Organic electrodes are considered competitive candidates for the next-generation high-performance energy storage devices owing to their advantages of structural flexibility and abundant resources.However,solubility an...Organic electrodes are considered competitive candidates for the next-generation high-performance energy storage devices owing to their advantages of structural flexibility and abundant resources.However,solubility and low electronic conductivity have been major obstacles to the practical application.To address these challenges,the structural design and interfacial regulation of organic electrodes are crucial to the performance enhancement.Herein,we report on aπ-conjugated polymer cathode material of poly(3,4,9,10-perylenetetracarboxylic diimide)(PPI)for metal ion batteries,and the performance optimization is achieved by matching suitable conductive carbons and liquid electrolytes.Ultimately,the carbon nanotubes(CNTs)with weight content of 25%and 1 M NaPF6 in ethylene carbonate/diethyl carbonate electrolyte are introduced to assemble the batteries,and the discharge specific capacity,cycling stability and rate performance are enhanced effectively.The PPI-CNTjjNa battery displays high specific capacities of 146.4 and 117 mAh g^(-1) at current densities of 0.1 C and 5 C,respectively.Furthermore,PPI-CNTjjNa battery demonstrates excellent long-term cycling stability of 5000 cycles with low 0.007 mAh g^(-1)capacity decay per cycle at 1C due to the thin and uniform cathode electrolyte interphase.Moreover,the PPI-CNTjjNa battery presents good cycling stability at high temperatures of 60℃,and retains a capacity of 132.5 mAh g^(-1) after 300 cycles with a high capacity retention rate of 96.9%.Besides,PPI-CNT displays good electrochemical performance and compatibility in lithium-ion and potassium-ion batteries.This work provides an alternative optimization strategy for organic electrodes applied in long-lifetime metal ion batteries.展开更多
The penetration rate of new wind and photovoltaic energy in the power system has increased significantly,and the dramatic fluctuation of the net load of the grid has led to a severe lack of flexibility in the regional...The penetration rate of new wind and photovoltaic energy in the power system has increased significantly,and the dramatic fluctuation of the net load of the grid has led to a severe lack of flexibility in the regional grid.This paper proposes a hierarchical optimal dispatch strategy for a high proportion of new energy power systems that considers the balanced response of grid flexibility.Firstly,various flexibility resource regulation capabilities on the source-load side are analyzed,and then flexibility demand and flexibility response are matched,and flexibility demand response assessment is proposed;then,a hierarchical optimal dispatch model of the grid taking flexibility adjustment capability into account is established,and the upper model optimizes the net load curve with the objectives of minimizing the fluctuation of the net load,maximizing the benefits of energy storage and controllable loads,and optimizing the flexibility adjustment capability.The upper layer model optimizes the net load curve by minimizing net load fluctuation,maximizing energy storage and controllable load revenue,and optimizing flexibility adjustment capability.In contrast,the lower layer model optimizes the power allocation of thermal power units and regulates the lost load of wind and solar power generation by minimizing the total system operating cost.The results show that the proposed strategy improves the flexibility of the grid by 15.2%,gives full play to the regulation capability of each flexibility resource,and reduces the fluctuation of the net load by 15.6%to achieve optimal coordination between different types of flexibility resources.展开更多
Infectious wound healing is complicated with and limited by infection and oxidative stress at the wound site.In recent years,various evidences suggest that nanozymes with multiple enzymatic activities have enabled the...Infectious wound healing is complicated with and limited by infection and oxidative stress at the wound site.In recent years,various evidences suggest that nanozymes with multiple enzymatic activities have enabled the development of novel strategies for infectious wound healing.In this study,epigallocatechin gallate loaded polydopamine(P@E)was developed to act as a potent reactive oxygen species(ROS)scavenger for scavenging ROS,alleviating inflammatory responses,and promoting infectious wound healing.Combining with near infrared(NIR)irradiation,P@E presented excellent antibacterial ability of Escherichia coli(E.coli,93.6%)and methicillin-resistant Staphylococcus aureus(MRSA,87.6%).Specifically,P@E+NIR exhibited the most potent antioxidant,anti-inflammatory and cell proliferation behaviors through downregulating intracellular ROS levels(81.9%and 94.3%for NIH3T3 and RAW264.7 respectively)and inducible nitric oxide synthase(iNOS)expression level(55.7%),and up-regulating the expression levels of arginase-1(Arg-1,71.4%),heat shock protein 70(HSP70,48.6%)and platelet endothelial cell adhesion molecule(CD31,35.3%)compared to control group.Meanwhile,it also efficiently induced M2 directional polarization of lipopolysaccharide induced murine macrophages to achieve anti-inflammation,indicated by the down-regulation of CD86(86.2%),and up-regulation of CD206(85.6%).Significantly,it was also observed that P@E+NIR presented the excellent behaviors of inhibiting wound infection,alleviating wound inflammation,as well as promoting skin tissue repairing.Altogether,it has developed the strategy of using P@E combining with NIR irradiation for the synergistic enhanced healing of infectious skin wound,which can serve as a promising therapeutic strategy for its clinical treatment.展开更多
The development of high-performance lithium-ion batteries(LIBs)hinges on searching for advanced anode materials with large specific capacities as well as high cycling stability.However,traditional graphite anodes have...The development of high-performance lithium-ion batteries(LIBs)hinges on searching for advanced anode materials with large specific capacities as well as high cycling stability.However,traditional graphite anodes have not met the demand for higher energy storage owing to the deficiency of low lithium storage capacity.In the current work,we focus on designing one composite anode material with multiscale porous(MP)structure and phosphorus(P)doping.The coupling effects of three-dimensional(3D)interconnected skeleton,hollow pore channels,and P doping can facilitate the electrolyte diffusion and the mass transfer,as well as accommodate the volume changes during lithiation/delithiation processes.As expected,the as-prepared MP-SiGeSnSbPAl composite exhibits superior lithium storage performance,achieving a specific capacity of 827.9 mAh/g after 150 cycles at 200 mA/g and maintaining the high capacity of 456.7 mAh/g after 400 cycles at 1 A/g.Contrastively,the corresponding surplus capacities are only 590.3 and 225.7 mAh/g for the non-doped counterparts,respectively.In particular,MP-SiGeSnSbPAl displays much more stable cycling performances under the measurement of high areal mass loading of~3 mg/cm^(2)and the full-cell tests with the lithium iron phosphate as the cathode.This work witnesses one scalable protocol for preparing multinary Si-based composite in terms of facile operation and high lithium storage performances.展开更多
After the integration of large-scale DistributedGeneration(DG)into the distribution network,the randomness and volatility of its output result in a reduction of spatiotemporal alignment between power generation and de...After the integration of large-scale DistributedGeneration(DG)into the distribution network,the randomness and volatility of its output result in a reduction of spatiotemporal alignment between power generation and demand in the distribution network,exacerbating the phenomenon of wind and solar power wastage.As a novel power system model,the fundamental concept of Regional Autonomous Power Grids(RAPGs)is to achieve localized management and energy autonomy,thereby facilitating the effective consumption of DGs.Therefore,this paper proposes a distributed resource planning strategy that enhances the autonomy capabilities of regional power grids by considering multiple evaluation indexes for autonomy.First,a regional Energy Storage(ES)configuration strategy is proposed.This strategy can select a suitable reference value for the upper limit of ES configuration based on the regional load andDGoutput to maximize the elimination of source load deviations in the region as the upper limit constraint of ES capacity.Then,a control strategy for regional ES is proposed,the charging and discharging reference line of ES is set,and multiple autonomy and economic indexes are used as objective functions to select different proportions of ES to control the distributed resources of the regional power grid and establish evaluation indexes of the internal regional generation and load power ratio,the proportion of power supply matching hours,new energy consumption rate and tie line power imbalance outside the region to evaluate changes in the regional autonomy capabilities.The final simulation results showthat in the real regional grid example,the planning method in the planning year in the region of the overall power supply matching hour ratio and new energy consumption rate increased by 3.9%and 4.8%on average,and the power imbalance of the tie line decreased by 7.8%on average.The proposed planning approach enables the maximization of regional autonomy while effectively smoothing the fluctuation of power exchange between the regional grid and the higher-level grid.This presents a rational and effective planning solution for the regional grid,facilitating the coordinated development between the region and the distribution network.展开更多
Peak load and wind energy emission pressure rise more as wind energy penetration keeps growing,which affects the stabilization of the PS(power system).This paper suggests integrated optimal dispatching of thermal powe...Peak load and wind energy emission pressure rise more as wind energy penetration keeps growing,which affects the stabilization of the PS(power system).This paper suggests integrated optimal dispatching of thermal power generators and BESS(battery energy storage system)taking wind energy emission grading punishment and deep peak clipping into consideration.Firstly,in order to minimize wind abandonment,a hierarchical wind abandonment penalty strategy based on fuzzy control is designed and introduced,and the optimal grid-connected power of wind energy is determined as a result of minimizing the peak cutting cost of the system.Secondly,considering BESS and thermal power,the management approach of BESS-assisted virtual peak clipping of thermal power generators is aimed at reducing the degree of deep peak clipping of thermal power generators and optimizing the output of thermal power generators and the charging and discharging power of BESS.Finally,Give an example of how this strategy has been effective in reducing abandonment rates by 0.66% and 7.46% individually for different wind penetration programs,and the daily average can reduce the peak clipping power output of thermal power generators by 42.97 and 72.31 MWh and enhances the effect and economy of system peak clipping.展开更多
In recent years,the proportion of installed wind power in the three north regions where wind power bases are concentrated is increasing,but the peak regulation capacity of the power grid in the three north regions of ...In recent years,the proportion of installed wind power in the three north regions where wind power bases are concentrated is increasing,but the peak regulation capacity of the power grid in the three north regions of China is limited,resulting in insufficient local wind power consumption capacity.Therefore,this paper proposes a two-layer optimal scheduling strategy based on wind power consumption benefits to improve the power grid’s wind power consumption capacity.The objective of the uppermodel is tominimize the peak-valley difference of the systemload,which ismainly to optimize the system load by using the demand response resources,and to reduce the peak-valley difference of the system load to improve the peak load regulation capacity of the grid.The lower scheduling model is aimed at maximizing the system operation benefit,and the scheduling model is selected based on the rolling schedulingmethod.The load-side schedulingmodel needs to reallocate the absorbed wind power according to the response speed,absorption benefit,and curtailment penalty cost of the two DR dispatching resources.Finally,the measured data of a power grid are simulated by MATLAB,and the results show that:the proposed strategy can improve the power grid’s wind power consumption capacity and get a large wind power consumption benefit.展开更多
In the existing power system with a large-scale hydrogen storage system,there are problems such as low efficiency of electric-hydrogen-electricity conversion and single modeling of the hydrogen storage system.In order...In the existing power system with a large-scale hydrogen storage system,there are problems such as low efficiency of electric-hydrogen-electricity conversion and single modeling of the hydrogen storage system.In order to improve the hydrogen utilization rate of hydrogen storage system in the process of participating in the power grid operation,and speed up the process of electric-hydrogen-electricity conversion.This article provides a detailed introduction to the mathematical and electrical models of various components of the hydrogen storage unit,and also establishes a charging and discharging efficiency model that considers the temperature and internal gas partial pressure of the hydrogen storage unit.These models are of great significance for studying and optimizing gas storage technology.Through these models,the performance of gas storage units can be better understood and improved.These studies are very helpful for improving energy storage efficiency and sustainable development.The factors affecting the charge-discharge efficiency of hydrogen storage units are analyzed.By integrating the models of each unit and considering the capacity degradation of the hydrogen storage system,we can construct an efficiency model for a large hydrogen storage system and power conversion system.In addition,the simulation models of the hydrogen production system and hydrogen consumption system were established in MATLAB/Simulink.The accuracy and effectiveness of the simulation model were proved by comparing the output voltage variation curve of the simulation with the polarization curve of the typical hydrogen production system and hydrogen consumption system.The results show that the charge-discharge efficiency of the hydrogen storage unit increases with the increase of operating temperature,and H2 and O2 partial voltage have little influence on the charge-discharge efficiency.In the process of power conversion system converter rectification operation,its efficiency decreases with the increase of temperature,while in the process of inverter operation,power conversion system efficiency increases with the increase of temperature.Combined with the efficiency of each hydrogen storage unit and power conversion system converter,the upper limit of the capacity loss of different hydrogen storage units was set.The optimal charge-discharge efficiency of the hydrogen storage system was obtained by using the Cplex solver at 36.46%and 66.34%.展开更多
From a global perspective, local awareness and People Standard in three ways, conditions to establish and improve a social security system covering urban and rural areas has matured its localization requirements have ...From a global perspective, local awareness and People Standard in three ways, conditions to establish and improve a social security system covering urban and rural areas has matured its localization requirements have become more evident. Therefore, to explore the social security system with Chinese characteristics model, not only is the key to solve China＇s current social conflicts, as well as building a socialist harmonious society and a necessary step in the inevitable choice. Globalization and global governance movement accelerated economic globalization, social security, face the opportunities and challenges, China should establish a “China model” of pension security.展开更多
High-temperature microwave absorbing materials(MAMs)and structures are increasingly appealing due to their critical role in stealth applications under harsh environments.However,the impedance mismatch caused by increa...High-temperature microwave absorbing materials(MAMs)and structures are increasingly appealing due to their critical role in stealth applications under harsh environments.However,the impedance mismatch caused by increased conduction loss often leads to a significant decline in electromagnetic wave absorp-tion(EMWA)performance at elevated temperatures,which severely restricts their practical application.In this study,we propose a novel approach for efficient electromagnetic wave absorption across a wide temperature range using reduced graphene oxide(RGO)/epoxy resin(EP)metacomposites that integrate both electromagnetic parameters and metamaterial design concepts.Due to the discrete distribution of the units,electromagnetic waves can more easily penetrate the interior of materials,thereby exhibiting stable microwave absorption(MA)performance and impedance-matching characteristics suitable across a wide temperature range.Consequently,exceptional MA properties can be achieved within the tem-perature range from 298 to 473 K.Furthermore,by carefully controlling the structural parameters in RGO metacomposites,both the resonant frequency and effective absorption bandwidth(EAB)can be optimized based on precise manipulation of equivalent electromagnetic parameters.This study not only provides an effective approach for the rational design of MA performance but also offers novel insights into achieving super metamaterials with outstanding performance across a wide temperature spectrum.展开更多
In high-renewable-energy power systems,the demand for fast-responding capabilities is growing.To address the limitations of conventional closed-loop frequency control,where the integral coefficient cannot dynamically ...In high-renewable-energy power systems,the demand for fast-responding capabilities is growing.To address the limitations of conventional closed-loop frequency control,where the integral coefficient cannot dynamically adjust the frequency regulation command based on the state of charge(SoC)of energy storage units,this paper proposes a secondary frequency regulation control strategy based on variable integral coefficients for multiple energy storage units.First,a power-uniform controller is designed to ensure that thermal power units gradually take on more regulation power during the frequency regulation process.Next,a control framework based on variable integral coefficients is proposed within the secondary frequency regulation model,along with an objective function that simultaneously considers both Automatic Generation Control(AGC)command tracking performance and SoC recovery requirements of energy storage units.Finally,a gradient descent optimization method is used to dynamically adjust the gain of the energy storage integral controller,allowingmultiple energy storage units to respond in real-time to AGC instructions and SoC variations.Simulation results confirmthe effectiveness of the proposedmethod.Compared to traditional strategies,the proposed approach takes into account the SoCdiscrepancies amongmultiple energy storage units and the duration of system net power imbalances.It successfully implements secondary frequency regulation while achieving dynamic power allocation among the units.展开更多
Electrocatalytic conversion of carbon dioxide(CO_(2))into formate offers a sustainable pathway to mitigate environmental degradation and the energy crisis.Tin(Sn)-based materials are promising electrocatalysts for CO_...Electrocatalytic conversion of carbon dioxide(CO_(2))into formate offers a sustainable pathway to mitigate environmental degradation and the energy crisis.Tin(Sn)-based materials are promising electrocatalysts for CO_(2)reduction to formate;however,their efficiency is limited by weak CO_(2)adsorption and activation,as well as sluggish reaction kinetics.In this work,we designed an intercrossing nanoporous Cu_(6)Sn_(5)/Sn intermetallic heterojunction via a scalable alloying-etching protocol.The resulting Cu_(6)Sn_(5)/Sn catalyst with abundant interfacial sites exhibited enhanced formate selectivity(60.79%)at−0.93 V versus the reversible hydrogen electrode(RHE),together with a high partial current density of 12.56 mA/cm^(2)and stable operation for 16 h.The modulated electronic structure of Cu_(6)Sn_(5)coupled with the robust interfacial interaction between Sn and Cu_(6)Sn_(5)synergistically promoted CO_(2)adsorption and activation,thereby improving CO_(2)reduction reaction(CO_(2)RR)performance.Electrochemical measurements and in situ infrared spectroscopy confirmed that the dual-phase interfaces facilitate H_(2)O decomposition and the generation of abundant*H intermediates,which in turn accelerate the protonation of CO_(2)to formate.This work highlights a scalable strategy for constructing intermetallic heterojunction catalysts that combine facile synthesis,reproducibility,and superior catalytic activity for CO_(2)RR.展开更多
Acute lung injury(ALI)was characterized by excessive reactive oxygen species(ROS)levels and inflammatory response in the lung.Scavenging ROS could inhibit the excessive inflammatory response,further treating ALI.Herei...Acute lung injury(ALI)was characterized by excessive reactive oxygen species(ROS)levels and inflammatory response in the lung.Scavenging ROS could inhibit the excessive inflammatory response,further treating ALI.Herein,we designed a novel nanozyme(P@Co)comprised of polydopamine(PDA)nanoparticles(NPs)loading with ultra-small Co,combining with near infrared(NIR)irradiation,which could efficiently scavenge intracellular ROS and suppress inflammatory responses against ALI.For lipopolysaccharide(LPS)induced macrophages,P@Co+NIR presented excellent antioxidant and anti-inflammatory capacities through lowering intracellular ROS levels,decreasing the expression levels of interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)as well as inducing macrophage M2 directional polarization.Significantly,it displayed the outstanding activities of lowering acute lung inflammation,relieving diffuse alveolar damage,and up-regulating heat shock protein 70(HSP70)expression,resulting in synergistic enhanced ALI therapy effect.It offers a novel strategy for the clinical treatment of ROS related diseases.展开更多
The exploration of remarkable electromagnetic wave(EMW)absorbing materials with temperature-stable absorbing properties at a wide temperature range holds significant implications for both military operations and civil...The exploration of remarkable electromagnetic wave(EMW)absorbing materials with temperature-stable absorbing properties at a wide temperature range holds significant implications for both military operations and civilian life.Herein,the titanium nitride/zirconium oxide/carbon(TiN/ZrO_(2)/C)ternary nanofiber membranes have been synthesized by electrospinning followed by preoxidation-nitridation process.Thanks to the flexibility of the prepared ceramic membranes,the corresponding metacomposites,characterized by a unique hierarchical structure,were fabricated through the systematic incorporation of subwavelength scale functional units(square fiber membranes)within a polydimethylsiloxane(PDMS)matrix.This approach effectively expanded the transmission path of EMW,contributing to additional multiple reflections and scattering within the system.As a result,when the content of the functional units was as low as 10.0 wt%,the engineered metacomposites exhibited exceptional EMW absorption properties across a broad temperature range(298–573 K).This performance can be attributed to the synergistic effects of optimized impedance matching and enhanced attenuation capacity.Furthermore,the metacomposites achieved a minimum reflection loss(RL)value of−51.7 dB at 453 K,with an effective absorption bandwidth(EAB)spanning 2.3 GHz.This study may serve as a valuable reference for the design of high attenuation capacity EMW absorbing materials under complex variable high-temperature conditions.展开更多
In response to the issue of determining the appropriate capacity when hybrid energy storage systems(HESS)collaborate with thermal power units(TPU)in the system’s secondary frequency regulation,a configuration method ...In response to the issue of determining the appropriate capacity when hybrid energy storage systems(HESS)collaborate with thermal power units(TPU)in the system’s secondary frequency regulation,a configuration method for HESS based on the analysis of frequency regulation demand analysis is proposed.And a corresponding simulation platform is developed.Firstly,a frequency modulation demand method for reducing the frequency modulation losses of TPU is proposed.Secondly,taking into comprehensive consideration that flywheel energy storage features rapid power response and battery energy storage has the characteristic of high energy density,a coordinated control strategy for HESS considering the self-recovery of state of charge(SOC)is put forward.Then,to measure the economic and technical performance of HESS in assisting the secondary frequency modulation of TPU,an optimized configurationmodel considering the full-life-cycle economy and frequency modulation performance of TPU and HESS system is constructed.Finally,a visual simulation platform for the combined frequency modulation of TPU and HESS is developed based on Matlab Appdesigner.Theresults of calculation examples indicate that the proposed configuration method can improve the overall economic efficiency and frequency modulation performance of TPU and HESS;The control strategy can not only prolong the service life of battery energy storage but also enhance the continuous response ability of HESS;The visual simulation platform is easy to use,and the simulation results are accurate and reliable.展开更多
Responding to the stochasticity and uncertainty in the power height of distributed photovoltaic power generation.This paper presents a distributed photovoltaic ultra-short-term power forecasting method based on Variat...Responding to the stochasticity and uncertainty in the power height of distributed photovoltaic power generation.This paper presents a distributed photovoltaic ultra-short-term power forecasting method based on Variational Mode Decomposition(VMD)and Channel Attention Mechanism.First,Pearson’s correlation coefficient was utilized to filter out the meteorological factors that had a high impact on historical power.Second,the distributed PV power data were decomposed into a relatively smooth power series with different fluctuation patterns using variational modal decomposition(VMD).Finally,the reconstructed distributed PV power as well as other features are input into the combined CNN-SENet-BiLSTM model.In this model,the convolutional neural network(CNN)and channel attention mechanism dynamically adjust the weights while capturing the spatial features of the input data to improve the discriminative ability of key features.The extracted data is then fed into the bidirectional long short-term memory network(BiLSTM)to capture the time-series features,and the final output is the prediction result.The verification is conducted using a dataset from a distributed photovoltaic power station in the Northwest region of China.The results show that compared with other prediction methods,the method proposed in this paper has a higher prediction accuracy,which helps to improve the proportion of distributed PV access to the grid,and can guarantee the safe and stable operation of the power grid.展开更多
Currently,the microwave absorbers usually suffer dreadful electromagnetic wave absorption(EMWA)performance damping at elevated temperature due to impedance mismatching induced by increased conduction loss.Consequently...Currently,the microwave absorbers usually suffer dreadful electromagnetic wave absorption(EMWA)performance damping at elevated temperature due to impedance mismatching induced by increased conduction loss.Consequently,the development of high-performance EMWA materials with good impedance matching and strong loss ability in wide temperature spectrum has emerged as a top priority.Herein,due to the high melting point,good electrical conductivity,excellent environmental stability,EM coupling effect,and abundant interfaces of titanium nitride(TiN)nanotubes,they were designed based on the controlling kinetic diffusion procedure and Ostwald ripening process.Benefiting from boosted heterogeneous interfaces between TiN nanotubes and polydimethylsiloxane(PDMS),enhanced polarization loss relaxations were created,which could not only improve the depletion efficiency of EMWA,but also contribute to the optimized impedance matching at elevated temperature.Therefore,the TiN nanotubes/PDMS composite showed excellent EMWA performances at varied temperature(298-573 K),while achieved an effective absorption bandwidth(EAB)value of 3.23 GHz and a minimum reflection loss(RLmin)value of−44.15 dB at 423 K.This study not only clarifies the relationship between dielectric loss capacity(conduction loss and polarization loss)and temperature,but also breaks new ground for EM absorbers in wide temperature spectrum based on interface engineering.展开更多
Pentachlorophenol（PCP） is a widespread,persistent environmental contaminant,and it is enzymatically activated to form a reactive metabolite,tetrachloro-l,4-benzoquinone（TCBQ）.To our knowledge,there is no informati...Pentachlorophenol（PCP） is a widespread,persistent environmental contaminant,and it is enzymatically activated to form a reactive metabolite,tetrachloro-l,4-benzoquinone（TCBQ）.To our knowledge,there is no information about TCBQ toxicity on embryonic stem cells.Here,we demonstrated that TCBQ induced significantly apoptosis of mouse embryonic stem cells in a concentration-dependent manner.We also showed that TCBQ elevated genomic5-hydroxymethylcytosine（5hmC） by affecting ten-eleven translocation（Tet） dioxygenases in mouse embryonic stem cells.We further investigated whether Tet dioxygenases were implicated in TCBQ-induced apoptosis.By depleting all three dioxygenases（Tet1-3）,we found that Tet dioxygenases slightly inhibited both early and late apoptosis induced by TCBQ at a low concentration（30 μmol/L）.Meanwhile,treated by TCBQ at higher concentrations（40and 50 μmol/L）,the total percentage of apoptotic cells was not affected by Tet dioxygenases.However,Tet dioxygenases tended to arrest mouse ES cells to be at early apoptotic stage and to reduce the cells to enter later apoptotic stage.These results indicate that Tet dioxygenases play a role in shaping TCBQ-induced apoptosis in mouse embryonic stem cells.Our study provides new insights into the toxicology of PCP and its reactive metabolite TCBQ.展开更多
基金supported by Open Foundation of Shanghai Jiao Tong University Shaoxing Research Institute of Renewable Energy and Molecular Engineering(Grant No.JDSX2023008)Joint Fund of Scientific and Technological Research and Development Program of Henan Province(222301420009)the funding of Zhengzhou University.
文摘Organic electrodes are considered competitive candidates for the next-generation high-performance energy storage devices owing to their advantages of structural flexibility and abundant resources.However,solubility and low electronic conductivity have been major obstacles to the practical application.To address these challenges,the structural design and interfacial regulation of organic electrodes are crucial to the performance enhancement.Herein,we report on aπ-conjugated polymer cathode material of poly(3,4,9,10-perylenetetracarboxylic diimide)(PPI)for metal ion batteries,and the performance optimization is achieved by matching suitable conductive carbons and liquid electrolytes.Ultimately,the carbon nanotubes(CNTs)with weight content of 25%and 1 M NaPF6 in ethylene carbonate/diethyl carbonate electrolyte are introduced to assemble the batteries,and the discharge specific capacity,cycling stability and rate performance are enhanced effectively.The PPI-CNTjjNa battery displays high specific capacities of 146.4 and 117 mAh g^(-1) at current densities of 0.1 C and 5 C,respectively.Furthermore,PPI-CNTjjNa battery demonstrates excellent long-term cycling stability of 5000 cycles with low 0.007 mAh g^(-1)capacity decay per cycle at 1C due to the thin and uniform cathode electrolyte interphase.Moreover,the PPI-CNTjjNa battery presents good cycling stability at high temperatures of 60℃,and retains a capacity of 132.5 mAh g^(-1) after 300 cycles with a high capacity retention rate of 96.9%.Besides,PPI-CNT displays good electrochemical performance and compatibility in lithium-ion and potassium-ion batteries.This work provides an alternative optimization strategy for organic electrodes applied in long-lifetime metal ion batteries.
文摘The penetration rate of new wind and photovoltaic energy in the power system has increased significantly,and the dramatic fluctuation of the net load of the grid has led to a severe lack of flexibility in the regional grid.This paper proposes a hierarchical optimal dispatch strategy for a high proportion of new energy power systems that considers the balanced response of grid flexibility.Firstly,various flexibility resource regulation capabilities on the source-load side are analyzed,and then flexibility demand and flexibility response are matched,and flexibility demand response assessment is proposed;then,a hierarchical optimal dispatch model of the grid taking flexibility adjustment capability into account is established,and the upper model optimizes the net load curve with the objectives of minimizing the fluctuation of the net load,maximizing the benefits of energy storage and controllable loads,and optimizing the flexibility adjustment capability.The upper layer model optimizes the net load curve by minimizing net load fluctuation,maximizing energy storage and controllable load revenue,and optimizing flexibility adjustment capability.In contrast,the lower layer model optimizes the power allocation of thermal power units and regulates the lost load of wind and solar power generation by minimizing the total system operating cost.The results show that the proposed strategy improves the flexibility of the grid by 15.2%,gives full play to the regulation capability of each flexibility resource,and reduces the fluctuation of the net load by 15.6%to achieve optimal coordination between different types of flexibility resources.
基金financially supported by the Natural Science Foundation of Guangxi(Nos.2022GXNSFAA035505 and 2024GXNSFAA010164)the Key Research&Development Program of Guangxi(No.GuiKe2024AB08057)+1 种基金the Guangxi Medical and Health Suitable Technology Development and Popularization Applications Project(Nos.S2023093 and S2021084)the Major Talent Project of Guangxi Autonomous Region.
文摘Infectious wound healing is complicated with and limited by infection and oxidative stress at the wound site.In recent years,various evidences suggest that nanozymes with multiple enzymatic activities have enabled the development of novel strategies for infectious wound healing.In this study,epigallocatechin gallate loaded polydopamine(P@E)was developed to act as a potent reactive oxygen species(ROS)scavenger for scavenging ROS,alleviating inflammatory responses,and promoting infectious wound healing.Combining with near infrared(NIR)irradiation,P@E presented excellent antibacterial ability of Escherichia coli(E.coli,93.6%)and methicillin-resistant Staphylococcus aureus(MRSA,87.6%).Specifically,P@E+NIR exhibited the most potent antioxidant,anti-inflammatory and cell proliferation behaviors through downregulating intracellular ROS levels(81.9%and 94.3%for NIH3T3 and RAW264.7 respectively)and inducible nitric oxide synthase(iNOS)expression level(55.7%),and up-regulating the expression levels of arginase-1(Arg-1,71.4%),heat shock protein 70(HSP70,48.6%)and platelet endothelial cell adhesion molecule(CD31,35.3%)compared to control group.Meanwhile,it also efficiently induced M2 directional polarization of lipopolysaccharide induced murine macrophages to achieve anti-inflammation,indicated by the down-regulation of CD86(86.2%),and up-regulation of CD206(85.6%).Significantly,it was also observed that P@E+NIR presented the excellent behaviors of inhibiting wound infection,alleviating wound inflammation,as well as promoting skin tissue repairing.Altogether,it has developed the strategy of using P@E combining with NIR irradiation for the synergistic enhanced healing of infectious skin wound,which can serve as a promising therapeutic strategy for its clinical treatment.
基金supported by National Science Foundation of Shandong Province(Nos.ZR2023ME155 and ZR2023ME085)the Taishan Scholar Project of Shandong Province(Nos.tsqn202306226 and tsqn202211171).
文摘The development of high-performance lithium-ion batteries(LIBs)hinges on searching for advanced anode materials with large specific capacities as well as high cycling stability.However,traditional graphite anodes have not met the demand for higher energy storage owing to the deficiency of low lithium storage capacity.In the current work,we focus on designing one composite anode material with multiscale porous(MP)structure and phosphorus(P)doping.The coupling effects of three-dimensional(3D)interconnected skeleton,hollow pore channels,and P doping can facilitate the electrolyte diffusion and the mass transfer,as well as accommodate the volume changes during lithiation/delithiation processes.As expected,the as-prepared MP-SiGeSnSbPAl composite exhibits superior lithium storage performance,achieving a specific capacity of 827.9 mAh/g after 150 cycles at 200 mA/g and maintaining the high capacity of 456.7 mAh/g after 400 cycles at 1 A/g.Contrastively,the corresponding surplus capacities are only 590.3 and 225.7 mAh/g for the non-doped counterparts,respectively.In particular,MP-SiGeSnSbPAl displays much more stable cycling performances under the measurement of high areal mass loading of~3 mg/cm^(2)and the full-cell tests with the lithium iron phosphate as the cathode.This work witnesses one scalable protocol for preparing multinary Si-based composite in terms of facile operation and high lithium storage performances.
基金supported by the State Grid Henan Economic Research Institute Science and Technology Project“Calculation and Demonstration of Distributed Photovoltaic Open Capacity Based on Multi-Source Heterogeneous Data”(5217L0230013).
文摘After the integration of large-scale DistributedGeneration(DG)into the distribution network,the randomness and volatility of its output result in a reduction of spatiotemporal alignment between power generation and demand in the distribution network,exacerbating the phenomenon of wind and solar power wastage.As a novel power system model,the fundamental concept of Regional Autonomous Power Grids(RAPGs)is to achieve localized management and energy autonomy,thereby facilitating the effective consumption of DGs.Therefore,this paper proposes a distributed resource planning strategy that enhances the autonomy capabilities of regional power grids by considering multiple evaluation indexes for autonomy.First,a regional Energy Storage(ES)configuration strategy is proposed.This strategy can select a suitable reference value for the upper limit of ES configuration based on the regional load andDGoutput to maximize the elimination of source load deviations in the region as the upper limit constraint of ES capacity.Then,a control strategy for regional ES is proposed,the charging and discharging reference line of ES is set,and multiple autonomy and economic indexes are used as objective functions to select different proportions of ES to control the distributed resources of the regional power grid and establish evaluation indexes of the internal regional generation and load power ratio,the proportion of power supply matching hours,new energy consumption rate and tie line power imbalance outside the region to evaluate changes in the regional autonomy capabilities.The final simulation results showthat in the real regional grid example,the planning method in the planning year in the region of the overall power supply matching hour ratio and new energy consumption rate increased by 3.9%and 4.8%on average,and the power imbalance of the tie line decreased by 7.8%on average.The proposed planning approach enables the maximization of regional autonomy while effectively smoothing the fluctuation of power exchange between the regional grid and the higher-level grid.This presents a rational and effective planning solution for the regional grid,facilitating the coordinated development between the region and the distribution network.
基金supported by Jilin Province Higher Education Teaching Reform Research Project in 2021(JLJY202186163419).
文摘Peak load and wind energy emission pressure rise more as wind energy penetration keeps growing,which affects the stabilization of the PS(power system).This paper suggests integrated optimal dispatching of thermal power generators and BESS(battery energy storage system)taking wind energy emission grading punishment and deep peak clipping into consideration.Firstly,in order to minimize wind abandonment,a hierarchical wind abandonment penalty strategy based on fuzzy control is designed and introduced,and the optimal grid-connected power of wind energy is determined as a result of minimizing the peak cutting cost of the system.Secondly,considering BESS and thermal power,the management approach of BESS-assisted virtual peak clipping of thermal power generators is aimed at reducing the degree of deep peak clipping of thermal power generators and optimizing the output of thermal power generators and the charging and discharging power of BESS.Finally,Give an example of how this strategy has been effective in reducing abandonment rates by 0.66% and 7.46% individually for different wind penetration programs,and the daily average can reduce the peak clipping power output of thermal power generators by 42.97 and 72.31 MWh and enhances the effect and economy of system peak clipping.
基金The study was supported by the State Grid Henan Economic Research Institute Regional Autonomy Project.
文摘In recent years,the proportion of installed wind power in the three north regions where wind power bases are concentrated is increasing,but the peak regulation capacity of the power grid in the three north regions of China is limited,resulting in insufficient local wind power consumption capacity.Therefore,this paper proposes a two-layer optimal scheduling strategy based on wind power consumption benefits to improve the power grid’s wind power consumption capacity.The objective of the uppermodel is tominimize the peak-valley difference of the systemload,which ismainly to optimize the system load by using the demand response resources,and to reduce the peak-valley difference of the system load to improve the peak load regulation capacity of the grid.The lower scheduling model is aimed at maximizing the system operation benefit,and the scheduling model is selected based on the rolling schedulingmethod.The load-side schedulingmodel needs to reallocate the absorbed wind power according to the response speed,absorption benefit,and curtailment penalty cost of the two DR dispatching resources.Finally,the measured data of a power grid are simulated by MATLAB,and the results show that:the proposed strategy can improve the power grid’s wind power consumption capacity and get a large wind power consumption benefit.
基金supported by the Jilin Province Higher Education TeachingReform Research Project Funding(Contract No.2020285O73B005E).
文摘In the existing power system with a large-scale hydrogen storage system,there are problems such as low efficiency of electric-hydrogen-electricity conversion and single modeling of the hydrogen storage system.In order to improve the hydrogen utilization rate of hydrogen storage system in the process of participating in the power grid operation,and speed up the process of electric-hydrogen-electricity conversion.This article provides a detailed introduction to the mathematical and electrical models of various components of the hydrogen storage unit,and also establishes a charging and discharging efficiency model that considers the temperature and internal gas partial pressure of the hydrogen storage unit.These models are of great significance for studying and optimizing gas storage technology.Through these models,the performance of gas storage units can be better understood and improved.These studies are very helpful for improving energy storage efficiency and sustainable development.The factors affecting the charge-discharge efficiency of hydrogen storage units are analyzed.By integrating the models of each unit and considering the capacity degradation of the hydrogen storage system,we can construct an efficiency model for a large hydrogen storage system and power conversion system.In addition,the simulation models of the hydrogen production system and hydrogen consumption system were established in MATLAB/Simulink.The accuracy and effectiveness of the simulation model were proved by comparing the output voltage variation curve of the simulation with the polarization curve of the typical hydrogen production system and hydrogen consumption system.The results show that the charge-discharge efficiency of the hydrogen storage unit increases with the increase of operating temperature,and H2 and O2 partial voltage have little influence on the charge-discharge efficiency.In the process of power conversion system converter rectification operation,its efficiency decreases with the increase of temperature,while in the process of inverter operation,power conversion system efficiency increases with the increase of temperature.Combined with the efficiency of each hydrogen storage unit and power conversion system converter,the upper limit of the capacity loss of different hydrogen storage units was set.The optimal charge-discharge efficiency of the hydrogen storage system was obtained by using the Cplex solver at 36.46%and 66.34%.
文摘From a global perspective, local awareness and People Standard in three ways, conditions to establish and improve a social security system covering urban and rural areas has matured its localization requirements have become more evident. Therefore, to explore the social security system with Chinese characteristics model, not only is the key to solve China＇s current social conflicts, as well as building a socialist harmonious society and a necessary step in the inevitable choice. Globalization and global governance movement accelerated economic globalization, social security, face the opportunities and challenges, China should establish a “China model” of pension security.
基金supported by the National Nature Science Foundation of China(Nos.22305066 and 52372041).
文摘High-temperature microwave absorbing materials(MAMs)and structures are increasingly appealing due to their critical role in stealth applications under harsh environments.However,the impedance mismatch caused by increased conduction loss often leads to a significant decline in electromagnetic wave absorp-tion(EMWA)performance at elevated temperatures,which severely restricts their practical application.In this study,we propose a novel approach for efficient electromagnetic wave absorption across a wide temperature range using reduced graphene oxide(RGO)/epoxy resin(EP)metacomposites that integrate both electromagnetic parameters and metamaterial design concepts.Due to the discrete distribution of the units,electromagnetic waves can more easily penetrate the interior of materials,thereby exhibiting stable microwave absorption(MA)performance and impedance-matching characteristics suitable across a wide temperature range.Consequently,exceptional MA properties can be achieved within the tem-perature range from 298 to 473 K.Furthermore,by carefully controlling the structural parameters in RGO metacomposites,both the resonant frequency and effective absorption bandwidth(EAB)can be optimized based on precise manipulation of equivalent electromagnetic parameters.This study not only provides an effective approach for the rational design of MA performance but also offers novel insights into achieving super metamaterials with outstanding performance across a wide temperature spectrum.
文摘In high-renewable-energy power systems,the demand for fast-responding capabilities is growing.To address the limitations of conventional closed-loop frequency control,where the integral coefficient cannot dynamically adjust the frequency regulation command based on the state of charge(SoC)of energy storage units,this paper proposes a secondary frequency regulation control strategy based on variable integral coefficients for multiple energy storage units.First,a power-uniform controller is designed to ensure that thermal power units gradually take on more regulation power during the frequency regulation process.Next,a control framework based on variable integral coefficients is proposed within the secondary frequency regulation model,along with an objective function that simultaneously considers both Automatic Generation Control(AGC)command tracking performance and SoC recovery requirements of energy storage units.Finally,a gradient descent optimization method is used to dynamically adjust the gain of the energy storage integral controller,allowingmultiple energy storage units to respond in real-time to AGC instructions and SoC variations.Simulation results confirmthe effectiveness of the proposedmethod.Compared to traditional strategies,the proposed approach takes into account the SoCdiscrepancies amongmultiple energy storage units and the duration of system net power imbalances.It successfully implements secondary frequency regulation while achieving dynamic power allocation among the units.
基金supported by Natural Science Foundation of Shandong Province(No.ZR2023ME155)the project of“20 Items of University”of Jinan(No.202228046)the Tais-han Scholar Project of Shandong Province(Nos.tsqn202306226 and tsqn202211171).
文摘Electrocatalytic conversion of carbon dioxide(CO_(2))into formate offers a sustainable pathway to mitigate environmental degradation and the energy crisis.Tin(Sn)-based materials are promising electrocatalysts for CO_(2)reduction to formate;however,their efficiency is limited by weak CO_(2)adsorption and activation,as well as sluggish reaction kinetics.In this work,we designed an intercrossing nanoporous Cu_(6)Sn_(5)/Sn intermetallic heterojunction via a scalable alloying-etching protocol.The resulting Cu_(6)Sn_(5)/Sn catalyst with abundant interfacial sites exhibited enhanced formate selectivity(60.79%)at−0.93 V versus the reversible hydrogen electrode(RHE),together with a high partial current density of 12.56 mA/cm^(2)and stable operation for 16 h.The modulated electronic structure of Cu_(6)Sn_(5)coupled with the robust interfacial interaction between Sn and Cu_(6)Sn_(5)synergistically promoted CO_(2)adsorption and activation,thereby improving CO_(2)reduction reaction(CO_(2)RR)performance.Electrochemical measurements and in situ infrared spectroscopy confirmed that the dual-phase interfaces facilitate H_(2)O decomposition and the generation of abundant*H intermediates,which in turn accelerate the protonation of CO_(2)to formate.This work highlights a scalable strategy for constructing intermetallic heterojunction catalysts that combine facile synthesis,reproducibility,and superior catalytic activity for CO_(2)RR.
基金financially supported by the Key Research&Development Program of Guangxi(No.GuiKeAB22080088)the Joint Project on Regional High-Incidence Diseases Research of Guangxi Natural Science Foundation(No.2023GXNSFDA026023)+3 种基金the Natural Science Foundation of Guangxi(No.2023JJA140322)the National Natural Science Foundation of China(No.82360372)the High-level Medical Expert Training Program of Guangxi“139 Plan Funding(No.G202003010)the Medical Appropriate Technology Development and Popularization and Application Project of Guangxi(No.S2020099)。
文摘Acute lung injury(ALI)was characterized by excessive reactive oxygen species(ROS)levels and inflammatory response in the lung.Scavenging ROS could inhibit the excessive inflammatory response,further treating ALI.Herein,we designed a novel nanozyme(P@Co)comprised of polydopamine(PDA)nanoparticles(NPs)loading with ultra-small Co,combining with near infrared(NIR)irradiation,which could efficiently scavenge intracellular ROS and suppress inflammatory responses against ALI.For lipopolysaccharide(LPS)induced macrophages,P@Co+NIR presented excellent antioxidant and anti-inflammatory capacities through lowering intracellular ROS levels,decreasing the expression levels of interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)as well as inducing macrophage M2 directional polarization.Significantly,it displayed the outstanding activities of lowering acute lung inflammation,relieving diffuse alveolar damage,and up-regulating heat shock protein 70(HSP70)expression,resulting in synergistic enhanced ALI therapy effect.It offers a novel strategy for the clinical treatment of ROS related diseases.
基金supported by the National Nature Science Foundation of China(Nos.22475065 and 22305066)the Natural Science Foundation of Henan Province Youth Fund(No.242300421466).
文摘The exploration of remarkable electromagnetic wave(EMW)absorbing materials with temperature-stable absorbing properties at a wide temperature range holds significant implications for both military operations and civilian life.Herein,the titanium nitride/zirconium oxide/carbon(TiN/ZrO_(2)/C)ternary nanofiber membranes have been synthesized by electrospinning followed by preoxidation-nitridation process.Thanks to the flexibility of the prepared ceramic membranes,the corresponding metacomposites,characterized by a unique hierarchical structure,were fabricated through the systematic incorporation of subwavelength scale functional units(square fiber membranes)within a polydimethylsiloxane(PDMS)matrix.This approach effectively expanded the transmission path of EMW,contributing to additional multiple reflections and scattering within the system.As a result,when the content of the functional units was as low as 10.0 wt%,the engineered metacomposites exhibited exceptional EMW absorption properties across a broad temperature range(298–573 K).This performance can be attributed to the synergistic effects of optimized impedance matching and enhanced attenuation capacity.Furthermore,the metacomposites achieved a minimum reflection loss(RL)value of−51.7 dB at 453 K,with an effective absorption bandwidth(EAB)spanning 2.3 GHz.This study may serve as a valuable reference for the design of high attenuation capacity EMW absorbing materials under complex variable high-temperature conditions.
基金supported by a Key Project of the National Natural Science Foundation of China under Grant 52337004.
文摘In response to the issue of determining the appropriate capacity when hybrid energy storage systems(HESS)collaborate with thermal power units(TPU)in the system’s secondary frequency regulation,a configuration method for HESS based on the analysis of frequency regulation demand analysis is proposed.And a corresponding simulation platform is developed.Firstly,a frequency modulation demand method for reducing the frequency modulation losses of TPU is proposed.Secondly,taking into comprehensive consideration that flywheel energy storage features rapid power response and battery energy storage has the characteristic of high energy density,a coordinated control strategy for HESS considering the self-recovery of state of charge(SOC)is put forward.Then,to measure the economic and technical performance of HESS in assisting the secondary frequency modulation of TPU,an optimized configurationmodel considering the full-life-cycle economy and frequency modulation performance of TPU and HESS system is constructed.Finally,a visual simulation platform for the combined frequency modulation of TPU and HESS is developed based on Matlab Appdesigner.Theresults of calculation examples indicate that the proposed configuration method can improve the overall economic efficiency and frequency modulation performance of TPU and HESS;The control strategy can not only prolong the service life of battery energy storage but also enhance the continuous response ability of HESS;The visual simulation platform is easy to use,and the simulation results are accurate and reliable.
基金supported by the Inner Mongolia Power Company 2024 Staff Innovation Studio Innovation Project“Research on Cluster Output Prediction and Group Control Technology for County-Wide Distributed Photovoltaic Construction”.
文摘Responding to the stochasticity and uncertainty in the power height of distributed photovoltaic power generation.This paper presents a distributed photovoltaic ultra-short-term power forecasting method based on Variational Mode Decomposition(VMD)and Channel Attention Mechanism.First,Pearson’s correlation coefficient was utilized to filter out the meteorological factors that had a high impact on historical power.Second,the distributed PV power data were decomposed into a relatively smooth power series with different fluctuation patterns using variational modal decomposition(VMD).Finally,the reconstructed distributed PV power as well as other features are input into the combined CNN-SENet-BiLSTM model.In this model,the convolutional neural network(CNN)and channel attention mechanism dynamically adjust the weights while capturing the spatial features of the input data to improve the discriminative ability of key features.The extracted data is then fed into the bidirectional long short-term memory network(BiLSTM)to capture the time-series features,and the final output is the prediction result.The verification is conducted using a dataset from a distributed photovoltaic power station in the Northwest region of China.The results show that compared with other prediction methods,the method proposed in this paper has a higher prediction accuracy,which helps to improve the proportion of distributed PV access to the grid,and can guarantee the safe and stable operation of the power grid.
基金the National Nature Science Foundation of China(No.22305066).
文摘Currently,the microwave absorbers usually suffer dreadful electromagnetic wave absorption(EMWA)performance damping at elevated temperature due to impedance mismatching induced by increased conduction loss.Consequently,the development of high-performance EMWA materials with good impedance matching and strong loss ability in wide temperature spectrum has emerged as a top priority.Herein,due to the high melting point,good electrical conductivity,excellent environmental stability,EM coupling effect,and abundant interfaces of titanium nitride(TiN)nanotubes,they were designed based on the controlling kinetic diffusion procedure and Ostwald ripening process.Benefiting from boosted heterogeneous interfaces between TiN nanotubes and polydimethylsiloxane(PDMS),enhanced polarization loss relaxations were created,which could not only improve the depletion efficiency of EMWA,but also contribute to the optimized impedance matching at elevated temperature.Therefore,the TiN nanotubes/PDMS composite showed excellent EMWA performances at varied temperature(298-573 K),while achieved an effective absorption bandwidth(EAB)value of 3.23 GHz and a minimum reflection loss(RLmin)value of−44.15 dB at 423 K.This study not only clarifies the relationship between dielectric loss capacity(conduction loss and polarization loss)and temperature,but also breaks new ground for EM absorbers in wide temperature spectrum based on interface engineering.
基金supported by the National Natural Science Foundation of China(Nos.21327006,21435008,21321004)the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDB14030200)
文摘Pentachlorophenol（PCP） is a widespread,persistent environmental contaminant,and it is enzymatically activated to form a reactive metabolite,tetrachloro-l,4-benzoquinone（TCBQ）.To our knowledge,there is no information about TCBQ toxicity on embryonic stem cells.Here,we demonstrated that TCBQ induced significantly apoptosis of mouse embryonic stem cells in a concentration-dependent manner.We also showed that TCBQ elevated genomic5-hydroxymethylcytosine（5hmC） by affecting ten-eleven translocation（Tet） dioxygenases in mouse embryonic stem cells.We further investigated whether Tet dioxygenases were implicated in TCBQ-induced apoptosis.By depleting all three dioxygenases（Tet1-3）,we found that Tet dioxygenases slightly inhibited both early and late apoptosis induced by TCBQ at a low concentration（30 μmol/L）.Meanwhile,treated by TCBQ at higher concentrations（40and 50 μmol/L）,the total percentage of apoptotic cells was not affected by Tet dioxygenases.However,Tet dioxygenases tended to arrest mouse ES cells to be at early apoptotic stage and to reduce the cells to enter later apoptotic stage.These results indicate that Tet dioxygenases play a role in shaping TCBQ-induced apoptosis in mouse embryonic stem cells.Our study provides new insights into the toxicology of PCP and its reactive metabolite TCBQ.
