Purpose: The present study aimed to assess the accuracies of arterial stimulation with simultaneous venous sampling(ASVS) in preoperative localization of insulinomas. Materials and Methods: A cohort consisting of 6 ma...Purpose: The present study aimed to assess the accuracies of arterial stimulation with simultaneous venous sampling(ASVS) in preoperative localization of insulinomas. Materials and Methods: A cohort consisting of 6 males and 14 females(median age, 48.5y; range, 28–62y) with pathologically proven insulinomas were included in this study. Selective angiographies were performed with the superior mesenteric artery(SMA), gastroduodenal artery(GDA), proximal splenic artery, and midsplenic artery in all individuals. Then ASVS procedures were followed after angiographies for these arteries. Clinical characteristics of the patient and the tumor number, location, and size were recorded. The accuracy of preoperative localization of insulinomas was tested. Results: A total of 22 tumors were identified by histopathological diagnosis. The mean size of the tumor was 1.40±0.60 cm. Five tumors were in the head/neck region and 17 in the body/tail region. ASVS accurately localized 17/20(85%) cases with only biochemical data and 19/20(95%) cases with biochemical data and angiography images. Variant pancreatic arterial anatomy was revealed in 2 false cases with inferior pancreatic artery replaced by the superior mesenteric artery. Conclusion: ASVS was highly accurate in localizing insulinomas and should be performed in most of the patients with suspected insulinomas before the operation.展开更多
A continuous hot embossing method is reported in this paper. The continuous means that the extruder and the hot embossing equipment is used in series, the polymer film is embossed after extrusion immediately. The basi...A continuous hot embossing method is reported in this paper. The continuous means that the extruder and the hot embossing equipment is used in series, the polymer film is embossed after extrusion immediately. The basic principle of this method, the key design point and the corresponding operate process of the embossing equipment is described in this paper. The polymer diffuser with micro-lens matrix on its surface is designed and the optical properties are simulated. Then, the diffuser is fabricated by the embossing equipment. The optical properties of the diffuser are tested and compared with the results of the simulation to verify the reproducibility of the equipment. By this method, the diffuser with large area can be fabricated with high precision of graphic replication, high efficiency and low cost.展开更多
Exposure to indium tin oxide(ITO)nanoparticles(NPs)is strongly correlated with the development of indium lung disease.Preliminary studies have explored mechanisms of ITO NP-induced pulmonary toxicity,but a gap remains...Exposure to indium tin oxide(ITO)nanoparticles(NPs)is strongly correlated with the development of indium lung disease.Preliminary studies have explored mechanisms of ITO NP-induced pulmonary toxicity,but a gap remains in effective methods for risk assessments.To address this issue,we integrated data from population disease databases with traditional toxicology and RNA sequencing to conduct mechanistic studies and establish an adverse outcome pathway(AOP)for ITO NP-induced lung injury.Our findings demonstrate that exposure to ITO NPs induces early pulmonary fibrosis,characterized by a persistent inflammatory response in mice.Mechanistic analysis reveals that lung injury is driven by the activation of the NF-κB signaling pathway mediated by IL-17A in macrophages.In the AOP framework for ITO-induced pulmonary fibrosis,IL-17A serves as a molecular initiating event,initiating the activation of the NF-κB signaling pathway in macrophages.This activation results in the production of inflammatory cytokines(IL-1βand TNF-α)and fibrogenic factors(TGF-β1),ultimately triggering a cellular-level inflammatory response.The sustained inflammation further promotes microvascular leakage,which is a key contributor to the progression of pulmonary fibrosis.The qualitative and quantitative evaluations of supportive inconsistent evidence for MIE and KEs show that the confidence of this AOP is moderate.展开更多
With the rapid development of electronic equipment and communication technology,the demand for polymer composites with high thermal conductivity and mechanical properties has increased significantly.However,its nondeg...With the rapid development of electronic equipment and communication technology,the demand for polymer composites with high thermal conductivity and mechanical properties has increased significantly.However,its nondegradable polymer matrix will inevitably bring more and more serious environmental pollution.Therefore,it is urgent to develop biodegradable thermally conductive polymer composites.In this work,biodegradable poly(butylene adipate-coterephthalate)(PBAT)is used as the matrix material,and vacuum-assisted filtration technology is employed to prepare carbon nanotube(CNT)and cellulose nanocrystal(CNC)networks with high thermal conductivity.Then CNT-CNC/PBAT composites with high thermal conductivity and excellent mechanical properties are prepared by the ultrasonic-assisted forced infiltration method.Both experiment and simulation methods are used to systematically investigate the thermally conductive and dissipation performances of the CNT-CNC/PBAT composites.Above all,a simple alcoholysis reaction is applied to realize the separation of the PBAT matrix and functional fillers without destroying the conductive network skeleton,which makes it possible for the recycling of thermally conductive polymer composites.展开更多
基金This work was supported by the Shanghai Pujiang Program(16PJ1406200)the Scientific Research Innovation Projects of Shanghai Municipal Education Commission(15ZZ060)
文摘Purpose: The present study aimed to assess the accuracies of arterial stimulation with simultaneous venous sampling(ASVS) in preoperative localization of insulinomas. Materials and Methods: A cohort consisting of 6 males and 14 females(median age, 48.5y; range, 28–62y) with pathologically proven insulinomas were included in this study. Selective angiographies were performed with the superior mesenteric artery(SMA), gastroduodenal artery(GDA), proximal splenic artery, and midsplenic artery in all individuals. Then ASVS procedures were followed after angiographies for these arteries. Clinical characteristics of the patient and the tumor number, location, and size were recorded. The accuracy of preoperative localization of insulinomas was tested. Results: A total of 22 tumors were identified by histopathological diagnosis. The mean size of the tumor was 1.40±0.60 cm. Five tumors were in the head/neck region and 17 in the body/tail region. ASVS accurately localized 17/20(85%) cases with only biochemical data and 19/20(95%) cases with biochemical data and angiography images. Variant pancreatic arterial anatomy was revealed in 2 false cases with inferior pancreatic artery replaced by the superior mesenteric artery. Conclusion: ASVS was highly accurate in localizing insulinomas and should be performed in most of the patients with suspected insulinomas before the operation.
文摘A continuous hot embossing method is reported in this paper. The continuous means that the extruder and the hot embossing equipment is used in series, the polymer film is embossed after extrusion immediately. The basic principle of this method, the key design point and the corresponding operate process of the embossing equipment is described in this paper. The polymer diffuser with micro-lens matrix on its surface is designed and the optical properties are simulated. Then, the diffuser is fabricated by the embossing equipment. The optical properties of the diffuser are tested and compared with the results of the simulation to verify the reproducibility of the equipment. By this method, the diffuser with large area can be fabricated with high precision of graphic replication, high efficiency and low cost.
基金supported by the National Natural Science Foundation of China(grant number 82241087&82373618)and SEU Innovation Capability Enhancement Plan for Doctoral Student.
文摘Exposure to indium tin oxide(ITO)nanoparticles(NPs)is strongly correlated with the development of indium lung disease.Preliminary studies have explored mechanisms of ITO NP-induced pulmonary toxicity,but a gap remains in effective methods for risk assessments.To address this issue,we integrated data from population disease databases with traditional toxicology and RNA sequencing to conduct mechanistic studies and establish an adverse outcome pathway(AOP)for ITO NP-induced lung injury.Our findings demonstrate that exposure to ITO NPs induces early pulmonary fibrosis,characterized by a persistent inflammatory response in mice.Mechanistic analysis reveals that lung injury is driven by the activation of the NF-κB signaling pathway mediated by IL-17A in macrophages.In the AOP framework for ITO-induced pulmonary fibrosis,IL-17A serves as a molecular initiating event,initiating the activation of the NF-κB signaling pathway in macrophages.This activation results in the production of inflammatory cytokines(IL-1βand TNF-α)and fibrogenic factors(TGF-β1),ultimately triggering a cellular-level inflammatory response.The sustained inflammation further promotes microvascular leakage,which is a key contributor to the progression of pulmonary fibrosis.The qualitative and quantitative evaluations of supportive inconsistent evidence for MIE and KEs show that the confidence of this AOP is moderate.
基金Basic Science Center Program,Grant/Award Number:51988102National Natural Science Foundation of China,Grant/Award Numbers:52003019,52073011+1 种基金National Natural Science Foundation of China,Sinopec Key Projects,Grant/Award Number:420043-6Talents Introduction Project in Beijing University of Chemical Technology,Grant/Award Number:buctrc201909。
文摘With the rapid development of electronic equipment and communication technology,the demand for polymer composites with high thermal conductivity and mechanical properties has increased significantly.However,its nondegradable polymer matrix will inevitably bring more and more serious environmental pollution.Therefore,it is urgent to develop biodegradable thermally conductive polymer composites.In this work,biodegradable poly(butylene adipate-coterephthalate)(PBAT)is used as the matrix material,and vacuum-assisted filtration technology is employed to prepare carbon nanotube(CNT)and cellulose nanocrystal(CNC)networks with high thermal conductivity.Then CNT-CNC/PBAT composites with high thermal conductivity and excellent mechanical properties are prepared by the ultrasonic-assisted forced infiltration method.Both experiment and simulation methods are used to systematically investigate the thermally conductive and dissipation performances of the CNT-CNC/PBAT composites.Above all,a simple alcoholysis reaction is applied to realize the separation of the PBAT matrix and functional fillers without destroying the conductive network skeleton,which makes it possible for the recycling of thermally conductive polymer composites.
