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一种新型中药配方通过触发磷酸戊糖途径依赖的氧化应激抑制非小细胞肺癌 被引量:6
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作者 程钏 吴巍 +3 位作者 俞嘉鑫 袁冬冬 王玉炯 李乐 《中国肺癌杂志》 CAS CSCD 北大核心 2023年第9期639-649,共11页
背景与目的非小细胞肺癌(non-small cell lung cancer,NSCLC)是世界范围内死亡率较高的恶性肿瘤之一。一种新型中药配方(novel Chinese medicine formula-01,NCHF-01)在治疗NSCLC方面已显示出显著的临床疗效,但此配方治疗NSCLC的作用机... 背景与目的非小细胞肺癌(non-small cell lung cancer,NSCLC)是世界范围内死亡率较高的恶性肿瘤之一。一种新型中药配方(novel Chinese medicine formula-01,NCHF-01)在治疗NSCLC方面已显示出显著的临床疗效,但此配方治疗NSCLC的作用机制尚不完全清楚。本研究拟探讨中药配方抑制NSCLC的作用及其分子机制。方法建立Lewis肺癌细胞(lewis lung cells,LLC)荷瘤小鼠,检测NCHF-01抑制肿瘤的效果;苏木素-伊红(hematoxylin-eosin staining,HE)染色检测LLC荷瘤小鼠组织器官的形态变化;NCHF-01处理NSCLC细胞,MTT和结晶紫染色实验检测其对细胞活力和增殖的影响;流式细胞术检测细胞周期、凋亡和活性氧(reactive oxygen species,ROS)水平;网络药理学预测其抑制NSCLC的作用机制;Western blot和免疫组织化学(immunohistochemistry,IHC)检测相关蛋白的表达。结果NCHF-01能够抑制LLC荷瘤小鼠肿瘤的生长,并对其他组织器官无明显毒副作用;NCHF-01能够抑制细胞活力和增殖,诱导细胞的G2/M期停滞和细胞凋亡,促进细胞内ROS水平的升高;网络药理学分析显示,NCHF-01通过氧化应激和中枢碳代谢等多种生物学过程发挥抗NSCLC作用;NCHF-01能够降低磷酸戊糖途径(pentose phosphate pathway,PPP)关键酶6-磷酸葡萄糖脱氢酶(6-phosphate glucose dehydrogenase,G6PD)和6-磷酸葡萄糖酸脱氢酶(6-phosphogluconate dehydrogenase,6PGD)的蛋白表达以及酶活性。结论NCHF-01能够通过PPP依赖的氧化应激抑制NSCLC。 展开更多
关键词 肺肿瘤 中药配方 网络药理学 氧化应激 磷酸戊糖途径
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Transformation toughening of Al_2O_3/ZrO_2 laminated ceramics with residual compressive stress 被引量:3
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作者 Bei Chen chuan cheng +1 位作者 Lan Xiong Li-Ao Wang 《Journal of University of Science and Technology Beijing》 CSCD 2007年第5期449-453,共5页
With the help of scanning electronic microscopy and X-ray diffraction, the relationships of microstructure characteristics, phase assemblage, and fracture micrograph of Al2O3/ZrO2 laminated ceramics were studied. Comp... With the help of scanning electronic microscopy and X-ray diffraction, the relationships of microstructure characteristics, phase assemblage, and fracture micrograph of Al2O3/ZrO2 laminated ceramics were studied. Compared with monolithic Al2O3/ZrO2 ceramics, the existence of surface compressive stresses greatly restrained the growth of ZrO2 and Al2O3 grains at high sinter temperature, fined the grain size, and increased the content of metastable t-ZrO2, which made the fracture transformation energy quantity 70% higher than that of the monolithic ceramics. The trans-granular and inter-granular fracture features were observed in the surface and center layers, which further verified that transformation toughening is the main mechanism, whereas, micro-crack toughening is helpful for enhancing fracture toughness. 展开更多
关键词 laminated ceramics transformation toughening fracture micrograph grain size surface compressive stress
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An integration method based on a novel combined flow for aerodynamic configuration of strutjet engine 被引量:1
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作者 Longsheng XUE chuan cheng +1 位作者 chengpeng WANG Keming cheng 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2021年第9期156-167,共12页
In this paper a novel design method of aerodynamic configuration is proposed to integrate forebody,strut and inlet for strutjet engine,and a model at design point of Mach number6 is generated to investigate the aerody... In this paper a novel design method of aerodynamic configuration is proposed to integrate forebody,strut and inlet for strutjet engine,and a model at design point of Mach number6 is generated to investigate the aerodynamic performance by both simulations and experiments.The basic flow field employed by proposed method is a combined flow named IBB,which is combined by Internal Conical Flow A(ICFA),truncated Busemann flow I(BI)for external section,and truncated Busemann flow II(BII)for internal section.The model configuration is generated by streamline tracing method from basic flow field,in which the forebody section is traced from ICFA and BI flows,and the inlet as well as strut section is traced from BII flow.The simulations in Mach number 4,5,and 6 demonstrate uniform starting flow fields with relatively high total pressure recovery,which agree well with experiments in wind tunnel.Additionally,in low Mach number cases,this inlet could start at Mach number 3 while it is unstarted at Mach number 2.7;in high Mach number cases,a uniform flow could still exist in Mach number 6.5 while a relatively strong shock wave boundary layer interaction is found in cowl area of Mach number 7 case,indicating the inlet designed by proposed method works in a relatively wide Mach number range. 展开更多
关键词 Airframe-propulsion integration Busemann flow Combined flow Hypersonics Wind tunnel test
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Oblique shock train motion based on schlieren image processing 被引量:1
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作者 Longsheng XUE chuan cheng +3 位作者 chengpeng WANG Lantian ZHANG Kang LI Keming cheng 《Chinese Journal of Aeronautics》 SCIE EI CAS CSCD 2023年第3期30-41,共12页
In this paper,shock train motion in a Mach number 2.7 duct is studied experimentally,and large numbers of schlieren images are obtained by a high-speed camera.An image processing method based on Maximum Correlation De... In this paper,shock train motion in a Mach number 2.7 duct is studied experimentally,and large numbers of schlieren images are obtained by a high-speed camera.An image processing method based on Maximum Correlation Detection(MCD)is proposed to detect shock train motion from the schlieren images,based on which the key structures,e.g.,separation positions and separation shock angles on the top and bottom walls,can be analysed in detail.The oscillations of the shock train are generated by rhombus and ellipse shafts at various excitation frequencies.According to the analysis of MCD results,the distributions of the frequency components of shock train oscillation generated by the two shafts are distinctly different,in which the motion generated by the ellipse shaft is much smoother;shock train motion is mainly characterized by the oscillation of separation position while the separation shock strength is not so sensitive to downstream disturbance;there is a hysteresis loop relation between the downstream pressure and separation position. 展开更多
关键词 Frequency components Hysteresis loop Maximum Correlation Detection(MCD) Schlieren image processing Shock train oscillation
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