The goal of this research was to study how people feel about sharing personal information on social networks. The research was done by interviews;50 people were interviewed, mostly from China's Mainland, Hong Kong...The goal of this research was to study how people feel about sharing personal information on social networks. The research was done by interviews;50 people were interviewed, mostly from China's Mainland, Hong Kong, and Finland. This paper presents the included 12 questions and discusses the collected answers. It was discovered, e.g., that 38 out of the 50 answerers use social media every day and share versatile personal information on the Internet. Half of the answerers also share information about other people on the Internet. It was also discovered that compared to male answerers, the female answerers were more active in sharing information about other people. There was a significant variety in opinions: what should be the age limit for sharing personal information online, while 22 out of the 50 answerers felt that there is no need for an age limit at all. According to the answers, only a few people use social media for making new friends. Instead, an important reason for using social media is that their existing friends are using. An interesting finding was that the answerers see the Internet as a part of the real world;the privacy that you have on the Internet is the privacy that you have in the real world.展开更多
The caseinolytic protease complex ClpP1P2 is crucial for protein homeostasis in mycobacteria and stress response and virulence of the pathogens.Its role as a potential drug target for combating tuberculosis(TB)has jus...The caseinolytic protease complex ClpP1P2 is crucial for protein homeostasis in mycobacteria and stress response and virulence of the pathogens.Its role as a potential drug target for combating tuberculosis(TB)has just begun to be substantiated in drug discovery research.We conducted a biochemical screening targeting the ClpP1P2 using a library of compounds phenotypically active against Mycobacterium tuberculosis(Mtb).The screening identified a phenyl ester compound GDI-5755,inhibiting the growth of Mtb and M.bovis BCG,the model organism of mycobacteria.GDI-5755 covalently modified the activesite serine residue of ClpP1,rendering the peptidase inactive,which was delineated through protein mass spectrometry and kinetic analyses.GDI-5755 exerted antibacterial activity by inhibiting ClpP1P2 in the bacteria,which could be demonstrated through a minimum inhibitory concentration(MIC)shift assay with a clpP1 CRISPRi knockdown(clpP1-KD)mutant GH189.The knockdown also remarkably heightened the mutant's sensitivity to ethionamide and meropenem,but not to many other TB drugs.On the other hand,a comparative proteomic analysis of wild-type cells exposed to GDI-5755 revealed the dysregulated proteome,specifically showing changes in the expression levels of multiple TB drug targets,including EthA,LdtMt2,and PanD.Subsequent evaluation confirmed the synergistic activity of GDI-5755 when combined with the TB drugs to inhibit mycobacterial growth.Our findings indicate that small-molecule inhibitors targeting ClpP1P2,when used alongside existing TB medications,could represent novel therapeutic strategies.展开更多
The purpose of this paper is to study the convergence problem of the iteration scheme xn＋l = λn＋1y ＋ （1 - λn＋1）Tn＋1xn for a family of infinitely many nonexpansive mappings T1, T2,... in a Hilbert space. It is...The purpose of this paper is to study the convergence problem of the iteration scheme xn＋l = λn＋1y ＋ （1 - λn＋1）Tn＋1xn for a family of infinitely many nonexpansive mappings T1, T2,... in a Hilbert space. It is proved that under suitable conditions this iteration scheme converges strongly to the nearest common fixed point of this family of nonexpansive mappings. The results presented in this paper extend and improve some recent results.展开更多
The purpose of this paper is by using the modified block iterative method to propose an algorithm for finding a common element in the intersection of the set of common fixed points of an infinite family of quasi-C-asy...The purpose of this paper is by using the modified block iterative method to propose an algorithm for finding a common element in the intersection of the set of common fixed points of an infinite family of quasi-C-asymptotically nonexpansive and the set of solutions to an equilibrium problem and the set of solutions to a variational inequality. Under suitable conditions some strong convergence theorems are established in 2-uniformly convex and uniformly smooth Banach spaces. As applications we utilize the results presented in the paper to solving the convex feasibility problem （CFP） and zero point problem of maximal monotone mappings in Banach spaces. The results presented in the paper improve and extend the corresponding results announced by many authors.展开更多
文摘The goal of this research was to study how people feel about sharing personal information on social networks. The research was done by interviews;50 people were interviewed, mostly from China's Mainland, Hong Kong, and Finland. This paper presents the included 12 questions and discusses the collected answers. It was discovered, e.g., that 38 out of the 50 answerers use social media every day and share versatile personal information on the Internet. Half of the answerers also share information about other people on the Internet. It was also discovered that compared to male answerers, the female answerers were more active in sharing information about other people. There was a significant variety in opinions: what should be the age limit for sharing personal information online, while 22 out of the 50 answerers felt that there is no need for an age limit at all. According to the answers, only a few people use social media for making new friends. Instead, an important reason for using social media is that their existing friends are using. An interesting finding was that the answerers see the Internet as a part of the real world;the privacy that you have on the Internet is the privacy that you have in the real world.
基金supported by the Bill&Melinda Gates Foundation(grant number:INV-008249)GHDDI sponsors in Beijing,China.
文摘The caseinolytic protease complex ClpP1P2 is crucial for protein homeostasis in mycobacteria and stress response and virulence of the pathogens.Its role as a potential drug target for combating tuberculosis(TB)has just begun to be substantiated in drug discovery research.We conducted a biochemical screening targeting the ClpP1P2 using a library of compounds phenotypically active against Mycobacterium tuberculosis(Mtb).The screening identified a phenyl ester compound GDI-5755,inhibiting the growth of Mtb and M.bovis BCG,the model organism of mycobacteria.GDI-5755 covalently modified the activesite serine residue of ClpP1,rendering the peptidase inactive,which was delineated through protein mass spectrometry and kinetic analyses.GDI-5755 exerted antibacterial activity by inhibiting ClpP1P2 in the bacteria,which could be demonstrated through a minimum inhibitory concentration(MIC)shift assay with a clpP1 CRISPRi knockdown(clpP1-KD)mutant GH189.The knockdown also remarkably heightened the mutant's sensitivity to ethionamide and meropenem,but not to many other TB drugs.On the other hand,a comparative proteomic analysis of wild-type cells exposed to GDI-5755 revealed the dysregulated proteome,specifically showing changes in the expression levels of multiple TB drug targets,including EthA,LdtMt2,and PanD.Subsequent evaluation confirmed the synergistic activity of GDI-5755 when combined with the TB drugs to inhibit mycobacterial growth.Our findings indicate that small-molecule inhibitors targeting ClpP1P2,when used alongside existing TB medications,could represent novel therapeutic strategies.
基金Supported by The Research Foundation Grant of The Hong Kong Polytechnic University and Yibin University(2005Z3)
文摘The purpose of this paper is to study the convergence problem of the iteration scheme xn＋l = λn＋1y ＋ （1 - λn＋1）Tn＋1xn for a family of infinitely many nonexpansive mappings T1, T2,... in a Hilbert space. It is proved that under suitable conditions this iteration scheme converges strongly to the nearest common fixed point of this family of nonexpansive mappings. The results presented in this paper extend and improve some recent results.
基金Supported by Natural Science Foundation of Yibin University(Z-2009,No.3)
文摘The purpose of this paper is by using the modified block iterative method to propose an algorithm for finding a common element in the intersection of the set of common fixed points of an infinite family of quasi-C-asymptotically nonexpansive and the set of solutions to an equilibrium problem and the set of solutions to a variational inequality. Under suitable conditions some strong convergence theorems are established in 2-uniformly convex and uniformly smooth Banach spaces. As applications we utilize the results presented in the paper to solving the convex feasibility problem （CFP） and zero point problem of maximal monotone mappings in Banach spaces. The results presented in the paper improve and extend the corresponding results announced by many authors.
