Sonodynamic therapy(SDT)exhibits promising clinical applications in cancer treatment owing to its ad-vantages,including ultrasonic cavitation effect,mechanical effect,and deep tissue penetration.Titanium dioxide(TiO_(...Sonodynamic therapy(SDT)exhibits promising clinical applications in cancer treatment owing to its ad-vantages,including ultrasonic cavitation effect,mechanical effect,and deep tissue penetration.Titanium dioxide(TiO_(2))nanomaterials,recognized as excellent sonosensitizers,have been extensively studied in cancer SDT.This review first outlines the mechanism of TiO_(2)-based SDT,then systematically discusses the regulation of TiO_(2) sonosensitivity,covering aspects such as morphology,particle size,element doping,defect engineering,heterojunction structure,and interactions with the tumor microenvironment.Further-more,the review generalizes ultrasound-responsive TiO_(2)-based therapeutic modalities for tumor treat-ment,including SDT,SDT combined with chemotherapy,chemodynamic therapy,photothermal therapy,immunotherapy,and treatment visualization.Finally,the review navigates the ongoing challenges and prospects in TiO_(2)-based cancer SDT.展开更多
基金supported by the National Natural Science Foundation of China(Nos.31971292,32025021,32171359,32111540257,32311530040)the Zhejiang Province Financial Supporting(No.2020c03110)the Key Scientific and Technological Special Project of Ningbo City(Nos.2020Z094,2023Z189).
文摘Sonodynamic therapy(SDT)exhibits promising clinical applications in cancer treatment owing to its ad-vantages,including ultrasonic cavitation effect,mechanical effect,and deep tissue penetration.Titanium dioxide(TiO_(2))nanomaterials,recognized as excellent sonosensitizers,have been extensively studied in cancer SDT.This review first outlines the mechanism of TiO_(2)-based SDT,then systematically discusses the regulation of TiO_(2) sonosensitivity,covering aspects such as morphology,particle size,element doping,defect engineering,heterojunction structure,and interactions with the tumor microenvironment.Further-more,the review generalizes ultrasound-responsive TiO_(2)-based therapeutic modalities for tumor treat-ment,including SDT,SDT combined with chemotherapy,chemodynamic therapy,photothermal therapy,immunotherapy,and treatment visualization.Finally,the review navigates the ongoing challenges and prospects in TiO_(2)-based cancer SDT.
