系统整合中国母乳营养数据,探究不同喂养方式对婴幼儿成长的不良影响,为婴幼儿乳粉开发提供数据支撑和对比。利用检索数据库——知网、万方、PubMed和Web of Science,全面收集2000年至2024年中国母乳喂养、人工喂养及母乳营养成分数据...系统整合中国母乳营养数据,探究不同喂养方式对婴幼儿成长的不良影响,为婴幼儿乳粉开发提供数据支撑和对比。利用检索数据库——知网、万方、PubMed和Web of Science,全面收集2000年至2024年中国母乳喂养、人工喂养及母乳营养成分数据相关文献,采用Revman和SPSS 26.0软件定量分析人工喂养及母乳喂养对婴幼儿成长的不良影响,同时探讨二胎政策实施前、后中国母乳营养成分数据差异,并剖析差异来源;此外,对比国内外市售知名婴幼儿配方奶粉与母乳的营养成分差异。经系统检索,初筛获得3217篇文献,严格遵循纳入与排斥标准,最终纳入18篇文献进行Meta分析。结果显示,母乳喂养对婴幼儿产生的不良影响显著低于人工喂养[风险比(RR)=0.58、95%置信区间(CI)(0.46,0.73),P<0.00001]。此外,通过SPSS 26.0对32篇文献中的中国母乳营养数据进行分析,构建母乳数据库,并对比二胎政策前、后的母乳数据变化。现有数据表明母乳喂养更有益于12个月内的婴幼儿成长。二胎政策开放前、后母乳营养数据的波动变化,为研发更贴近母乳的婴幼儿配方奶粉提供了数据支撑。展开更多
Continuous research on Cephalotaxus plants has ultimately led to the US food and drug administration (FDA) ap-provalof homoharringtonine in 2012 for the treatment of chronic myeloid leukemia. Additionally, another imp...Continuous research on Cephalotaxus plants has ultimately led to the US food and drug administration (FDA) ap-provalof homoharringtonine in 2012 for the treatment of chronic myeloid leukemia. Additionally, another important class of natural products from Cephalotaxus plants is cephalotane diterpenoids. Since the discovery of the first member, harring-tonolide,in 1978, cephalotane diterpenoids have garnered significant attention from the scientific community due to their re-markableanti-cancer activity. The unique structural features of cephalotane diterpenoids, a 7/6/5/6-fused tetracyclic carbon skeleton and a bridged lactone, make them ideal targets for synthetic chemists. Successfully synthesizing these complex diterpenoids is of great importance for the discovery and development of anti-tumor drugs. To date, ten research groups have completed the total synthesis of 24 cephalotane diterpenoids. The latest progress in the total synthesis of cephalotane diterpe-noidsis reviewed, showcasing the importance of these innovative synthetic strategies in the efficient synthesis of complex natural products and their potential significance in advancing the field of drug discovery.展开更多
文摘系统整合中国母乳营养数据,探究不同喂养方式对婴幼儿成长的不良影响,为婴幼儿乳粉开发提供数据支撑和对比。利用检索数据库——知网、万方、PubMed和Web of Science,全面收集2000年至2024年中国母乳喂养、人工喂养及母乳营养成分数据相关文献,采用Revman和SPSS 26.0软件定量分析人工喂养及母乳喂养对婴幼儿成长的不良影响,同时探讨二胎政策实施前、后中国母乳营养成分数据差异,并剖析差异来源;此外,对比国内外市售知名婴幼儿配方奶粉与母乳的营养成分差异。经系统检索,初筛获得3217篇文献,严格遵循纳入与排斥标准,最终纳入18篇文献进行Meta分析。结果显示,母乳喂养对婴幼儿产生的不良影响显著低于人工喂养[风险比(RR)=0.58、95%置信区间(CI)(0.46,0.73),P<0.00001]。此外,通过SPSS 26.0对32篇文献中的中国母乳营养数据进行分析,构建母乳数据库,并对比二胎政策前、后的母乳数据变化。现有数据表明母乳喂养更有益于12个月内的婴幼儿成长。二胎政策开放前、后母乳营养数据的波动变化,为研发更贴近母乳的婴幼儿配方奶粉提供了数据支撑。
文摘Continuous research on Cephalotaxus plants has ultimately led to the US food and drug administration (FDA) ap-provalof homoharringtonine in 2012 for the treatment of chronic myeloid leukemia. Additionally, another important class of natural products from Cephalotaxus plants is cephalotane diterpenoids. Since the discovery of the first member, harring-tonolide,in 1978, cephalotane diterpenoids have garnered significant attention from the scientific community due to their re-markableanti-cancer activity. The unique structural features of cephalotane diterpenoids, a 7/6/5/6-fused tetracyclic carbon skeleton and a bridged lactone, make them ideal targets for synthetic chemists. Successfully synthesizing these complex diterpenoids is of great importance for the discovery and development of anti-tumor drugs. To date, ten research groups have completed the total synthesis of 24 cephalotane diterpenoids. The latest progress in the total synthesis of cephalotane diterpe-noidsis reviewed, showcasing the importance of these innovative synthetic strategies in the efficient synthesis of complex natural products and their potential significance in advancing the field of drug discovery.
