The induction of antitumor immunity by tumor antigens released from cancer cells following regional photothermal therapy(PTT)alone may not be adequate for achieving complete tumor elimination.Combination therapy with ...The induction of antitumor immunity by tumor antigens released from cancer cells following regional photothermal therapy(PTT)alone may not be adequate for achieving complete tumor elimination.Combination therapy with immune adjuvants enhances antitumor immune responses,but faces challenges such as targeting deficiencies,systemic toxicity,and uncontrolled release behavior.Herein,we introduce a novel dual-functional hybrid membrane nanoparticle(HM-NP)incorporating gold nanorods(GNRs)and a thermally responsive polymer shell.HM-NP demonstrates exceptional homotypic targeting efficacy beneath the tumor cell membrane(TM),leading to substantial tumor accumulation.Upon in situ near-infrared(NIR)stimulation,GNRs within HM-NP generate heat,triggering the burst release of HM by facilitating the contraction and disintegration of the thermally responsive polymer shell.HM-NP exhibits excellent photothermal conversion efficiency under NIR irradiation,enabling effective destruction of primary tumors,release of tumor-associated antigens,and stimulation of potent anti-cancer immune.Simultaneously,the immune responses are strengthened by TM and Escherichia coli membrane(EM)through promoting the maturation of antigen presenting cells(APCs)and activating cytotoxic T lymphocytes(CTLs).Moreover,the use of polymer shells enables efficient cancer therapy with minimal host clearance and adverse effects.This photothermally triggered immunotherapy holds promise for precise and personalized treatment of tumors.展开更多
Effect of cooling rates,i.e.,air cooling and furnace cooling,after solution in α+β phase-field on variant selection,coarsening behavior of α phase and microstructure evolution were investigated in α+β TC21 alloy....Effect of cooling rates,i.e.,air cooling and furnace cooling,after solution in α+β phase-field on variant selection,coarsening behavior of α phase and microstructure evolution were investigated in α+β TC21 alloy.The textures of primary α(α_(p))and lamellar α(α_(L))in β phase transformation microstructure(β_(t))were analysed separately,and the orientation relationship among α_(p),α_(L) and the parent β phase were studied.In addition,the influence of the microstructure characteristics on the tensile properties was investigated.The results showed that all parent β grains,despite their different orientations,produced 12 ideal α_(L) variants with the same texture components and interweave to form a basketweave β_(t) structure under the air-cooling condition.The α_(p) without Burgers orientation relationship(BOR)with β phase exhibited obviously texture component without overlapping theαL texture component.The volume fraction of α_(p) in the furnace-cooled sample(about 50%)was higher than that of the air-cooled sample(about 12%),while the size of it slightly increased with decreasing the cooling rate.In each β grain,the thick α_(L) in the same orientation formed anαcolony.A typical 3 variant colonies which were related to each other were observed.Consequently,the α_(L) spatial orientation distribution showed more heterogeneity.Moreover,the BOR between α_(p) and β and the same orientation of some α_(L) and the surrounding α_(p) grains resulting in the overlapping of α_(p) texture component and α_(L) texture component.At last,the relationship between microstructure and tensile properties was analysed.展开更多
Ti-6Al,Ti-6Al-2Mo and Ti-6Al-3Nb alloys were prepared to investigate the toughening effects ofβstabilizers Mo and Nb on impact toughness and crack resistance of titanium alloys.Instrumented Charpy impact tests showed...Ti-6Al,Ti-6Al-2Mo and Ti-6Al-3Nb alloys were prepared to investigate the toughening effects ofβstabilizers Mo and Nb on impact toughness and crack resistance of titanium alloys.Instrumented Charpy impact tests showed that the total impact absorbed energy of Ti-6Al-2Mo and Ti-6Al-3Nb(∼64 J)were two times higher than that of Ti-6Al(∼30 J),indicating the higher impact toughness of Ti-6Al-2Mo and Ti-6Al-3Nb alloys.Analysis of load-displacement curves revealed the similar crack initiation energy of Ti-6Al,Ti-6Al-2Mo and Ti-6Al-3Nb(15.4 J,16.1 J and 15.0 J,respectively).However,the higher crack propagation energy of Ti-6Al-2Mo and Ti-6Al-3Nb(46.7 J and 48.3 J,respectively)were about three times higher than that of Ti-6Al(14.4 J),indicating the stronger resistance to crack propagation in Ti-6Al-2Mo and Ti-6Al-3Nb.Post-mortem analysis of impact samples demonstrated that the increased dislocation density and deformation twinning were mainly responsible for the stronger resistance to crack propagation in Ti-6Al-2Mo and Ti-6Al-3Nb.Due to the invisibility of dislocation activation and deformation twinning during the Charpy impact process,a mathematical model has been proposed to evaluate the effects of Al,Mo and Nb elements on dislocation mobility based on the Yu Rui-huang electron theory.Addition of Mo and Nb elements significantly improved the dislocation mobility in Ti-6Al-2Mo and Ti-6Al-3Nb compared to that in Ti-6Al alloy.Therefore,more dislocations were activated in Ti-6Al-2Mo and Ti-6Al-3Nb which supplied the larger plastic deformation under impact loading.A dislocation-based model also has been proposed to interpret the nucleation and propagation of deformation twinning under the impact loading.Dislocation pileup atα/βinterfaces provided potential sites for nucleation of deformation twinning in Ti-6Al-2Mo and Ti-6Al-3Nb.Furthermore,deformation twinning facilitated the dislocation motion inαgrains with hard orientations.The increased dislocation mobility and deformation twinning were responsible for the stronger crack resistance as well as the higher impact toughness of Ti-6Al-2Mo and Ti-6Al-3Nb alloys.展开更多
A randomized,double-blind,placebo-controlled multicenter trial was conducted in healthy Chinese infants to assess the efficacy and safety of a hexavalent live human-bovine reassortant rotavirus vaccine(HRV)against rot...A randomized,double-blind,placebo-controlled multicenter trial was conducted in healthy Chinese infants to assess the efficacy and safety of a hexavalent live human-bovine reassortant rotavirus vaccine(HRV)against rotavirus gastroenteritis(RVGE).A total of 6400 participants aged 6-12 weeks were enrolled and randomly assigned to either HRV(n?3200)or placebo(n?3200)group.All the subjects received three oral doses of vaccine four weeks apart.The vaccine efficacy(VE)against RVGE caused by rotavirus serotypes contained in HRV was evaluated from 14 days after three doses of administration up until the end of the second rotavirus season.VE against severe RVGE,VE against RVGE hospitalization caused by serotypes contained in HRV,and VE against RVGE,severe RVGE,and RVGE hospitalization caused by natural infection of any serotype of rotavirus were also investigated.All adverse events(AEs)were collected for 30 days after each dose.Serious AEs(SAEs)and intussusception cases were collected during the entire study.Our data showed that VE against RVGE caused by serotypes contained in HRV was 69.21%(95%CI:53.31-79.69).VE against severe RVGE and RVGE hospitalization caused by serotypes contained in HRV were 91.36%(95%CI:78.45-96.53)and 89.21%(95%CI:64.51-96.72)respectively.VE against RVGE,severe RVGE,and RVGE hospitalization caused by natural infection of any serotype of rotavirus were 62.88%(95%CI:49.11-72.92),85.51%(95%CI:72.74-92.30)and 83.68%(95%CI:61.34-93.11).Incidences of AEs from the first dose to one month post the third dose in HRV and placebo groups were comparable.There was no significant difference in incidences of SAEs in HRV and placebo groups.This study shows that this hexavalent reassortant rotavirus vaccine is an effective,well-tolerated,and safe vaccine for Chinese infants.展开更多
The deformation behavior ofβ-quenched nearβTi-5321(Ti-5Al-3Mo-3V-2Cr-2Zr-1Nb-1Fe)alloy was systematically studied using in-situ tensile test monitored by the scanning electron microscopy(SEM).Besides,the electron ba...The deformation behavior ofβ-quenched nearβTi-5321(Ti-5Al-3Mo-3V-2Cr-2Zr-1Nb-1Fe)alloy was systematically studied using in-situ tensile test monitored by the scanning electron microscopy(SEM).Besides,the electron backscatter diffraction(EBSD)was performed to thoroughly discuss the deformation mechanisms.The results indicated that slip activities,crystal rotation and stress induced martensite transformation were the major deformation mechanisms in theβ-quenched Ti-5321 alloy during in-situ tensile testing.The slip activities were investigated by using the EBSD-trace analysis,which demonstrated that{110}<111>,{112}<111>and{123}<111>slip systems were activated and the{110}<111>slip system dominated.Besides,βgrains rotated about 7.8°to accommodate the increased macrostrain.Notably,the stress induced martensiteα″which was related to the double yielding behavior during tensile process exhibited multiple characteristics.The differentα″variants divided theβmatrix into smallerβblocks with a typical zigzag morphology,in which oneα″variant passed through another one by deflecting its initial growth direction.Moreover,the deformation twinning in martensiteα″and slip bands cutting through martensiteα″effectively accommodated the local strain.These systematically analysis can provide insightful information about the deformation mechanisms in nearβtitanium alloys.展开更多
Near β titanium alloys are attractive materials for aeronautical applications due to their high specific strength,excellent damage tolerance performance and good hardenability.Their mechanical properties are strongly...Near β titanium alloys are attractive materials for aeronautical applications due to their high specific strength,excellent damage tolerance performance and good hardenability.Their mechanical properties are strongly governed by the microstructural characteristics,especially the morphology,volume fraction,orientation and distribution of theαphase.展开更多
Development of high-efficiency and low-cost electrocatalyst for oxygen evolution reaction(OER) is very important for use at alkaline water electrolysis.Metal-organic frameworks(MOF) provide a rich platform for designi...Development of high-efficiency and low-cost electrocatalyst for oxygen evolution reaction(OER) is very important for use at alkaline water electrolysis.Metal-organic frameworks(MOF) provide a rich platform for designing multi-functional materials due to their controllable composition and ultra-high surface area.Herein,we report our findings in the development of amorphous nickel-cobalt bimetal-organic framework nanosheets with crystalline motifs via a simple "ligands hybridization engineering" strategy.These complexes' ligands contain inorganic ligands(H_2 O and NO_3) and organic ones,hexamethylenetetramine(HMT).Further,we investigated a series of mixed-metal with multi-ligands materials as OER catalysts to explore their possible advantages and features.It is found that the Ni doping is an effective approach for optimizing the electronic configuration,changing lattice ordering degree,and thus enhancing activities of HMT-based electrocatalysts.Also,the crystalline-amorphous boundaries of various HMTbased electrocatalyst can be easily controlled by simply changing amounts of Ni-precursor added.As a result,the optimized ultrathin(Co,0.3 Ni)-HMT nanosheets can reach a current density of 10 mA cm^(-2)at low overpotential of 330 mV with a small Tafel slope of 66 mV dec^(-1).Our findings show that the electronic structure changes induced by Ni doping,2 D nanosheet structure,and MOF frameworks with multiligands compositions play critical roles in the enhancement of the kinetically sluggish electrocatalytic OER.The present study emphasizes the importance of ligands and active metals via hybridization for exploring novel efficient electrocatalysts.展开更多
The economic benefits of interconnecting the power grids of Europe(EU) and China(CN) were assessed considering 100% reliance on renewable energy(RE). Four different scenarios, energy storage without interconnection, i...The economic benefits of interconnecting the power grids of Europe(EU) and China(CN) were assessed considering 100% reliance on renewable energy(RE). Four different scenarios, energy storage without interconnection, installing additional renewable energy sources without interconnection, energy storage with interconnection, and installing additional RE sources with interconnection, were considered for the economic benefit analysis. A comparative study of these four scenarios was conducted to identify the best option for achieving hourly power balance. Further, sensitivity analysis was carried out to demonstrate the robustness of the results. Electricity interconnection between CN and EU decreases the annual additional costs by more than 30% when compared to the absence of interconnection, which demonstrates the necessity and benefits of CN-EU electricity interconnection.展开更多
This study aims at investigating the impact of using the Magnetorheological Elastomers(MREs)medium to improve the formability of T-shaped Inconel 718 tubes during the bulging process.Besides,the influence of the punch...This study aims at investigating the impact of using the Magnetorheological Elastomers(MREs)medium to improve the formability of T-shaped Inconel 718 tubes during the bulging process.Besides,the influence of the punch size and the intensity of the magnetic field on the branch height and wall thickness distribution of the T-shaped Inconel 718 tubes are also explored.The results showed that the parts formed by the punch with a length of 5 mm in the pressurization zone have better forming quality.The external magnetic field can promote a high branch,and by increasing the intensity of the magnetic field,the branch height was increased and then decreased.At the same time,the magnetic field reduced the amount of material accumulation between the guiding zone and the bulging zone.Besides,it promotes the material in the guiding zone to enter the bulging zone and improve the bulging ability of the T-shaped tube.展开更多
Lithium-ion batteries(LIBs) have been developed for over 30 years;however, existing electrode materials cannot satisfy the increasing requirements of high-energy density, stable cycling, and low cost. Here, we present...Lithium-ion batteries(LIBs) have been developed for over 30 years;however, existing electrode materials cannot satisfy the increasing requirements of high-energy density, stable cycling, and low cost. Here, we present a perovskite-type LaNiO3 oxide(LNO) as a new negative electrode material. LNO was successfully synthesized by a sol-gel method. The microstructure and electrochemical performance of LNO calcined at various temperatures have been systematically investigated. The LNO electrode shows a high rate capability and long cycling stability. In a C-rate test, a specific capacity of 77 mAh/g was exhibited at 6 C. LNO can also deliver a specific capacity of 92 mAh/g after 200 cycles at 1 C. This paper presents a type of binary metal oxide as a new anode material for high-performance LIBs.展开更多
结节性硬化症(tuberous sclerosis,TS)是临床上以面部血管纤维瘤、鲨鱼皮样斑、视网膜错构瘤、肾错构瘤(hamartoma of kidney,HK)、脏器结节、癫痫及智力障碍等特征为主的一类疾病,目前TS存在较多的误诊、漏诊。南昌大学第一附属医院近...结节性硬化症(tuberous sclerosis,TS)是临床上以面部血管纤维瘤、鲨鱼皮样斑、视网膜错构瘤、肾错构瘤(hamartoma of kidney,HK)、脏器结节、癫痫及智力障碍等特征为主的一类疾病,目前TS存在较多的误诊、漏诊。南昌大学第一附属医院近年收治2例以肾功能不全为主要临床表现的TS患者,现报道如下。展开更多
In this investigation,a new silicone rubber-based MRE material was prepared to be used as a forming medium in manufacturing thin-walled complexshaped Ni-based tubes through the bulging process.Thus,it is significant t...In this investigation,a new silicone rubber-based MRE material was prepared to be used as a forming medium in manufacturing thin-walled complexshaped Ni-based tubes through the bulging process.Thus,it is significant to investigate the effect of magnetic field intensity,magnetic field loading time,and angle on the mechanical properties of the prepared MRE material during the curing process.The obtained results showed that increasing the magnetic field intensity during the curing process can improve the orientation of the chain structure in the elastomer matrix effectively.However,its mechanical properties are the best under the corresponding magnetic field intensity of 321 mT.Besides,by extending the magnetic field loading time in the curing process,the orientation of the chain structure was optimized,at the same time,the mechanical properties were also improved,and the best loading time is about 20–25 min.By changing the loading angle of the magnetic field during the curing process,the mechanical properties of the MRE were improved.When the loading angle of the magnetic field is 90°,the elastomer showed the best compression mechanical properties and excellent compression reversibility.Besides,for the anisotropic MRE material,the performance with magnetic compression is always better than that without magnetic compression.展开更多
Autophagy is a process of lysosome degradation,which plays an important role in maintaining cell homeostasis and organ integrity through the degradation of misfolded proteins,removal of damaged organelles and excess l...Autophagy is a process of lysosome degradation,which plays an important role in maintaining cell homeostasis and organ integrity through the degradation of misfolded proteins,removal of damaged organelles and excess lipids,which is one of the research hotspots in recent years.Liver disease often develops into chronic disease with high mortality,which seriously affects the life safety and quality of life of patients.Studies have shown that autophagy participates in the processes of cellular immunity and oxidative stress,plays an important role in a variety of liver diseases,has the characteristics of two-way regulation,and moderate autophagy has a protective effect.Excessive or dysfunctional autophagy can promote cell death and lead to the occurrence and development of the disease.at present,regulating autophagy is considered as a potential treatment.Based on chronic viral hepatitis,liver fibrosis,non-alcoholic fatty liver disease,acute liver failure and primary liver cancer,this paper reviews the functional characteristics and regulatory mechanism of autophagy in liver diseases.to explore new therapeutic targets for liver diseases,in order to provide new ideas and basis for clinical diagnosis and treatment.展开更多
Hepatocytes can divide rapidly and proliferate in the absence of inflammation and fibroplasia in the damaged or partial hepatectomy(PHx)of the liver,which is essential for the recovery of related patients.Recent studi...Hepatocytes can divide rapidly and proliferate in the absence of inflammation and fibroplasia in the damaged or partial hepatectomy(PHx)of the liver,which is essential for the recovery of related patients.Recent studies have found that bile acids(BA)play an important role in the process of liver regeneration.In the early stages of PHx,bile acid overload occurs,and liver injury is aggravated by loading.Later bile acids can induce protective and proliferative responses in the liver and promote liver regeneration.In this paper,we summarize the negative effects after bile acid overload and its positive role as a signaling molecule involved in related signaling pathways on liver regeneration,including protection of the liver and promotion of liver regeneration,and its double-edswordged"in Liver regeneration.This provides a theoretical basis for subsequent in-depth study of the mechanism and benefit avoidance in clinical treatment.展开更多
The incidence of liver fibrosis is increasing worldwide,and if left untreated,it will later develop into cirrhosis with a high mortality rate.In this paper,the activation pathway and related mechanism of stellate cell...The incidence of liver fibrosis is increasing worldwide,and if left untreated,it will later develop into cirrhosis with a high mortality rate.In this paper,the activation pathway and related mechanism of stellate cells in liver fibrosis are introduced,and some current therapeutic methods are summarized.These results suggest that stellate cells play an important role in liver fibrosis,and targeted therapy for the purpose of inhibiting the activation of stellate cells and inducing their apoptosis is expected to be an effective regimen to reverse liver fibrosis.However,there are some problems such as insufficient in-depth study of related mechanisms and imperfect experiments.In future animal experiments and clinical trials,more studies can be carried out to provide high-quality protocols for the treatment of liver fibrosis.展开更多
基金supported by the National Natural Science Foundation of China(Nos.92059112,82072821 and 31470964)University of Shanghai for Science and Technology(No.10-21302-405)+1 种基金the Program of Shanghai Academic/Technology Research Leader(No.22XD1404700)the Shanghai Songjiang Municipal Science and Technology Commission Natural Science Foundation(No.20SJKJGG250)。
文摘The induction of antitumor immunity by tumor antigens released from cancer cells following regional photothermal therapy(PTT)alone may not be adequate for achieving complete tumor elimination.Combination therapy with immune adjuvants enhances antitumor immune responses,but faces challenges such as targeting deficiencies,systemic toxicity,and uncontrolled release behavior.Herein,we introduce a novel dual-functional hybrid membrane nanoparticle(HM-NP)incorporating gold nanorods(GNRs)and a thermally responsive polymer shell.HM-NP demonstrates exceptional homotypic targeting efficacy beneath the tumor cell membrane(TM),leading to substantial tumor accumulation.Upon in situ near-infrared(NIR)stimulation,GNRs within HM-NP generate heat,triggering the burst release of HM by facilitating the contraction and disintegration of the thermally responsive polymer shell.HM-NP exhibits excellent photothermal conversion efficiency under NIR irradiation,enabling effective destruction of primary tumors,release of tumor-associated antigens,and stimulation of potent anti-cancer immune.Simultaneously,the immune responses are strengthened by TM and Escherichia coli membrane(EM)through promoting the maturation of antigen presenting cells(APCs)and activating cytotoxic T lymphocytes(CTLs).Moreover,the use of polymer shells enables efficient cancer therapy with minimal host clearance and adverse effects.This photothermally triggered immunotherapy holds promise for precise and personalized treatment of tumors.
基金financially supported by the National Key Research and Development Program of China (No.2016YFB0301201)
文摘Effect of cooling rates,i.e.,air cooling and furnace cooling,after solution in α+β phase-field on variant selection,coarsening behavior of α phase and microstructure evolution were investigated in α+β TC21 alloy.The textures of primary α(α_(p))and lamellar α(α_(L))in β phase transformation microstructure(β_(t))were analysed separately,and the orientation relationship among α_(p),α_(L) and the parent β phase were studied.In addition,the influence of the microstructure characteristics on the tensile properties was investigated.The results showed that all parent β grains,despite their different orientations,produced 12 ideal α_(L) variants with the same texture components and interweave to form a basketweave β_(t) structure under the air-cooling condition.The α_(p) without Burgers orientation relationship(BOR)with β phase exhibited obviously texture component without overlapping theαL texture component.The volume fraction of α_(p) in the furnace-cooled sample(about 50%)was higher than that of the air-cooled sample(about 12%),while the size of it slightly increased with decreasing the cooling rate.In each β grain,the thick α_(L) in the same orientation formed anαcolony.A typical 3 variant colonies which were related to each other were observed.Consequently,the α_(L) spatial orientation distribution showed more heterogeneity.Moreover,the BOR between α_(p) and β and the same orientation of some α_(L) and the surrounding α_(p) grains resulting in the overlapping of α_(p) texture component and α_(L) texture component.At last,the relationship between microstructure and tensile properties was analysed.
基金The authors acknowledge the financial supports of National Key Research and Development Program of China(2016YFB0301201)。
文摘Ti-6Al,Ti-6Al-2Mo and Ti-6Al-3Nb alloys were prepared to investigate the toughening effects ofβstabilizers Mo and Nb on impact toughness and crack resistance of titanium alloys.Instrumented Charpy impact tests showed that the total impact absorbed energy of Ti-6Al-2Mo and Ti-6Al-3Nb(∼64 J)were two times higher than that of Ti-6Al(∼30 J),indicating the higher impact toughness of Ti-6Al-2Mo and Ti-6Al-3Nb alloys.Analysis of load-displacement curves revealed the similar crack initiation energy of Ti-6Al,Ti-6Al-2Mo and Ti-6Al-3Nb(15.4 J,16.1 J and 15.0 J,respectively).However,the higher crack propagation energy of Ti-6Al-2Mo and Ti-6Al-3Nb(46.7 J and 48.3 J,respectively)were about three times higher than that of Ti-6Al(14.4 J),indicating the stronger resistance to crack propagation in Ti-6Al-2Mo and Ti-6Al-3Nb.Post-mortem analysis of impact samples demonstrated that the increased dislocation density and deformation twinning were mainly responsible for the stronger resistance to crack propagation in Ti-6Al-2Mo and Ti-6Al-3Nb.Due to the invisibility of dislocation activation and deformation twinning during the Charpy impact process,a mathematical model has been proposed to evaluate the effects of Al,Mo and Nb elements on dislocation mobility based on the Yu Rui-huang electron theory.Addition of Mo and Nb elements significantly improved the dislocation mobility in Ti-6Al-2Mo and Ti-6Al-3Nb compared to that in Ti-6Al alloy.Therefore,more dislocations were activated in Ti-6Al-2Mo and Ti-6Al-3Nb which supplied the larger plastic deformation under impact loading.A dislocation-based model also has been proposed to interpret the nucleation and propagation of deformation twinning under the impact loading.Dislocation pileup atα/βinterfaces provided potential sites for nucleation of deformation twinning in Ti-6Al-2Mo and Ti-6Al-3Nb.Furthermore,deformation twinning facilitated the dislocation motion inαgrains with hard orientations.The increased dislocation mobility and deformation twinning were responsible for the stronger crack resistance as well as the higher impact toughness of Ti-6Al-2Mo and Ti-6Al-3Nb alloys.
基金supported by National Health Commission of the People’s Republic of China (grant number:2019ZX09302059)sponsored and funded by Wuhan Institute of Biological Products Co.,Ltd.,Hubei,China
文摘A randomized,double-blind,placebo-controlled multicenter trial was conducted in healthy Chinese infants to assess the efficacy and safety of a hexavalent live human-bovine reassortant rotavirus vaccine(HRV)against rotavirus gastroenteritis(RVGE).A total of 6400 participants aged 6-12 weeks were enrolled and randomly assigned to either HRV(n?3200)or placebo(n?3200)group.All the subjects received three oral doses of vaccine four weeks apart.The vaccine efficacy(VE)against RVGE caused by rotavirus serotypes contained in HRV was evaluated from 14 days after three doses of administration up until the end of the second rotavirus season.VE against severe RVGE,VE against RVGE hospitalization caused by serotypes contained in HRV,and VE against RVGE,severe RVGE,and RVGE hospitalization caused by natural infection of any serotype of rotavirus were also investigated.All adverse events(AEs)were collected for 30 days after each dose.Serious AEs(SAEs)and intussusception cases were collected during the entire study.Our data showed that VE against RVGE caused by serotypes contained in HRV was 69.21%(95%CI:53.31-79.69).VE against severe RVGE and RVGE hospitalization caused by serotypes contained in HRV were 91.36%(95%CI:78.45-96.53)and 89.21%(95%CI:64.51-96.72)respectively.VE against RVGE,severe RVGE,and RVGE hospitalization caused by natural infection of any serotype of rotavirus were 62.88%(95%CI:49.11-72.92),85.51%(95%CI:72.74-92.30)and 83.68%(95%CI:61.34-93.11).Incidences of AEs from the first dose to one month post the third dose in HRV and placebo groups were comparable.There was no significant difference in incidences of SAEs in HRV and placebo groups.This study shows that this hexavalent reassortant rotavirus vaccine is an effective,well-tolerated,and safe vaccine for Chinese infants.
基金financially supported by the National International Science and Technology Cooperation Project of China(No.2015DF151430)。
文摘The deformation behavior ofβ-quenched nearβTi-5321(Ti-5Al-3Mo-3V-2Cr-2Zr-1Nb-1Fe)alloy was systematically studied using in-situ tensile test monitored by the scanning electron microscopy(SEM).Besides,the electron backscatter diffraction(EBSD)was performed to thoroughly discuss the deformation mechanisms.The results indicated that slip activities,crystal rotation and stress induced martensite transformation were the major deformation mechanisms in theβ-quenched Ti-5321 alloy during in-situ tensile testing.The slip activities were investigated by using the EBSD-trace analysis,which demonstrated that{110}<111>,{112}<111>and{123}<111>slip systems were activated and the{110}<111>slip system dominated.Besides,βgrains rotated about 7.8°to accommodate the increased macrostrain.Notably,the stress induced martensiteα″which was related to the double yielding behavior during tensile process exhibited multiple characteristics.The differentα″variants divided theβmatrix into smallerβblocks with a typical zigzag morphology,in which oneα″variant passed through another one by deflecting its initial growth direction.Moreover,the deformation twinning in martensiteα″and slip bands cutting through martensiteα″effectively accommodated the local strain.These systematically analysis can provide insightful information about the deformation mechanisms in nearβtitanium alloys.
基金funded by the National Key Research and Development Program of China(No.2016YFB0301201)the National International Science and Technology Cooperation Project of China(No.2015DF151430)。
文摘Near β titanium alloys are attractive materials for aeronautical applications due to their high specific strength,excellent damage tolerance performance and good hardenability.Their mechanical properties are strongly governed by the microstructural characteristics,especially the morphology,volume fraction,orientation and distribution of theαphase.
基金financial support from the National Natural Science Foundation of China (No. 51768016)Guangxi Natural Science Foundation (No. 2018GXNSFAA138199)Guangxi Engineering and Technology Center for Utilization of Industrial Waste Residue in Building Materials, Guangxi Key Laboratory of New Energy and Building Energy Saving (19-J-21-17)。
文摘Development of high-efficiency and low-cost electrocatalyst for oxygen evolution reaction(OER) is very important for use at alkaline water electrolysis.Metal-organic frameworks(MOF) provide a rich platform for designing multi-functional materials due to their controllable composition and ultra-high surface area.Herein,we report our findings in the development of amorphous nickel-cobalt bimetal-organic framework nanosheets with crystalline motifs via a simple "ligands hybridization engineering" strategy.These complexes' ligands contain inorganic ligands(H_2 O and NO_3) and organic ones,hexamethylenetetramine(HMT).Further,we investigated a series of mixed-metal with multi-ligands materials as OER catalysts to explore their possible advantages and features.It is found that the Ni doping is an effective approach for optimizing the electronic configuration,changing lattice ordering degree,and thus enhancing activities of HMT-based electrocatalysts.Also,the crystalline-amorphous boundaries of various HMTbased electrocatalyst can be easily controlled by simply changing amounts of Ni-precursor added.As a result,the optimized ultrathin(Co,0.3 Ni)-HMT nanosheets can reach a current density of 10 mA cm^(-2)at low overpotential of 330 mV with a small Tafel slope of 66 mV dec^(-1).Our findings show that the electronic structure changes induced by Ni doping,2 D nanosheet structure,and MOF frameworks with multiligands compositions play critical roles in the enhancement of the kinetically sluggish electrocatalytic OER.The present study emphasizes the importance of ligands and active metals via hybridization for exploring novel efficient electrocatalysts.
基金sponsored partly by EPSRC (Engineering and Physical Sciences Research Council) Grant EP/L017725/1,and Grant EP/N032888/1ATETA (Accelerating Thermal Energy Technology Adoption) projectChina Scholarship Council.of Ministry of Education of China
文摘The economic benefits of interconnecting the power grids of Europe(EU) and China(CN) were assessed considering 100% reliance on renewable energy(RE). Four different scenarios, energy storage without interconnection, installing additional renewable energy sources without interconnection, energy storage with interconnection, and installing additional RE sources with interconnection, were considered for the economic benefit analysis. A comparative study of these four scenarios was conducted to identify the best option for achieving hourly power balance. Further, sensitivity analysis was carried out to demonstrate the robustness of the results. Electricity interconnection between CN and EU decreases the annual additional costs by more than 30% when compared to the absence of interconnection, which demonstrates the necessity and benefits of CN-EU electricity interconnection.
基金supported by the Key Program of the National Natural Foundation of China(No.U1937206)Jiangsu Province Key Research and Development Project(No.BE2019007-2)+2 种基金Opening Project of Jiangsu Key Laboratory of Advanced Structural MaterialsApplication Technology(No.ASMA201903)Basic scientific research operating expenses(No.NT2020015).
文摘This study aims at investigating the impact of using the Magnetorheological Elastomers(MREs)medium to improve the formability of T-shaped Inconel 718 tubes during the bulging process.Besides,the influence of the punch size and the intensity of the magnetic field on the branch height and wall thickness distribution of the T-shaped Inconel 718 tubes are also explored.The results showed that the parts formed by the punch with a length of 5 mm in the pressurization zone have better forming quality.The external magnetic field can promote a high branch,and by increasing the intensity of the magnetic field,the branch height was increased and then decreased.At the same time,the magnetic field reduced the amount of material accumulation between the guiding zone and the bulging zone.Besides,it promotes the material in the guiding zone to enter the bulging zone and improve the bulging ability of the T-shaped tube.
基金supported by the National Natural Science Foundations of China (No. 21805185)ShanghaiTech University Start-Up Funding.
文摘Lithium-ion batteries(LIBs) have been developed for over 30 years;however, existing electrode materials cannot satisfy the increasing requirements of high-energy density, stable cycling, and low cost. Here, we present a perovskite-type LaNiO3 oxide(LNO) as a new negative electrode material. LNO was successfully synthesized by a sol-gel method. The microstructure and electrochemical performance of LNO calcined at various temperatures have been systematically investigated. The LNO electrode shows a high rate capability and long cycling stability. In a C-rate test, a specific capacity of 77 mAh/g was exhibited at 6 C. LNO can also deliver a specific capacity of 92 mAh/g after 200 cycles at 1 C. This paper presents a type of binary metal oxide as a new anode material for high-performance LIBs.
文摘结节性硬化症(tuberous sclerosis,TS)是临床上以面部血管纤维瘤、鲨鱼皮样斑、视网膜错构瘤、肾错构瘤(hamartoma of kidney,HK)、脏器结节、癫痫及智力障碍等特征为主的一类疾病,目前TS存在较多的误诊、漏诊。南昌大学第一附属医院近年收治2例以肾功能不全为主要临床表现的TS患者,现报道如下。
基金The funding for the investigation in this paper mainly comes from the following funds.Funded by the National Natural Science Foundation Key Project of China(Grant No.U1937206)the authors are Li,Xu,Guo,the specific grant numbers was RMB 100,000.Funded by the Jiangsu Province Key Research and Development Project(No.BE2019007-2)+2 种基金the authors are Abd,Cheng,the specific grant numbers was RMB 200,000.Funded by the Opening Project of Jiangsu Key Laboratory of Advanced Structural Materials and Application Technology(No.ASMA201903)the authors are Wu,Yang,Hu,the specific grant numbers was RMB 50,000.Funded by the Basic Scientific Research Operations(Approval No.NT2020015)the authors are Shen,Tao,Guo,the specific grant numbers was RMB 100,000.
文摘In this investigation,a new silicone rubber-based MRE material was prepared to be used as a forming medium in manufacturing thin-walled complexshaped Ni-based tubes through the bulging process.Thus,it is significant to investigate the effect of magnetic field intensity,magnetic field loading time,and angle on the mechanical properties of the prepared MRE material during the curing process.The obtained results showed that increasing the magnetic field intensity during the curing process can improve the orientation of the chain structure in the elastomer matrix effectively.However,its mechanical properties are the best under the corresponding magnetic field intensity of 321 mT.Besides,by extending the magnetic field loading time in the curing process,the orientation of the chain structure was optimized,at the same time,the mechanical properties were also improved,and the best loading time is about 20–25 min.By changing the loading angle of the magnetic field during the curing process,the mechanical properties of the MRE were improved.When the loading angle of the magnetic field is 90°,the elastomer showed the best compression mechanical properties and excellent compression reversibility.Besides,for the anisotropic MRE material,the performance with magnetic compression is always better than that without magnetic compression.
基金General Program of National Natural Science Foundation of China(No.81774236)National Natural Science Foundation of China(No.81960841)+1 种基金Guangxi Science and Technology Planning Project(No.GuikeAD17129001)Project supported by Guangxi Natural Science Foundation(No.2018GXNSFAA281096)。
文摘Autophagy is a process of lysosome degradation,which plays an important role in maintaining cell homeostasis and organ integrity through the degradation of misfolded proteins,removal of damaged organelles and excess lipids,which is one of the research hotspots in recent years.Liver disease often develops into chronic disease with high mortality,which seriously affects the life safety and quality of life of patients.Studies have shown that autophagy participates in the processes of cellular immunity and oxidative stress,plays an important role in a variety of liver diseases,has the characteristics of two-way regulation,and moderate autophagy has a protective effect.Excessive or dysfunctional autophagy can promote cell death and lead to the occurrence and development of the disease.at present,regulating autophagy is considered as a potential treatment.Based on chronic viral hepatitis,liver fibrosis,non-alcoholic fatty liver disease,acute liver failure and primary liver cancer,this paper reviews the functional characteristics and regulatory mechanism of autophagy in liver diseases.to explore new therapeutic targets for liver diseases,in order to provide new ideas and basis for clinical diagnosis and treatment.
基金General Program of National Natural Science Foundation of China(No.81774236,81960841)。
文摘Hepatocytes can divide rapidly and proliferate in the absence of inflammation and fibroplasia in the damaged or partial hepatectomy(PHx)of the liver,which is essential for the recovery of related patients.Recent studies have found that bile acids(BA)play an important role in the process of liver regeneration.In the early stages of PHx,bile acid overload occurs,and liver injury is aggravated by loading.Later bile acids can induce protective and proliferative responses in the liver and promote liver regeneration.In this paper,we summarize the negative effects after bile acid overload and its positive role as a signaling molecule involved in related signaling pathways on liver regeneration,including protection of the liver and promotion of liver regeneration,and its double-edswordged"in Liver regeneration.This provides a theoretical basis for subsequent in-depth study of the mechanism and benefit avoidance in clinical treatment.
基金Fund Project:General Program of National Natural Science Foundation of China(No.81774236)General Program of National Natural Science Foundation of China(No.81960841)。
文摘The incidence of liver fibrosis is increasing worldwide,and if left untreated,it will later develop into cirrhosis with a high mortality rate.In this paper,the activation pathway and related mechanism of stellate cells in liver fibrosis are introduced,and some current therapeutic methods are summarized.These results suggest that stellate cells play an important role in liver fibrosis,and targeted therapy for the purpose of inhibiting the activation of stellate cells and inducing their apoptosis is expected to be an effective regimen to reverse liver fibrosis.However,there are some problems such as insufficient in-depth study of related mechanisms and imperfect experiments.In future animal experiments and clinical trials,more studies can be carried out to provide high-quality protocols for the treatment of liver fibrosis.
