Leveraging unique resource advantages of traditional Chinese medicine(TCM)to achieve innovative breakthroughs in research constitutes a core strategic imperative for its inheritance,innovation and development.At prese...Leveraging unique resource advantages of traditional Chinese medicine(TCM)to achieve innovative breakthroughs in research constitutes a core strategic imperative for its inheritance,innovation and development.At present,the academic advances and scientific achievements in TCM serve as a key driving force for industry growth and advancement of the inheritance and innovation of TCM.To continuously strengthen the leading role of academic research,the China Association of Chinese Medicine(CACM)attaches great importance to the latest research directions and academic results in TCM,and spotlights key advances and emerging trends in TCM scholarship.Since 2020,CACM has conducted the selection and release of the“top 10 academic advances in traditional Chinese medicine”on a yearly basis.The selection of“top 10 academic advances in traditional Chinese medicine in 2024”prioritized research that addresses clinical needs,answers scientific questions and drives industrial development.Highlighting exploratory,forward-looking,innovative and groundbreaking achievements,the following 10 breakthroughs were selected through a process of collection,systematic review and expert evaluation:New advances in prevention and treatment of digestive system diseases with“brain-gut”cross-organ strategy,high-level evidence support for prevention and treatment of cardiovascular disease(CVD)continuum with TCM,important breakthrough in the research on prevention and treatment of acute radiation injury with TCM,elucidation of molecular mechanisms underlying“excellent shape and high quality”variation in cultivated American ginseng through domestication,biosynthesis of trace active ingredients such as benzylisoquinoline alkaloids,pilot application of artificial intelligence(AI)technology,research technology for unelucidated constituents of TCM,new drug delivery system in TCM,and establishment and preliminary application of integrated evidence chain-based effectiveness evaluation of TCM(iEC-Eff).展开更多
抵抗素样分子β(resistin-like molecule beta,RELMβ)是近年来发现的参与多种慢性疾病的炎症因子,同时又被称为FIZZ2(found in inflammatory zone 2)。由于RELMβ在疾病过程中起不可忽视的作用,国内外对该蛋白的研究越来越多。目前该...抵抗素样分子β(resistin-like molecule beta,RELMβ)是近年来发现的参与多种慢性疾病的炎症因子,同时又被称为FIZZ2(found in inflammatory zone 2)。由于RELMβ在疾病过程中起不可忽视的作用,国内外对该蛋白的研究越来越多。目前该蛋白在血管生长、平滑肌增殖、气道炎症等方面的作用已有相关研究。本文就RELMβ的结构、调控、生物学功能,重点对RELMβ在肺部疾病和消化道疾病中的作用作一综述。展开更多
抵抗素样分子(resistin like molecule,RELM)家族是一类富含半胱氨酸的分泌蛋白,其结构在进化过程中十分保守,然而其分布却有着较大的种属和组织特异性。目前国内外对该蛋白家族的关注越来越多,该蛋白家族成员在低氧与炎症相关生理病理...抵抗素样分子(resistin like molecule,RELM)家族是一类富含半胱氨酸的分泌蛋白,其结构在进化过程中十分保守,然而其分布却有着较大的种属和组织特异性。目前国内外对该蛋白家族的关注越来越多,该蛋白家族成员在低氧与炎症相关生理病理过程中起到不可忽视的作用,其在血管生长、平滑肌增殖、气道炎症、肠道免疫等方面的作用已有相关研究。本文就RELM家族成员的结构、分布特点、调控方式、下游信号通路和生物学功能,重点对其在人与鼠类的区别与联系以及该家族与低氧和炎症的关系作一综述。展开更多
ObjectiveTo investigate the expression of hypoxia-inducible factor 1 alpha(HIF-1a)and inducible nitric oxide synthase(iNOS)genes in rats’pulmonary arteries in different phases of hypoxia-induced pulmonary hypertensio...ObjectiveTo investigate the expression of hypoxia-inducible factor 1 alpha(HIF-1a)and inducible nitric oxide synthase(iNOS)genes in rats’pulmonary arteries in different phases of hypoxia-induced pulmonary hypertension development.MethodsModels of chronic hypoxic pulmonary hypertension rat were duplicated by intermittent hypoxia.Mean pulmonary arterial pressure(mPAP)was measured by right-heart catheterization.HIF-1a and iNOS messenger ribonucleic acid(mRNA)were detected by in situ hybridization.HIF-1a and iNOS protein were measured by immunohistochemical analysis.Resuits Expression of HIF-1a protein was upregulated in pulmonary arterial tunica intimae of all hypoxic rats.In pulmonary arterial tunica media,the level of HIF-1a protein was markedly upregulated at days 3 and 7 of hypoxia(P<0.01),then tended to restore at 14 days and 21 days.HIF-1a mRNA levels in pulmonary arteries of rats began to increase significantly at day 14 of hypoxia(P<0.01).Expression of iNOS mRNA and protein in pulmonary arteries of rats were upregulated by hypoxia for 3 days(P<0.01),then reached its peak and maitained the same level while the extension of hypoxia.Linear correlation analysis showed that iNOS protein was associated with both mean pulmonary arterial pressure(r=0.74,P<0.01)and hypoxic pulmonary vascular remodeling(r=0.78,P<0.01),whereas the inverse was associated with HIF-1a protein(r=-0.52,P<0.01).Conclusions HIF-1a and iNOS are both involved in the pathogenesis of hypoxia-induced pulmonary hypertension in rat.HIF-1a protein may upregulate the expression of iNOS gene by transcriptional activation;in addition,iNOS protein may inhibit the expression of HIF-1a protein.展开更多
基金supported by the Project of Map of Scientific and Technological Talents in the Field of Traditional Chinese Medicine(No.XMSB20240923106).
文摘Leveraging unique resource advantages of traditional Chinese medicine(TCM)to achieve innovative breakthroughs in research constitutes a core strategic imperative for its inheritance,innovation and development.At present,the academic advances and scientific achievements in TCM serve as a key driving force for industry growth and advancement of the inheritance and innovation of TCM.To continuously strengthen the leading role of academic research,the China Association of Chinese Medicine(CACM)attaches great importance to the latest research directions and academic results in TCM,and spotlights key advances and emerging trends in TCM scholarship.Since 2020,CACM has conducted the selection and release of the“top 10 academic advances in traditional Chinese medicine”on a yearly basis.The selection of“top 10 academic advances in traditional Chinese medicine in 2024”prioritized research that addresses clinical needs,answers scientific questions and drives industrial development.Highlighting exploratory,forward-looking,innovative and groundbreaking achievements,the following 10 breakthroughs were selected through a process of collection,systematic review and expert evaluation:New advances in prevention and treatment of digestive system diseases with“brain-gut”cross-organ strategy,high-level evidence support for prevention and treatment of cardiovascular disease(CVD)continuum with TCM,important breakthrough in the research on prevention and treatment of acute radiation injury with TCM,elucidation of molecular mechanisms underlying“excellent shape and high quality”variation in cultivated American ginseng through domestication,biosynthesis of trace active ingredients such as benzylisoquinoline alkaloids,pilot application of artificial intelligence(AI)technology,research technology for unelucidated constituents of TCM,new drug delivery system in TCM,and establishment and preliminary application of integrated evidence chain-based effectiveness evaluation of TCM(iEC-Eff).
文摘抵抗素样分子β(resistin-like molecule beta,RELMβ)是近年来发现的参与多种慢性疾病的炎症因子,同时又被称为FIZZ2(found in inflammatory zone 2)。由于RELMβ在疾病过程中起不可忽视的作用,国内外对该蛋白的研究越来越多。目前该蛋白在血管生长、平滑肌增殖、气道炎症等方面的作用已有相关研究。本文就RELMβ的结构、调控、生物学功能,重点对RELMβ在肺部疾病和消化道疾病中的作用作一综述。
文摘抵抗素样分子(resistin like molecule,RELM)家族是一类富含半胱氨酸的分泌蛋白,其结构在进化过程中十分保守,然而其分布却有着较大的种属和组织特异性。目前国内外对该蛋白家族的关注越来越多,该蛋白家族成员在低氧与炎症相关生理病理过程中起到不可忽视的作用,其在血管生长、平滑肌增殖、气道炎症、肠道免疫等方面的作用已有相关研究。本文就RELM家族成员的结构、分布特点、调控方式、下游信号通路和生物学功能,重点对其在人与鼠类的区别与联系以及该家族与低氧和炎症的关系作一综述。
基金supported by grants from the National Natural Science Foundation of China(No.30270581)the Natural Science Foundation of Hunan Province(No.99JJY20033)+1 种基金theHunan Province Educational Committee Foundation(No.00C164 and 00B004)Hunan Province Health Committee(No.9852).
文摘ObjectiveTo investigate the expression of hypoxia-inducible factor 1 alpha(HIF-1a)and inducible nitric oxide synthase(iNOS)genes in rats’pulmonary arteries in different phases of hypoxia-induced pulmonary hypertension development.MethodsModels of chronic hypoxic pulmonary hypertension rat were duplicated by intermittent hypoxia.Mean pulmonary arterial pressure(mPAP)was measured by right-heart catheterization.HIF-1a and iNOS messenger ribonucleic acid(mRNA)were detected by in situ hybridization.HIF-1a and iNOS protein were measured by immunohistochemical analysis.Resuits Expression of HIF-1a protein was upregulated in pulmonary arterial tunica intimae of all hypoxic rats.In pulmonary arterial tunica media,the level of HIF-1a protein was markedly upregulated at days 3 and 7 of hypoxia(P<0.01),then tended to restore at 14 days and 21 days.HIF-1a mRNA levels in pulmonary arteries of rats began to increase significantly at day 14 of hypoxia(P<0.01).Expression of iNOS mRNA and protein in pulmonary arteries of rats were upregulated by hypoxia for 3 days(P<0.01),then reached its peak and maitained the same level while the extension of hypoxia.Linear correlation analysis showed that iNOS protein was associated with both mean pulmonary arterial pressure(r=0.74,P<0.01)and hypoxic pulmonary vascular remodeling(r=0.78,P<0.01),whereas the inverse was associated with HIF-1a protein(r=-0.52,P<0.01).Conclusions HIF-1a and iNOS are both involved in the pathogenesis of hypoxia-induced pulmonary hypertension in rat.HIF-1a protein may upregulate the expression of iNOS gene by transcriptional activation;in addition,iNOS protein may inhibit the expression of HIF-1a protein.
