Liangshan Prefecture in Sichuan province,China,has a high prevalence of HIV infection,which is reflective of a change in the mode of transmission from injection drug use(IDU)to heterosexual intercourse.However,few stu...Liangshan Prefecture in Sichuan province,China,has a high prevalence of HIV infection,which is reflective of a change in the mode of transmission from injection drug use(IDU)to heterosexual intercourse.However,few studies focus on HIV-related heterosexual risk behaviours among the majority Yi population.The objectives of this study were to explore the characteristics of an egocentric sexual network and estimate the prevalence of casual sexual behaviour.Yi villagers(n=108),aged 15-35 years,who reported having had sex within the previous year were interviewed as to their sexual behaviours and networks.In-depth interviews and focus group discussions provided supplementary information on sexual norms.Logistic regression analysis was used to calculate unadjusted odds ratios(ORs)and 95%confidence intervals(CIs).Most of the respondents reported having had casual sex at some time in their life,and 66.7%reported multiple sexual partnerships.Only 21.3%reported ever having used a condom.During the study year,a total of 137 partners were involved in 153 sexual partnerships.Among the reported sexual partnerships,67.3%originated from a casual sexual relationship.For network members in components of size≥3,56,9%were involved in concurrent sexual partnerships.Having never been married(OR:2.11;95%CI:1.03-4.33)and younger age(OR:0.89;95%CI:0.83-0.95)were both associated with being in a component of size≥3.Size(OR:2.99;95%Ch 1.17-7.66),pair(OR:0.54;95%Ch 0.039-0.74),the number of weak components of the egocentric sexual network(OR-30.04;95%Ch 6.47-139.46)and gender(OR.0.19;95%Ch.0.06-0.67)were all associated with being in concurrent sexual partnerships.HIV-related interventions for the Yi ethnic minority in Sichuan province must therefore address concurrent sexual partnerships and promote condom use.展开更多
The p53 tumor suppressor protein coordinates the cellular responses to a broad range of cellular stresses, leading to DNA repair, cell cycle arrest or apoptosis. The stability of p53 is essential for its tumor suppres...The p53 tumor suppressor protein coordinates the cellular responses to a broad range of cellular stresses, leading to DNA repair, cell cycle arrest or apoptosis. The stability of p53 is essential for its tumor suppressor function, which is tightly controlled by ubiquitin-dependent degradation primarily through its negative regulator mudne double minute 2 （Mdm2）. To better understand the regulation of p53, we tested the interaction between p53 and USP11 using co-immunoprecipitation. The results show that USP11, an ubiquitin-specific protease, forms specific complexes with p53 and stabilizes p53 by deubiquitinating it. Moreover, down-regulation of USP11 dramatically attenuated p53 in- duction in response to DNA damage stress. These findings reveal that USP11 is a novel regulator of p53, which is required for p53 activation in response to DNA damage.展开更多
Objective To explore prevalence of casual sex among the Yi. Methods Cross-sectional survey of 89 Yi male villagers was used. In-depth interview, interview and focus group discussion were used to collect supplementary ...Objective To explore prevalence of casual sex among the Yi. Methods Cross-sectional survey of 89 Yi male villagers was used. In-depth interview, interview and focus group discussion were used to collect supplementary information. Results About 96.63% respondents had had casual sex at some time in their life, and 78. 65% had had multiple partners （maximum number was 40）; 41.57% respondents had heard of condoms, but only 20.22% had used them and no one used them consistently. In the past one year, 26.97% had had multiple partners （maximum number was 6）. Conclusion Casual sex is a Yi young men＇s lifestyle, but is denied. It is urgent for researchers and policy makers to pay attention to casual sex.展开更多
文摘Liangshan Prefecture in Sichuan province,China,has a high prevalence of HIV infection,which is reflective of a change in the mode of transmission from injection drug use(IDU)to heterosexual intercourse.However,few studies focus on HIV-related heterosexual risk behaviours among the majority Yi population.The objectives of this study were to explore the characteristics of an egocentric sexual network and estimate the prevalence of casual sexual behaviour.Yi villagers(n=108),aged 15-35 years,who reported having had sex within the previous year were interviewed as to their sexual behaviours and networks.In-depth interviews and focus group discussions provided supplementary information on sexual norms.Logistic regression analysis was used to calculate unadjusted odds ratios(ORs)and 95%confidence intervals(CIs).Most of the respondents reported having had casual sex at some time in their life,and 66.7%reported multiple sexual partnerships.Only 21.3%reported ever having used a condom.During the study year,a total of 137 partners were involved in 153 sexual partnerships.Among the reported sexual partnerships,67.3%originated from a casual sexual relationship.For network members in components of size≥3,56,9%were involved in concurrent sexual partnerships.Having never been married(OR:2.11;95%CI:1.03-4.33)and younger age(OR:0.89;95%CI:0.83-0.95)were both associated with being in a component of size≥3.Size(OR:2.99;95%Ch 1.17-7.66),pair(OR:0.54;95%Ch 0.039-0.74),the number of weak components of the egocentric sexual network(OR-30.04;95%Ch 6.47-139.46)and gender(OR.0.19;95%Ch.0.06-0.67)were all associated with being in concurrent sexual partnerships.HIV-related interventions for the Yi ethnic minority in Sichuan province must therefore address concurrent sexual partnerships and promote condom use.
基金Project supported by the Key Project of Colleges and Universities in Fujian Province Serving the Construction of the West-strait(No.A101)the Foundation for the 2013 Research Plan of University Key Teacher Domestic Visitor of the Ministry of Educationthe Foundation for the Second Batch of Key Teacher of Quanzhou Normal College(the personnel department of QNC[2012]No.1),China
文摘The p53 tumor suppressor protein coordinates the cellular responses to a broad range of cellular stresses, leading to DNA repair, cell cycle arrest or apoptosis. The stability of p53 is essential for its tumor suppressor function, which is tightly controlled by ubiquitin-dependent degradation primarily through its negative regulator mudne double minute 2 （Mdm2）. To better understand the regulation of p53, we tested the interaction between p53 and USP11 using co-immunoprecipitation. The results show that USP11, an ubiquitin-specific protease, forms specific complexes with p53 and stabilizes p53 by deubiquitinating it. Moreover, down-regulation of USP11 dramatically attenuated p53 in- duction in response to DNA damage stress. These findings reveal that USP11 is a novel regulator of p53, which is required for p53 activation in response to DNA damage.
基金supported by Sichuan Branch of Global Fund AIDS Office (Round 4)
文摘Objective To explore prevalence of casual sex among the Yi. Methods Cross-sectional survey of 89 Yi male villagers was used. In-depth interview, interview and focus group discussion were used to collect supplementary information. Results About 96.63% respondents had had casual sex at some time in their life, and 78. 65% had had multiple partners （maximum number was 40）; 41.57% respondents had heard of condoms, but only 20.22% had used them and no one used them consistently. In the past one year, 26.97% had had multiple partners （maximum number was 6）. Conclusion Casual sex is a Yi young men＇s lifestyle, but is denied. It is urgent for researchers and policy makers to pay attention to casual sex.
