The first catalytic atroposelective synthesis of indole derivatives bearing N-N/C-C diaxes has been established by the strategy of de novo ring formation.By this strategy,various indolyl quinazolinones bearing vicinal...The first catalytic atroposelective synthesis of indole derivatives bearing N-N/C-C diaxes has been established by the strategy of de novo ring formation.By this strategy,various indolyl quinazolinones bearing vicinal N-N/C-C diaxes were synthesized in high yields with overall good diastereoselectivities and excellent enantioselectivities via chiral phosphoric acid-catalyzed onepot asymmetric formal(5+1)cycloaddition/oxidation reaction.Moreover,such indolyl quinazolinones bearing vicinal N-N/CC diaxes have good configurational stability and could be converted into new chiral ligands with applications in asymmetric catalysis.Therefore,this work not only offered a new member for the family of diaxial atropisomers,but also provided a powerful strategy for catalytic asymmetric synthesis of atropisomers bearing N-N/C-C diaxes.展开更多
As an important quantum communication protocol,quantum teleportation has broad applications in quantum information science and technology.For the application,it is essential to enhance the ability of quantum teleporta...As an important quantum communication protocol,quantum teleportation has broad applications in quantum information science and technology.For the application,it is essential to enhance the ability of quantum teleportation by teleporting multiple quantum states simultaneously.Here,we experimentally demonstrate deterministic quantum teleportation of multiple sideband qumodes of coherent states,which corresponds to teleporting multiple quantum states simultaneously,with the assistance of continuous-variable(CV)quantum entanglement.By fine-tuning the phases of two classical channels according to different adjustable frequencies,we successfully realize deterministic CV quantum teleportation with up to 5 sideband qumodes simultaneously within the frequency bandwidth of 24 MHz.We show that the number of teleported multiple qumodes is controllable by changing the phases of two classical channels.The obtained fidelities of output multiple qumodes are around 70%,which are all beyond the non-cloning limit.The results present a novel method for quantum teleportation of multiple quantum states simultaneously and take a crucial step in enhancing the teleporting ability of quantum teleportation.展开更多
Iodine extravasation is commonly seen in stroke patients after successful mechanical thrombectomy.Iodine extravasation may be associated with patient prognosis,and more iodine extravasation is highly associated with t...Iodine extravasation is commonly seen in stroke patients after successful mechanical thrombectomy.Iodine extravasation may be associated with patient prognosis,and more iodine extravasation is highly associated with the development of severe hemorrhagic transformation(HT).Hence,it is essential to identify early hemorrhage after intra-artery therapy and the imaging indicators that can predict late hemorrhage transformation.展开更多
Asymmetric ring-expansion reactions of silacyclobutanes(SCBs)with alkynes have evolved as one of the powerful protocols for the construction of silicon-stereogenic compounds.However,the achievement of highly enantiose...Asymmetric ring-expansion reactions of silacyclobutanes(SCBs)with alkynes have evolved as one of the powerful protocols for the construction of silicon-stereogenic compounds.However,the achievement of highly enantioselective annulation of SCBs with terminal alkynes remains a challenge.Herein,we report a rhodium-catalyzed asymmetric annulation reaction of SCBs with terminal alkynes,which relies on the newly identified chiral sulfinamide phosphine ligand Ming-Phos.This catalytic system exhibits unique effects under mild conditions,leading to the direct synthesis of structurally diverse chiral silacycles in moderate to good yields with high enantioselectivities(up to 95%ee).展开更多
基金supported by the National Natural Science Foundation of China(22125104,22101103,22401115)the Natural Science Foundation of Jiangsu Province(BK20240052)the Project for Excellent Scientific and Technological Innovation Team of Jiangsu Province。
文摘The first catalytic atroposelective synthesis of indole derivatives bearing N-N/C-C diaxes has been established by the strategy of de novo ring formation.By this strategy,various indolyl quinazolinones bearing vicinal N-N/C-C diaxes were synthesized in high yields with overall good diastereoselectivities and excellent enantioselectivities via chiral phosphoric acid-catalyzed onepot asymmetric formal(5+1)cycloaddition/oxidation reaction.Moreover,such indolyl quinazolinones bearing vicinal N-N/CC diaxes have good configurational stability and could be converted into new chiral ligands with applications in asymmetric catalysis.Therefore,this work not only offered a new member for the family of diaxial atropisomers,but also provided a powerful strategy for catalytic asymmetric synthesis of atropisomers bearing N-N/C-C diaxes.
基金supported by the Quantum Science and Technology-National Science and Technology Major Project(2024ZD0302403)the National Natural Science Foundation of China(12434015 and 62275145)+1 种基金the Fundamental Research Program of Shanxi Province(202403021224001)the Fund for Shanxi“331 Project”Key Subjects Construction.
文摘As an important quantum communication protocol,quantum teleportation has broad applications in quantum information science and technology.For the application,it is essential to enhance the ability of quantum teleportation by teleporting multiple quantum states simultaneously.Here,we experimentally demonstrate deterministic quantum teleportation of multiple sideband qumodes of coherent states,which corresponds to teleporting multiple quantum states simultaneously,with the assistance of continuous-variable(CV)quantum entanglement.By fine-tuning the phases of two classical channels according to different adjustable frequencies,we successfully realize deterministic CV quantum teleportation with up to 5 sideband qumodes simultaneously within the frequency bandwidth of 24 MHz.We show that the number of teleported multiple qumodes is controllable by changing the phases of two classical channels.The obtained fidelities of output multiple qumodes are around 70%,which are all beyond the non-cloning limit.The results present a novel method for quantum teleportation of multiple quantum states simultaneously and take a crucial step in enhancing the teleporting ability of quantum teleportation.
基金This study was supported by a grant from the Deyang City Science and Technology Research Foundation(No.2018SZS059)。
文摘Iodine extravasation is commonly seen in stroke patients after successful mechanical thrombectomy.Iodine extravasation may be associated with patient prognosis,and more iodine extravasation is highly associated with the development of severe hemorrhagic transformation(HT).Hence,it is essential to identify early hemorrhage after intra-artery therapy and the imaging indicators that can predict late hemorrhage transformation.
基金the funding support of the National Key R&D Program of China(No.2021YFF0701601)NSFC(Nos.22031004 and 21921003)+1 种基金Shanghai Municipal Education Commission(No.20212308)Science and Technology Commission of Shanghai Municipality(No.23ZR1404800).
文摘Asymmetric ring-expansion reactions of silacyclobutanes(SCBs)with alkynes have evolved as one of the powerful protocols for the construction of silicon-stereogenic compounds.However,the achievement of highly enantioselective annulation of SCBs with terminal alkynes remains a challenge.Herein,we report a rhodium-catalyzed asymmetric annulation reaction of SCBs with terminal alkynes,which relies on the newly identified chiral sulfinamide phosphine ligand Ming-Phos.This catalytic system exhibits unique effects under mild conditions,leading to the direct synthesis of structurally diverse chiral silacycles in moderate to good yields with high enantioselectivities(up to 95%ee).
