ComGIS is the mainstream of developing GIS currently.Developing Geographic Information System with the technology of components can reduce the difficulties of developing,improving the developing efficiency and enhanci...ComGIS is the mainstream of developing GIS currently.Developing Geographic Information System with the technology of components can reduce the difficulties of developing,improving the developing efficiency and enhancing the flexibility and opening of system.ArcObjects(AO) is based on the technology of COM,and ArcGIS Engine(AE) is a set of embedded AO which can extend to various platforms.Compared with AO,ArcGIS Engine can shorten the period of developing and improve the efficiency greatly.Having introduced the techniques of ArcObjects and ArcGIS Engine,we offer the method of developing GIS with Visual Basic and ArcGIS Engine with Oil and Gas Geologic Information System.展开更多
Small-molecule hydrogels based on amino acid derivatives have promising applications in many biological fields,including cell culture,drug delivery,and tissue engineering.Although these hydrogels have been widely repo...Small-molecule hydrogels based on amino acid derivatives have promising applications in many biological fields,including cell culture,drug delivery,and tissue engineering.Although these hydrogels have been widely reported to have low cytotoxicity,biocompatibility,and tunable bioactivity,problems such as harsh preparation conditions and complex material design hinder their application.Herein,by adjusting pH to induce non-covalent interactions between small-molecule tryptophan derivatives(N-[(phenylmethoxy)carbonyl]-L-tryptophan,Mw:338.35),we developed a self-assembled three-dimensional network hydrogel that can be rapidly formed in seconds.And the supramolecular self-assembly mechanism of the hydrogels was also investigated in detail through experimental characterizations and density functional theory calculation.As-prepared hydrogels also exhibit reversible pH-stimulated response and self-healing properties.This study details a research process for the simple and rapid preparation of tryptophan derivative-based hydrogels,which provides more reference ideas for the future development of materials based on other amino acid derivatives.展开更多
[Aims]This study aims to explore the relationship between epidermal growth factor receptor(EGFR)mutations and clinical characteristics,as well as serum tumor markers,in patients with non-small cell lung cancer(NSCLC),...[Aims]This study aims to explore the relationship between epidermal growth factor receptor(EGFR)mutations and clinical characteristics,as well as serum tumor markers,in patients with non-small cell lung cancer(NSCLC),and to assess the implications of these findings.[Methods]The study included 105 NSCLC patients diagnosed at the Seventh Affiliated Hospital of Sun Yat-sen University between January 2020 and November 2024.Based on EGFR gene testing results,the patients were divided into two groups:the mutation group(63 patients)and the wild-type group(42 patients).The clinical characteristics of both groups were compared,and the associations between serum blood tumor markers(carcinoembryonic antigen[CEA],carbohydrate antigen 125[CA125],carbohydrate antigen 199[CA199],squamous cell carcinoma antigen[SCCA])and EGFR mutations were analyzed.[Results]In the mutation group,the proportion of females and non-smokers was significantly higher compared to the wild-type group(P<0.05).Moreover,the mutation group exhibited a higher positive rate of CEA(P<0.05)and a lower positive rate of SCCA(P<0.05)compared to the wild-type group.Spearman correlation analysis revealed significant relationship between EGFR mutation status and patient gender,smoking history,CEA,and SCCA(P<0.05).Multivariate logistic regression analysis identified smoking history,CEA,and SCCA as independent factors influencing EGFR mutations.[Conclusion]EGFR mutations are significantly associated with patient gender,smoking history,CEA,and SCCA in NSCLC.Clinical characteristics and monitoring of serum CEA and SCCA levels may provide valuable insights for predicting EGFR mutation status.展开更多
Extracellular vesicles from skin-derived precursor Schwann cells(SKP-SC-EVs)promote neurite outgrowth in culture and enhance peripheral nerve regeneration in rats.This study aimed at expanding the application of SKPSC...Extracellular vesicles from skin-derived precursor Schwann cells(SKP-SC-EVs)promote neurite outgrowth in culture and enhance peripheral nerve regeneration in rats.This study aimed at expanding the application of SKPSC-EVs in nerve grafting by creating a chitosan/PLGA-based,SKP-SC-EVs-containing tissue engineered nerve graft(TENG)to bridge a 40-mm long sciatic nerve defect in dogs.SKP-SC-EVs contained in TENGs significantly accelerated the recovery of hind limb motor and electrophysiological functions,supported the outgrowth and myelination of regenerated axons,and alleviated the denervation-induced atrophy of target muscles in dogs.To clarify the underlying molecular mechanism,we observed that SKP-SC-EVs were rich in a variety of miRNAs linked to the axon growth of neurons,and miR-30b-5p was the most important among others.We further noted that miR-30b-5p contained within SKP-SC-EVs exerted nerve regeneration-promoting effects by targeting the Sin3a/HDAC complex and activating the phosphorylation of ERK,STAT3 or CREB.Our findings suggested that SKP-SC-EVs-incorporating TENGs represent a novel type of bioactive material with potential application for peripheral nerve repair in the clinic.展开更多
Driven by their many unique features,perovskite solar cells(PSCs)have become one of the most promising candidates in the photovoltaic field.Two-step preparation of perovskite film is advantageous for its higher stabil...Driven by their many unique features,perovskite solar cells(PSCs)have become one of the most promising candidates in the photovoltaic field.Two-step preparation of perovskite film is advantageous for its higher stability and reproducibility compared to the one-step method,which is more suitable for practical application.However,the incomplete conversion of the dense lead iodide(PbI_(2))layer during the sequential spin-coating of formamidinium/methylammonium(FA^(+)/MA^(+))organic amine salts severely affect the performance of PSCs.Herein,sodium bicarbonate(NaHCO_(3))is used to induce the formation of porous PbI_(2),which facilitates the penetration of the FA^(+)/MA^(+)ions and the formation of a perovskite film with high crystallinity and large grain microstructure.Meanwhile,the introduction of Na^(+)not only improves the energetic alignment of the PSC,but also increases the conductivity via p-doping.As a result,the optimized NaHCO_(3)-modified PSC achieves a champion power conversion efficiency of 24.0% with suppressed hysteresis.Moreover,the significant reduction in defect density and ion migration as well as a mild alkaline environment enhance the stability of device.The unencapsulated NaHCO_(3)-modified PSCs maintain over 90% of their original efficiency upon storage in ambient air(30%–40% relative humidity)for 2160 h.We have demonstrated an ingenious strategy for controlling the quality of perovskite and improving the performance of device by low-temperature foaming of simple inorganic molecules of NaHCO_(3).展开更多
基金Supported by National Oil-gas Project:No XQ-2004-07
文摘ComGIS is the mainstream of developing GIS currently.Developing Geographic Information System with the technology of components can reduce the difficulties of developing,improving the developing efficiency and enhancing the flexibility and opening of system.ArcObjects(AO) is based on the technology of COM,and ArcGIS Engine(AE) is a set of embedded AO which can extend to various platforms.Compared with AO,ArcGIS Engine can shorten the period of developing and improve the efficiency greatly.Having introduced the techniques of ArcObjects and ArcGIS Engine,we offer the method of developing GIS with Visual Basic and ArcGIS Engine with Oil and Gas Geologic Information System.
基金This work was financially supported by the National Natural Science Foundation of China(Nos.21773311 and 21972169)Hunan Provincial Science and Technology Plan Project(No.2017TP1001)Thanks for the software support provided by the High Performance Computing Center of CSU and NMR data support provided by the Institute of Chemistry Chinese Academy of Sciences.
文摘Small-molecule hydrogels based on amino acid derivatives have promising applications in many biological fields,including cell culture,drug delivery,and tissue engineering.Although these hydrogels have been widely reported to have low cytotoxicity,biocompatibility,and tunable bioactivity,problems such as harsh preparation conditions and complex material design hinder their application.Herein,by adjusting pH to induce non-covalent interactions between small-molecule tryptophan derivatives(N-[(phenylmethoxy)carbonyl]-L-tryptophan,Mw:338.35),we developed a self-assembled three-dimensional network hydrogel that can be rapidly formed in seconds.And the supramolecular self-assembly mechanism of the hydrogels was also investigated in detail through experimental characterizations and density functional theory calculation.As-prepared hydrogels also exhibit reversible pH-stimulated response and self-healing properties.This study details a research process for the simple and rapid preparation of tryptophan derivative-based hydrogels,which provides more reference ideas for the future development of materials based on other amino acid derivatives.
文摘[Aims]This study aims to explore the relationship between epidermal growth factor receptor(EGFR)mutations and clinical characteristics,as well as serum tumor markers,in patients with non-small cell lung cancer(NSCLC),and to assess the implications of these findings.[Methods]The study included 105 NSCLC patients diagnosed at the Seventh Affiliated Hospital of Sun Yat-sen University between January 2020 and November 2024.Based on EGFR gene testing results,the patients were divided into two groups:the mutation group(63 patients)and the wild-type group(42 patients).The clinical characteristics of both groups were compared,and the associations between serum blood tumor markers(carcinoembryonic antigen[CEA],carbohydrate antigen 125[CA125],carbohydrate antigen 199[CA199],squamous cell carcinoma antigen[SCCA])and EGFR mutations were analyzed.[Results]In the mutation group,the proportion of females and non-smokers was significantly higher compared to the wild-type group(P<0.05).Moreover,the mutation group exhibited a higher positive rate of CEA(P<0.05)and a lower positive rate of SCCA(P<0.05)compared to the wild-type group.Spearman correlation analysis revealed significant relationship between EGFR mutation status and patient gender,smoking history,CEA,and SCCA(P<0.05).Multivariate logistic regression analysis identified smoking history,CEA,and SCCA as independent factors influencing EGFR mutations.[Conclusion]EGFR mutations are significantly associated with patient gender,smoking history,CEA,and SCCA in NSCLC.Clinical characteristics and monitoring of serum CEA and SCCA levels may provide valuable insights for predicting EGFR mutation status.
基金supported by the Major Research Plan of the National Natural Science Foundation of China(92068112)the National Key Research and Development Program of China(2017YFA0104700)+1 种基金the National Natural Science Foundation of China(82201509)the National Major Project of Research and Development(2022YFA1105500).
文摘Extracellular vesicles from skin-derived precursor Schwann cells(SKP-SC-EVs)promote neurite outgrowth in culture and enhance peripheral nerve regeneration in rats.This study aimed at expanding the application of SKPSC-EVs in nerve grafting by creating a chitosan/PLGA-based,SKP-SC-EVs-containing tissue engineered nerve graft(TENG)to bridge a 40-mm long sciatic nerve defect in dogs.SKP-SC-EVs contained in TENGs significantly accelerated the recovery of hind limb motor and electrophysiological functions,supported the outgrowth and myelination of regenerated axons,and alleviated the denervation-induced atrophy of target muscles in dogs.To clarify the underlying molecular mechanism,we observed that SKP-SC-EVs were rich in a variety of miRNAs linked to the axon growth of neurons,and miR-30b-5p was the most important among others.We further noted that miR-30b-5p contained within SKP-SC-EVs exerted nerve regeneration-promoting effects by targeting the Sin3a/HDAC complex and activating the phosphorylation of ERK,STAT3 or CREB.Our findings suggested that SKP-SC-EVs-incorporating TENGs represent a novel type of bioactive material with potential application for peripheral nerve repair in the clinic.
基金The authors acknowledge the joint financial support from the National Natural Science Foundation of China(Nos.51972123,U1705256,22271106,and U20A20150)。
文摘Driven by their many unique features,perovskite solar cells(PSCs)have become one of the most promising candidates in the photovoltaic field.Two-step preparation of perovskite film is advantageous for its higher stability and reproducibility compared to the one-step method,which is more suitable for practical application.However,the incomplete conversion of the dense lead iodide(PbI_(2))layer during the sequential spin-coating of formamidinium/methylammonium(FA^(+)/MA^(+))organic amine salts severely affect the performance of PSCs.Herein,sodium bicarbonate(NaHCO_(3))is used to induce the formation of porous PbI_(2),which facilitates the penetration of the FA^(+)/MA^(+)ions and the formation of a perovskite film with high crystallinity and large grain microstructure.Meanwhile,the introduction of Na^(+)not only improves the energetic alignment of the PSC,but also increases the conductivity via p-doping.As a result,the optimized NaHCO_(3)-modified PSC achieves a champion power conversion efficiency of 24.0% with suppressed hysteresis.Moreover,the significant reduction in defect density and ion migration as well as a mild alkaline environment enhance the stability of device.The unencapsulated NaHCO_(3)-modified PSCs maintain over 90% of their original efficiency upon storage in ambient air(30%–40% relative humidity)for 2160 h.We have demonstrated an ingenious strategy for controlling the quality of perovskite and improving the performance of device by low-temperature foaming of simple inorganic molecules of NaHCO_(3).
