Skin-integrated wearable electronics enable continuous,medical-grade monitoring and therapy in daily life,but must balance conflicting needs related to mechanics,power,and communication.This review uses a dual-interfa...Skin-integrated wearable electronics enable continuous,medical-grade monitoring and therapy in daily life,but must balance conflicting needs related to mechanics,power,and communication.This review uses a dual-interface approach that separates the sensor-receiver interface,which handles wireless data and energy transfer,from the sensor-skin interface,where physiological signals are converted and mechanical and biological integration occur.We first reviewed wireless connections designed for skin electronics,focusing on Bluetooth Low Energy(BLE),Radio Frequency Identification(RFID)/Near-Field Communication(NFC)systems,and hybrid systems.Next,we examine sensor-skin interfaces ranging from mediated contact layers such as hydrogels for wearable ultrasound and soft conductive electrodes,to skin-conformal direct-contact methods based on structural mechanics,and ultrathin epidermal devices.Finally,we discuss cross-interface coupling,emphasizing how antenna layouts,power budgets,and body-induced RF effects limit mechanical design,and how skin mechanics influence link reliability.We conclude by exploring opportunities in battery-free and energy-autonomous systems,body-coupled communication,and integration with artificial intelligence(AI)-enabled digital health,positioning future electronic skins as soft,networked platforms that are comfortable and reliable.展开更多
Undruggable targets typically refer to a class of therapeutic targets that are difficult to target through conventional methods or have not yet been targeted,but are of great clinical significance.According to statist...Undruggable targets typically refer to a class of therapeutic targets that are difficult to target through conventional methods or have not yet been targeted,but are of great clinical significance.According to statistics,over 80%of disease-related pathogenic proteins cannot be targeted by current conventional treatment methods.In recent years,with the advancement of basic research and new technologies,the development of various new technologies and mechanisms has brought new perspectives to overcome challenging drug targets.Among them,targeted protein degradation technology is a breakthrough drug development strategy for challenging drug targets.This technology can specifically identify target proteins and directly degrade pathogenic target proteins by utilizing the inherent protein degradation pathways within cells.This new form of drug development includes various types such as proteolysis targeting chimera(PROTAC),molecular glue,lysosome-targeting Chimaera(LYTAC),autophagosometethering compound(ATTEC),autophagy-targeting chimera(AUTAC),autophagy-targeting chimera(AUTOTAC),degrader-antibody conjugate(DAC).This article systematically summarizes the application of targeted protein degradation technology in the development of degraders for challenging drug targets.Finally,the article looks forward to the future development direction and application prospects of targeted protein degradation technology.展开更多
基金supported by the Rutgers Startup Package,NJ Health Foundation(Grant No.PC 221-25)Rutgers-New Brunswick OVPR Behavioral Health and Equity Pilot Seed Funding Award,MIT Lincoln Lab Collaboration Award,NJ Commission on Brain Injury Research(Grant No.CBIR25IRG024)the National Research Foundation(Grant No.RS-2024-00406674)funded by the Ministry of Science and ICT of Korea.
文摘Skin-integrated wearable electronics enable continuous,medical-grade monitoring and therapy in daily life,but must balance conflicting needs related to mechanics,power,and communication.This review uses a dual-interface approach that separates the sensor-receiver interface,which handles wireless data and energy transfer,from the sensor-skin interface,where physiological signals are converted and mechanical and biological integration occur.We first reviewed wireless connections designed for skin electronics,focusing on Bluetooth Low Energy(BLE),Radio Frequency Identification(RFID)/Near-Field Communication(NFC)systems,and hybrid systems.Next,we examine sensor-skin interfaces ranging from mediated contact layers such as hydrogels for wearable ultrasound and soft conductive electrodes,to skin-conformal direct-contact methods based on structural mechanics,and ultrathin epidermal devices.Finally,we discuss cross-interface coupling,emphasizing how antenna layouts,power budgets,and body-induced RF effects limit mechanical design,and how skin mechanics influence link reliability.We conclude by exploring opportunities in battery-free and energy-autonomous systems,body-coupled communication,and integration with artificial intelligence(AI)-enabled digital health,positioning future electronic skins as soft,networked platforms that are comfortable and reliable.
基金supported by the National Key R&D Program of China(2021YFA1300200,2021YFA1302100 and 2020YFE0202200)the National Natural Science Foundation of China(82125034,82330115)。
文摘Undruggable targets typically refer to a class of therapeutic targets that are difficult to target through conventional methods or have not yet been targeted,but are of great clinical significance.According to statistics,over 80%of disease-related pathogenic proteins cannot be targeted by current conventional treatment methods.In recent years,with the advancement of basic research and new technologies,the development of various new technologies and mechanisms has brought new perspectives to overcome challenging drug targets.Among them,targeted protein degradation technology is a breakthrough drug development strategy for challenging drug targets.This technology can specifically identify target proteins and directly degrade pathogenic target proteins by utilizing the inherent protein degradation pathways within cells.This new form of drug development includes various types such as proteolysis targeting chimera(PROTAC),molecular glue,lysosome-targeting Chimaera(LYTAC),autophagosometethering compound(ATTEC),autophagy-targeting chimera(AUTAC),autophagy-targeting chimera(AUTOTAC),degrader-antibody conjugate(DAC).This article systematically summarizes the application of targeted protein degradation technology in the development of degraders for challenging drug targets.Finally,the article looks forward to the future development direction and application prospects of targeted protein degradation technology.
