Microglia have been recognized as a unique cell population in the central nervous system(CNS)for more than a century[1].However,it was not until 2010 that their developmental origin was clarified.Rather than arising f...Microglia have been recognized as a unique cell population in the central nervous system(CNS)for more than a century[1].However,it was not until 2010 that their developmental origin was clarified.Rather than arising from the neuroectoderm,microglia are derived from erythromyeloid progenitors in the embryonic yolk sac[2].展开更多
With the development of new experimental techniques(e.g.,single-cell RNA sequencing(scRNA-seq),light sheet microscopy,and clustered regularly interspaced palindromic repeats(CRISPR)/CRISPR-associated protein 9(Cas9),e...With the development of new experimental techniques(e.g.,single-cell RNA sequencing(scRNA-seq),light sheet microscopy,and clustered regularly interspaced palindromic repeats(CRISPR)/CRISPR-associated protein 9(Cas9),emerging studies have begun to uncover the interactions between the nervous system and the immune system,both in health and diseases.For example,in mucosal tissues such as the lung and the intestine,neurotransmitters including acetylcholine[1]and adrenaline[2]can directly regulate the immune cell functions thus affect the results of allergy,asthma,and anti-pathogen host defense[3].展开更多
基金supported in part by National Science and Technology Major Project of National Health Commission of China(2023ZD0520300)the National Natural Science Foundation of China(32130037 and 32370953)the Tsinghua University Initiative Scientific Research Program,SXMU-Tsinghua Collaborative Innovation Center for Frontier Medicine and the Research Fund of Vanke School of Public Health,Tsinghua University.H.Q.is a New Cornerstone Investigator.
文摘Microglia have been recognized as a unique cell population in the central nervous system(CNS)for more than a century[1].However,it was not until 2010 that their developmental origin was clarified.Rather than arising from the neuroectoderm,microglia are derived from erythromyeloid progenitors in the embryonic yolk sac[2].
基金supported by the National Natural Science Foundation of China(32370953 and 82072737)the Research Fund of Vanke School of Public Health,Tsinghua University.
文摘With the development of new experimental techniques(e.g.,single-cell RNA sequencing(scRNA-seq),light sheet microscopy,and clustered regularly interspaced palindromic repeats(CRISPR)/CRISPR-associated protein 9(Cas9),emerging studies have begun to uncover the interactions between the nervous system and the immune system,both in health and diseases.For example,in mucosal tissues such as the lung and the intestine,neurotransmitters including acetylcholine[1]and adrenaline[2]can directly regulate the immune cell functions thus affect the results of allergy,asthma,and anti-pathogen host defense[3].
