BACKGROUND The non-high-density lipoprotein cholesterol(non-HDL-C)/HDL-C ratio(NHHR)is linked to cardiovascular event risk,but its prognostic value in diabetes mellitus(DM)patients remains unclear.AIM To explore the a...BACKGROUND The non-high-density lipoprotein cholesterol(non-HDL-C)/HDL-C ratio(NHHR)is linked to cardiovascular event risk,but its prognostic value in diabetes mellitus(DM)patients remains unclear.AIM To explore the association of NHHR and cardiovascular mortality in patients with DM and generate predictive model.METHODS This cohort study analyzed data from 8425 DM patients in National Health and Nutrition Examination Survey.NHHR was calculated as(total cholesterol-HDLC)/HDL-C.Cardiovascular mortality was determined via the National Death Index.Feature selection was performed using the Boruta algorithm and least absolute shrinkage and selection operator regression,followed by Cox proportional hazards models to evaluate NHHR’s relationship with cardiovascular mortality.Stratified and sensitivity analyses assessed the findings’robustness.A nomogram was developed to predict cardiovascular mortality,with model performance evaluated using receiver operating characteristic curves and calibration plots.RESULTS Over an average follow-up of 94.2 months,671 cardiovascular deaths(8.0%)occurred.Six key features including age,education,ethnicity,poverty-income ratio,history of heart failure,and NHHR,were selected.A non-linear association was found,with the highest NHHR quartile showing a 39%higher risk of cardiovascular death compared to the lowest quartile(Q4,hazard ratio:1.39,95%confidence interval:1.11-1.73).Stratified analyses confirmed the increased risk across all subgroups.Sensitivity analyses supported the stability of the results.The nomogram for predicting cardiovascular mortality demonstrated high accuracy.CONCLUSION Elevated NHHR is associated with increased cardiovascular mortality risk in DM patients.NHHR could be a valuable prognostic marker,aiding in identifying high-risk patients and guiding targeted lipid management strategies.展开更多
Prostate cancer(PCa)is one of the most common malignant tumors in the male genitourinary system,ranking second in incidence worldwide.Traditional Chinese medicine(TCM),as an important component of complementary and al...Prostate cancer(PCa)is one of the most common malignant tumors in the male genitourinary system,ranking second in incidence worldwide.Traditional Chinese medicine(TCM),as an important component of complementary and alternative medicine,shows unique advantages in cancer treatment.Chinese herbal medicine is usually composed of multiple ingredients and involves multiple signaling pathways,which showed function of inducing apoptosis of cancer cells,arresting the cell cycle,inhibiting invasion and metastasis,reducing drug resistance,and regulating immune function.Physical therapy is also an important treatment of TCM.Currently,Physical therapy such as acupuncture or Tai Chi and Qigong are gaining increased recognition in the management of PCa,particularly in addressing issues like urinary incontinence and bone metastasis-related pain.This article reviews the TCM treatment and therapy of PCa,in order to provide new research avenues and treatment options for the treatment of PCa with TCM and improve the quality of life of patients.展开更多
基金Supported by Hospital Capability Enhancement Project of Xiyuan Hospital,China Academy of Chinese Medical Sciences,No.XYZX0404-15Zhejiang Provincial Medical Association Clinical Medical Research Special Funding Projects,No.2023ZYC-A13.
文摘BACKGROUND The non-high-density lipoprotein cholesterol(non-HDL-C)/HDL-C ratio(NHHR)is linked to cardiovascular event risk,but its prognostic value in diabetes mellitus(DM)patients remains unclear.AIM To explore the association of NHHR and cardiovascular mortality in patients with DM and generate predictive model.METHODS This cohort study analyzed data from 8425 DM patients in National Health and Nutrition Examination Survey.NHHR was calculated as(total cholesterol-HDLC)/HDL-C.Cardiovascular mortality was determined via the National Death Index.Feature selection was performed using the Boruta algorithm and least absolute shrinkage and selection operator regression,followed by Cox proportional hazards models to evaluate NHHR’s relationship with cardiovascular mortality.Stratified and sensitivity analyses assessed the findings’robustness.A nomogram was developed to predict cardiovascular mortality,with model performance evaluated using receiver operating characteristic curves and calibration plots.RESULTS Over an average follow-up of 94.2 months,671 cardiovascular deaths(8.0%)occurred.Six key features including age,education,ethnicity,poverty-income ratio,history of heart failure,and NHHR,were selected.A non-linear association was found,with the highest NHHR quartile showing a 39%higher risk of cardiovascular death compared to the lowest quartile(Q4,hazard ratio:1.39,95%confidence interval:1.11-1.73).Stratified analyses confirmed the increased risk across all subgroups.Sensitivity analyses supported the stability of the results.The nomogram for predicting cardiovascular mortality demonstrated high accuracy.CONCLUSION Elevated NHHR is associated with increased cardiovascular mortality risk in DM patients.NHHR could be a valuable prognostic marker,aiding in identifying high-risk patients and guiding targeted lipid management strategies.
基金supported by China Postdoctoral Science Foundation(2022M722674)Peixian Science and Technology Plan Project(P202410)Xuzhou Medical Reserve Talents Project(XWRCHT20220009).
文摘Prostate cancer(PCa)is one of the most common malignant tumors in the male genitourinary system,ranking second in incidence worldwide.Traditional Chinese medicine(TCM),as an important component of complementary and alternative medicine,shows unique advantages in cancer treatment.Chinese herbal medicine is usually composed of multiple ingredients and involves multiple signaling pathways,which showed function of inducing apoptosis of cancer cells,arresting the cell cycle,inhibiting invasion and metastasis,reducing drug resistance,and regulating immune function.Physical therapy is also an important treatment of TCM.Currently,Physical therapy such as acupuncture or Tai Chi and Qigong are gaining increased recognition in the management of PCa,particularly in addressing issues like urinary incontinence and bone metastasis-related pain.This article reviews the TCM treatment and therapy of PCa,in order to provide new research avenues and treatment options for the treatment of PCa with TCM and improve the quality of life of patients.
