The efficiency of organic semiconductor photocatalysts is typically limited by their capability of photogenerated electron transport.Herein,a photocatalyst is proposed initially through the specific axial coordination...The efficiency of organic semiconductor photocatalysts is typically limited by their capability of photogenerated electron transport.Herein,a photocatalyst is proposed initially through the specific axial coordination interaction between imidazole-C_(60)(ImC_(60))and zinc tetraphenyl porphyrin(ZnTPP)named ImC_(60)-ZnTPP.Subsequently,detailed structural characterizations along with theoretical calculation reveal that the unique ImC_(60)-ZnTPP possesses head-to-tail stacking supra-structures,leading to the formation of a continuous array of C_(60)–C_(60) with ultrashort spacing and ensuring strongπ–πinteractions and homogeneous electronic coupling,which could tremendously promote electron transport along the(−111)crystal facet of ImC_(60)-ZnTPP.Consequently,compared to other fullerene-based photocatalysts,ImC_(60)-ZnTPP shows exceptional photocatalytic hydrogen production activity,with an efficiency of up to 80.95 mmol g^(-1) h^(-1).This study provides a novel strategy to design highly efficient fullerene-based photocatalytic systems for solar-driven energy conversion and extend their artificial photosynthetic use.展开更多
Perovskite solar cells(PSCs),which utilize a hybrid organic–inorganic lead halide perovskite as the light-absorbing semiconductor,have emerged as a highly promising photovoltaic technology over the past decade[1−5].
Comorbidity with PTSD has been studied at home and abroad in follow-up studies following major traumatic events, indexing patients diagnosed with PTSD and investigating rates of comorbidity and other psychiatric disor...Comorbidity with PTSD has been studied at home and abroad in follow-up studies following major traumatic events, indexing patients diagnosed with PTSD and investigating rates of comorbidity and other psychiatric disorders. In practical clinical practice, the majority of patients with PTSD are diagnosed with neurosis and depression, but the clinical manifestations and treatment of some of these patients are more complicated and difficult, and it is clinically found that these patients may have comorbidit</span><span style="font-family:Verdana;">ie</span><span style="font-family:Verdana;">s and other mental disorders. This study in hospitalized patients with neurosis and depression as the main research object, through the investigation found that some patients (36.4%) of comorbid PTSD, just, this part of the patients reported by a traumatic event is not CCMD-3 defined in the </span><span style="font-family:Verdana;">“</span><span style="font-family:Verdana;">unusual</span><span style="font-family:Verdana;">”</span><span style="font-family:Verdana;"> traumatic event</span><span style="font-family:Verdana;">.</span><span style="font-family:Verdana;"> Therefore, the results of this study suggest that attention should be paid to the collection of patients</span><span style="font-family:Verdana;">’</span><span style="font-family:Verdana;"> medical history, especially the inquiry of traumatic experiences. This study is only a preliminary study with a small sample size, and the conclusions obtained need to be further confirmed in future studies.展开更多
Objective: To investigate the effects of cognitive behavioral intervention on psychological stress response in breast cancer patients by cognitive behavioral intervention in breast cancer patients. Methods: Adopting t...Objective: To investigate the effects of cognitive behavioral intervention on psychological stress response in breast cancer patients by cognitive behavioral intervention in breast cancer patients. Methods: Adopting the random comparison method, 100 patients with breast cancer were divided into comparison group and intervention group by 50 cases. The intervention group underwent cognitive behavioral intervention at the same time as the comparison group only received conventional treatment without cognitive behavioral intervention. Two groups of breast cancer patients were enrolled in the general questionnaire, the Self-Rating Anxiety Scale (SAS), and the Medical Coping Modes Questionnaire (MCMQ) within one week after admission and one month after treatment to understand the psychological stress levels of the two groups. Results: There was no significant difference in the scores of SAS and MCMQ between the intervention group and the comparison group before intervention (P > 0.05). But after intervention, the scores of SAS and MCMQ in the comparison group were significantly higher than those in the intervention group (P 0.05). It shows that the implementation of cognitive behavioral intervention therapy for breast cancer patients has the effect of improving their psychological status. Conclusion: Cognitive behavioral intervention therapy combined with psychology for breast cancer patients can effectively reduce their stress level, improve mental health status and improve their positive coping ability.展开更多
The soaring global prevalence of diabetes makes it urgent to explore new drugs with high efficacy and safety.Nanomaterial-derived bioactive agents are emerging as one of the most promising candidates for biomedical ap...The soaring global prevalence of diabetes makes it urgent to explore new drugs with high efficacy and safety.Nanomaterial-derived bioactive agents are emerging as one of the most promising candidates for biomedical application.In the present study,we investigated the anti-diabetic effects of a functionalized gadofullerene(GF)using obese db/db and non-obese mouse model of type 2 diabete mellitus(MKR)mouse type 2 diabetes mellitus(T2DM)models.In both mouse models,the diabetic phenotypes,including hyperglycemia,impaired glucose tolerance,and insulin sensitivity,were ameliorated after two or four weeks of intraperitoneal administration of GF.GF lowered blood glucose levels in a dose-dependent manner.Importantly,the restored blood glucose levels could persist ten days after withdrawal of GF treatment.The hepatic AKT/GSK3β/FoxO1 pathway is shown to be the main target of GF for rebalancing gluconeogenesis and glycogen synthesis in vivo and in vitro.Furthermore,GF treatment significantly reduced weight gain of db/db mice with reduced hepatic fat storage by the inhibition of de novo lipogenesis through m TOR/S6K/SREBP1 pathway.Our data provide compelling evidence to support the promising application of GF for the treatment of T2DM.展开更多
Objective: To research the relationship between psychological stress and doctor-patient relationship of cancer patients and their families. Methods: The patients were randomly divided into the intervention group and t...Objective: To research the relationship between psychological stress and doctor-patient relationship of cancer patients and their families. Methods: The patients were randomly divided into the intervention group and the control group, and PDRQ-15, pcl-c, SAS and SDS scales were selected as evaluation indexes, and the levels of norepinephrine and dopamine were compared between the patients diagnosed with PTSD cancer and those without PTSD. Results: 1) The total score of PCL-C, SAS, SDS, PDRQ-15 scale of the cancer patients and their families after the intervention of clinical psychological care was significantly lower than that of before intervention and the control group. 2) The correlation coefficients between PCL-C, SAS, SDS and PDRQ-15 of cancer patients and their relatives were 0.971, 0.952 and 0.939 respectively. The significant test P value was less than 0.05 and the difference was statistically significant. 3) The plasma levels of dopamine and norepinephrine in cancer patients under stress were significantly higher than those in cancer patients without stress (P Conclusion: After psychological Intervention of cancer patients and their families, post-traumatic stress disorder, anxiety, depression and doctor-patient relationship were all improved.展开更多
In the ongoing construction of an international tourism island in Hainan, China, the research on the mental health of the residents in the tourism destination is one of the main contents of the research on tourism dev...In the ongoing construction of an international tourism island in Hainan, China, the research on the mental health of the residents in the tourism destination is one of the main contents of the research on tourism development. Tourism area is the cell of Hainan International Tourism Island. The mental health service of the residents in the tourism area is an important part of the health work construction of the international tourism island and the basic way to realize the health care for everyone. Nowadays, people’s demand for mental health services is far greater than the current supply. In view of the current situation of the limited mental health services provided, we put forward higher requirements and directions for the future development of mental health services in tourist areas. It is planned to carry out the first large-scale publicity and education on mental health of residents in Hainan tourism area in China, and evaluate the effect;carry out a large-scale investigation on mental health of residents in the tourism area, and carry out professional intervention and treatment for patients with mental diseases. Finally, the mental health service network and service institutions covering the tourism areas of Hainan Province were established to provide scientific support for the harmonious and healthy development of the international tourism island in Hainan Province.展开更多
Subcellular inter-organellar crosstalk among lysosome,endoplasmic reticulum(ER),and mitochondrion is crucial for cancer cell survival and is a promising target in cancer treatment;however,efficiently disrupting these ...Subcellular inter-organellar crosstalk among lysosome,endoplasmic reticulum(ER),and mitochondrion is crucial for cancer cell survival and is a promising target in cancer treatment;however,efficiently disrupting these interactive networks is challenging.Herein,a communication interception strategy is presented,which specifically disrupts inter-organellar crosstalk by lysosomal contents leakage along with their trajectory and pre-activates autophagic flux to augment the lysosome-associated autophagy blocking for preventing the self-repair of this subcellular disorder.Briefly,fullerenols containing multiple hydroxyl groups(MF)tear the lysosomal phospholipid membrane through direct interaction,which causes lysosomal contents(calcium ions and cathepsins)to leak into the cytoplasm,subsequently leading to endoplasmic reticulum stress and mitochondrial dysfunction with redox imbalance and metabolic reprogramming.mTOR inhibitors activate and amplify autophagy,then impaired lysosomes prevent their fusion with autophagosome,and thus autophagy is paralyzed along with autolysosome accumulation.Consequently,the cellular homeostasis is compromised by destroyed inter-organellar networks without self-repair by autophagy,thereby triggering PANoptotic processes and leading to a remarkable anti-tumor therapeutic efficacy in vitro and in vivo.This strategy demonstrates the selective cytotoxicity of non-toxic nanomaterials that interfere with subcellular inter-organellar crosstalk,offering a novel method for designing tumor therapies.展开更多
Lipid metabolism imbalance combined with over-activated inflammation are two key factors for hepatic stestosis.However,on-demand anchoring inflammation and lipid metabolism disorder for hepatic stestosis treatment has...Lipid metabolism imbalance combined with over-activated inflammation are two key factors for hepatic stestosis.However,on-demand anchoring inflammation and lipid metabolism disorder for hepatic stestosis treatment has yet to be realized.Here we propose a charge reversal fullerene based nano-assembly to migrate hepatic steatosis via inhibiting macrophage-mediated inflammation and normalizing hepatocellular lipid metabolism in obesity mice.Our nano-assembly(abbreviated as FPPD)is comprised of electropositive polyetherimide(PEI),charge-shielded dimethylmaleic anhydride(DMA),and poly(lactic-co-glycolic acid)(PLGA),which provides hydrophobic chains for self-assembly with anti-oxidative dicarboxy fullerene poly(ethylene glycol)molecule(FP).The obtained FPPD nano-assembly owns a charge reversal ability that switches to a positive charge in an acidic environment that targets the electronegative mitochondria both in pro-inflammatory macrophages and steatosis hepatocytes.We demonstrate that the anti-oxidative and mitochondria-targeting FPPD notably reduces inflammation in macrophages and lipid accumulation in hepatocytes by quenching excessive reactive oxygen species(ROS)and improving mitochondrial function in vitro.Importantly,FPPD nano-assembly reveals a superior anti-hepatic steatosis effect via migrating inflammation and facilitating lipid transport in obesity mice.Overall,the charge reversal nano-assembly reduces over-activated inflammation and promotes lipid metabolism that provides an effectiveness of a multi-target strategy for hepatic steatosis treatment.展开更多
Solid-state lithium-ion batteries(SSBs)represent a promising advancement in energy storage technology.They offer enhanced safety,higher energy density,and better thermal stability compared to traditional liquid electr...Solid-state lithium-ion batteries(SSBs)represent a promising advancement in energy storage technology.They offer enhanced safety,higher energy density,and better thermal stability compared to traditional liquid electrolyte-based batteries.However,the commercialization of SSBs faces significant challenges,primarily due to various failure mechanisms associated with solid-state electrolytes and electrode materials.This review provides a comprehensive overview of the recent advances in the failure analysis of SSBs,with a focus on the electrochemical,mechanical,and interfacial degradation processes.Key issues such as lithium dendrite formation,interfacial instability,mechanical cracking,and the role of pores and voids are examined in detail.Additionally,this review explores the impact of materials properties and battery architecture on the longevity and performance of SSBs.The review also highlights advanced characterization techniques employed to diagnose and understand these failure modes.By addressing these challenges through innovative materials design,interface engineering,and optimized manufacturing processes,the reliability and commercial viability of SSBs can be significantly improved.This review aims to guide future research efforts toward overcoming the critical obstacles hindering the widespread adoption of SSB technology.展开更多
In this paper,the third-order nonlinear optical(NLO)properties of covalent organic framework(COF)materials with conjugated amphoteric ion structure are studied for the first time.A highly ordered crystalline ultrathin...In this paper,the third-order nonlinear optical(NLO)properties of covalent organic framework(COF)materials with conjugated amphoteric ion structure are studied for the first time.A highly ordered crystalline ultrathin films of the ionic COF material PySQ-iCOF was successfully fabricated using a solid-liquid interface method,meanwhile the building units extracted to be independent small molecule,1-PySA,were synthesized for comparative studies.Compared to 1-PySA,PySQ-iCOF possesses not only a larger conjugated system but also exhibits enhanced polarization and charge transfer capabilities.The NLO properties of PySQ-iCOF and the small molecule 1-PySA were investigated using Z-scan technique at a wavelength of 532 nm,revealing the PySQ-iCOF thin film exhibits outstanding NLO performance.Specifically,it demonstrates saturable absorption under nanosecond(ns)pulse laser irradiation(β=9.59×10^(-6) m/W),while exhibiting reverse saturable absorption under femtosecond(fs)pulse conditions(β=6.91×10^(-8) m/W).Furthermore,the PySQ-iCOF film exhibits strong negative refractive nonlinearity,−6×10^(-12) m^(2)/W for ns and -3.8×10^(-13) m^(2)/W for fs,respectively.Transient absorption spectroscopy studies indicate that the pulse-width-dependent nonlinear absorption char-acteristics of the PySQ-iCOF film originate from the generation of triplet excited states.Both nonlinear absorption coefficient and nonlinear refractive index of the PySQ-iCOF film surpass those of most reported organic materials measured under comparable conditions,which provides huge potential in all-optical manipulating and switching at the nanoscale as outstanding NLO materials.展开更多
The anti-vascular therapy has been extensively studied for high performance tumor therapy by suppressing the tumor angiogenesis or cutting off the existing tumor vasculature. We have previously reported a novel anti-t...The anti-vascular therapy has been extensively studied for high performance tumor therapy by suppressing the tumor angiogenesis or cutting off the existing tumor vasculature. We have previously reported a novel anti-tumor treatment technique using radiofrequency （RF）-assisted ga- dofullerene nanocrystals （GFNCs） to selectively disrupt the tumor vasculature. In this work, we further revealed the changes on morphology and functionality of the tumor vas-culature during the high-performance RF-assisted GFNCs treatment in vivo. Here, a dearly evident mechanism of this technique in tumor vascular disruption was elucidated. Based on the H22 tumor bearing mice with dorsal skin flap chamber （DSFC） mode] and the dynamic contrast enhanced magnetic resonance imaging （DCE-MRI） technique, it was revealed that the GFNCs would selectively inset in the gaps of tumor vas-culature due to the innately incomplete structures and unique microenvironment of tumor vasculature,＇ and they damaged the surrounding endothelia cells excited by the RF to induce a phase transition accompanying with size expansion. Soon afterwards, the blood flow of the tumor blood vessels was permanently shut off, causing the entire tumor vascular net- work to collapse within 24 h after the treatment. The RF-as- sistant GFNCs technique was proved to aim at the tumor vasculatnre precisely, and was harmless to the normal vascu- lature. The current studies provide a rational explanation on the high efficiency anticancer activity of the RF-assisted GFNCs treatment, suggesting a novel technique with potent clinical application.展开更多
High-efficiency photocatalysts are of great importance to satisfy the requirements of green chemistry nowadays.Here we reported a novel solar-driven photocatalyst fabricated by a facile surface modification method,wit...High-efficiency photocatalysts are of great importance to satisfy the requirements of green chemistry nowadays.Here we reported a novel solar-driven photocatalyst fabricated by a facile surface modification method,with the two-dimensional carboxylated zinc phthalocyanine-carboxylated C60-titanium dioxide(Zn Pc-C3-Ti O2)nanosheets,in which the surface modifications of Zn Pc and C60derivative were designed to extend the absorption range and promote charge separation,respectively.Benefiting from the unique structure and positive synergetic effect,the Zn Pc-C3-Ti O2 nanocomposite shows promising applications in selective reduction of nitroarenes for high-value-added aromatic amines under solar light.Especially,for the photocatalytic reduction of nitrobenzene to aniline,the Zn Pc-C3-Ti O2 nanocomposite possesses both high efficiency and selectivity(up to 99%).展开更多
Magneto-luminescent molecules have significant applications in data storage and quantum computing.However,design of these bi-functional molecules coupled with magnetic behavior and photoluminescence is still challengi...Magneto-luminescent molecules have significant applications in data storage and quantum computing.However,design of these bi-functional molecules coupled with magnetic behavior and photoluminescence is still challenging.In this work,we report a metallofullerene DyErScN @In-C80 exhibiting single-molecule magnet (SMM) behavior and near-infrared emission.For DyErScN @Ih-C80,two functional lanthanide metal ions of Dy^3+(SMM function) and Er^3+(luminescent function) are integrated inside a fullerene cage using a trimetallic nitride template,and its structure has been unambiguously characterized by single-crystal X-ray diffraction.Magnetic measurements revealed that DyErScN @Ih-C80 behaves as a SMM with a blocking temperature up to 9 K resulting from the intramolecular magnetic interaction between Dy^3+ and Er^3+ ions.Moreover,DyErScN @In-C80 exhibits temperature-dependent near-infrared emission around 1.5 pm with multiple splitting peaks from Er^3+,which arises from the influence of Dy^3+ ion.This study provides a new strategy to synthesize new magneto-luminescent molecule materials.展开更多
NiFe composites have been regarded as promising candidates to replace commercial noble-based electrocatalysts for the oxygen evolution reaction(OER).However,their practical applications still suffer from poor conducti...NiFe composites have been regarded as promising candidates to replace commercial noble-based electrocatalysts for the oxygen evolution reaction(OER).However,their practical applications still suffer from poor conductivity,limited activity,durability.To address these issues,herein,by utilizing three-dimensional covalent organic framework(3D-COF)with porous confined structures and abundant coordinate N sites as the precursor,the partially oxidized Ni_(3)Fe nanoalloys wrapped by Ndoped carbon(N-C)layers are constructed via simple pyrolysis and subsequent oxidization.Benefiting from the 3D curved hierarchical structure,high-conductivity of Ni_(3)Fe and N-C layers,well-distributed active sites,the as-synthesized O-Ni_(3)Fe-NC catalyst demonstrates excellent activity and durability for catalyzing OER.Experimental and theoretical analyses disclose that both high-temperature oxidization and the OER process greatly promote the formation and exposure of the Ni(Fe)OOH active species as well as lower charge transfer resistance,inducing its optimized OER activity.The robust graphitized N-C layers with superior conductivity and their couplings with oxidized Ni_(3)Fe nanoalloys are beneficial for stabilizing catalytic centers,thereby imparting O-Ni_(3)Fe-N-C with such outstanding stability.This work not only provides a rational guidance for enriching and stabilizing high-activity catalytic sites towards OER but also offers more insights into the structural evolution of NiFe-based OER catalysts.展开更多
Ulcerative colitis(UC) is a long-term,recurrent inflammatory bowel disease for which no effective cure is yet available in the clinical setting.Repairing the barrier dysfunction of the colon and reducing intestinal in...Ulcerative colitis(UC) is a long-term,recurrent inflammatory bowel disease for which no effective cure is yet available in the clinical setting.Repairing the barrier dysfunction of the colon and reducing intestinal inflammation are considered key objectives to cure UC.Here we demonstrate a novel therapeutic strategy based on a C_(60) fullerene suspension(C_(60)FS) to treat dinitrobenzene sulfonic acid-induced UC in an animal model.C_(60)FS can repair the barrier dysfunction of UC and effectively promote the healing of ulcers;it also manifests better treatment effects compared with mesalazine enema.C_(60)FS can reduce the numbers of basophils in the blood of UC rats and mast cells in the colorectal tissue,thereby effectively alleviating inflammation.The expression of H1R,H4R,and VEGFR2 receptors in colorectal tissues is inhibited by C_(60)FS,and the levels of histamine and prostaglandin in the rat blood are reduced.This work presents a reliable strategy based on fullerene to cure UC and provides a novel guide for UC treatment.展开更多
In this work, four fused ring electron acceptors(FREAs), 2F-C5, 2F-C6, 2F-C8 and 2F-C10, are developed to investigate the effect of side-chain size on the molecular properties and photovoltaic performance of FREA syst...In this work, four fused ring electron acceptors(FREAs), 2F-C5, 2F-C6, 2F-C8 and 2F-C10, are developed to investigate the effect of side-chain size on the molecular properties and photovoltaic performance of FREA systematically. The elongation of side-chains in the FREAs not only improves their solubility in the processing solvent, but also enhances their miscibility with the donor PBDB-T. It helps the FREA diffuse into the donor PBDB-T during film-formation, thus leading to the decrease in domain size and domain purity from PBDB-T:2F-C5 to PBDB-T:2F-C10 blend films in sequence. The smaller domain size affords more D/A interfaces to benefit exciton dissociation and inhibit monomolecular recombination. However, severe bimolecular recombination occurs when the domain purity decreases to a critical point. Due to the dual function of the increment of side-chain length, both short-circuit current density(J_(SC)) and fill factor(FF) of devices exhibit an evolution of first increasing then decreasing from 2F-C5, 2F-C6, 2F-C8 to 2F-C10 based OSCs. The PBDB-T:2F-C8 based OSCs get a fine balance in morphology with moderate domain size as well as high domain purity simultaneously for the least charge carrier recombination, thus achieving the highest power conversion efficiency of 12.28% with the best J_(SC)(21.27 mA cm^(-2)) and FF(71.96%).展开更多
Polarization of tumor associated macrophages(TAMs)has been a promising therapeutic paradigm for tumor.However,how to achieve precise regulation of TAMs and high efficiency of tumor immunotherapy is still a huge challe...Polarization of tumor associated macrophages(TAMs)has been a promising therapeutic paradigm for tumor.However,how to achieve precise regulation of TAMs and high efficiency of tumor immunotherapy is still a huge challenge.Here,we report dicarboxy fullerene modified with mannose(DCFM)as an immunomodulator to selectively polarize TAMs and prominently boost anti-tumor immunity.The dicarboxy fullerene molecule was synthesized through the Prato reaction and further covalently bonded with mannose,obtaining the DCFM with well-defined structure.Due to the exist of mannose in DCFM,it could accurately recognize mannose receptor in TAMs.Our cellular experiment results showed that mannose modification could notably promote the uptake of DCFM by the immunosuppressive M2-type macrophages that effectively reprogrammed M2-type macrophages into anti-tumor M1-type macrophages,leading to enhance the phagocytosis of tumor cells by macrophages and inhibiting tumor cells migration.Subsequently,we observed that DCFM could significantly distribute into tumor tissues by in vivo fluorescence imaging.Importantly,DCFM exhibited a superior anti-tumor efficiency in the subcutaneous colorectal tumor model.In addition,it showed that DCFM precisely polarized TAMs into M1-type macrophages and actively increased the infiltration of cytotoxic T lymphocytes(CTLs),inducing profound tumor growth inhibition.展开更多
Paramagnetic endohedral metallofullerenes with well protected unpaired spin have potential applications in molecular-scale qubit processing and magnetoreception system. In this study, a paramagnetic metallofullerene S...Paramagnetic endohedral metallofullerenes with well protected unpaired spin have potential applications in molecular-scale qubit processing and magnetoreception system. In this study, a paramagnetic metallofullerene Sc_(3)C_(2)@C_(80) dimer with covalently bonded two spin centers was synthesized. Electron paramagnetic resonance (EPR) results further revealed the varied spin-nuclei couplings and paramagnetic property for Sc_(3)C_(2)@C_(80) dimer. Briefly, the Sc_(3)C_(2)@C_(80) dimer in toluene solution shows EPR hyperfine splittings originating from the spin-Sc couplings. However, the Sc_(3)C_(2)@C_(80) dimer in solid state shows the disappearance of hyperfine structure and a single EPR signal caused by its two-spin-center structure. The transformation of EPR signals can be further finely modulated by controlling the dynamic motion of Sc_(3)C_(2)@C80 dimer in chloronaphthalene. The Sc_(3)C_(2)@C_(80) dimer with two spin centers possesses varied paramagnetic properties, demonstrating its potential as new magnetic material.展开更多
基金supported by the National Natural Science Foundation of China(52322204,52072374,52272052)the National Key R&D Program of China(Grant No.2022YFA1205900)the Youth Innovation Promotion Association of CAS(Y2022015).
文摘The efficiency of organic semiconductor photocatalysts is typically limited by their capability of photogenerated electron transport.Herein,a photocatalyst is proposed initially through the specific axial coordination interaction between imidazole-C_(60)(ImC_(60))and zinc tetraphenyl porphyrin(ZnTPP)named ImC_(60)-ZnTPP.Subsequently,detailed structural characterizations along with theoretical calculation reveal that the unique ImC_(60)-ZnTPP possesses head-to-tail stacking supra-structures,leading to the formation of a continuous array of C_(60)–C_(60) with ultrashort spacing and ensuring strongπ–πinteractions and homogeneous electronic coupling,which could tremendously promote electron transport along the(−111)crystal facet of ImC_(60)-ZnTPP.Consequently,compared to other fullerene-based photocatalysts,ImC_(60)-ZnTPP shows exceptional photocatalytic hydrogen production activity,with an efficiency of up to 80.95 mmol g^(-1) h^(-1).This study provides a novel strategy to design highly efficient fullerene-based photocatalytic systems for solar-driven energy conversion and extend their artificial photosynthetic use.
文摘Perovskite solar cells(PSCs),which utilize a hybrid organic–inorganic lead halide perovskite as the light-absorbing semiconductor,have emerged as a highly promising photovoltaic technology over the past decade[1−5].
文摘Comorbidity with PTSD has been studied at home and abroad in follow-up studies following major traumatic events, indexing patients diagnosed with PTSD and investigating rates of comorbidity and other psychiatric disorders. In practical clinical practice, the majority of patients with PTSD are diagnosed with neurosis and depression, but the clinical manifestations and treatment of some of these patients are more complicated and difficult, and it is clinically found that these patients may have comorbidit</span><span style="font-family:Verdana;">ie</span><span style="font-family:Verdana;">s and other mental disorders. This study in hospitalized patients with neurosis and depression as the main research object, through the investigation found that some patients (36.4%) of comorbid PTSD, just, this part of the patients reported by a traumatic event is not CCMD-3 defined in the </span><span style="font-family:Verdana;">“</span><span style="font-family:Verdana;">unusual</span><span style="font-family:Verdana;">”</span><span style="font-family:Verdana;"> traumatic event</span><span style="font-family:Verdana;">.</span><span style="font-family:Verdana;"> Therefore, the results of this study suggest that attention should be paid to the collection of patients</span><span style="font-family:Verdana;">’</span><span style="font-family:Verdana;"> medical history, especially the inquiry of traumatic experiences. This study is only a preliminary study with a small sample size, and the conclusions obtained need to be further confirmed in future studies.
文摘Objective: To investigate the effects of cognitive behavioral intervention on psychological stress response in breast cancer patients by cognitive behavioral intervention in breast cancer patients. Methods: Adopting the random comparison method, 100 patients with breast cancer were divided into comparison group and intervention group by 50 cases. The intervention group underwent cognitive behavioral intervention at the same time as the comparison group only received conventional treatment without cognitive behavioral intervention. Two groups of breast cancer patients were enrolled in the general questionnaire, the Self-Rating Anxiety Scale (SAS), and the Medical Coping Modes Questionnaire (MCMQ) within one week after admission and one month after treatment to understand the psychological stress levels of the two groups. Results: There was no significant difference in the scores of SAS and MCMQ between the intervention group and the comparison group before intervention (P > 0.05). But after intervention, the scores of SAS and MCMQ in the comparison group were significantly higher than those in the intervention group (P 0.05). It shows that the implementation of cognitive behavioral intervention therapy for breast cancer patients has the effect of improving their psychological status. Conclusion: Cognitive behavioral intervention therapy combined with psychology for breast cancer patients can effectively reduce their stress level, improve mental health status and improve their positive coping ability.
基金supported by the National Natural Science Foundation of China (31871163, 81471000)the Ministry of Science and Technology of China (2014DFA32120)
文摘The soaring global prevalence of diabetes makes it urgent to explore new drugs with high efficacy and safety.Nanomaterial-derived bioactive agents are emerging as one of the most promising candidates for biomedical application.In the present study,we investigated the anti-diabetic effects of a functionalized gadofullerene(GF)using obese db/db and non-obese mouse model of type 2 diabete mellitus(MKR)mouse type 2 diabetes mellitus(T2DM)models.In both mouse models,the diabetic phenotypes,including hyperglycemia,impaired glucose tolerance,and insulin sensitivity,were ameliorated after two or four weeks of intraperitoneal administration of GF.GF lowered blood glucose levels in a dose-dependent manner.Importantly,the restored blood glucose levels could persist ten days after withdrawal of GF treatment.The hepatic AKT/GSK3β/FoxO1 pathway is shown to be the main target of GF for rebalancing gluconeogenesis and glycogen synthesis in vivo and in vitro.Furthermore,GF treatment significantly reduced weight gain of db/db mice with reduced hepatic fat storage by the inhibition of de novo lipogenesis through m TOR/S6K/SREBP1 pathway.Our data provide compelling evidence to support the promising application of GF for the treatment of T2DM.
文摘Objective: To research the relationship between psychological stress and doctor-patient relationship of cancer patients and their families. Methods: The patients were randomly divided into the intervention group and the control group, and PDRQ-15, pcl-c, SAS and SDS scales were selected as evaluation indexes, and the levels of norepinephrine and dopamine were compared between the patients diagnosed with PTSD cancer and those without PTSD. Results: 1) The total score of PCL-C, SAS, SDS, PDRQ-15 scale of the cancer patients and their families after the intervention of clinical psychological care was significantly lower than that of before intervention and the control group. 2) The correlation coefficients between PCL-C, SAS, SDS and PDRQ-15 of cancer patients and their relatives were 0.971, 0.952 and 0.939 respectively. The significant test P value was less than 0.05 and the difference was statistically significant. 3) The plasma levels of dopamine and norepinephrine in cancer patients under stress were significantly higher than those in cancer patients without stress (P Conclusion: After psychological Intervention of cancer patients and their families, post-traumatic stress disorder, anxiety, depression and doctor-patient relationship were all improved.
文摘In the ongoing construction of an international tourism island in Hainan, China, the research on the mental health of the residents in the tourism destination is one of the main contents of the research on tourism development. Tourism area is the cell of Hainan International Tourism Island. The mental health service of the residents in the tourism area is an important part of the health work construction of the international tourism island and the basic way to realize the health care for everyone. Nowadays, people’s demand for mental health services is far greater than the current supply. In view of the current situation of the limited mental health services provided, we put forward higher requirements and directions for the future development of mental health services in tourist areas. It is planned to carry out the first large-scale publicity and education on mental health of residents in Hainan tourism area in China, and evaluate the effect;carry out a large-scale investigation on mental health of residents in the tourism area, and carry out professional intervention and treatment for patients with mental diseases. Finally, the mental health service network and service institutions covering the tourism areas of Hainan Province were established to provide scientific support for the harmonious and healthy development of the international tourism island in Hainan Province.
基金supported by the National Natural Science Foundation of China(52272048)Beijing Natural Science Foundation(2222090)+1 种基金Ministry of Science and Technology of China(2022YFA1205900)Key Research Program of the Chinese Academy of Sciences(QYKJZD-SSW-SLH01).
文摘Subcellular inter-organellar crosstalk among lysosome,endoplasmic reticulum(ER),and mitochondrion is crucial for cancer cell survival and is a promising target in cancer treatment;however,efficiently disrupting these interactive networks is challenging.Herein,a communication interception strategy is presented,which specifically disrupts inter-organellar crosstalk by lysosomal contents leakage along with their trajectory and pre-activates autophagic flux to augment the lysosome-associated autophagy blocking for preventing the self-repair of this subcellular disorder.Briefly,fullerenols containing multiple hydroxyl groups(MF)tear the lysosomal phospholipid membrane through direct interaction,which causes lysosomal contents(calcium ions and cathepsins)to leak into the cytoplasm,subsequently leading to endoplasmic reticulum stress and mitochondrial dysfunction with redox imbalance and metabolic reprogramming.mTOR inhibitors activate and amplify autophagy,then impaired lysosomes prevent their fusion with autophagosome,and thus autophagy is paralyzed along with autolysosome accumulation.Consequently,the cellular homeostasis is compromised by destroyed inter-organellar networks without self-repair by autophagy,thereby triggering PANoptotic processes and leading to a remarkable anti-tumor therapeutic efficacy in vitro and in vivo.This strategy demonstrates the selective cytotoxicity of non-toxic nanomaterials that interfere with subcellular inter-organellar crosstalk,offering a novel method for designing tumor therapies.
基金supported by the National Key R&D Program of China(Grant No.2022YFA1205900)the National Natural Science Foundation of China(52172055)+1 种基金the Key Research Program of the Chinese Academy of Sciences(QYZDJ-SSW-SLH01)Mingming Zhen particularly thanks the Youth Innovation Promotion Association of CAS(2022036).
文摘Lipid metabolism imbalance combined with over-activated inflammation are two key factors for hepatic stestosis.However,on-demand anchoring inflammation and lipid metabolism disorder for hepatic stestosis treatment has yet to be realized.Here we propose a charge reversal fullerene based nano-assembly to migrate hepatic steatosis via inhibiting macrophage-mediated inflammation and normalizing hepatocellular lipid metabolism in obesity mice.Our nano-assembly(abbreviated as FPPD)is comprised of electropositive polyetherimide(PEI),charge-shielded dimethylmaleic anhydride(DMA),and poly(lactic-co-glycolic acid)(PLGA),which provides hydrophobic chains for self-assembly with anti-oxidative dicarboxy fullerene poly(ethylene glycol)molecule(FP).The obtained FPPD nano-assembly owns a charge reversal ability that switches to a positive charge in an acidic environment that targets the electronegative mitochondria both in pro-inflammatory macrophages and steatosis hepatocytes.We demonstrate that the anti-oxidative and mitochondria-targeting FPPD notably reduces inflammation in macrophages and lipid accumulation in hepatocytes by quenching excessive reactive oxygen species(ROS)and improving mitochondrial function in vitro.Importantly,FPPD nano-assembly reveals a superior anti-hepatic steatosis effect via migrating inflammation and facilitating lipid transport in obesity mice.Overall,the charge reversal nano-assembly reduces over-activated inflammation and promotes lipid metabolism that provides an effectiveness of a multi-target strategy for hepatic steatosis treatment.
基金supported by the National Natural Science Foundation of China(grant no.22209202).
文摘Solid-state lithium-ion batteries(SSBs)represent a promising advancement in energy storage technology.They offer enhanced safety,higher energy density,and better thermal stability compared to traditional liquid electrolyte-based batteries.However,the commercialization of SSBs faces significant challenges,primarily due to various failure mechanisms associated with solid-state electrolytes and electrode materials.This review provides a comprehensive overview of the recent advances in the failure analysis of SSBs,with a focus on the electrochemical,mechanical,and interfacial degradation processes.Key issues such as lithium dendrite formation,interfacial instability,mechanical cracking,and the role of pores and voids are examined in detail.Additionally,this review explores the impact of materials properties and battery architecture on the longevity and performance of SSBs.The review also highlights advanced characterization techniques employed to diagnose and understand these failure modes.By addressing these challenges through innovative materials design,interface engineering,and optimized manufacturing processes,the reliability and commercial viability of SSBs can be significantly improved.This review aims to guide future research efforts toward overcoming the critical obstacles hindering the widespread adoption of SSB technology.
基金the National Natural Science Foundation of China(22171076)Jing Li at the Technical Institute of Physics and Chemistry,Chinese Academy of Sciences(CAS),for his measurement of dynamic processes.
文摘In this paper,the third-order nonlinear optical(NLO)properties of covalent organic framework(COF)materials with conjugated amphoteric ion structure are studied for the first time.A highly ordered crystalline ultrathin films of the ionic COF material PySQ-iCOF was successfully fabricated using a solid-liquid interface method,meanwhile the building units extracted to be independent small molecule,1-PySA,were synthesized for comparative studies.Compared to 1-PySA,PySQ-iCOF possesses not only a larger conjugated system but also exhibits enhanced polarization and charge transfer capabilities.The NLO properties of PySQ-iCOF and the small molecule 1-PySA were investigated using Z-scan technique at a wavelength of 532 nm,revealing the PySQ-iCOF thin film exhibits outstanding NLO performance.Specifically,it demonstrates saturable absorption under nanosecond(ns)pulse laser irradiation(β=9.59×10^(-6) m/W),while exhibiting reverse saturable absorption under femtosecond(fs)pulse conditions(β=6.91×10^(-8) m/W).Furthermore,the PySQ-iCOF film exhibits strong negative refractive nonlinearity,−6×10^(-12) m^(2)/W for ns and -3.8×10^(-13) m^(2)/W for fs,respectively.Transient absorption spectroscopy studies indicate that the pulse-width-dependent nonlinear absorption char-acteristics of the PySQ-iCOF film originate from the generation of triplet excited states.Both nonlinear absorption coefficient and nonlinear refractive index of the PySQ-iCOF film surpass those of most reported organic materials measured under comparable conditions,which provides huge potential in all-optical manipulating and switching at the nanoscale as outstanding NLO materials.
基金supported by the National Natural Science Foundation of China(51472248 and 51502301)National Major Scientific Instruments and Equipments Development Project(ZDYZ2015-2)the Key Research Program of the Chinese Academy of Sciences(QYZDJ-SSW-SLH025)
文摘The anti-vascular therapy has been extensively studied for high performance tumor therapy by suppressing the tumor angiogenesis or cutting off the existing tumor vasculature. We have previously reported a novel anti-tumor treatment technique using radiofrequency （RF）-assisted ga- dofullerene nanocrystals （GFNCs） to selectively disrupt the tumor vasculature. In this work, we further revealed the changes on morphology and functionality of the tumor vas-culature during the high-performance RF-assisted GFNCs treatment in vivo. Here, a dearly evident mechanism of this technique in tumor vascular disruption was elucidated. Based on the H22 tumor bearing mice with dorsal skin flap chamber （DSFC） mode] and the dynamic contrast enhanced magnetic resonance imaging （DCE-MRI） technique, it was revealed that the GFNCs would selectively inset in the gaps of tumor vas-culature due to the innately incomplete structures and unique microenvironment of tumor vasculature,＇ and they damaged the surrounding endothelia cells excited by the RF to induce a phase transition accompanying with size expansion. Soon afterwards, the blood flow of the tumor blood vessels was permanently shut off, causing the entire tumor vascular net- work to collapse within 24 h after the treatment. The RF-as- sistant GFNCs technique was proved to aim at the tumor vasculatnre precisely, and was harmless to the normal vascu- lature. The current studies provide a rational explanation on the high efficiency anticancer activity of the RF-assisted GFNCs treatment, suggesting a novel technique with potent clinical application.
基金supported by Beijing Natural Science Foundation(2182094)the National Natural Science Foundation of China(51772300 and 51832008)the Youth Innovation Promotion Association of CAS(2018039)。
文摘High-efficiency photocatalysts are of great importance to satisfy the requirements of green chemistry nowadays.Here we reported a novel solar-driven photocatalyst fabricated by a facile surface modification method,with the two-dimensional carboxylated zinc phthalocyanine-carboxylated C60-titanium dioxide(Zn Pc-C3-Ti O2)nanosheets,in which the surface modifications of Zn Pc and C60derivative were designed to extend the absorption range and promote charge separation,respectively.Benefiting from the unique structure and positive synergetic effect,the Zn Pc-C3-Ti O2 nanocomposite shows promising applications in selective reduction of nitroarenes for high-value-added aromatic amines under solar light.Especially,for the photocatalytic reduction of nitrobenzene to aniline,the Zn Pc-C3-Ti O2 nanocomposite possesses both high efficiency and selectivity(up to 99%).
基金supported by the National Natural Science Foundation of China (Nos.51672281,61227902,5183200& and 51772195)Beijing Natural Science Foundation (No.2162050)+1 种基金the Youth Innovation Promotion Association of CAS (No.2015025)supported by High-performance Computing Platform of Peking University.We thank Dr.
文摘Magneto-luminescent molecules have significant applications in data storage and quantum computing.However,design of these bi-functional molecules coupled with magnetic behavior and photoluminescence is still challenging.In this work,we report a metallofullerene DyErScN @In-C80 exhibiting single-molecule magnet (SMM) behavior and near-infrared emission.For DyErScN @Ih-C80,two functional lanthanide metal ions of Dy^3+(SMM function) and Er^3+(luminescent function) are integrated inside a fullerene cage using a trimetallic nitride template,and its structure has been unambiguously characterized by single-crystal X-ray diffraction.Magnetic measurements revealed that DyErScN @Ih-C80 behaves as a SMM with a blocking temperature up to 9 K resulting from the intramolecular magnetic interaction between Dy^3+ and Er^3+ ions.Moreover,DyErScN @In-C80 exhibits temperature-dependent near-infrared emission around 1.5 pm with multiple splitting peaks from Er^3+,which arises from the influence of Dy^3+ ion.This study provides a new strategy to synthesize new magneto-luminescent molecule materials.
基金the National Natural Science Foundation of China(Nos.22075062 and 21871167)and the Volkswagen Foundation(Freigeist Fellowship)。
文摘NiFe composites have been regarded as promising candidates to replace commercial noble-based electrocatalysts for the oxygen evolution reaction(OER).However,their practical applications still suffer from poor conductivity,limited activity,durability.To address these issues,herein,by utilizing three-dimensional covalent organic framework(3D-COF)with porous confined structures and abundant coordinate N sites as the precursor,the partially oxidized Ni_(3)Fe nanoalloys wrapped by Ndoped carbon(N-C)layers are constructed via simple pyrolysis and subsequent oxidization.Benefiting from the 3D curved hierarchical structure,high-conductivity of Ni_(3)Fe and N-C layers,well-distributed active sites,the as-synthesized O-Ni_(3)Fe-NC catalyst demonstrates excellent activity and durability for catalyzing OER.Experimental and theoretical analyses disclose that both high-temperature oxidization and the OER process greatly promote the formation and exposure of the Ni(Fe)OOH active species as well as lower charge transfer resistance,inducing its optimized OER activity.The robust graphitized N-C layers with superior conductivity and their couplings with oxidized Ni_(3)Fe nanoalloys are beneficial for stabilizing catalytic centers,thereby imparting O-Ni_(3)Fe-N-C with such outstanding stability.This work not only provides a rational guidance for enriching and stabilizing high-activity catalytic sites towards OER but also offers more insights into the structural evolution of NiFe-based OER catalysts.
基金supported by the National Natural Science Foundation of China (51832008,51772300,and 52072374)。
文摘Ulcerative colitis(UC) is a long-term,recurrent inflammatory bowel disease for which no effective cure is yet available in the clinical setting.Repairing the barrier dysfunction of the colon and reducing intestinal inflammation are considered key objectives to cure UC.Here we demonstrate a novel therapeutic strategy based on a C_(60) fullerene suspension(C_(60)FS) to treat dinitrobenzene sulfonic acid-induced UC in an animal model.C_(60)FS can repair the barrier dysfunction of UC and effectively promote the healing of ulcers;it also manifests better treatment effects compared with mesalazine enema.C_(60)FS can reduce the numbers of basophils in the blood of UC rats and mast cells in the colorectal tissue,thereby effectively alleviating inflammation.The expression of H1R,H4R,and VEGFR2 receptors in colorectal tissues is inhibited by C_(60)FS,and the levels of histamine and prostaglandin in the rat blood are reduced.This work presents a reliable strategy based on fullerene to cure UC and provides a novel guide for UC treatment.
基金supported by the National Postdoctoral Program for Innovative Talents (BX201700253)the China Postdoctoral Science Foundation (2017M620068, 2018M630208)+1 种基金the National Natural Science Foundation of China (21673257, 21805288)the Ministry of Science and Technology (2016YFA0200700)
文摘In this work, four fused ring electron acceptors(FREAs), 2F-C5, 2F-C6, 2F-C8 and 2F-C10, are developed to investigate the effect of side-chain size on the molecular properties and photovoltaic performance of FREA systematically. The elongation of side-chains in the FREAs not only improves their solubility in the processing solvent, but also enhances their miscibility with the donor PBDB-T. It helps the FREA diffuse into the donor PBDB-T during film-formation, thus leading to the decrease in domain size and domain purity from PBDB-T:2F-C5 to PBDB-T:2F-C10 blend films in sequence. The smaller domain size affords more D/A interfaces to benefit exciton dissociation and inhibit monomolecular recombination. However, severe bimolecular recombination occurs when the domain purity decreases to a critical point. Due to the dual function of the increment of side-chain length, both short-circuit current density(J_(SC)) and fill factor(FF) of devices exhibit an evolution of first increasing then decreasing from 2F-C5, 2F-C6, 2F-C8 to 2F-C10 based OSCs. The PBDB-T:2F-C8 based OSCs get a fine balance in morphology with moderate domain size as well as high domain purity simultaneously for the least charge carrier recombination, thus achieving the highest power conversion efficiency of 12.28% with the best J_(SC)(21.27 mA cm^(-2)) and FF(71.96%).
基金supported by the National Natural Science Foundation of China(No.92061123).M.M.Z.particularly thanks the Youth Innovation Promotion Association of CAS(No.2022036).
文摘Polarization of tumor associated macrophages(TAMs)has been a promising therapeutic paradigm for tumor.However,how to achieve precise regulation of TAMs and high efficiency of tumor immunotherapy is still a huge challenge.Here,we report dicarboxy fullerene modified with mannose(DCFM)as an immunomodulator to selectively polarize TAMs and prominently boost anti-tumor immunity.The dicarboxy fullerene molecule was synthesized through the Prato reaction and further covalently bonded with mannose,obtaining the DCFM with well-defined structure.Due to the exist of mannose in DCFM,it could accurately recognize mannose receptor in TAMs.Our cellular experiment results showed that mannose modification could notably promote the uptake of DCFM by the immunosuppressive M2-type macrophages that effectively reprogrammed M2-type macrophages into anti-tumor M1-type macrophages,leading to enhance the phagocytosis of tumor cells by macrophages and inhibiting tumor cells migration.Subsequently,we observed that DCFM could significantly distribute into tumor tissues by in vivo fluorescence imaging.Importantly,DCFM exhibited a superior anti-tumor efficiency in the subcutaneous colorectal tumor model.In addition,it showed that DCFM precisely polarized TAMs into M1-type macrophages and actively increased the infiltration of cytotoxic T lymphocytes(CTLs),inducing profound tumor growth inhibition.
基金This work was supported by the National Natural Science Foundation of China(Nos.52022098,51672281,51972309,and 51832008)T.Wang particularly thanks the Youth Innovation Promotion Association of CAS(Y201910).
文摘Paramagnetic endohedral metallofullerenes with well protected unpaired spin have potential applications in molecular-scale qubit processing and magnetoreception system. In this study, a paramagnetic metallofullerene Sc_(3)C_(2)@C_(80) dimer with covalently bonded two spin centers was synthesized. Electron paramagnetic resonance (EPR) results further revealed the varied spin-nuclei couplings and paramagnetic property for Sc_(3)C_(2)@C_(80) dimer. Briefly, the Sc_(3)C_(2)@C_(80) dimer in toluene solution shows EPR hyperfine splittings originating from the spin-Sc couplings. However, the Sc_(3)C_(2)@C_(80) dimer in solid state shows the disappearance of hyperfine structure and a single EPR signal caused by its two-spin-center structure. The transformation of EPR signals can be further finely modulated by controlling the dynamic motion of Sc_(3)C_(2)@C80 dimer in chloronaphthalene. The Sc_(3)C_(2)@C_(80) dimer with two spin centers possesses varied paramagnetic properties, demonstrating its potential as new magnetic material.
