Glutathione(GSH) and GSH-related enzymes play a great role in protecting organisms from oxidative damage. The GSH level and GSH-related enzymes activities were investigated as well as the growth yield and malonyldiald...Glutathione(GSH) and GSH-related enzymes play a great role in protecting organisms from oxidative damage. The GSH level and GSH-related enzymes activities were investigated as well as the growth yield and malonyldialdehyde(MDA) content in the Antarctic ice microalga Chlamydomonas sp. ICE-L exposure to the different cadmium concentration in this paper. The results showed that the higher concentration Cd inhibited the growth of ICE-L significantly and Cd would induce formation of MDA. At the same time, it is clear that GSH level, glutathione peroxidases(GPx) activity and glutathione S\|transferases(GST), activity were higher in ICE-L exposed to Cd than the control. But GR activity dropped notably when ICE-L were cultured in the medium containing Cd. Increase of GSH level, GPx and GST activities acclimate to oxidative stress induced by Cd and protect Antarctic ice microalga Chlamydomonas sp. ICE-L from toxicity caused by Cd exposure. These parameters may be used to assess the biological impact of Cd in the Antarctic pole region environment.展开更多
OBJECTIVE To observe the effects and adverse reactions of a OXA-HCPT LV/5FU 3 regimen for patients with advanced gastric cancer.METHODS OHLF3 regimen: OXA 130 mg/m^2iv d 1, HCPT6 mg/m^2, iv d 1-5, LV 200 mg/m2iv 2 h f...OBJECTIVE To observe the effects and adverse reactions of a OXA-HCPT LV/5FU 3 regimen for patients with advanced gastric cancer.METHODS OHLF3 regimen: OXA 130 mg/m^2iv d 1, HCPT6 mg/m^2, iv d 1-5, LV 200 mg/m2iv 2 h followed by a 5FU 400 mg/m2 iv bolus and 5FU 600mg/m2 iv d 1-3, were given, every 21 days as 1 cycle. Assessment of the tumor was conducted after 3 cycles and the effective cases were confirmed after 4 weeks.RESULTS Among 39 patients, 36 were actually evaluable. Overall response rates (CR + PR} were 50%' the major adverse reactions were mild hematological toxicity, nausea and vomiting and peripheral nerve abnormalities.CONCLUSION The OHLF 3 regimen using OXA and HCPT is effective and results in mild toxicity when used in combined chemotherapy for advanced gastric cancer.展开更多
Commercial health insurance is the standard configuration of life insurance. It can make the insured get a compensation for the cost when they are ill or injured again, reducing their own pressure. However, the develo...Commercial health insurance is the standard configuration of life insurance. It can make the insured get a compensation for the cost when they are ill or injured again, reducing their own pressure. However, the development of commercial insurance in China is relatively late. At present, the state attaches great importance to the commercial insurance policy. For this situation, the state has issued a series of insurance policies. In this regard, the government of Hefei actively responded to the call of the state and attached great importance to the policy of commercial insurance, so that every insured can be assured. Although the continuous improvement of Hefeis commercial medical insurance system has provided a good guarantee for the economic development and the safety of peoples lives in Hefei, we must also be soberly aware that the current commercial medical insurance in Hefei is still in its infancy. Based on the actual development situation, this paper first analyzes the development trend and current situation of commercial health insurance in Hefei through a questionnaire survey, pointing out that the overall level of commercial health insurance in Hefei is low, and residents awareness of health insurance is insufficient. In this regard, the coverage of commercial insurance is not broad enough to provide a comprehensive supplement to medical insurance, which needs to be expanded. Secondly, the factors influencing commercial health insurance are comprehensively analyzed in terms of income, education level, disease factors and insurance company factors.展开更多
Underwriting refers to the selection and evaluation of the insured by the insurer, and the implementation of a scientific life insurance underwriting process, which helps life insurance companies effectively control u...Underwriting refers to the selection and evaluation of the insured by the insurer, and the implementation of a scientific life insurance underwriting process, which helps life insurance companies effectively control underwriting risks, improve underwriting quality, and ensure the sustainable and stable operation of the company in the underwriting process. The underwriting of life insurance is not only related to the enterprises own construction, but also to social environment, legal system, industrial development and other factors. Due to the constant changes in the external environment, a series of problems have emerged in Chinas life insurance. If we do not pay attention to them, they will have a negative impact on the healthy development of Chinas insurance industry. Based on the current situation of life insurance underwriting in China, this paper makes a detailed analysis of the problems in the process of life insurance underwriting, and puts forward corresponding solutions and countermeasures. Therefore, we can clearly realize that underwriting is extremely important as the first line of defense for insurance companies risk management. The progress of medicine, the change of environment and the development of new technologies have brought both opportunities and challenges to life insurance. To grasp the development trend of underwriting and explore the effective management of risk control is the only way for insurance enterprises to reduce costs and enhance market competitiveness.展开更多
文摘Glutathione(GSH) and GSH-related enzymes play a great role in protecting organisms from oxidative damage. The GSH level and GSH-related enzymes activities were investigated as well as the growth yield and malonyldialdehyde(MDA) content in the Antarctic ice microalga Chlamydomonas sp. ICE-L exposure to the different cadmium concentration in this paper. The results showed that the higher concentration Cd inhibited the growth of ICE-L significantly and Cd would induce formation of MDA. At the same time, it is clear that GSH level, glutathione peroxidases(GPx) activity and glutathione S\|transferases(GST), activity were higher in ICE-L exposed to Cd than the control. But GR activity dropped notably when ICE-L were cultured in the medium containing Cd. Increase of GSH level, GPx and GST activities acclimate to oxidative stress induced by Cd and protect Antarctic ice microalga Chlamydomonas sp. ICE-L from toxicity caused by Cd exposure. These parameters may be used to assess the biological impact of Cd in the Antarctic pole region environment.
文摘OBJECTIVE To observe the effects and adverse reactions of a OXA-HCPT LV/5FU 3 regimen for patients with advanced gastric cancer.METHODS OHLF3 regimen: OXA 130 mg/m^2iv d 1, HCPT6 mg/m^2, iv d 1-5, LV 200 mg/m2iv 2 h followed by a 5FU 400 mg/m2 iv bolus and 5FU 600mg/m2 iv d 1-3, were given, every 21 days as 1 cycle. Assessment of the tumor was conducted after 3 cycles and the effective cases were confirmed after 4 weeks.RESULTS Among 39 patients, 36 were actually evaluable. Overall response rates (CR + PR} were 50%' the major adverse reactions were mild hematological toxicity, nausea and vomiting and peripheral nerve abnormalities.CONCLUSION The OHLF 3 regimen using OXA and HCPT is effective and results in mild toxicity when used in combined chemotherapy for advanced gastric cancer.
文摘Commercial health insurance is the standard configuration of life insurance. It can make the insured get a compensation for the cost when they are ill or injured again, reducing their own pressure. However, the development of commercial insurance in China is relatively late. At present, the state attaches great importance to the commercial insurance policy. For this situation, the state has issued a series of insurance policies. In this regard, the government of Hefei actively responded to the call of the state and attached great importance to the policy of commercial insurance, so that every insured can be assured. Although the continuous improvement of Hefeis commercial medical insurance system has provided a good guarantee for the economic development and the safety of peoples lives in Hefei, we must also be soberly aware that the current commercial medical insurance in Hefei is still in its infancy. Based on the actual development situation, this paper first analyzes the development trend and current situation of commercial health insurance in Hefei through a questionnaire survey, pointing out that the overall level of commercial health insurance in Hefei is low, and residents awareness of health insurance is insufficient. In this regard, the coverage of commercial insurance is not broad enough to provide a comprehensive supplement to medical insurance, which needs to be expanded. Secondly, the factors influencing commercial health insurance are comprehensively analyzed in terms of income, education level, disease factors and insurance company factors.
文摘Underwriting refers to the selection and evaluation of the insured by the insurer, and the implementation of a scientific life insurance underwriting process, which helps life insurance companies effectively control underwriting risks, improve underwriting quality, and ensure the sustainable and stable operation of the company in the underwriting process. The underwriting of life insurance is not only related to the enterprises own construction, but also to social environment, legal system, industrial development and other factors. Due to the constant changes in the external environment, a series of problems have emerged in Chinas life insurance. If we do not pay attention to them, they will have a negative impact on the healthy development of Chinas insurance industry. Based on the current situation of life insurance underwriting in China, this paper makes a detailed analysis of the problems in the process of life insurance underwriting, and puts forward corresponding solutions and countermeasures. Therefore, we can clearly realize that underwriting is extremely important as the first line of defense for insurance companies risk management. The progress of medicine, the change of environment and the development of new technologies have brought both opportunities and challenges to life insurance. To grasp the development trend of underwriting and explore the effective management of risk control is the only way for insurance enterprises to reduce costs and enhance market competitiveness.
