Extracellular polysaccharide from Tremella aurantialba (TEP) significantly inhibited H2O2-induced haemolysis of RBCs, significantly decreased the amount of malondialdehyde (MDA) produced in mice liver homogenates as a...Extracellular polysaccharide from Tremella aurantialba (TEP) significantly inhibited H2O2-induced haemolysis of RBCs, significantly decreased the amount of malondialdehyde (MDA) produced in mice liver homogenates as a result of autoxidation, and inhibited VitC-Fe2+-induced swelling of liver mitochondria.展开更多
Bakuchiol isolated from Psoralea corylifolia is a naturally occurring prenylated phenolic monoterpene with a variety of bioactivities.The aim of this study was to improve the water solubility and thermal stability of ...Bakuchiol isolated from Psoralea corylifolia is a naturally occurring prenylated phenolic monoterpene with a variety of bioactivities.The aim of this study was to improve the water solubility and thermal stability of bakuchiol through complexing it with hydroxypropyl-β-cyclodextrin(HP-β-CD).The bakuchiol/HP-β-CD inclusion complex's behavior and characterization were investigated by ultraviolet-visible(UV-vis)spectroscopy,Fourier transform infrared spectroscopy(FT-IR),thermogravimetric analysis(TGA),X-ray diffraction(XRD),1H nuclear magnetic resonance(NMR),and two-dimensional(2D)NMR.The obtained results indicated the formation of 1∶1 inclusion complex for bakuchiol with HP-β-CD.Water solubility of bakuchiol was significantly improved by complexation with HP-β-CD as demonstrated by phase solubility studies.The encapsulation of bakuchiol was confirmed by UV-vis,FT-IR,and XRD.The thermal stability was effectively enhanced by TGA and derivative thermogravimetry(DTG)analysis.In vitro antioxidant activity showed that bakuchiol/HP-β-CD inclusion complex had a little higher antioxidant ability than free bakuchiol.Moreover,we got the possible inclusion mode for the bakuchiol/HP-β-CD inclusion complex through NMR analysis.These results suggest that the inclusion complex can be a potentially useful approach in the design of novel formulations of bakuchiol for medical applications.展开更多
目的探讨黏弹性成像(VE)联合超声造影(CEUS)评估桥本甲状腺炎(HT)背景下甲状腺结节良恶性的应用价值。方法选取2023年5月至2025年2月广西壮族自治区人民医院经病理证实的172个甲状腺结节,分为良性组(77个)及恶性组(95个),根据是否合并H...目的探讨黏弹性成像(VE)联合超声造影(CEUS)评估桥本甲状腺炎(HT)背景下甲状腺结节良恶性的应用价值。方法选取2023年5月至2025年2月广西壮族自治区人民医院经病理证实的172个甲状腺结节,分为良性组(77个)及恶性组(95个),根据是否合并HT分为HT组(89个)及非HT组(83个),比较甲状腺良恶性结节间及HT与非HT组间黏弹性参数、CEUS定性特征与定量参数的差异;绘制ROC曲线对比评价VE与CEUS最优参数单独及联合诊断HT背景下甲状腺结节良恶性的诊断效能。结果①恶性结节内及结节周围1 mm结节周围腺体组织(shell)的黏度系数最大值(Vmax)、黏度系数平均值(Vmean)、黏度系数标准差(Vsd)、频散系数最大值(Dmax)、频散系数平均值(Dmean)、频散系数标准差(Dsd)、弹性最大值(Emax)、弹性平均值(Emean)、弹性标准差(Esd)大于良性结节(均P<0.05)。良性或恶性结节组内HT组与非HT组间比较,黏弹性测值差异无统计学意义(P>0.05)。②良恶性结节组间CEUS定性特征及定量参数差异有统计学意义(均P<0.05)。③结节周围1 mm shell Vmax、1 mm shell Emax、低增强、峰值强度为诊断HT背景下甲状腺恶性结节的最优参数;VE+CEUS联合诊断HT背景下甲状腺恶性结节的敏感性、特异性、准确性分别为0.933、0.750、0.843,曲线下面积为0.889(95%CI=0.822~0.956),诊断效能优于单一诊断方法。HT背景对于VE与CEUS参数评估甲状腺结节良恶性的诊断效能无明显影响。结论VE、CEUS均可有效诊断HT背景下甲状腺结节良恶性,VE与CEUS联合可提高甲状腺恶性结节诊断的准确性。展开更多
文摘Extracellular polysaccharide from Tremella aurantialba (TEP) significantly inhibited H2O2-induced haemolysis of RBCs, significantly decreased the amount of malondialdehyde (MDA) produced in mice liver homogenates as a result of autoxidation, and inhibited VitC-Fe2+-induced swelling of liver mitochondria.
基金Fundamental Research Funds for the Central Universities(No.2232018D3-40)National Natural Science Foundation of China(No.81671508)。
文摘Bakuchiol isolated from Psoralea corylifolia is a naturally occurring prenylated phenolic monoterpene with a variety of bioactivities.The aim of this study was to improve the water solubility and thermal stability of bakuchiol through complexing it with hydroxypropyl-β-cyclodextrin(HP-β-CD).The bakuchiol/HP-β-CD inclusion complex's behavior and characterization were investigated by ultraviolet-visible(UV-vis)spectroscopy,Fourier transform infrared spectroscopy(FT-IR),thermogravimetric analysis(TGA),X-ray diffraction(XRD),1H nuclear magnetic resonance(NMR),and two-dimensional(2D)NMR.The obtained results indicated the formation of 1∶1 inclusion complex for bakuchiol with HP-β-CD.Water solubility of bakuchiol was significantly improved by complexation with HP-β-CD as demonstrated by phase solubility studies.The encapsulation of bakuchiol was confirmed by UV-vis,FT-IR,and XRD.The thermal stability was effectively enhanced by TGA and derivative thermogravimetry(DTG)analysis.In vitro antioxidant activity showed that bakuchiol/HP-β-CD inclusion complex had a little higher antioxidant ability than free bakuchiol.Moreover,we got the possible inclusion mode for the bakuchiol/HP-β-CD inclusion complex through NMR analysis.These results suggest that the inclusion complex can be a potentially useful approach in the design of novel formulations of bakuchiol for medical applications.
文摘目的探讨黏弹性成像(VE)联合超声造影(CEUS)评估桥本甲状腺炎(HT)背景下甲状腺结节良恶性的应用价值。方法选取2023年5月至2025年2月广西壮族自治区人民医院经病理证实的172个甲状腺结节,分为良性组(77个)及恶性组(95个),根据是否合并HT分为HT组(89个)及非HT组(83个),比较甲状腺良恶性结节间及HT与非HT组间黏弹性参数、CEUS定性特征与定量参数的差异;绘制ROC曲线对比评价VE与CEUS最优参数单独及联合诊断HT背景下甲状腺结节良恶性的诊断效能。结果①恶性结节内及结节周围1 mm结节周围腺体组织(shell)的黏度系数最大值(Vmax)、黏度系数平均值(Vmean)、黏度系数标准差(Vsd)、频散系数最大值(Dmax)、频散系数平均值(Dmean)、频散系数标准差(Dsd)、弹性最大值(Emax)、弹性平均值(Emean)、弹性标准差(Esd)大于良性结节(均P<0.05)。良性或恶性结节组内HT组与非HT组间比较,黏弹性测值差异无统计学意义(P>0.05)。②良恶性结节组间CEUS定性特征及定量参数差异有统计学意义(均P<0.05)。③结节周围1 mm shell Vmax、1 mm shell Emax、低增强、峰值强度为诊断HT背景下甲状腺恶性结节的最优参数;VE+CEUS联合诊断HT背景下甲状腺恶性结节的敏感性、特异性、准确性分别为0.933、0.750、0.843,曲线下面积为0.889(95%CI=0.822~0.956),诊断效能优于单一诊断方法。HT背景对于VE与CEUS参数评估甲状腺结节良恶性的诊断效能无明显影响。结论VE、CEUS均可有效诊断HT背景下甲状腺结节良恶性,VE与CEUS联合可提高甲状腺恶性结节诊断的准确性。
