Biomedicine is one of the fastest growing areas of additive manufacturing.Especially,in the field of in vitro diagnostics(IVD),contributions of 3D printing include i)rapid prototyping and iterative IVD proof-of-concep...Biomedicine is one of the fastest growing areas of additive manufacturing.Especially,in the field of in vitro diagnostics(IVD),contributions of 3D printing include i)rapid prototyping and iterative IVD proof-of-concept designing ranging from materials,devices to system integration;ii)conceptual design simpli-fication and improved practicality of IVD products;iii)shifting the IVD applications from centralized labs to point-of-care testing(POCT).In this review,the latest developments of 3D printing and its advantages in IVD applications are summarized.A series of 3D-printed objects for IVD applications,including single-function modules,multi-function devices which integrate several single-function modules for specific an-alytical applications such as sample pre-treatment and chemo-/bio-sensing,and all-in-one systems which integrate multi-function devices and the instrument operating them,are analyzed from the perspective of functional integration.The current and potential commercial applications of 3D-printed objects in the IVD field are highlighted.The features of 3D printing,especially rapid prototyping and low start-up,en-able the easy fabrication of bespoke modules,devices and systems for a range of analytical applications,and broadens the commercial IVD prospects.展开更多
Rheumatoid arthritis(RA),as a chronic autoimmune disease,damages the bone and cartilage of patients,and even leads to disability.Therefore,the diagnosis and treatment of RA is particularly important.However,due to the...Rheumatoid arthritis(RA),as a chronic autoimmune disease,damages the bone and cartilage of patients,and even leads to disability.Therefore,the diagnosis and treatment of RA is particularly important.However,due to the complexity of RA,it is difficult to make effective early diagnosis of RA,which is detrimental to RA treatment.Besides,long-term intake of anti-RA drugs can also cause damage to patients' organs.The emergence of nanotechnology provides the new train of thoughts for the diagnosis and treatment of RA.And the combination of diagnosis and therapy is an ideal method to solve the problem of disease management of RA patients.In this review,we summarize the mechanism and microenvironment of RA,discuss the commonly used diagnostic techniques and therapeutic drugs for RA,and review their advantages and disadvantages.New nanotherapy strategies such as drug-carrying nanoparticles,PTT,PDT are listed,and their applications in RA treatment are also summarized.In addition,multimodal imaging,combined therapy and responsive diagnosis and treatment are also summarized as important contents.At last,we also review typical nanocarriers that can be used in the integration of diagnosis and therapy,and discussed their potential applications in RA theranostics.展开更多
基金supported by the National Nat-ural Science Foundation of China(No.51975597)the Guang-dong Natural Science Foundation(No.2020A1515010661)+2 种基金the Sci-ence and Technology Project of Guangzhou(No.201803020026)the General Program of Shenzhen Innovation Funding(Nos.JCYJ20170818164246179 and JCYJ20170307140752183)the Fundamental Research Funds for the Central Universities(No.20lgzd27).
文摘Biomedicine is one of the fastest growing areas of additive manufacturing.Especially,in the field of in vitro diagnostics(IVD),contributions of 3D printing include i)rapid prototyping and iterative IVD proof-of-concept designing ranging from materials,devices to system integration;ii)conceptual design simpli-fication and improved practicality of IVD products;iii)shifting the IVD applications from centralized labs to point-of-care testing(POCT).In this review,the latest developments of 3D printing and its advantages in IVD applications are summarized.A series of 3D-printed objects for IVD applications,including single-function modules,multi-function devices which integrate several single-function modules for specific an-alytical applications such as sample pre-treatment and chemo-/bio-sensing,and all-in-one systems which integrate multi-function devices and the instrument operating them,are analyzed from the perspective of functional integration.The current and potential commercial applications of 3D-printed objects in the IVD field are highlighted.The features of 3D printing,especially rapid prototyping and low start-up,en-able the easy fabrication of bespoke modules,devices and systems for a range of analytical applications,and broadens the commercial IVD prospects.
基金The financial support from Shenzhen Basic Research Program(No.JCYJ20170307140752183)Guangdong Natural Science Foundation(Nos.S2017A030313076,2020A1515010661)is gratefully acknowledged。
文摘Rheumatoid arthritis(RA),as a chronic autoimmune disease,damages the bone and cartilage of patients,and even leads to disability.Therefore,the diagnosis and treatment of RA is particularly important.However,due to the complexity of RA,it is difficult to make effective early diagnosis of RA,which is detrimental to RA treatment.Besides,long-term intake of anti-RA drugs can also cause damage to patients' organs.The emergence of nanotechnology provides the new train of thoughts for the diagnosis and treatment of RA.And the combination of diagnosis and therapy is an ideal method to solve the problem of disease management of RA patients.In this review,we summarize the mechanism and microenvironment of RA,discuss the commonly used diagnostic techniques and therapeutic drugs for RA,and review their advantages and disadvantages.New nanotherapy strategies such as drug-carrying nanoparticles,PTT,PDT are listed,and their applications in RA treatment are also summarized.In addition,multimodal imaging,combined therapy and responsive diagnosis and treatment are also summarized as important contents.At last,we also review typical nanocarriers that can be used in the integration of diagnosis and therapy,and discussed their potential applications in RA theranostics.
