An NHC-catalyzed regiospecific allylation ofα-substituted allenoates with MBH carbonates derived from aryl aldehyde furnished highly functionalized 1,5-enynes bearing a quaternary carbon successfully.Combining with D...An NHC-catalyzed regiospecific allylation ofα-substituted allenoates with MBH carbonates derived from aryl aldehyde furnished highly functionalized 1,5-enynes bearing a quaternary carbon successfully.Combining with DFT calculations,the reaction mechanism of this conversion was proposed.This method has the advantages of high regioselectivity,good yields and mild reaction conditions.This transformation not only provided a new access to 1,5-enyne,but also enriched the chemistry of allenoates and NHC catalysis.展开更多
基金support by National Natural Science Foundation of China(No.21871113,21773214,21372101)a project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institution and TAPP.
文摘An NHC-catalyzed regiospecific allylation ofα-substituted allenoates with MBH carbonates derived from aryl aldehyde furnished highly functionalized 1,5-enynes bearing a quaternary carbon successfully.Combining with DFT calculations,the reaction mechanism of this conversion was proposed.This method has the advantages of high regioselectivity,good yields and mild reaction conditions.This transformation not only provided a new access to 1,5-enyne,but also enriched the chemistry of allenoates and NHC catalysis.
