Colorectal cancer(CRC)is the most frequently diagnosed malignancy of the digestive system and the second leading cause of cancer-related deaths worldwide(1).In China,CRC ranks as the second most common cancer with inc...Colorectal cancer(CRC)is the most frequently diagnosed malignancy of the digestive system and the second leading cause of cancer-related deaths worldwide(1).In China,CRC ranks as the second most common cancer with incidence and mortality rates continuing to rise(2).The Chinese Society of Clinical Oncology(CSCO)first introduced its guidelines in 2017,and since then,they have been updated annually to incorporate the latest clinical research findings,drug availability,and expert consensus(3-8).This article presents the key updates in the 2025 edition compared to the 2024 version.展开更多
Colorectal cancer(CRC) is the third most common cancer worldwide and the second most common in tumor-related mortality by Global Cancer Statistics 2020(1). Recent data show that the incidence and mortality of CRC in C...Colorectal cancer(CRC) is the third most common cancer worldwide and the second most common in tumor-related mortality by Global Cancer Statistics 2020(1). Recent data show that the incidence and mortality of CRC in China are increasing(2-4), with the number of new cases and deaths reaching 607,900 and 261,777 in 2019.展开更多
In a prospective phase 2 study recently published in The New England Journal of Medicine,Cercek et al.investigated the efficacy of the programmed death 1(PD-1)inhibitor dostarlimab in patients with mismatch repair–de...In a prospective phase 2 study recently published in The New England Journal of Medicine,Cercek et al.investigated the efficacy of the programmed death 1(PD-1)inhibitor dostarlimab in patients with mismatch repair–deficient(dMMR),locally advanced rectal cancer(LARC).The work aimed to present preliminary evidence for the revolutionary therapeutic transition from neoadjuvant chemotherapy/radiotherapy followed by surgery to immunotherapy followed by nonoperative management in this subgroup of patients.展开更多
In a recently published article in Nature,Oliveira et al.presented new insights on the relationship between the phenotype and antigen specificity of CD4^(+)tumor-infiltrating cells(TILs)in melanoma,indicating that exh...In a recently published article in Nature,Oliveira et al.presented new insights on the relationship between the phenotype and antigen specificity of CD4^(+)tumor-infiltrating cells(TILs)in melanoma,indicating that exhausted cytotoxic CD4^(+)T cells could be directly elicited by HLA class II-restricted neoantigens.展开更多
The diversity of CD8^(+)tumor-infiltrating lymphocyte(TIL)phenotypes has been described in several cancer types,but the specific relevance remains ambiguous.In a recent article published in Nature,Oliveira et al.1 unv...The diversity of CD8^(+)tumor-infiltrating lymphocyte(TIL)phenotypes has been described in several cancer types,but the specific relevance remains ambiguous.In a recent article published in Nature,Oliveira et al.1 unveiled the relationship between phenotypic properties and specificities of TCRs and they highlighted that the exhausted states are enriched in cells with antitumor reactivity.展开更多
基金supported by the National Natural Science Foundation of China(No.82373415)Beijing Xisike Clinical Oncology Research Foundation(No.Ytongshu2021/ms-0003)。
文摘Colorectal cancer(CRC)is the most frequently diagnosed malignancy of the digestive system and the second leading cause of cancer-related deaths worldwide(1).In China,CRC ranks as the second most common cancer with incidence and mortality rates continuing to rise(2).The Chinese Society of Clinical Oncology(CSCO)first introduced its guidelines in 2017,and since then,they have been updated annually to incorporate the latest clinical research findings,drug availability,and expert consensus(3-8).This article presents the key updates in the 2025 edition compared to the 2024 version.
基金supported by the National Natural Science Foundation of China(No.81872481)the Provincial Key R&D Program of Zhejiang Province(No.2021C03125)。
文摘Colorectal cancer(CRC) is the third most common cancer worldwide and the second most common in tumor-related mortality by Global Cancer Statistics 2020(1). Recent data show that the incidence and mortality of CRC in China are increasing(2-4), with the number of new cases and deaths reaching 607,900 and 261,777 in 2019.
基金supported by the National Natural Science Foundation of China(42288201,41725014,and 41888101)the State Key Laboratory of Lithospheric Evolution(SKL-Z202302)the China Geological Survey Project(DD20190098).
基金National Natural Science Foundation of China(82103102 to C.Y.Y.)Provincial Key R&D Program of Zhejiang Province(2021C03125 to Y.Y.).
文摘In a prospective phase 2 study recently published in The New England Journal of Medicine,Cercek et al.investigated the efficacy of the programmed death 1(PD-1)inhibitor dostarlimab in patients with mismatch repair–deficient(dMMR),locally advanced rectal cancer(LARC).The work aimed to present preliminary evidence for the revolutionary therapeutic transition from neoadjuvant chemotherapy/radiotherapy followed by surgery to immunotherapy followed by nonoperative management in this subgroup of patients.
基金This work was supported by research grants from the National Natural Science Foundation of China(82103102 to C.Y.Y.,82203602 to J.W.)Zhejiang Provincial Natural Science Foundation of China under Grant No.LQ22H160020 to J.W+1 种基金This work was also supported by Start-up funding of Zhejiang Provincial People’s Hospital(ZRY2021A001 to J.W.)Basic Scientific Research Funds of Department of Education of Zhejiang Province(KYQN202109 to J.W.).
文摘In a recently published article in Nature,Oliveira et al.presented new insights on the relationship between the phenotype and antigen specificity of CD4^(+)tumor-infiltrating cells(TILs)in melanoma,indicating that exhausted cytotoxic CD4^(+)T cells could be directly elicited by HLA class II-restricted neoantigens.
基金This work was supported by research grants from the National Natural Science Foundation of China(82103102 to CYY).
文摘The diversity of CD8^(+)tumor-infiltrating lymphocyte(TIL)phenotypes has been described in several cancer types,but the specific relevance remains ambiguous.In a recent article published in Nature,Oliveira et al.1 unveiled the relationship between phenotypic properties and specificities of TCRs and they highlighted that the exhausted states are enriched in cells with antitumor reactivity.
