BACKGROUND Few studies have specifically modeled the risk of venous thromboembolism(VTE)for postoperative hepatocellular carcinoma(HCC)patients,although HCC is the third leading cause of cancer death worldwide.This st...BACKGROUND Few studies have specifically modeled the risk of venous thromboembolism(VTE)for postoperative hepatocellular carcinoma(HCC)patients,although HCC is the third leading cause of cancer death worldwide.This study aimed to develop and validate a nomogram that accurately predicts the risk of VTE in patients after HCC surgery.AIM To develop and validate a nomogram to accurately predict the risk of VTE in postoperative HCC patients by integrating clinical and laboratory risk factors.The model seeks to provide a user-friendly tool for identifying high-risk individuals who may benefit from targeted anticoagulation therapy,thereby improving clinical decision-making and patient outcomes.METHODS Data from patients who underwent HCC surgery at Chongqing University Cancer Hospital in China were analyzed.Through univariate and multivariate logistic regression analyses,independent risk factors for VTE were identified and integrated into a nomogram.The predictive performance of the nomogram was assessed via receiver operating characteristic curves,calibration curves,decision curve analysis and other relevant metrics.RESULTS Of 905 postoperative HCC patients were included in the study.The nomogram incorporated eight independent risk factors for VTE:Karnofsky Performance Scale,base disease,cancer stage(tumor-node-metastasis),chemotherapy,D-dimer concentration,white blood cell count,hemoglobin,and fibrinogen.The C-index for the nomogram model was 0.825 in the training cohort and 0.820 in the validation cohort,indicating good discriminative ability.Calibration plots of the model revealed high concordance between the predicted probabilities and observed outcomes.CONCLUSION We developed and validated a novel nomogram that can accurately estimate the risk of VTE in individual postoperative HCC patients.This model can identify high-risk patients who may benefit from targeted anticoagulation therapy.展开更多
In this paper,by using scalarization techniques and a minimax strategy,error bound results in terms of gap functions for a generalized mixed vector equilibrium problem are established,where the solutions for vector pr...In this paper,by using scalarization techniques and a minimax strategy,error bound results in terms of gap functions for a generalized mixed vector equilibrium problem are established,where the solutions for vector problems may be general sets under natural assumptions,but are not limited to singletons.The other essentially equivalent approach via a separation principle is analyzed.Special cases to the classical vector equilibrium problem and vector variational inequality are also discussed.展开更多
The aim of this paper is to investigate the continuity of solution mappings for para-metric set optimization problems with upper and lower set less order relations by scalarization methods.First,we recall some linear ...The aim of this paper is to investigate the continuity of solution mappings for para-metric set optimization problems with upper and lower set less order relations by scalarization methods.First,we recall some linear and nonlinear scalarization prop-erties used to characterize the set order relations.Subsequently,we introduce new monotonicity concepts of the set-valued mapping by linear and nonlinear scalarization methods.Finally,we obtain the semicontinuity and closedness of solution mappings for parametric set optimization problems(both convex and nonconvex cases)under the monotonicity assumption and other suitable conditions.The results achieved do not impose the continuity of the set-valued objective mapping,which are obviously different from the related ones in the literature.展开更多
文摘BACKGROUND Few studies have specifically modeled the risk of venous thromboembolism(VTE)for postoperative hepatocellular carcinoma(HCC)patients,although HCC is the third leading cause of cancer death worldwide.This study aimed to develop and validate a nomogram that accurately predicts the risk of VTE in patients after HCC surgery.AIM To develop and validate a nomogram to accurately predict the risk of VTE in postoperative HCC patients by integrating clinical and laboratory risk factors.The model seeks to provide a user-friendly tool for identifying high-risk individuals who may benefit from targeted anticoagulation therapy,thereby improving clinical decision-making and patient outcomes.METHODS Data from patients who underwent HCC surgery at Chongqing University Cancer Hospital in China were analyzed.Through univariate and multivariate logistic regression analyses,independent risk factors for VTE were identified and integrated into a nomogram.The predictive performance of the nomogram was assessed via receiver operating characteristic curves,calibration curves,decision curve analysis and other relevant metrics.RESULTS Of 905 postoperative HCC patients were included in the study.The nomogram incorporated eight independent risk factors for VTE:Karnofsky Performance Scale,base disease,cancer stage(tumor-node-metastasis),chemotherapy,D-dimer concentration,white blood cell count,hemoglobin,and fibrinogen.The C-index for the nomogram model was 0.825 in the training cohort and 0.820 in the validation cohort,indicating good discriminative ability.Calibration plots of the model revealed high concordance between the predicted probabilities and observed outcomes.CONCLUSION We developed and validated a novel nomogram that can accurately estimate the risk of VTE in individual postoperative HCC patients.This model can identify high-risk patients who may benefit from targeted anticoagulation therapy.
基金This research was supported by the National Natural Science Foundation of China(Nos.11301567 and 11571055)the Fundamental Research Funds for the Central Universities(No.106112015CDJXY100002).
文摘In this paper,by using scalarization techniques and a minimax strategy,error bound results in terms of gap functions for a generalized mixed vector equilibrium problem are established,where the solutions for vector problems may be general sets under natural assumptions,but are not limited to singletons.The other essentially equivalent approach via a separation principle is analyzed.Special cases to the classical vector equilibrium problem and vector variational inequality are also discussed.
基金This research was supported by the National Natural Science Foundation of China(Nos.11301567 and 11571055)the Fundamental Research Funds for the Central Universities(No.106112017CDJZRPY0020).
文摘The aim of this paper is to investigate the continuity of solution mappings for para-metric set optimization problems with upper and lower set less order relations by scalarization methods.First,we recall some linear and nonlinear scalarization prop-erties used to characterize the set order relations.Subsequently,we introduce new monotonicity concepts of the set-valued mapping by linear and nonlinear scalarization methods.Finally,we obtain the semicontinuity and closedness of solution mappings for parametric set optimization problems(both convex and nonconvex cases)under the monotonicity assumption and other suitable conditions.The results achieved do not impose the continuity of the set-valued objective mapping,which are obviously different from the related ones in the literature.
