Background:Minimally invasive surgeries are increasingly central to modern medicine,particularly in liver transplantation.These techniques,which offer reduced trauma,precise operations,minimal bleeding,and swift recov...Background:Minimally invasive surgeries are increasingly central to modern medicine,particularly in liver transplantation.These techniques,which offer reduced trauma,precise operations,minimal bleeding,and swift recovery,are,however,unevenly adopted across China.Only a limited number of centers routinely perform minimally invasive donor hepatectomies,indicating a significant imbalance in the development and application of these advanced procedures.Additionally,there lacks a set of standardized guidelines that are tailored to meet China’s unique healthcare challenges and conditions.Methods:In August 2023,the Branch of Organ Transplant of Chinese Medical Association and the Branch of Organ Transplant Physicians of Chinese Medical Doctor Association convened a group of national liver transplantation experts to establish a guideline development committee.This committee conducted a thorough review of relevant literature,evaluated existing guidelines and consensus,and assessed factors such as the evidence base,patient preferences,and the cost-effectiveness of interventions within China.After multiple rounds of discussions,both online and offline,the committee finalized the guidelines.Results:This collaborative effort led to the creation of the“Chinese guidelines for minimally invasive donor hepatectomy in living donor liver transplantation(2024 edition)”.These guidelines address crucial aspects such as the safety and advantages of minimally invasive surgery for living donor liver transplantation,donor selection criteria,anesthesia strategies,surgical technical details,and learning curves associated with these procedures,resulting in a comprehensive set of 26 recommendations.Conclusions:The formulation of these guidelines represents a significant advancement towards standardizing minimally invasive liver transplantation surgeries in China.They are designed to enhance outcomes for both donors and recipients by synthesizing expert consensus with contemporary research and clinical practices.Moreover,they serve as a crucial reference for surgeons and medical institutions,promoting the refinement and adoption of minimally invasive surgical techniques in liver transplantation.展开更多
The traditional view that adult human liver tumors,mainly hepatocellular carcinoma(HCC),arise from mature cell types has been challenged in recent dec-ades.The results of several studies suggest that HCC can be derive...The traditional view that adult human liver tumors,mainly hepatocellular carcinoma(HCC),arise from mature cell types has been challenged in recent dec-ades.The results of several studies suggest that HCC can be derived from liver stem cells.There are four levels of cells in the liver stem cell lineage:hepatocytes,hepatic stem cells/oval cells,bone marrow stem cells and hepato-pancreas stem cells.However,whether HCC is resulted from the differentiation block of stem cells and,moreover,which liver stem cell lineage is the source cell of hepatocarcinogenesis remain controversial.In this review,we focus on the current status of liver stem cell research and their roles in carcinogenesis of HCC,in order to explore new approaches for stem cell therapy of HCC.展开更多
基金supported by grants from National Key R&D Program of China(No.2022YFC2304705 to Jiayin Yang)National Natural Science Foundation of China(No.82270691 to Jiayin Yang)+2 种基金Sichuan Province Key Research and Development Project(Nos.2023YFS0026 and 23ZDYF2182 to Jiayin Yang)Chengdu Province Key Research and Development Project(No.2022YF0900009SN to Jiayin Yang)1.3.5 Project for Disciplines of Excellence from West China Hospital of Sichuan University(No.ZYGD24002 to Jiayin Yang).
文摘Background:Minimally invasive surgeries are increasingly central to modern medicine,particularly in liver transplantation.These techniques,which offer reduced trauma,precise operations,minimal bleeding,and swift recovery,are,however,unevenly adopted across China.Only a limited number of centers routinely perform minimally invasive donor hepatectomies,indicating a significant imbalance in the development and application of these advanced procedures.Additionally,there lacks a set of standardized guidelines that are tailored to meet China’s unique healthcare challenges and conditions.Methods:In August 2023,the Branch of Organ Transplant of Chinese Medical Association and the Branch of Organ Transplant Physicians of Chinese Medical Doctor Association convened a group of national liver transplantation experts to establish a guideline development committee.This committee conducted a thorough review of relevant literature,evaluated existing guidelines and consensus,and assessed factors such as the evidence base,patient preferences,and the cost-effectiveness of interventions within China.After multiple rounds of discussions,both online and offline,the committee finalized the guidelines.Results:This collaborative effort led to the creation of the“Chinese guidelines for minimally invasive donor hepatectomy in living donor liver transplantation(2024 edition)”.These guidelines address crucial aspects such as the safety and advantages of minimally invasive surgery for living donor liver transplantation,donor selection criteria,anesthesia strategies,surgical technical details,and learning curves associated with these procedures,resulting in a comprehensive set of 26 recommendations.Conclusions:The formulation of these guidelines represents a significant advancement towards standardizing minimally invasive liver transplantation surgeries in China.They are designed to enhance outcomes for both donors and recipients by synthesizing expert consensus with contemporary research and clinical practices.Moreover,they serve as a crucial reference for surgeons and medical institutions,promoting the refinement and adoption of minimally invasive surgical techniques in liver transplantation.
文摘The traditional view that adult human liver tumors,mainly hepatocellular carcinoma(HCC),arise from mature cell types has been challenged in recent dec-ades.The results of several studies suggest that HCC can be derived from liver stem cells.There are four levels of cells in the liver stem cell lineage:hepatocytes,hepatic stem cells/oval cells,bone marrow stem cells and hepato-pancreas stem cells.However,whether HCC is resulted from the differentiation block of stem cells and,moreover,which liver stem cell lineage is the source cell of hepatocarcinogenesis remain controversial.In this review,we focus on the current status of liver stem cell research and their roles in carcinogenesis of HCC,in order to explore new approaches for stem cell therapy of HCC.
