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高脂饮食与1,2-二甲基肼对大鼠肠道的作用及抗氧化机制研究 被引量:1
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作者 杜艳平 区俊文 +2 位作者 习文韬 金昭延 杨鹏程 《海南医学》 CAS 2020年第3期273-276,共4页
目的研究高脂饮食与1,2-二甲基肼(DMH)对回肠及结肠的影响,并探讨其可能的作用机制。方法将30只SD大鼠按照随机分组的方法分为对照组、DMH组和DMH+高脂组,每组10只。除对照组外,另外两组大鼠颈部皮下注射0.4%的DMH溶液,对照组和DMH组给... 目的研究高脂饮食与1,2-二甲基肼(DMH)对回肠及结肠的影响,并探讨其可能的作用机制。方法将30只SD大鼠按照随机分组的方法分为对照组、DMH组和DMH+高脂组,每组10只。除对照组外,另外两组大鼠颈部皮下注射0.4%的DMH溶液,对照组和DMH组给予普通饲料,DMH+高脂组给予高脂饲料,实验第15 d,处死大鼠后制作回肠及结肠切片,采用HE染色法观察肠道病理;制作回肠和结肠匀浆,按试剂盒说明方法,分别检测各组大鼠肠组织匀浆的总抗氧化能力(T-AOC)、丙二醛(MDA)和一氧化氮(NO)含量,超氧化物歧化酶(SOD)和髓过氧化物酶(MPO)活性。结果DMH组大鼠体质量增长缓慢,第6天后低于对照组和DMH+高脂组,差异均有统计学意义(P<0.05);实验第15天,注射DMH的两组大鼠均见回肠和结肠损伤,DMH组大鼠回肠湿重和结肠湿重分别为(40.54±4.15)mg/cm和(63.79±5.07)mg/cm,DMH+高脂组分别为(41.60±5.06)mg/cm和(62.47±4.96)mg/cm,明显低于对照组的(47.96±4.69)mg/cm和(69.25±3.61)mg/cm,差异均具有统计学意义(P<0.05);对照组、DMH组、DMH+高脂组大鼠回肠T-AOC分别为(1.939±0.546)U/mg、(2.669±0.737)U/mg、(3.338±0.539)U/mg,结肠T-AOC分别为(0.5637±0.054)U/mg、(0.7846±0.094)U/mg、(0.7886±0.100)U/mg,回肠MDA分别为(1.542±0.357)nmol/mg、(2.028±0.443)nmol/mg、(2.472±0.560)nmol/mg,结肠MDA分别为(1.502±0.350)nmol/mg、(2.217±0.629)nmol/mg、(2.368±0.406)nmol/mg,回肠SOD分别为(32.68±3.915)U/mg、(32.17±3.447)U/mg、(29.85±2.261)U/mg,结肠SOD分别为(37.58±3.583)U/mg、(33.92±3.756)U/mg、(30.73±2.697)U/mg,回肠MPO分别为(0.5938±0.059)U/mg、(0.5938±0.059)U/mg、(0.6809±0.079)U/mg,结肠MPO分别为(0.6218±0.036)U/mg、(0.7756±0.066)U/mg、(0.7649±0.086)U/mg,回肠NO分别为(1.513±0.389)μmol/g、(2.237±0.523)μmol/g、(2.113±0.620)μmol/g,结肠NO分别为(1.561±0.243)μmol/g、(2.094±0.545)μmol/g、(2.372±0.435)μmol/g,注射DMH的两组大鼠回肠和结肠中T-AOC、MDA、MPO和NO明显高于对照组,而结肠中SOD明显低于对照组,其中DMH+高脂组大鼠的T-AOC、MDA明显高于DMH组,而SOD水平明显低于DMH组,差异均有统计学意义(P<0.05)。结论高脂饮食可加重DMH所致的肠道损伤,促进肠道氧化-抗氧化系统失衡,在诱发大鼠结肠癌的过程中可能起重要作用。 展开更多
关键词 高脂饮食 肠道损伤 脂质过氧化 氧化应激 抗氧化作用
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Effect of SEN Parameters on 3D Flow Field in Mould of Beam Blank Continuous Caster
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作者 YANGJian-wei duyan-ping +2 位作者 SHIRong CUIXiao-chao LIUCai 《Journal of Iron and Steel Research International》 SCIE EI CAS CSCD 2004年第6期20-24,共5页
Due to the complexity of thickness and shape synthetical adjustment system and the difficulties to build a mathematical model, a thickness and shape synthetical adjustment scheme on DC mill based on dynamic nerve-fuzz... Due to the complexity of thickness and shape synthetical adjustment system and the difficulties to build a mathematical model, a thickness and shape synthetical adjustment scheme on DC mill based on dynamic nerve-fuzzy control was put forward, and a self-organizing fuzzy control model was established. The structure of the network can be optimized dynamically. In the course of studying, the network can automatically adjust its structure based on the specific questions and make its structure the optimal. The input and output of the network are fuzzy sets, and the trained network can complete the composite relation, the fuzzy inference. For decreasing the off-line training time of BP network, the fuzzy sets are encoded. The simulation results indicate that the self-organizing fuzzy control based on dynamic neural network is better than traditional decoupling PID control. 展开更多
关键词 dynamic BP network self-organizing fuzzy control encode DC mill thickness SHAPE synthetical adjustment
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