal amplification techniques play a crucial role in aptamer-based early detection of tumors and are increasingly garnering attention from researchers.AIM To investigate the current research status,developmental trajectories,and hotspots in signal amplification for aptamer-based tumor detection through bibliometric analysis.METHODS English publications pertaining to signal amplification in aptamer-based tumor detection were retrieved from the Web of Science Core Collection database.VOSviewer and CiteSpace software were employed to analyze various information within this field,including countries,institutions,authors,co-cited authors,journals,co-cited journals,cited references,and keywords.RESULTS A total of 757 publications were included in this study.China accounted for 85.47%of all publications,with Nanjing University(China)emerging as the institution with the highest publication output.The most influential authors and journals were Hasanzadeh M.from Iran and"Biosensors and Bioelectronics",respectively.Exosomes and carcinoembryonic antigen(CEA)stood out as the most researched tumor-related molecules.Currently,the predominant signal amplification technique,nanomaterial,and signal transduction method were identified as hybridization chain reactions,gold nanoparticles,and electrochemical methods,respectively.Over the past 3 years,exosomes,CEA,electrochemical biosensors,and nanosheets have emerged as research hotspots,exhibiting a robust burst of intensity.CONCLUSION This study is the first bibliometric analysis of literature on signal amplification in aptamer-based tumor detection and elucidates the current status,hotspots,and prospective research directions within this realm.Additionally,it provides an important reference for researchers.
文摘<abstract>Aim: To evaluate the efficacy of biofeedback therapy in patients with chronic pelvic pain syndrome (CPPS). Methods: From November 2001 to April 2002, patients visiting the Urological Outpatient Clinic of this Hospital were evaluated by means of the National Institute of Health Chronic Prostatitis Symptom Index (NIH-CPSI) and classified by the NIH classification standard. Sixty-two patients of CPPS category Ⅲwere involved in this study. All patients had been treated by conventional approaches such as antibiotics and alpha-blockers for more than half a year without any improvement. The expressed prostatic secretion results were as follows: WBC 5 to 9/high power field, lipid +-+++and bacterial culture negative. Their NIH-CPSI were 12-40. All the 62 cases complained of micturitional irritation (frequency, urgency, splitted stream and sense of residual urine), 32 cases, of pain or discomfort at the testicular, penile, scrotal, pelvic or rectal region and 13 cases, of white secretion-dripping. The patients were treated by the Urostym Biofeedback equipment (Laborie Co., Canada) 5 times a week for 2 weeks with a stimulus intensity of 15 mA-23 mA and duration of 20 minutes. Results: Sixty patients were significantly improved or cured, while no significant improvement in the remaining 2. No apparent side effect was observed. The NIH-CPSI dropped to 6 to 14 with an average reduction of 21 (P<0.01). In the 60 improved cases, pain was relieved after 2-3 treatment courses and other symptoms disappeared after 4-5 courses. Conclusion: Biofeedback therapy is a safe and effective treatment for CPPS. Large randomized clinical trials are needed to confirm its efficacy and to explore the mechanism of action.
基金financial support from the NSFC(Nos.51361005,U1501242,51371060 and 51671062)the Guangxi Natural Science Foundation(Nos.AD17195073,2014GXNSFAA118319 and 2014GXNAFDA118005)+1 种基金the Guangxi Key Laboratory of Information Materials(Nos.161002-Z and 161002-K)the Guangxi Scientific Technology Team(No.2012GXNSFGA06002)
文摘Nitrogen-doped porous carbon materials（NPCs） have been successfully fabricated by a simple one-step pyrolysis of diethylenetriaminepentaacetic acid（DTPA） in the presence of KOH. The as-synthesized NPCs displayed a high specific surface area(3214 m;g;) and a well-defined porous structure when the annealing temperature reached 800 ℃, which showed superior electrochemical performance as supercapacitor electrode materials. Electrochemical tests showed that the NPCs achieved an impressive specific capacitance of 323 F g;at a current density of 0.5 A g;in 6 M KOH aqueous solution and an outstanding cycle stability, negligible specific capacitance decay after 5000 cycles at 10 A g;. This strategy offered a new insight into the preparation of novel carbon materials for the advanced energy storage devices, such as supercapacitors, fuel cells and lithium ion batteries.
基金supported in part by the Free Exploration Fund of Guangxi Key Laboratory of Structure-Activity Relationship of Electronic Information Materials(No.211019-Z)Guangxi Natural Science Foundation(No.2024GXNSFAA010493)+3 种基金Innovation Project of GUET Graduate Education(No.2022YCXS193)Chinesisch-Deutsche Kooperationsgruppe(No.GZ1528)National Key Research and Development Program(No.SQ2022YFB4000136)Science and Technology Development Project of Guilin(No.20210102-4).
文摘The exploration of computer vision applications for fabric defect detection has immense potential value.However,current relevant research in this area has primarily focused on detection models that aim for high detection accuracy and algorithmic efficiency,while neglecting the practical industrial production requirements.Therefore,we propose a fabric defect detection and post-processing system that integrates an optimized region with convolutional neural network(CNN)features(i.e.,Faster R-CNN)for defect detection,defect localization and detection model evaluation.In addition,the proposed intelligent system incorporates novel approaches,such as a rearranged fabric dataset,anomaly detection,recommended clipping region division,and a replenishment device.This study illustrates an example of artificial intelligence(AI)-driven automated technology in fabric manufacturing.The accuracy and detection speed of different detection models under identical hardware conditions are evaluated and compared with related work.Experimental results demonstrate that the proposed approach achieves comparable performance to other models,while significantly reducing computational resource requirements.The potential efficiency of using two-stage networks on hardware systems for fabric defect detection tasks is highlighted,which is likely to have relevant implications for the textile industry.
文摘Objective:The present study aimed to document the economic profiles of inactivated COVID-19 vaccines in Hong Kong SAR,Indonesia,China's Mainland,Philippines,Singapore,and Thailand,the evidence on which is currently absent.Methods:Decision tree models were developed to assess the cost-effectiveness of two doses of inactivated COVID-19 vaccines at a population vaccination rate of 50%in the base case,which was an estimate of feasible vaccination coverage according to previous studies.Epidemiological,mortality,cost,and health state utility information were sourced from the literature.Vaccine efficacy against COVID-19 cases by severity were estimated using metaanalyses of publicly accessible phase 3 trial results of inactivated vaccines.The health outcomes were quantified as quality-adjusted life years(QALYs)and compared across the vaccination and no vaccination strategies.In scenario analyses,incidence and vaccination rates were changed semi-continuously over spectrums,the results of which were presented as contour lines informing the efficiency frontiers of vaccination strategies.Oneway and probabilistic sensitivity analyses were also conducted.Results:The vaccination strategy was dominant in all jurisdictions in the base case by producing 105.18,98.15,99.70,60.48,112.00,and 103.47 QALYs while saving US$40.26 million,US$5.26 million,US$7.60 million,US$5.91 million,US$21.33 million,and US$7.18 million in Hong Kong SAR,Indonesia,China's Mainland,Philippines,Singapore,and Thailand per every 100,000 vaccinated individuals,respectively.Results were robust in alternative model specifications.Conclusions:Inactivated COVID-19 vaccines may be cost-saving options in Hong Kong SAR,Indonesia,China's Mainland,Philippines,Singapore,and Thailand.Mass vaccination programs using inactivated COVID-19 vaccines should be considered in these jurisdictions.
文摘Summary What is already known about this topic?The coronavirus disease 2019(COVID-19)pandemic has caused severe health consequences.Though most COVID-19 deaths occurred among very old people,their life-year loss might be very large because of their life expectancy at that age.
