Causal associations between viral infections and acute myocardial injury are not fully understood,with mech-anisms potentially involving direct cardiovascular involvement or systemic inflammation.This review explores ...Causal associations between viral infections and acute myocardial injury are not fully understood,with mech-anisms potentially involving direct cardiovascular involvement or systemic inflammation.This review explores plausible mechanisms of vascular fibrosis in patients with post-COVID-19 syndrome,focusing on extracellular matrix remodelling.Despite global attention,significant mechanistic or translational breakthroughs in the man-agement of post-viral syndromes remain limited.No effective pharmacological or non-pharmacological interven-tions are currently available for patients experiencing persistent symptoms following COVID-19 infection.The substantial expansion of scientific knowledge resulting from collaborative efforts by medical experts,scientists,and government organisations in undertaking COVID-19 research could inform treatment strategies for other post-viral syndromes and respiratory illnesses.There is a critical need for clinical trials to evaluate potential therapeutic candidates,providing evidence to guide treatment decisions for post-COVID-19 syndromes.展开更多
基金Ms Anna Kamdar is supported by research funding from the British Heart Foundation MBPhD(FS/MBPhD/22/28011)Robert Sykes is supported by funding from the British Heart Foundation Centre of Research Excellence award(RE/18/6/34217)+4 种基金NHS Greater Glasgow and Clyde Endowment Fund-ing(GN21CA394)Cameron Thomson is supported by research funding from The University of Glasgow Doctoral Training Programme.Dr Kenneth Mangion is supported by research funding from the Chief Scientist Office(COV/LTE/20/10,COV/GLA/20/05)Ms Michelle Lee is supported by research funding from the British Heart Foundation Centre of Research Excel-lence(RE/18/6/34217)Professor Tom Van Agtmael is supported by research funding from EPSRC-Horizon Europe(EP/X031721/1[EU Ref:101072766])and MRC(MR/R005567/1)Professor Colin Berry is supported by research funding from the British Heart Foundation(FS/17/26/32744,PG/18/52-33892,RE/18/6/34217)and Medical Research Council(MR/SO18905/1).
文摘Causal associations between viral infections and acute myocardial injury are not fully understood,with mech-anisms potentially involving direct cardiovascular involvement or systemic inflammation.This review explores plausible mechanisms of vascular fibrosis in patients with post-COVID-19 syndrome,focusing on extracellular matrix remodelling.Despite global attention,significant mechanistic or translational breakthroughs in the man-agement of post-viral syndromes remain limited.No effective pharmacological or non-pharmacological interven-tions are currently available for patients experiencing persistent symptoms following COVID-19 infection.The substantial expansion of scientific knowledge resulting from collaborative efforts by medical experts,scientists,and government organisations in undertaking COVID-19 research could inform treatment strategies for other post-viral syndromes and respiratory illnesses.There is a critical need for clinical trials to evaluate potential therapeutic candidates,providing evidence to guide treatment decisions for post-COVID-19 syndromes.
