AIM:lo evaluate the changes on optical coherence tomography angiography(OCTA) and fluorescein angiography(FA) and their correlation in neovascular agerelated macular degeneration(nAMD) before and after intravitreal af...AIM:lo evaluate the changes on optical coherence tomography angiography(OCTA) and fluorescein angiography(FA) and their correlation in neovascular agerelated macular degeneration(nAMD) before and after intravitreal aflibercept injections(IAIs).METHODS:In 43 treatment-na?ve patients with nAMD,choroidal neovascularization(CNV) in OCTA were morphologically and quantitatively analyzed before and after IAIs to determine whether they are correlated with leakage on FA or not.By combining CNV in OCTA and leakage in FA,lesions were characterized as three types:L+C+(with both CNV and leakage),L-C+(with CNV but without leakage),or L+C-lesion(with leakage outside CNV).RESULTS:Before IAI,while 27 eyes had L+C+lesion only,16 eyes had both L+C+and L-C+lesions simultaneously.Tiny capillaries and anastomosis in CNV were more developed in L+C+lesion,at 86.0% and58.1%,respectively,relative to 9.3% and 9.3% in L-C+lesions(P<0.001).After IAIs in 33 eyes,tiny capillaries and anastomosis were decreased in the lesions with cessation of leakage on FA(P<0.001 and P=0.001,respectively).In quantitative analysis,neovascularization length and numbers of junctions and endpoints were also significantly decreased.CONCLUSION:Leakage on FA is associated with CNV morphology in OCTA and remained so after IAls.Therefore,by carefully assessing the morphological and quantitative changes of CNV in OCTA before and after treatment,activity of nAMD is expected even though CNV on OCTA is not completely matched with fluorescein leakage.展开更多
Dear Editor,I am Cheolmin Yun,from the Department of Ophthalmology,Korea University College of Medicine.I write to present a case report of a female patient with a myopic patient suffering from atrophic choroidal neov...Dear Editor,I am Cheolmin Yun,from the Department of Ophthalmology,Korea University College of Medicine.I write to present a case report of a female patient with a myopic patient suffering from atrophic choroidal neovascularization（CNV）and a full thickness macular hole（FTMH）,who was treated with an intravitreal anti-vascular endothelial growth factor （VEGF） injection without vitrectomy.展开更多
AIM: To investigate whether the response of a central hexagonal element corresponding to the macular area in conventional multifocal electroretinography(mfERG) tests was the same as that of experimental mfERG using si...AIM: To investigate whether the response of a central hexagonal element corresponding to the macular area in conventional multifocal electroretinography(mfERG) tests was the same as that of experimental mfERG using single central hexagonal element stimulation. METHODS: Prospective, observational study. Thirty healthy subjects were included in this study. mfERG recordings were performed according to two protocols: stimulus with 37 hexagonal elements(protocol 1), and stimulus with a single central element created by deactivating the other 36 hexagonal elements(protocol 2). We compared differences between ring 1 parameters in each protocol. RESULTS: In protocol 1, the first positive component(P1) implicit time and P1 amplitude were 37.8±1.8 ms and 6.3±2.7 μV. After single element stimulation(protocol 2), double positive waves appeared. The implicit time and amplitude of P1 were 40.7±2.4 ms(P<0.001) and 9.1±3.3 μV(P=0.001), respectively. The implicit time and amplitude of the second positive component(P2) were 68.0±4.5 ms(P<0.001, compared with P1 in protocol 1) and 12.3±4.7 μV(P<0.001, compared with P1 in protocol 1), respectively. The amplitude of P2 in protocol 2 was about two times higher than that of P1 in protocol 1. CONCLUSION: mfERG responses of a central hexagonal element in a single element stimulation protocol are different from those of multiple element stimulation. The positive wave is more enhanced compared to that of the conventional protocol and it elongated into two wavelets.展开更多
基金Supported in part by the Bio&Medical Technology Development Program of the NRF funded in part by the Korean government and the Ministry of Science and ICT (MSIP,NRF-2017M3A9E2056458,No.2020R1A2C1005729)。
文摘AIM:lo evaluate the changes on optical coherence tomography angiography(OCTA) and fluorescein angiography(FA) and their correlation in neovascular agerelated macular degeneration(nAMD) before and after intravitreal aflibercept injections(IAIs).METHODS:In 43 treatment-na?ve patients with nAMD,choroidal neovascularization(CNV) in OCTA were morphologically and quantitatively analyzed before and after IAIs to determine whether they are correlated with leakage on FA or not.By combining CNV in OCTA and leakage in FA,lesions were characterized as three types:L+C+(with both CNV and leakage),L-C+(with CNV but without leakage),or L+C-lesion(with leakage outside CNV).RESULTS:Before IAI,while 27 eyes had L+C+lesion only,16 eyes had both L+C+and L-C+lesions simultaneously.Tiny capillaries and anastomosis in CNV were more developed in L+C+lesion,at 86.0% and58.1%,respectively,relative to 9.3% and 9.3% in L-C+lesions(P<0.001).After IAIs in 33 eyes,tiny capillaries and anastomosis were decreased in the lesions with cessation of leakage on FA(P<0.001 and P=0.001,respectively).In quantitative analysis,neovascularization length and numbers of junctions and endpoints were also significantly decreased.CONCLUSION:Leakage on FA is associated with CNV morphology in OCTA and remained so after IAls.Therefore,by carefully assessing the morphological and quantitative changes of CNV in OCTA before and after treatment,activity of nAMD is expected even though CNV on OCTA is not completely matched with fluorescein leakage.
文摘Dear Editor,I am Cheolmin Yun,from the Department of Ophthalmology,Korea University College of Medicine.I write to present a case report of a female patient with a myopic patient suffering from atrophic choroidal neovascularization（CNV）and a full thickness macular hole（FTMH）,who was treated with an intravitreal anti-vascular endothelial growth factor （VEGF） injection without vitrectomy.
基金Supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF)funded by the Ministry of Education (NRF2016R1D1A1A02937018)the Bio & Medical Technology Development Program of the NRF, which is funded in part by the Korean government, the Ministry of Science, and ICT (MSIP) (NRF-2017M3A9E2056458)
文摘AIM: To investigate whether the response of a central hexagonal element corresponding to the macular area in conventional multifocal electroretinography(mfERG) tests was the same as that of experimental mfERG using single central hexagonal element stimulation. METHODS: Prospective, observational study. Thirty healthy subjects were included in this study. mfERG recordings were performed according to two protocols: stimulus with 37 hexagonal elements(protocol 1), and stimulus with a single central element created by deactivating the other 36 hexagonal elements(protocol 2). We compared differences between ring 1 parameters in each protocol. RESULTS: In protocol 1, the first positive component(P1) implicit time and P1 amplitude were 37.8±1.8 ms and 6.3±2.7 μV. After single element stimulation(protocol 2), double positive waves appeared. The implicit time and amplitude of P1 were 40.7±2.4 ms(P<0.001) and 9.1±3.3 μV(P=0.001), respectively. The implicit time and amplitude of the second positive component(P2) were 68.0±4.5 ms(P<0.001, compared with P1 in protocol 1) and 12.3±4.7 μV(P<0.001, compared with P1 in protocol 1), respectively. The amplitude of P2 in protocol 2 was about two times higher than that of P1 in protocol 1. CONCLUSION: mfERG responses of a central hexagonal element in a single element stimulation protocol are different from those of multiple element stimulation. The positive wave is more enhanced compared to that of the conventional protocol and it elongated into two wavelets.
