A prototype cleanroom for hazardous testing and handling of satellites prior to launcher encapsulation,satisfying the ISO8 standard has been designed and analyzed in terms of performances.Unsteady Reynolds Averaged Na...A prototype cleanroom for hazardous testing and handling of satellites prior to launcher encapsulation,satisfying the ISO8 standard has been designed and analyzed in terms of performances.Unsteady Reynolds Averaged Navier-Stokes(URANS)models have been used to study the related flow field and particulate matter(PM)dispersion.The outcomes of the URANS models have been validated through comparison with equivalent large-eddy simulations.Special attention has been paid to the location and shape of the air intakes and their orientation in space,in order to balance the PM convection and diffusion inside the cleanroom.Forming a cyclone-type flow pattern inside the cleanroom is a key to maintaining a high ventilation efficiency.展开更多
Background:Malaria rapid diagnostic tests have become a primary and critical tool for malaria diagnosis in malariaendemic countries where Plasmodium falciparum Histidine Rich Protein 2-based rapid diagnostic tests(Pfl...Background:Malaria rapid diagnostic tests have become a primary and critical tool for malaria diagnosis in malariaendemic countries where Plasmodium falciparum Histidine Rich Protein 2-based rapid diagnostic tests(PflHRP2-based RDTs)are widely used.However,in the last decade,the accuracy of PflHRP2-based RDTs has been challenged by the emerge nee of P.falciparum strains harbouring deletions of the P.falciparum histidine rich protein 2(pflnrp2)gene,resulting in false-negative results.In the Democratic Republic of Congo(D.R.Congo),little is known about the prevalence of the pfhrp2 gene deletion among P.falciparum isolates infecting symptomatic patients,especially in low to moderate transmission areas where pfhrp2 deletion parasites are assumed to emerge and spread.Here we determine the local prevalence and factors associated with pfhrp2 gene deletions among symptomatic malaria patients in the Kwilu Province of the D.R.Congo.展开更多
基金funded by Space Research and Innovation Network (www.sprint.ac.uk)for Technology Grants (OW131743P4V4M,OW131797P4V2B,ZX and CY)grateful to NERC (www.nerc.ac.uk)for the Grant (NE/W002841/1,ZX)to complete the writing of the paper。
文摘A prototype cleanroom for hazardous testing and handling of satellites prior to launcher encapsulation,satisfying the ISO8 standard has been designed and analyzed in terms of performances.Unsteady Reynolds Averaged Navier-Stokes(URANS)models have been used to study the related flow field and particulate matter(PM)dispersion.The outcomes of the URANS models have been validated through comparison with equivalent large-eddy simulations.Special attention has been paid to the location and shape of the air intakes and their orientation in space,in order to balance the PM convection and diffusion inside the cleanroom.Forming a cyclone-type flow pattern inside the cleanroom is a key to maintaining a high ventilation efficiency.
文摘Background:Malaria rapid diagnostic tests have become a primary and critical tool for malaria diagnosis in malariaendemic countries where Plasmodium falciparum Histidine Rich Protein 2-based rapid diagnostic tests(PflHRP2-based RDTs)are widely used.However,in the last decade,the accuracy of PflHRP2-based RDTs has been challenged by the emerge nee of P.falciparum strains harbouring deletions of the P.falciparum histidine rich protein 2(pflnrp2)gene,resulting in false-negative results.In the Democratic Republic of Congo(D.R.Congo),little is known about the prevalence of the pfhrp2 gene deletion among P.falciparum isolates infecting symptomatic patients,especially in low to moderate transmission areas where pfhrp2 deletion parasites are assumed to emerge and spread.Here we determine the local prevalence and factors associated with pfhrp2 gene deletions among symptomatic malaria patients in the Kwilu Province of the D.R.Congo.
