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妊娠期高血压患者肠道菌群分布及其与血清HtrA3、25(OH)D水平的关系 被引量:1
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作者 李文辉 崔丽茹 +1 位作者 张慧然 田莹珺 《中国妇幼健康研究》 2024年第4期84-89,共6页
目的 探讨妊娠期高血压患者肠道菌群分布特征及其与血清丝氨酸蛋白酶A3(HtrA3)、25羟基维生素D[25(OH)D]水平的相关性。方法 选取2021年5月至2023年5月期间在本院就诊的106例妊娠期高血压患者作为研究组,选取同期体检健康的妊娠孕妇98... 目的 探讨妊娠期高血压患者肠道菌群分布特征及其与血清丝氨酸蛋白酶A3(HtrA3)、25羟基维生素D[25(OH)D]水平的相关性。方法 选取2021年5月至2023年5月期间在本院就诊的106例妊娠期高血压患者作为研究组,选取同期体检健康的妊娠孕妇98例作为对照组;同时收集整理其临床特征资料。采用16s rDNA测序技术检测两组肠道菌群,并比较两组肠道菌群多样性及其相对丰度;采用ELISA法检测两组血清HtrA3、25(OH)D水平;采用Pearson法分析妊娠期高血压患者肠道菌群与血清HtrA3、25(OH)D水平的相关性。结果 与对照组相比,研究组Chao1指数、Ace指数、Shannon指数明显降低,Simpson指数明显升高(Z值介于2.462~5.163之间,均P<0.05)。门水平上,与对照组相比,研究组厚壁菌门、拟杆菌门、放线菌门菌群相对丰度明显降低(t值介于2.976~10.722之间),变形菌门相对丰度明显升高(t=2.569);属水平上,乳杆菌属、双歧杆菌属、毛螺菌属、Rikenellaceae属、真杆菌属相对丰度明显降低(t值介于2.344~11.277之间),肠球菌属相对丰度明显升高(t=4.220)(均P<0.05)。与对照组相比,研究组血清HtrA3水平明显升高,25(OH)D水平明显降低(t=8.425、8.308,P<0.05)。Pearson相关性分析结果显示,乳杆菌属、双歧杆菌属、真杆菌属、毛螺菌属、Rikenellaceae属与血清HtrA3水平呈负相关(r值介于-0.581~-0.478之间),与25(OH)D水平呈正相关(r值介于0.470~0.638之间);肠球菌属与血清HtrA3水平呈正相关(r=0.527),与25(OH)D水平呈负相关(r=-0.479)(均P<0.05)。结论 妊娠期高血压患者肠道菌群与血清HtrA3、25(OH)D之间有明显相关性,临床上检测二者相关性对治疗妊娠期高血压具有重要意义。 展开更多
关键词 妊娠期高血压 肠道菌群 血清丝氨酸蛋白酶A3 25羟基维生素D
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联合低频重复经颅磁刺激和神经肌肉关节促进法技术在改善卒中后肌张力增高的研究 被引量:4
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作者 崔莉茹 王寒明 +3 位作者 杨傲然 谭建 杨东亮 李春芳 《中国医学装备》 2024年第10期90-95,共6页
目的:分析联合低频重复经颅磁刺激(rTMS)和神经肌肉关节促进法技术(NJF)改善卒中后肌张力增高的临床效果。方法:选择2020年10月至2022年10月北京康复医院收治的114例卒中恢复期下肢肌张力增高患者,按照随机数表法将其分为观察组和对照组... 目的:分析联合低频重复经颅磁刺激(rTMS)和神经肌肉关节促进法技术(NJF)改善卒中后肌张力增高的临床效果。方法:选择2020年10月至2022年10月北京康复医院收治的114例卒中恢复期下肢肌张力增高患者,按照随机数表法将其分为观察组和对照组,每组57例,对照组接受常规康复治疗,观察组在常规康复治疗基础上增加低频rTMS和NJF训练。比较两组临床疗效及干预前后的下肢肌张力各指标的差异,包括改良Ashworth分级量表(MAS)、下肢运动功能性步行量表(FAC)、下肢Fugl-Meyer运动功能评定量表(FMA-L)、下肢痉挛状态临床痉挛指数(CSI)、日常生活活动能力改良Barthel指数(MBI),下肢肌电图胫骨前肌的积分肌电值(IEMG)及振幅均方根(RMS)。结果:康复治疗干预后观察组显效29例,有效23例,无效5例;对照组显效20例,有效20例,无效17例;观察组治疗总有效率为91.23%,明显高于对照组的70.18%,差异有统计学意义(χ^(2)=8.111,P<0.05)。干预前两组各指标差异均无统计学意义(P>0.05);干预后观察组FAC评分、FMA-L评分及MBI评分高于对照组,差异有统计学意义(t=3.377、4.398、5.554,P<0.05),观察组MAS评分、CSI评分、IEMG及RMS均低于对照组,差异有统计学意义(t=11.160、9.625、16.993、8.095,P<0.05)。结论:低频rTMS和NJF训练联合应用对卒中后肌张力增高的改善作用显著,可有效降低下肢肌张力,改善下肢运动功能、痉挛程度,提高日常生活活动能力。 展开更多
关键词 低频 重复经颅磁刺激(rTMS) 神经肌肉关节促进法技术(NJF) 脑卒中 下肢肌张力增高
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Changes in the International Pattern and Construction of the International Order in an Age of Multi-polarization
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作者 cui liru 《Contemporary International Relations》 2016年第3期1-13,共13页
Sino-US relations are vital for shaping future world order which, despite the two powers 'growing competition, calls for strategic cooperation inresponse to various threats. The Obama administration adjusted foreign ... Sino-US relations are vital for shaping future world order which, despite the two powers 'growing competition, calls for strategic cooperation inresponse to various threats. The Obama administration adjusted foreign policy in response to the current multipolarity but faced internal and external constraints. With ongoing order construction in the Middle East, Europe and the Asia-Pacific, multiple historical and realistic factors influence the international community. Multilateral security architecture is growing in significance for the long-term peace and development of East Asia as well as for the construction of an Asia-Pacific order. 展开更多
关键词 国际秩序 多极化 亚太地区 战略合作 外交政策 国际社会 安全体系 东亚地区
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Globalization Era vs.International Order Transformation
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作者 cui liru 《Contemporary International Relations》 2009年第3期1-5,共5页
The world has entered a globalization era in the true sense of the expression.In the words of Thomas Friedman,author of the best seller The World Is Flat,though the globalization process began in as early back as 1492... The world has entered a globalization era in the true sense of the expression.In the words of Thomas Friedman,author of the best seller The World Is Flat,though the globalization process began in as early back as 1492 when Christopher Columbus's first voyage to the 展开更多
关键词 全球化时代 国际秩序 全球化进程 畅销书作家 弗里德曼 世界 托马斯 哥伦布
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The Post-9/11 World and China (I)——Moving Towards a New Era
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作者 cui liru 《Contemporary International Relations》 2006年第9期1-6,共6页
Editor's note: The terrorist attack on September 11,2001 is the most notable event that has taken place since the end of the Cold War. On the fifth anniversary of the September 11 attacks, the editorial department ... Editor's note: The terrorist attack on September 11,2001 is the most notable event that has taken place since the end of the Cold War. On the fifth anniversary of the September 11 attacks, the editorial department of Contemporary International Relations sponsored by China Institutes of Contemporary International Relations held a seminar on Chinese diplomacy and the changing international situation. More than twenty specialists in the field of international relations attended the seminar. We have brought together some of their points in the hope that they would help our readers in their studies of international strategic circumstances as well as China's foreign strategy. 展开更多
关键词 “9·11”事件 恐怖主义 中国 对外战略 国际关系 美国因素
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Big Power Game/Cooperation in the Asia-Pacific
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作者 cui liru Ma Zongshi 《Contemporary International Relations》 2013年第2期90-100,5,共11页
The China-U.S.relationship that is of global influence is built not on the sharing of a common enemy but on common interests.Peaceful co-existence is the only sensible option that suits the best interests of both side... The China-U.S.relationship that is of global influence is built not on the sharing of a common enemy but on common interests.Peaceful co-existence is the only sensible option that suits the best interests of both sides.China and the U.S.are playing a game of chess,the Asia-Pacific being the most eye-catching theater for now and for the foreseeable future. 展开更多
关键词 游戏 合作 利益相关者 冷战 时髦
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Opening Remarks by CICIR President
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作者 cui liru 《Contemporary International Relations》 2012年第C00期1-2,共2页
Good evening! In the hospitable warmth of the early summer, we have the honor of gathering together eminent scholars and renowned experts on Afghanistan studies on this occasion of the 2nd CICIR Forum. Taking the agen... Good evening! In the hospitable warmth of the early summer, we have the honor of gathering together eminent scholars and renowned experts on Afghanistan studies on this occasion of the 2nd CICIR Forum. Taking the agenda as our theme, academics both at home and abroad will contribute to frank discussions and in-depth exchanges on the future of Afghanistan and regional cooperation. On behalf of the China Institutes of Contemporary International Relations (CICIR), I hereby extend our warmest welcome to you all. 展开更多
关键词 开幕词 区域合作 国际关系 阿富汗 学者
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Thoughts on the Evolving World Order
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作者 cui liru 《Contemporary International Relations》 2005年第10期1-13,共13页
Dramatic changes have occurred in the post-Cold War world strategic configuration and international order with their replacements burgeoning. This confronts nations, big powers in particular, with new strategic choice... Dramatic changes have occurred in the post-Cold War world strategic configuration and international order with their replacements burgeoning. This confronts nations, big powers in particular, with new strategic choices. Indeed unfolding before us is a contention among them for seizing the initiative in the emerging international landscape in the 21st century. Thus how to correctly assess and respond to these changes for pursuing a reasonable strategy and selecting a right policy option is not only a matter of primary concern for the academic community, but also a major foreign policy task before a rapidly growing China.For this, a symposium on this theme was recently sponsored by the Editorial Department of Contemporary International Relations to solicit from a dozen or so Beijingbased well-known scholars and experts for their views on and policy suggestions for such issues as the current overall strategic picture, global configuration, trends of the international order and the strategic environment facing China. Excerpts of their major views are as follows. 展开更多
关键词 中国 外交策略 中国威胁论 和平演变 国际形势
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The Multi-Polar Structure and New Balance of the China-US Relationship
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作者 cui liru 《Contemporary International Relations》 2017年第6期51-70,共20页
The multi-polar structure is a new international relationship structure, which differs greatly from both the bi-polar and uni-polar structures in both structure and nature, mainly emerging from the evolution of two as... The multi-polar structure is a new international relationship structure, which differs greatly from both the bi-polar and uni-polar structures in both structure and nature, mainly emerging from the evolution of two aspects: first, the meaning of "polar" has undergone a major change; and second, beyond the power structure, the relationship structure between nations is much different from the past and is inflicting an increasingly important impact on core implication of the multi-polar the structure. Decentralization is the structure. In the current reality of international politics, decentralization refers to the dissolution of US hegemony, as different nations and power centers are busy competing and cooperating with one another at different levels in accordance with their own advantages and characteristics. Globally, the multi-polar structure manifests a state in which the current power structure is loosening, while international relationships have become more diversified due to their ongoing development. This is the development of a new relationship structure that is of great significance and what calls for our closest attention. 展开更多
关键词 Multi-Polar Structure BALANCE China-US Relationship
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The Land & Sea Frontiers Issue and Adjustment to China's Foreign Strategy
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作者 cui liru Hong Jianjun 《Contemporary International Relations》 2012年第5期31-35,共5页
First of all I’d like to express my heartfelt thanks to everyone for attending this meeting.In particular I’m grateful to Professors Hu Dekun,Li Jinming and Huang Renwei,who have traveled far to participate in the d... First of all I’d like to express my heartfelt thanks to everyone for attending this meeting.In particular I’m grateful to Professors Hu Dekun,Li Jinming and Huang Renwei,who have traveled far to participate in the discussion.As the topic of this section is"How should 展开更多
关键词 国际关系 外交 外交政策 国际问题
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A Multipolar World in the Globalization Era
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作者 cui liru 《Contemporary International Relations》 2010年第B09期1-11,共11页
Tremendous transformations are underway in the world political and economic landscape for the first time in modern history.In essence,this highlights the transition from the post-Cold War period to the era of globaliz... Tremendous transformations are underway in the world political and economic landscape for the first time in modern history.In essence,this highlights the transition from the post-Cold War period to the era of globalization,and from a unipolar to a multipolar world. 展开更多
关键词 政治 后冷战时期 中国 多极世界
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Changes in the International Pattern and Construction of the International Order in an Age of Multi-polarization (Part Ⅰ)
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作者 cui liru 《Contemporary International Relations》 2016年第2期1-10,共10页
The world is standing at a moment of historical change. All countries have to experience temporary pains produced along with the formation of a new international order. Consequently, more light, less heat, is called f... The world is standing at a moment of historical change. All countries have to experience temporary pains produced along with the formation of a new international order. Consequently, more light, less heat, is called for in analyzing current power conglomerates to enhance understanding of what the historical trend is embracing, as well as what the change is dismantling. 展开更多
关键词 PART US
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Thirty Years of China's Diplomacy:Trajectory and Challenges Ahead
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作者 cui liru 《Contemporary International Relations》 2009年第6期1-7,共7页
The 60 years since the birth of New China can be divided into two equal parts with the second 30 years of Chinese diplomacy reflecting tremendous changes in the country and its society.And its central task in this per... The 60 years since the birth of New China can be divided into two equal parts with the second 30 years of Chinese diplomacy reflecting tremendous changes in the country and its society.And its central task in this period boils down to building a peaceful external environment for the domestic modernization drive.In the process,based on independence and the world-known Five Principles of Peaceful Co-existence,taking shape is a diplomatic strategy that is both all-directional in scope and rich in Chinese characteristics.Since the advent of the 21st century,the country has defined four areas of focus in its diplomacy and put forward the watchword of"peaceful development."Looking ahead,China is facing new challenges in its diplomacy of how to preserve harmonious relations with the outside world and set up a Chinese model reflecting its own core values,thereby investing with it greater international appeal and value of universal application. 展开更多
关键词 Thirty Years of China’s Diplomacy
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ABCC6基因变异所致婴儿泛发性动脉钙化1例患儿的遗传学分析
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作者 赵春娟 刘田田 +2 位作者 刘芳 崔丽茹 王军屏 《中华医学遗传学杂志》 CAS CSCD 2024年第6期734-740,共7页
目的:探讨1例罕见的ABCC6基因变异所致婴儿泛发性动脉钙化(GACI)患儿的临床表现与遗传学病因。方法:选取2022年8月26日就诊于首都医科大学附属北京儿童医院保定医院的1例44 d女性患儿作为研究对象。收集患儿的临床资料,通过核心家系全... 目的:探讨1例罕见的ABCC6基因变异所致婴儿泛发性动脉钙化(GACI)患儿的临床表现与遗传学病因。方法:选取2022年8月26日就诊于首都医科大学附属北京儿童医院保定医院的1例44 d女性患儿作为研究对象。收集患儿的临床资料,通过核心家系全外显子组测序(Trio-WES)、全基因组拷贝数变异测序(CNV-seq)以及Minigene剪接实验对变异进行致病性分析。结果:患儿主要表现为发热、炎症指标高、抗感染治疗无效,超声显示全身大、中动脉广泛钙化、管壁增厚,考虑为GACI以及相关的动脉炎,经糖皮质激素、生物制剂治疗后发热缓解。Trio-WES发现患儿携带ABCC6基因复合杂合变异c.4404-1G>A与c.4041+5G>T,后者既往未见报道。根据美国医学遗传学与基因组学学会(ACMG)相关指南,两个变异被分别判定为可能致病性(PVS1+PM2_Supporting)与临床意义不明(PM2_Supporting+PM3+PP3)。CNV-seq检测未见异常。Minigene剪接实验进一步验证两个变异均可影响剪接。结论:对于不明原因及常规治疗无效的发热,需要及时完善基因检测,避免GACI的漏诊。 展开更多
关键词 发热 泛发性动脉钙化 ABCC6基因变异 全外显子组测序 Minigene剪接
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关键肌运动点针刺联合运动训练对脊髓损伤患者的疗效观察
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作者 约日古丽·艾微拉 宋宁泽 +2 位作者 商帅 崔莉茹 王寒明 《天津医药》 2025年第12期1280-1284,共5页
目的 探讨关键肌运动点针刺联合运动训练对脊髓损伤(SCI)患者神经电生理指标、肢体功能及生活质量的影响。方法 选取2022年9月—2024年6月首都医科大学附属北京康复医院康复诊疗中心收治的SCI患者80例,采用随机数字表法分为对照组(予以... 目的 探讨关键肌运动点针刺联合运动训练对脊髓损伤(SCI)患者神经电生理指标、肢体功能及生活质量的影响。方法 选取2022年9月—2024年6月首都医科大学附属北京康复医院康复诊疗中心收治的SCI患者80例,采用随机数字表法分为对照组(予以常规针刺联合运动训练,40例)与观察组(予以关键肌运动点针刺联合运动训练,40例)。比较2组患者干预前、后神经电生理指标[运动神经传导速度(MNCV)、感觉神经传导速度(SNCV)]、肢体功能[Fugl-Meyer评估量表(FMA)、改良Ashworth量表(MAS)]及生活质量[Barthel指数、功能独立性测量(FIM)]。结果干预后,2组正中神经、尺神经、胫神经、腓总神经的MNCV、SNCV水平,FMA评分,Barthel指数,FIM评分均较干预前升高;MAS评分较干预前降低(P<0.05);且观察组上述各指标变化较对照组显著(P<0.05)。结论 关键肌运动点针刺联合运动训练能有效改善SCI患者的神经电生理指标、肢体功能及生活质量,是一种可行的康复干预方案。 展开更多
关键词 脊髓损伤 针刺 运动(Exercise) 关键肌 运动点 神经电生理
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