The hydrosilylation of unsaturated carbon-carbon bonds is one of the most critical reactions in silicone industrial production.The homogeneous Speier's catalyst,Karstedt's catalyst,and other noble metal-based ...The hydrosilylation of unsaturated carbon-carbon bonds is one of the most critical reactions in silicone industrial production.The homogeneous Speier's catalyst,Karstedt's catalyst,and other noble metal-based catalysts are widely used.However,simplifying the separation of the homogeneous catalyst from reaction products and reducing the high cost of precious metals is still challenging.This review describes the recent development of heterogeneous catalysts for alkene,alkyne,and allene hydrosilylations,which can effectively solve problems in homogeneous hydrosilylation.展开更多
The development of sustainable and efficient catalytic systems for the formation C-C,C-N,C-o bonds is a fundamental goal in modern synthetic chemistry.We present a biomass-derived Cu/Chitosan-800 catalyst that facilit...The development of sustainable and efficient catalytic systems for the formation C-C,C-N,C-o bonds is a fundamental goal in modern synthetic chemistry.We present a biomass-derived Cu/Chitosan-800 catalyst that facilitates a range of carbenoid insertion reactions into C-H,N-H,and O-H bonds.This catalyst demonstrates remarkable activity,enabling the functionalization of diverse substrates,including the late-stage modification of drug molecules with up to 95%yield and good recyclability.Our findings highlight the catalyst's potential in advancing environmentally friendly chemical transformations,offering a promising tool for pharmaceutical synthesis and organic synthesis.展开更多
Direct functionalization of inert C(sp^(3))–H bonds is a topic of immense contemporary interest and exceptional value in organic synthesis.The recent research has established a novel and practical protocol which feat...Direct functionalization of inert C(sp^(3))–H bonds is a topic of immense contemporary interest and exceptional value in organic synthesis.The recent research has established a novel and practical protocol which features the engagement of vinyl cation species to functionalize C(sp^(3))–H bonds.The discussion of the topic is arranged by the strategies to generate the reactive intermediates,including ionization of vinyl triflates,addition of electrophiles to alkynes,tandem cyclization of enynes or diynes,and decomposition ofβ-hydroxy-α-diazo ketones.This review closes with a personal perspective on the dynamic research area of unactivated C(sp^(3))–H functionalization via vinyl cations.Hopefully,it will provide timely illumination and beneficial guidance for organic chemists who are interested in this area.Meanwhile continued development of the field is strongly anticipated in the future.展开更多
基金the financial support from the National Natural Science Foundation of China(No.22001227)the Natural Science Foundation of Jiangsu Province(No.BK20200919)+1 种基金the“Jiangsu Specially-Appointed Professor Plan”the Priority Academic Program Development of Jiangsu Higher Education Institutions。
文摘The hydrosilylation of unsaturated carbon-carbon bonds is one of the most critical reactions in silicone industrial production.The homogeneous Speier's catalyst,Karstedt's catalyst,and other noble metal-based catalysts are widely used.However,simplifying the separation of the homogeneous catalyst from reaction products and reducing the high cost of precious metals is still challenging.This review describes the recent development of heterogeneous catalysts for alkene,alkyne,and allene hydrosilylations,which can effectively solve problems in homogeneous hydrosilylation.
基金supported by the National Natural Science Foundation of China(22371083,22001086)the Fundamental Research Funds for the Central Universities(2024BRB003,HUST 2020kfyXJJS094)+1 种基金the State Key Laboratory of Natural and Biomimetic Drugs,Peking University(K202409)the Innovation and Talent Recruitment Base of New Energy Chemistry and Device(B21003).
文摘The development of sustainable and efficient catalytic systems for the formation C-C,C-N,C-o bonds is a fundamental goal in modern synthetic chemistry.We present a biomass-derived Cu/Chitosan-800 catalyst that facilitates a range of carbenoid insertion reactions into C-H,N-H,and O-H bonds.This catalyst demonstrates remarkable activity,enabling the functionalization of diverse substrates,including the late-stage modification of drug molecules with up to 95%yield and good recyclability.Our findings highlight the catalyst's potential in advancing environmentally friendly chemical transformations,offering a promising tool for pharmaceutical synthesis and organic synthesis.
基金supported by the National Natural Science Foundation of China(21772161,21828102)the Natural Science Foundation of Fujian Province(2019J02001)+3 种基金the President Research Funds from Xiamen University(20720180036)NFFTBS(J1310024)the Foundation of Wenzhou Science&Technology Bureau(ZY2020027)the Science&Technology Co-operation Program of Xiamen(3502Z20183015)。
文摘Direct functionalization of inert C(sp^(3))–H bonds is a topic of immense contemporary interest and exceptional value in organic synthesis.The recent research has established a novel and practical protocol which features the engagement of vinyl cation species to functionalize C(sp^(3))–H bonds.The discussion of the topic is arranged by the strategies to generate the reactive intermediates,including ionization of vinyl triflates,addition of electrophiles to alkynes,tandem cyclization of enynes or diynes,and decomposition ofβ-hydroxy-α-diazo ketones.This review closes with a personal perspective on the dynamic research area of unactivated C(sp^(3))–H functionalization via vinyl cations.Hopefully,it will provide timely illumination and beneficial guidance for organic chemists who are interested in this area.Meanwhile continued development of the field is strongly anticipated in the future.
