Lithium-sulfur batteries(LSBs)hold significant promise as advanced energy storage systems due to their high energy density,low cost,and environmental advantages.However,despite recent advancements,their practical ener...Lithium-sulfur batteries(LSBs)hold significant promise as advanced energy storage systems due to their high energy density,low cost,and environmental advantages.However,despite recent advancements,their practical energy density still falls short of the levels required for commercial viability.The energy density is critically dependent on both sulfur loading and the amount of electrolyte used.Highsulfur loading coupled with lean electrolyte conditions presents several challenges,including the insulating nature of sulfur and Li_(2)S,insufficient electrolyte absorption,degradation of the cathode structure,severe lithium polysulfide shuttling,slow redox reaction kinetics,and instability of the Li metal anode.MXenes-based materials,with their metallic conductivity,large polar surfaces,and abundant active sites,have been identified as promising electrocatalysts to improve the redox reactions in LSBs.This review focuses on the significance and challenges associated with high-sulfur loading and lean electrolytes in LSBs,highlighting recent advancements in MXenes-based electrocatalysts aimed at optimizing sulfur cathodes and lithium anodes.It provides a comprehensive discussion on MXenes as both active materials and substrates in LSBs,with the goal of enhancing understanding of the regulatory mechanisms that govern sulfur conversion reactions and lithium plating/stripping behavior.Finally,the review explores future opportunities for MXenes-based electrocatalysts,paving the way for the practical application of LSBs.展开更多
The China Seismo-Electromagnetic Satellite, launched into orbit from Jiuquan Satellite Launch Centre on February 2 nd, 2018, is China's first space satellite dedicated to geophysical exporation. The satellite carr...The China Seismo-Electromagnetic Satellite, launched into orbit from Jiuquan Satellite Launch Centre on February 2 nd, 2018, is China's first space satellite dedicated to geophysical exporation. The satellite carries eight scientific payloads including high-precision magnetometers to detect electromagnetic changes in space, in particular changes associated with global earthquake disasters. In order to encourage and facilitate use by geophysical scientists of data from the satellite's payloads, this paper introduces the application systems developed for the China Seismo-Electromagnetic Satellite by the Institute of Crustal Dynamics, China Earthquake Administration;these include platform construction, data classification, data storage, data format, and data access and acquisition.展开更多
The CSES(China seismic electromagnetic satellite) was launched on February 2, 2018 in a circular polar orbit at an altitude of～507 km. One of the main objectives of CSES is to search for and characterize ionospheric ...The CSES(China seismic electromagnetic satellite) was launched on February 2, 2018 in a circular polar orbit at an altitude of～507 km. One of the main objectives of CSES is to search for and characterize ionospheric perturbations that can be associated with seismic activities, to better understand the generation mechanism of such perturbations. Its scientific payload can measure a broad frequency range of electromagnetic waves and some important plasma parameters. This paper is a first-hand study of unusual observations recorded by the CSES over seismic regions prior to four earthquakes with M >7.0 since the satellite's launch. CSES detectors measured irregularities near the epicenter of these four earthquakes. It is already clear that data from instruments onboard the CSES will be of significant help in studies of characteristics of ionospheric perturbations related to earthquakes and their generation mechanisms.展开更多
Frequency-invariant beamformer （FIB） design is a key issue in wideband array signal processing. To use commonly wideband linear array with tapped delay line （TDL） structure and complex weights, the FIB design is p...Frequency-invariant beamformer （FIB） design is a key issue in wideband array signal processing. To use commonly wideband linear array with tapped delay line （TDL） structure and complex weights, the FIB design is provided according to the rule of minimizing the sidelobe level of the beampattern at the reference frequency while keeping the distortionless response constraint in the mainlobe direction at the reference frequency, the norm constraint of the weight vector and the amplitude constraint of the averaged spatial response variation （SRV）. This kind of beamformer design problem can be solved with the interior-point method after being converted to the form of standard second order cone programming （SOCP）. The computer simulations are presented which illustrate the effectiveness of our FIB design method for the wideband linear array with TDL structure and complex weights.展开更多
The Langmuir Probe(LAP), onboard the China Seismo-Electromagnetic Satellite(CSES), has been designed for in situ measurements of bulk parameters of the ionosphere plasma, the first Chinese application of in-situ measu...The Langmuir Probe(LAP), onboard the China Seismo-Electromagnetic Satellite(CSES), has been designed for in situ measurements of bulk parameters of the ionosphere plasma, the first Chinese application of in-situ measurement technology in the field of space exploration. The two main parameters measured by LAP are electron density and temperature. In this paper, a brief description of the LAP and its work mode are provided. Based on characteristics of the LAP, and assuming an ideal plasma environment, we introduce in detail a method used to invert the I-V curve; the data products that can be accessed by users are shown. Based on the LAP data available, this paper reports that events such as earthquakes and magnetic storms are preceded and followed by obvious abnormal changes. We suggest that LAP could provide a valuable data set for studies of space weather, seismic events, and the ionospheric environment.展开更多
A modulator is an essential building block in the integrated photonics,connecting the electrical with optical signals.The microring modulator gains much attention because of the small footprint,low drive voltage and h...A modulator is an essential building block in the integrated photonics,connecting the electrical with optical signals.The microring modulator gains much attention because of the small footprint,low drive voltage and high extinction ratio.An ultra-low V_(pp)and high-modulation-depth indium phosphide-based racetrack microring modulator is demonstrated in this paper.The proposed device mainly comprises one racetrack microring,incorporating a semiconductor amplifier,and coupling with a bus waveguide through a multimode interference coupler.Traveling wave electrodes are employed to supply bidirectional bias ports,terminating with a 50-Ω impedance.The on/off extinction ratio of the microring reaches 43.3 dB due to the delicately tuning of the gain.An 11 mV V_(pp),a maximum 42.5 dB modulation depth and a 6.6 GHz bandwidth are realized,respectively.This proposed microring modulator could enrich the functionalities and designability of the fundamental integrated devices.展开更多
Organic electrochemical transistors(OECTs)have emerged as one type of promising building block for neuromorphic systems owing to their capability of mimicking the morphology and functions of biological neurons and syn...Organic electrochemical transistors(OECTs)have emerged as one type of promising building block for neuromorphic systems owing to their capability of mimicking the morphology and functions of biological neurons and synapses.Currently,numerous kinds of OECTs have been developed,while self-healing performance has been neglected in most reported OECTs.In this work,the OECTs using self-healing polymer electrolytes as dielectric layers are proposed.Several important synaptic behaviors are simulated in the OECTs by doping the channel layers with ions from the electrolytes.Benefitting from the dynamic hydrogen bonds in the self-healing polymer electrolytes,the OECTs can successfully maintain their electrical performance and the ability of emulating synaptic behaviors after self-healing compared with the initial state.More significantly,the sublinear spatial summation function is demonstrated in the OECTs and their potential in flexible electronics is also validated.These results suggest that our devices are expected to be a vital component in the development of future wearable and bioimplantable neuromorphic systems.展开更多
Internet of Things(IoT)is vulnerable to data-tampering(DT)attacks.Due to resource limitations,many anomaly detection systems(ADSs)for IoT have high false positive rates when detecting DT attacks.This leads to the misr...Internet of Things(IoT)is vulnerable to data-tampering(DT)attacks.Due to resource limitations,many anomaly detection systems(ADSs)for IoT have high false positive rates when detecting DT attacks.This leads to the misreporting of normal data,which will impact the normal operation of IoT.To mitigate the impact caused by the high false positive rate of ADS,this paper proposes an ADS management scheme for clustered IoT.First,we model the data transmission and anomaly detection in clustered IoT.Then,the operation strategy of the clustered IoT is formulated as the running probabilities of all ADSs deployed on every IoT device.In the presence of a high false positive rate in ADSs,to deal with the trade-off between the security and availability of data,we develop a linear programming model referred to as a security trade-off(ST)model.Next,we develop an analysis framework for the ST model,and solve the ST model on an IoT simulation platform.Last,we reveal the effect of some factors on the maximum combined detection rate through theoretical analysis.Simulations show that the ADS management scheme can mitigate the data unavailability loss caused by the high false positive rates in ADS.展开更多
Photodynamic therapy(PDT)has shown great merits in treating microbial in-fections due to its absence of bacterial resistance.However,the pronounced hypoxic microenvironment in the bacterial infections limits the thera...Photodynamic therapy(PDT)has shown great merits in treating microbial in-fections due to its absence of bacterial resistance.However,the pronounced hypoxic microenvironment in the bacterial infections limits the therapeutic effi-ciency of traditional type-II PDT,which is highly dependent on oxygen.Here type-I photosensitizer BTZ_(n)-Py(n=8,20)coordinates with chemical antibacterial agent Agþto fabricate metallo-supramolecular nanofibers.Under light irradiation,the formed nanofibers could not only generate type-Ⅱ reactive oxygen species(ROS),1O2,but also produce type-I ROS O2^(•-)which addressed the hypoxic issues within infected tissues.Moreover,the acid-and photo-active Agþrelease from the nano-fibers endowed the metallo-supramolecular nanofibers with controlled release characteristic,which showed good biocompatibility to normal tissues.Owing to controlled Agþrelease and photoinduced type-I ROS,the in vitro and in vivo ex-periments confirmed the significantly synergistic antibacterial performance of the metallo-supramolecular fibers against both Gram-positive and Gram-negative bacteria.展开更多
Metabolites in skeletal muscles play an important role in their growth,development,immunity and other physiological activities.However,the genetic basis of metabolites in skeletal muscle remains poorly understood.Here...Metabolites in skeletal muscles play an important role in their growth,development,immunity and other physiological activities.However,the genetic basis of metabolites in skeletal muscle remains poorly understood.Here,we identified 247 candidate divergent regions containing 905 protein-coding genes closely related to metabolic pathways,including lysine degradation and fatty acid biosynthesis.We then profiled 3,060 metabolites in 246 skeletal muscle samples from F_2 segregating population generated by mallard×Pekin duck crosses using metabolomic approaches.We identified 2,044 significant metabolome-based GWAS signals and 21 candidate genes potentially modulating metabolite contents in skeletal muscle.Among them,the levels of 2-aminoadipic acid in skeletal muscle were significantly correlated with body weight and intramuscular fat content,determined by a 939-bp CR1 LINE insertion in AADAT.We further found that the CR1 LINE insertion most possibly led to a splice mutation in AADAT,resulting in the downregulation of the lysine degradation pathway in skeletal muscle.Moreover,intramuscular fat content and fatty acids biosynthesis pathway was significantly increased in individuals with CR1 LINE insertion.This study enhances our understanding of the genetic basis of skeletal muscle metabolic traits and promotes the efficient utilization of metabolite traits in the genetic improvement of animals.展开更多
Significant attenuation and overheating, caused by the absorption of the excitation band （980 nm） in water, are the major obstacles in the in vivo application of lanthanide-doped upconversion nanoparticles （UCNPs）...Significant attenuation and overheating, caused by the absorption of the excitation band （980 nm） in water, are the major obstacles in the in vivo application of lanthanide-doped upconversion nanoparticles （UCNPs）. Therefore, appropriately- structured Nd3^＋-doped UCNPs with 808 nm excitation could be a promising alternative. Herein, we developed core-shell-shell structured Nd3^＋-sensitized UCNPs as imaging agents, and decorated them onto the surface of polydopamine （PDA） to construct a novel multifunctional core/satellite nanotheranostic （PDA@UCNPs） for in vivo imaging guidance photothermal therapy using single 808 nm laser irradiation. The core-shell-shell structured design enabled outstanding upconversion luminescence properties and strong X-ray attenuation, thereby making the nanocomposites potential candidates for excellent upconversion luminescence/computed tomography dual modal imaging. In addition, the PDA core not only provides high photothermal conversion efficiency and outstanding antitumor effect, but also endows the platform with robust biocompatibility owing to its natural features. Therefore, this multifunctional nanocomposite could be a promising theranostic in future oncotherapy, with high therapeutic effectiveness but low side effects. This study would stimulate interest in designing bio- application-compatible multifunctional nanocomposites, especially for cancer diagnosis and treatment in vivo.展开更多
Fibrous nanofluidic materials are ideal building blocks for implantable electrode,biomimetic actuator,wearable electronics due to their favorable features of intrinsic flexibility and unidirectional ion transport.Howe...Fibrous nanofluidic materials are ideal building blocks for implantable electrode,biomimetic actuator,wearable electronics due to their favorable features of intrinsic flexibility and unidirectional ion transport.However,the large-scale preparation of fibrous nanofluidic materials with desirable mechanical strength and good environment adaptability for practical use remains challenging.Herein,by fully taking advantage of the attractive mechanical,structural,chemical features of boron nitride(BN)nanosheet and nanofibrillated cellulose(NFC),a scalable and cost-effective three-dimensional(3D)printed macrofiber featuring abundant vertically aligned nanofluidic channels is demonstrated to exhibit a good combination of high tensile strength of 100 MPa,thermal stability of up to 230℃,ionic conductivity of 1.8×10^(−4)S/cm at low salt concentrations(<10^(−3)M).In addition,the versatile surface chemistry of cellulose allows us to stabilize the macrofiber at the molecular level via a facile postcross-linking method,which eventually enables the stable operation of the modified macrofiber in various extreme environments such as strong acidic,strong alkaline,high temperature.We believe this work implies a promising guideline for designing and manufacturing fibrous nanodevices towards extreme environment operations.展开更多
Organic field-effect transistors（OFETs） offer great potential applications in chemical and biological sensing for homeland security,environmental monitoring,industry manufacturing,and medical/biological detection. M...Organic field-effect transistors（OFETs） offer great potential applications in chemical and biological sensing for homeland security,environmental monitoring,industry manufacturing,and medical/biological detection. Many studies concentrate on sensitivity and selectivity improvement of OFET-based sensors. We report four organic semiconductors with different alkyl side chain lengths but the same π-conjugated core structure for OFETs. Our work focuses on the molecular structure of organic semiconductors（OSCs）. Alkyl side chains can hinder the diffusion of ammonia into the OSCs layer,which blocks the interaction between ammonia and conducting channel. The result also reveals the relationship between the alky chain and the film thickness in sensitivity control. These results are expected to be a guide to the molecular design of organic semiconductors and the choice of OSCs.展开更多
In this study, Co3O4@CeO2 core@shell nanowires were successfully prepared via thermal decomposition of Co（CO3）0.5（OH）.0.11H2O@CeO2 core@shell nanowire precursors. As a CO oxidation catalyst, Co3O4@CeO2 shows remar...In this study, Co3O4@CeO2 core@shell nanowires were successfully prepared via thermal decomposition of Co（CO3）0.5（OH）.0.11H2O@CeO2 core@shell nanowire precursors. As a CO oxidation catalyst, Co3O4@CeO2 shows remarkably enhanced catalytic performance compared to Co3O4 nanowires and CeO2 nanoparticles （NPs）, indicating obvious synergistic effects between the two components. It also suggests that the CeO2 shell coating can effectively prevent Co3O4 nanowires from agglomerating, hence effecting a substantial improvement in the structural stability of the Co3O4 catalyst. Furthermore, the fabrication of the welbdisperse4 core@shell structure results in a maximized interface area between Co3O4 and CeO2, as well as a reduced Co3O4 size, which may be responsible for the enhanced catalytic activity of Co3O4@CeO2. Further examination revealed that CO oxidation may occur at the interface of Co3O4 and CeO2. The influence of calcination temperatures and the component ratio between Co3O4 and CeO2 were then investigated in detail to determine the catalytic performance of Co3O4@CeO2 core@shell nanowires, the best of which was obtained by calcination at 250 ℃ for 3 h with a Ce molar concentration of about 38.5%. This sample achieved 100% CO conversion at a reduced temperature of 160 ℃. More importantly, more than 2.5 g of the Co3O4@CeO2 core@shell nanowires were produced in one pot by this simple process, which may be beneficial for practical applications as automobile-exhaust gas-treatment catalysts.展开更多
基金supported by the Research Funding of Hangzhou International Innovation Institute of Beihang University(Grant No.2024KQ102 and 2024KQ131)the National Natural Science Foundation of China(Grant No.524B2020,51925202,U22A20141,52432004,U23A20575,52472183,and 22379039).
文摘Lithium-sulfur batteries(LSBs)hold significant promise as advanced energy storage systems due to their high energy density,low cost,and environmental advantages.However,despite recent advancements,their practical energy density still falls short of the levels required for commercial viability.The energy density is critically dependent on both sulfur loading and the amount of electrolyte used.Highsulfur loading coupled with lean electrolyte conditions presents several challenges,including the insulating nature of sulfur and Li_(2)S,insufficient electrolyte absorption,degradation of the cathode structure,severe lithium polysulfide shuttling,slow redox reaction kinetics,and instability of the Li metal anode.MXenes-based materials,with their metallic conductivity,large polar surfaces,and abundant active sites,have been identified as promising electrocatalysts to improve the redox reactions in LSBs.This review focuses on the significance and challenges associated with high-sulfur loading and lean electrolytes in LSBs,highlighting recent advancements in MXenes-based electrocatalysts aimed at optimizing sulfur cathodes and lithium anodes.It provides a comprehensive discussion on MXenes as both active materials and substrates in LSBs,with the goal of enhancing understanding of the regulatory mechanisms that govern sulfur conversion reactions and lithium plating/stripping behavior.Finally,the review explores future opportunities for MXenes-based electrocatalysts,paving the way for the practical application of LSBs.
基金supported by the Civil Space Research project (ZH1 data validation: Ionospheric observatory theory)NFSC grant 41574139 and 41874174
文摘The China Seismo-Electromagnetic Satellite, launched into orbit from Jiuquan Satellite Launch Centre on February 2 nd, 2018, is China's first space satellite dedicated to geophysical exporation. The satellite carries eight scientific payloads including high-precision magnetometers to detect electromagnetic changes in space, in particular changes associated with global earthquake disasters. In order to encourage and facilitate use by geophysical scientists of data from the satellite's payloads, this paper introduces the application systems developed for the China Seismo-Electromagnetic Satellite by the Institute of Crustal Dynamics, China Earthquake Administration;these include platform construction, data classification, data storage, data format, and data access and acquisition.
基金supported by the National Natural Science Foundation of China (41404058)
文摘The CSES(China seismic electromagnetic satellite) was launched on February 2, 2018 in a circular polar orbit at an altitude of～507 km. One of the main objectives of CSES is to search for and characterize ionospheric perturbations that can be associated with seismic activities, to better understand the generation mechanism of such perturbations. Its scientific payload can measure a broad frequency range of electromagnetic waves and some important plasma parameters. This paper is a first-hand study of unusual observations recorded by the CSES over seismic regions prior to four earthquakes with M >7.0 since the satellite's launch. CSES detectors measured irregularities near the epicenter of these four earthquakes. It is already clear that data from instruments onboard the CSES will be of significant help in studies of characteristics of ionospheric perturbations related to earthquakes and their generation mechanisms.
基金supported by the President Award of Chinese Academy of Sciences (O729031511)
文摘Frequency-invariant beamformer （FIB） design is a key issue in wideband array signal processing. To use commonly wideband linear array with tapped delay line （TDL） structure and complex weights, the FIB design is provided according to the rule of minimizing the sidelobe level of the beampattern at the reference frequency while keeping the distortionless response constraint in the mainlobe direction at the reference frequency, the norm constraint of the weight vector and the amplitude constraint of the averaged spatial response variation （SRV）. This kind of beamformer design problem can be solved with the interior-point method after being converted to the form of standard second order cone programming （SOCP）. The computer simulations are presented which illustrate the effectiveness of our FIB design method for the wideband linear array with TDL structure and complex weights.
基金supported by the National Natural Science Foundation of China (41404058)Beijing Natural Science Foundation (8184091)
文摘The Langmuir Probe(LAP), onboard the China Seismo-Electromagnetic Satellite(CSES), has been designed for in situ measurements of bulk parameters of the ionosphere plasma, the first Chinese application of in-situ measurement technology in the field of space exploration. The two main parameters measured by LAP are electron density and temperature. In this paper, a brief description of the LAP and its work mode are provided. Based on characteristics of the LAP, and assuming an ideal plasma environment, we introduce in detail a method used to invert the I-V curve; the data products that can be accessed by users are shown. Based on the LAP data available, this paper reports that events such as earthquakes and magnetic storms are preceded and followed by obvious abnormal changes. We suggest that LAP could provide a valuable data set for studies of space weather, seismic events, and the ionospheric environment.
基金supported by the National Natural Science Foundation of China(61535012,61925505)the National Key R&D Program of China(2018YFB2201900)。
文摘A modulator is an essential building block in the integrated photonics,connecting the electrical with optical signals.The microring modulator gains much attention because of the small footprint,low drive voltage and high extinction ratio.An ultra-low V_(pp)and high-modulation-depth indium phosphide-based racetrack microring modulator is demonstrated in this paper.The proposed device mainly comprises one racetrack microring,incorporating a semiconductor amplifier,and coupling with a bus waveguide through a multimode interference coupler.Traveling wave electrodes are employed to supply bidirectional bias ports,terminating with a 50-Ω impedance.The on/off extinction ratio of the microring reaches 43.3 dB due to the delicately tuning of the gain.An 11 mV V_(pp),a maximum 42.5 dB modulation depth and a 6.6 GHz bandwidth are realized,respectively.This proposed microring modulator could enrich the functionalities and designability of the fundamental integrated devices.
基金supported by the National Key Research and Development Program of China(No.2021YFA1101303)the National Natural Science Foundation of China(Nos.62074111,62088101)+2 种基金the Science&Technology Foundation of Shanghai(No.20JC1415600)Shanghai Municipal Science and Technology Major Project(No.2021SHZDZX0100)the Innovation Program of Shanghai Municipal Education Commission(No.2021-01-07-0007-E00096)。
文摘Organic electrochemical transistors(OECTs)have emerged as one type of promising building block for neuromorphic systems owing to their capability of mimicking the morphology and functions of biological neurons and synapses.Currently,numerous kinds of OECTs have been developed,while self-healing performance has been neglected in most reported OECTs.In this work,the OECTs using self-healing polymer electrolytes as dielectric layers are proposed.Several important synaptic behaviors are simulated in the OECTs by doping the channel layers with ions from the electrolytes.Benefitting from the dynamic hydrogen bonds in the self-healing polymer electrolytes,the OECTs can successfully maintain their electrical performance and the ability of emulating synaptic behaviors after self-healing compared with the initial state.More significantly,the sublinear spatial summation function is demonstrated in the OECTs and their potential in flexible electronics is also validated.These results suggest that our devices are expected to be a vital component in the development of future wearable and bioimplantable neuromorphic systems.
基金This study was funded by the Chongqing Normal University Startup Foundation for PhD(22XLB021)was also supported by the Open Research Project of the State Key Laboratory of Industrial Control Technology,Zhejiang University,China(No.ICT2023B40).
文摘Internet of Things(IoT)is vulnerable to data-tampering(DT)attacks.Due to resource limitations,many anomaly detection systems(ADSs)for IoT have high false positive rates when detecting DT attacks.This leads to the misreporting of normal data,which will impact the normal operation of IoT.To mitigate the impact caused by the high false positive rate of ADS,this paper proposes an ADS management scheme for clustered IoT.First,we model the data transmission and anomaly detection in clustered IoT.Then,the operation strategy of the clustered IoT is formulated as the running probabilities of all ADSs deployed on every IoT device.In the presence of a high false positive rate in ADSs,to deal with the trade-off between the security and availability of data,we develop a linear programming model referred to as a security trade-off(ST)model.Next,we develop an analysis framework for the ST model,and solve the ST model on an IoT simulation platform.Last,we reveal the effect of some factors on the maximum combined detection rate through theoretical analysis.Simulations show that the ADS management scheme can mitigate the data unavailability loss caused by the high false positive rates in ADS.
基金supported financially by the National Key Research and Development Program of China(2023YFC 3403000)the National Natural Science Foundation of China(22378231)the Guangdong Basic and Applied Basic Research Foundation(2024A1515012493).
文摘Photodynamic therapy(PDT)has shown great merits in treating microbial in-fections due to its absence of bacterial resistance.However,the pronounced hypoxic microenvironment in the bacterial infections limits the therapeutic effi-ciency of traditional type-II PDT,which is highly dependent on oxygen.Here type-I photosensitizer BTZ_(n)-Py(n=8,20)coordinates with chemical antibacterial agent Agþto fabricate metallo-supramolecular nanofibers.Under light irradiation,the formed nanofibers could not only generate type-Ⅱ reactive oxygen species(ROS),1O2,but also produce type-I ROS O2^(•-)which addressed the hypoxic issues within infected tissues.Moreover,the acid-and photo-active Agþrelease from the nano-fibers endowed the metallo-supramolecular nanofibers with controlled release characteristic,which showed good biocompatibility to normal tissues.Owing to controlled Agþrelease and photoinduced type-I ROS,the in vitro and in vivo ex-periments confirmed the significantly synergistic antibacterial performance of the metallo-supramolecular fibers against both Gram-positive and Gram-negative bacteria.
基金supported by grants from the National Science Fund for Distinguished Young Scholars (32325047)the Innovation Program of Chinese Academy of Agricultural Sciences (CAAS-CS-202201)+1 种基金the China Agriculture Research System of MOF and MARA (CARS-42-05)the National Key R&D Program of China (2023YFD1300300,2022YFF1000100)。
文摘Metabolites in skeletal muscles play an important role in their growth,development,immunity and other physiological activities.However,the genetic basis of metabolites in skeletal muscle remains poorly understood.Here,we identified 247 candidate divergent regions containing 905 protein-coding genes closely related to metabolic pathways,including lysine degradation and fatty acid biosynthesis.We then profiled 3,060 metabolites in 246 skeletal muscle samples from F_2 segregating population generated by mallard×Pekin duck crosses using metabolomic approaches.We identified 2,044 significant metabolome-based GWAS signals and 21 candidate genes potentially modulating metabolite contents in skeletal muscle.Among them,the levels of 2-aminoadipic acid in skeletal muscle were significantly correlated with body weight and intramuscular fat content,determined by a 939-bp CR1 LINE insertion in AADAT.We further found that the CR1 LINE insertion most possibly led to a splice mutation in AADAT,resulting in the downregulation of the lysine degradation pathway in skeletal muscle.Moreover,intramuscular fat content and fatty acids biosynthesis pathway was significantly increased in individuals with CR1 LINE insertion.This study enhances our understanding of the genetic basis of skeletal muscle metabolic traits and promotes the efficient utilization of metabolite traits in the genetic improvement of animals.
基金Acknowledgements This work was supported by the financial aid from the National Natural Science Foundation of China （Nos. 51502284, 51372242, 51402286, 21521092, 21590794, and 21210001）, the Hong Kong, Macao and Taiwan Science and Technology Cooperation Special Project of Ministry of Science and Technology of China （No. 2014DFT10310）, the Program of Science and Technology Development Plan of Jilin Province of China （No. 20140201007GX）, the National Basic Research Program of China （No. 2014CB643802）, the Strategic Priority Research Program of the Chinese Academy of Sciences （No. XDB20030300） and the Jilin Province Youth Foundation （No. 20150520007JH）.
文摘Significant attenuation and overheating, caused by the absorption of the excitation band （980 nm） in water, are the major obstacles in the in vivo application of lanthanide-doped upconversion nanoparticles （UCNPs）. Therefore, appropriately- structured Nd3^＋-doped UCNPs with 808 nm excitation could be a promising alternative. Herein, we developed core-shell-shell structured Nd3^＋-sensitized UCNPs as imaging agents, and decorated them onto the surface of polydopamine （PDA） to construct a novel multifunctional core/satellite nanotheranostic （PDA@UCNPs） for in vivo imaging guidance photothermal therapy using single 808 nm laser irradiation. The core-shell-shell structured design enabled outstanding upconversion luminescence properties and strong X-ray attenuation, thereby making the nanocomposites potential candidates for excellent upconversion luminescence/computed tomography dual modal imaging. In addition, the PDA core not only provides high photothermal conversion efficiency and outstanding antitumor effect, but also endows the platform with robust biocompatibility owing to its natural features. Therefore, this multifunctional nanocomposite could be a promising theranostic in future oncotherapy, with high therapeutic effectiveness but low side effects. This study would stimulate interest in designing bio- application-compatible multifunctional nanocomposites, especially for cancer diagnosis and treatment in vivo.
文摘Fibrous nanofluidic materials are ideal building blocks for implantable electrode,biomimetic actuator,wearable electronics due to their favorable features of intrinsic flexibility and unidirectional ion transport.However,the large-scale preparation of fibrous nanofluidic materials with desirable mechanical strength and good environment adaptability for practical use remains challenging.Herein,by fully taking advantage of the attractive mechanical,structural,chemical features of boron nitride(BN)nanosheet and nanofibrillated cellulose(NFC),a scalable and cost-effective three-dimensional(3D)printed macrofiber featuring abundant vertically aligned nanofluidic channels is demonstrated to exhibit a good combination of high tensile strength of 100 MPa,thermal stability of up to 230℃,ionic conductivity of 1.8×10^(−4)S/cm at low salt concentrations(<10^(−3)M).In addition,the versatile surface chemistry of cellulose allows us to stabilize the macrofiber at the molecular level via a facile postcross-linking method,which eventually enables the stable operation of the modified macrofiber in various extreme environments such as strong acidic,strong alkaline,high temperature.We believe this work implies a promising guideline for designing and manufacturing fibrous nanodevices towards extreme environment operations.
基金financially supported by the National Natural Science Foundation of China(21302142 and 51603151)the National Key Research and Development Program of China(2017YFA0103900 and 2017YFA0103904)+1 种基金the 1000 Youth Talent Planthe Fundamental Research Funds for the Central Universities of China
文摘Organic field-effect transistors（OFETs） offer great potential applications in chemical and biological sensing for homeland security,environmental monitoring,industry manufacturing,and medical/biological detection. Many studies concentrate on sensitivity and selectivity improvement of OFET-based sensors. We report four organic semiconductors with different alkyl side chain lengths but the same π-conjugated core structure for OFETs. Our work focuses on the molecular structure of organic semiconductors（OSCs）. Alkyl side chains can hinder the diffusion of ammonia into the OSCs layer,which blocks the interaction between ammonia and conducting channel. The result also reveals the relationship between the alky chain and the film thickness in sensitivity control. These results are expected to be a guide to the molecular design of organic semiconductors and the choice of OSCs.
基金This work was supported by the financial aid from the National Natural Science Foundation of China （Nos. 91122030, 51272249, 21210001, 21221061 and 21401186）, and the National Key Basic Research Program of China （No. 2014CB643802）.
文摘In this study, Co3O4@CeO2 core@shell nanowires were successfully prepared via thermal decomposition of Co（CO3）0.5（OH）.0.11H2O@CeO2 core@shell nanowire precursors. As a CO oxidation catalyst, Co3O4@CeO2 shows remarkably enhanced catalytic performance compared to Co3O4 nanowires and CeO2 nanoparticles （NPs）, indicating obvious synergistic effects between the two components. It also suggests that the CeO2 shell coating can effectively prevent Co3O4 nanowires from agglomerating, hence effecting a substantial improvement in the structural stability of the Co3O4 catalyst. Furthermore, the fabrication of the welbdisperse4 core@shell structure results in a maximized interface area between Co3O4 and CeO2, as well as a reduced Co3O4 size, which may be responsible for the enhanced catalytic activity of Co3O4@CeO2. Further examination revealed that CO oxidation may occur at the interface of Co3O4 and CeO2. The influence of calcination temperatures and the component ratio between Co3O4 and CeO2 were then investigated in detail to determine the catalytic performance of Co3O4@CeO2 core@shell nanowires, the best of which was obtained by calcination at 250 ℃ for 3 h with a Ce molar concentration of about 38.5%. This sample achieved 100% CO conversion at a reduced temperature of 160 ℃. More importantly, more than 2.5 g of the Co3O4@CeO2 core@shell nanowires were produced in one pot by this simple process, which may be beneficial for practical applications as automobile-exhaust gas-treatment catalysts.
