Objective: To estimate prevalence, incidence, and rate of progression of mild cognitive impairment (MCI) to dementia and correlated vascular risk factors wit h incident MCI and its progression to dementia. Methods: Th...Objective: To estimate prevalence, incidence, and rate of progression of mild cognitive impairment (MCI) to dementia and correlated vascular risk factors wit h incident MCI and its progression to dementia. Methods: The authors evaluated 2 ,963 individuals from the population-based sample of 5,632 subjects 65 to 84 y ears old, at the first (1992 to 1993) and second survey (1995 to 1996) of the It alian Longitudinal Study on Aging (ILSA), with a 3.5- year follow-up. Dementi a, Alzheimer disease (AD), vascular dementia (VaD), other types of dementia, and MCI were classified using current clinical criteria. Results: Among the 2,963 p articipants, 139 MCI patients were diagnosed at the first ILSA survey. During th e 3.5- year followup, 113 new events of MCI were diagnosed with an estimated in cidence rate of 21.5 per 1,000 person-years. We found a progression rate to de mentia (all causes) of 3.8/100 person-years. Specific progression rates for AD , VaD, and other types of dementia were 2.3, 1.3, and 0.3/100 person-years. Fu rthermore,age was a risk factor for incident MCI (RR: 5.93, 95% CI: 3.17 to 11 .10), while education was protective (RR: 0.06, 95% CI: 0.03 to 0.10), and ser um total cholesterol evidenced a borderline nonsignificant trend for a protectiv e effect. There was a nonsignificant trend for stroke as a risk factor of progre ssion of MCI to dementia. Conclusions: In this population, among those who progr essed to dementia, 60% progressed to AD and 33% to VaD. Vascular risk factor s influence incident mild cognitive impairment and the rate of progression to de mentia.展开更多
文摘Objective: To estimate prevalence, incidence, and rate of progression of mild cognitive impairment (MCI) to dementia and correlated vascular risk factors wit h incident MCI and its progression to dementia. Methods: The authors evaluated 2 ,963 individuals from the population-based sample of 5,632 subjects 65 to 84 y ears old, at the first (1992 to 1993) and second survey (1995 to 1996) of the It alian Longitudinal Study on Aging (ILSA), with a 3.5- year follow-up. Dementi a, Alzheimer disease (AD), vascular dementia (VaD), other types of dementia, and MCI were classified using current clinical criteria. Results: Among the 2,963 p articipants, 139 MCI patients were diagnosed at the first ILSA survey. During th e 3.5- year followup, 113 new events of MCI were diagnosed with an estimated in cidence rate of 21.5 per 1,000 person-years. We found a progression rate to de mentia (all causes) of 3.8/100 person-years. Specific progression rates for AD , VaD, and other types of dementia were 2.3, 1.3, and 0.3/100 person-years. Fu rthermore,age was a risk factor for incident MCI (RR: 5.93, 95% CI: 3.17 to 11 .10), while education was protective (RR: 0.06, 95% CI: 0.03 to 0.10), and ser um total cholesterol evidenced a borderline nonsignificant trend for a protectiv e effect. There was a nonsignificant trend for stroke as a risk factor of progre ssion of MCI to dementia. Conclusions: In this population, among those who progr essed to dementia, 60% progressed to AD and 33% to VaD. Vascular risk factor s influence incident mild cognitive impairment and the rate of progression to de mentia.
