The objective of this study is to investigate the feasibility of using chitosanesodium alginate(CSeSA)based matrix tablets for extended-release of highly water-soluble drugs by changing formulation variables.Using tri...The objective of this study is to investigate the feasibility of using chitosanesodium alginate(CSeSA)based matrix tablets for extended-release of highly water-soluble drugs by changing formulation variables.Using trimetazidine hydrochloride(TH)as a water-soluble model drug,influence of dissolution medium,the amount of CSeSA,the CS:SA ratio,the type of SA,the type and amount of diluents,on in vitro drug release from CSeSA based matrix tablets were studied.Drug release kinetics and release mechanisms were elucidated.In vitro release experiments were conducted in simulated gastric fluid(SGF)followed by simulated intestinal fluid(SIF).Drug release rate decreased with the increase of CSeSA amount.CS:SA ratio had only slight effect on drug release and no influence of SA type on drug release was found.On the other hand,a large amount of water-soluble diluents could modify drug release profiles.It was found that drug release kinetics showed the best fit to Higuchi equation with Fickian diffusion as the main release mechanism.In conclusion,this study demonstrated that it is possible to design extended-release tablets of watersoluble drugs using CSeSA as the matrix by optimizing formulation components,and provide better understanding about drug release from CSeSA matrix tablets.展开更多
Terahertz(THz)waves are electromagnetic waves with frequency in the range from 0.1 to 10 THz.THz waves have great potential in the biomedical field,especially in cancer diagnosis,because they exhibit low ionization en...Terahertz(THz)waves are electromagnetic waves with frequency in the range from 0.1 to 10 THz.THz waves have great potential in the biomedical field,especially in cancer diagnosis,because they exhibit low ionization energy and can be used to discern most biomolecules based on their spectral fingerprints.In this paper,we review the recent progress in two applications of THz waves in cancer diagnosis:imaging and spectroscopy.THz imaging is expected to help researchers and doctors attain a direct intuitive understanding of a cancerous area.THz spectroscopy is an efficient tool for component analysis of tissue samples to identify cancer biomarkers.Additionally,the advantages and disadvantages of the developed technologies for cancer diagnosis are discussed.Furthermore,auxiliary techniques that have been used to enhance the spectral signal-to-noise ratio(SNR)are also reviewed.展开更多
With the non-ionizing,non-invasive,high penetration,high resolution and spectral fingerprinting features of terahertz(THz)wave,THz spectroscopy has great potential for the qualitative and quantitative identification o...With the non-ionizing,non-invasive,high penetration,high resolution and spectral fingerprinting features of terahertz(THz)wave,THz spectroscopy has great potential for the qualitative and quantitative identification of key substances in biomedical field,such as the early diagnosis of cancer,the accurate boundary determination of pathological tissue and non-destructive detection of superficial tissue.However,biological samples usually contain various of substances(such as water,proteins,fat and fiber),resulting in the signal-to-noise ratio(SNR)for the absorption peaks of target substances are very small and then the target substances are hard to be identified.Here,we present recent works for the SNR improvement of THz signal.These works include the usage of attenuated total reflection(ATR)spectroscopy,the fabrication of sample-sensitive metamaterials,the utilization of different agents(including contrast agents,optical clearing agents and aptamers),the application of reconstruction algorithms and the optimization of THz spectroscopy system.These methods have been proven to be effective theoretically,but only few of them have been applied into actual usage.We also analyze the reasons and summarize the advantages and disadvantages of each method.At last,we present the prospective application of THz spectroscopy in biomedical field.展开更多
Panax quinquefolium is a perennial herbaceous plant that contains many beneficial ginsenosides with diverse pharmacological effects.24(R)-pseudoginsenoside F_(11)is specific to P.quinquefolium,a useful biomarker for d...Panax quinquefolium is a perennial herbaceous plant that contains many beneficial ginsenosides with diverse pharmacological effects.24(R)-pseudoginsenoside F_(11)is specific to P.quinquefolium,a useful biomarker for distinguishing this species from other related plants.However,because of its nonconjugated property and the complexity of existing detection methods,this biomarker cannot be used as the identification standard.We herein present a stable 24(R)-pseudoginsenoside F_(11)fingerprint spectrum in the terahertz band,thereby proving that F_(11)can be detected and quantitatively analyzed via terahertz spectroscopy.We also analyzed the sample by high-performance liquid chromatography-triple quadrupole mass spectrometry.The difference between the normalized data for the two analytical methods was less than 5%.Furthermore,P.quinquefolium from different areas and other substances can be clearly distinguished based on these terahertz spectra with a standard principal component analysis.Our method is a fast,simple,and cost-effective approach for identifying and quantitatively analyzing P.quinquefolium.展开更多
基金supported by Liaoning Institutions excellent talents support plan(No.LR2013047).
文摘The objective of this study is to investigate the feasibility of using chitosanesodium alginate(CSeSA)based matrix tablets for extended-release of highly water-soluble drugs by changing formulation variables.Using trimetazidine hydrochloride(TH)as a water-soluble model drug,influence of dissolution medium,the amount of CSeSA,the CS:SA ratio,the type of SA,the type and amount of diluents,on in vitro drug release from CSeSA based matrix tablets were studied.Drug release kinetics and release mechanisms were elucidated.In vitro release experiments were conducted in simulated gastric fluid(SGF)followed by simulated intestinal fluid(SIF).Drug release rate decreased with the increase of CSeSA amount.CS:SA ratio had only slight effect on drug release and no influence of SA type on drug release was found.On the other hand,a large amount of water-soluble diluents could modify drug release profiles.It was found that drug release kinetics showed the best fit to Higuchi equation with Fickian diffusion as the main release mechanism.In conclusion,this study demonstrated that it is possible to design extended-release tablets of watersoluble drugs using CSeSA as the matrix by optimizing formulation components,and provide better understanding about drug release from CSeSA matrix tablets.
基金This study was supported by the National Major Project of Scientific Instrument and Equipment Development(2017YFF0106300)the National Natural Science Foundation of China(61922059,61771314,and 81961138014)+2 种基金the 111 Project(D18014)the International Joint Lab Program supported by Science and Technology Commission Shanghai Municipality(17590750300)the Key project supported by Science and Technology Commission Shanghai Municipality(YDZX20193100004960).
文摘Terahertz(THz)waves are electromagnetic waves with frequency in the range from 0.1 to 10 THz.THz waves have great potential in the biomedical field,especially in cancer diagnosis,because they exhibit low ionization energy and can be used to discern most biomolecules based on their spectral fingerprints.In this paper,we review the recent progress in two applications of THz waves in cancer diagnosis:imaging and spectroscopy.THz imaging is expected to help researchers and doctors attain a direct intuitive understanding of a cancerous area.THz spectroscopy is an efficient tool for component analysis of tissue samples to identify cancer biomarkers.Additionally,the advantages and disadvantages of the developed technologies for cancer diagnosis are discussed.Furthermore,auxiliary techniques that have been used to enhance the spectral signal-to-noise ratio(SNR)are also reviewed.
基金National Major Project of Scientific Instrument and Equipment Development(2017YFF0106300)National Natural Science Foundation of China(61922059,61771314,61722111,81961138014)+3 种基金Shanghai Rising-Star Program(17QA1402500)the 111 Project(D18014)the International Joint Lab Program supported by Science and Technology Commission Shanghai Municipality(17590750300)the Key project supported by Science and Technology Commission Shanghai Municipality(YDZX20193100004960).
文摘With the non-ionizing,non-invasive,high penetration,high resolution and spectral fingerprinting features of terahertz(THz)wave,THz spectroscopy has great potential for the qualitative and quantitative identification of key substances in biomedical field,such as the early diagnosis of cancer,the accurate boundary determination of pathological tissue and non-destructive detection of superficial tissue.However,biological samples usually contain various of substances(such as water,proteins,fat and fiber),resulting in the signal-to-noise ratio(SNR)for the absorption peaks of target substances are very small and then the target substances are hard to be identified.Here,we present recent works for the SNR improvement of THz signal.These works include the usage of attenuated total reflection(ATR)spectroscopy,the fabrication of sample-sensitive metamaterials,the utilization of different agents(including contrast agents,optical clearing agents and aptamers),the application of reconstruction algorithms and the optimization of THz spectroscopy system.These methods have been proven to be effective theoretically,but only few of them have been applied into actual usage.We also analyze the reasons and summarize the advantages and disadvantages of each method.At last,we present the prospective application of THz spectroscopy in biomedical field.
文摘Panax quinquefolium is a perennial herbaceous plant that contains many beneficial ginsenosides with diverse pharmacological effects.24(R)-pseudoginsenoside F_(11)is specific to P.quinquefolium,a useful biomarker for distinguishing this species from other related plants.However,because of its nonconjugated property and the complexity of existing detection methods,this biomarker cannot be used as the identification standard.We herein present a stable 24(R)-pseudoginsenoside F_(11)fingerprint spectrum in the terahertz band,thereby proving that F_(11)can be detected and quantitatively analyzed via terahertz spectroscopy.We also analyzed the sample by high-performance liquid chromatography-triple quadrupole mass spectrometry.The difference between the normalized data for the two analytical methods was less than 5%.Furthermore,P.quinquefolium from different areas and other substances can be clearly distinguished based on these terahertz spectra with a standard principal component analysis.Our method is a fast,simple,and cost-effective approach for identifying and quantitatively analyzing P.quinquefolium.
