Circulating tumor cells(CTCs),originating from primary neoplastic tissues,infiltrate blood vessels,migrate through the bloodstream,and establish secondary tumor foci.The detection of CTCs holds significant promise for...Circulating tumor cells(CTCs),originating from primary neoplastic tissues,infiltrate blood vessels,migrate through the bloodstream,and establish secondary tumor foci.The detection of CTCs holds significant promise for early-stage identification,diagnostic precision,therapeutic monitoring,and prognostic evaluation.It offers a non-invasive approach and has broad clinical relevance in cancer management.This comprehensive review primarily focused on CTCs as biomarkers in the diagnostic,therapeutic,and prognostic surveillance of hepatocellular carcinoma,compared their correlation with key clinical parameters and the identification of gene characteristics.It also highlighted current methodologies in CTC detection.Despite approval by the U.S.Food and Drug Administration for select malignancies,the comprehensive integration of CTCs into routine clinical practice requires procedural standardization and a deeper understanding of the underlying molecular intricacies.The challenges in CTC detection,including limited quantity,technical impediments,and cellular heterogeneity,call for concerted and further investigational efforts to advance precision in cancer diagnostics and prognostication,thus realizing the objectives of precise and personalized medicine.展开更多
基金supported in part by grants from the Ministry of Science and Technology,Taiwan(MOST 107-2314-B-037-082-MY3 to JFH,110-2314-B-03-073-MY3 to JFH)the National Science and Technology Council,Taiwan(NSTC112-2314-B-037-072 to YCL)+1 种基金the National Yang Ming Chiao Tung University-Kaohsiung Medical University Joint Research Project(NYCU-KMU-111-I001 to JFH,NYCU-KMU-112-I001 to JFH)and Kaohsiung Medical University Hospital(KMUH110-0R05 to JFH,KMUH110-0R20 to YCL,KMUH111-1M16 to YCL,KMUH111-1M17 to CMH,KMUH111-1R06 to JFH,KMUH SH11208 to YCL,KMUH-DK(B)110001-3 to YCL,KMUH-DK109006-2 to YCL).
文摘Circulating tumor cells(CTCs),originating from primary neoplastic tissues,infiltrate blood vessels,migrate through the bloodstream,and establish secondary tumor foci.The detection of CTCs holds significant promise for early-stage identification,diagnostic precision,therapeutic monitoring,and prognostic evaluation.It offers a non-invasive approach and has broad clinical relevance in cancer management.This comprehensive review primarily focused on CTCs as biomarkers in the diagnostic,therapeutic,and prognostic surveillance of hepatocellular carcinoma,compared their correlation with key clinical parameters and the identification of gene characteristics.It also highlighted current methodologies in CTC detection.Despite approval by the U.S.Food and Drug Administration for select malignancies,the comprehensive integration of CTCs into routine clinical practice requires procedural standardization and a deeper understanding of the underlying molecular intricacies.The challenges in CTC detection,including limited quantity,technical impediments,and cellular heterogeneity,call for concerted and further investigational efforts to advance precision in cancer diagnostics and prognostication,thus realizing the objectives of precise and personalized medicine.
