As pioneering materials,single atom catalysts(SACs)have demonstrated exceptional potential across a plethora of domains ranging from biomedicine to energy conversion,environmental preservation,and marine energy.The co...As pioneering materials,single atom catalysts(SACs)have demonstrated exceptional potential across a plethora of domains ranging from biomedicine to energy conversion,environmental preservation,and marine energy.The comprehensive review delves into the latest research advancements in the practical applications of SACs,meticulously dissecting their underlying principles,distinctive features,and versatile applications.Tailoring their operational paradigms to suit diverse application contexts,we elaborate on the operational mechanisms of SACs,accentuating their unparalleled catalytic efficacy and structural resilience.The review systematically delineates the design strategies for various SAC variations,encompassing prevalent materials alongside tactics to fortify their adaptability to environmental conditions and ensure enduring operational stability.Delving further,we scrutinized the potential domains,where SACs demonstrate breakthrough potential in biomedical targeted therapy,efficient energy electrocatalysis,and the deep degradation of pollutants by maximizing atomic utilization and controlling the coordination microenvironment.Conclusively,we deliberate on the challenges confronting SACs with regards to their catalytic prowess,proposing future trajectories and methodologies to amplify their ubiquitous deployment and further refine their efficacy in real-world applications.展开更多
Tissue engineering focuses on repairing tissue and restoring tissue functions by employing three elements： scaffolds, cells and biochemical signals. In tissue engineering, bioactive material scaffolds have been used ...Tissue engineering focuses on repairing tissue and restoring tissue functions by employing three elements： scaffolds, cells and biochemical signals. In tissue engineering, bioactive material scaffolds have been used to cure tissue and organ defects with stem cell-based therapies being one of the best documented approaches. In the review, different biomaterials which are used in several methods to fabricate tissue engineering scaffolds were explained and show good properties （biocompatibility, biodegradability, and mechanical properties etc.） for cell migration and infiltration. Stem cell homing is a recruitment process for inducing the migration of the systemically transplanted cells, or host cells, to defect sites. The mechanisms and modes of stem cell homing-based tissue engineering can be divided into two types depending on the source of the stem cells： endogenous and exogenous. Exogenous stem cell-based bioactive scaffolds have the challenge of long-term culturing in vitro and for endogenous stem cells the biochemical signal homing recruitment mechanism is not clear yet. Although the stem cell homing-based bioactive scaffolds are attractive candidates for tissue defect therapies, based on in vitro studies and animal tests, there is still a long way before clinical application.展开更多
基金supported by the Fundamental Research Funds for the Central Universities(No.22120220635)the Special Funds of the Tongji University for“Sino-German Cooperation 2.0 Strategy”(No.ZD2023026)+5 种基金the National Key R&D Program of China(No.2022YFF1202600)the National Natural Science Foundation of China(No.22305101)the Basic Research Program of Jiangsu(No.BK20231032)the Health Industry Clinical Research Project of Shanghai Health Commission(No.20224Y0393)the Science and Technology Development Fund of Shanghai Pudong New Area(No.PKJ2023-Y09)the Outstanding Leaders Training Program of Pudong Hospital affiliated to Fudan University(No.LX202201).
文摘As pioneering materials,single atom catalysts(SACs)have demonstrated exceptional potential across a plethora of domains ranging from biomedicine to energy conversion,environmental preservation,and marine energy.The comprehensive review delves into the latest research advancements in the practical applications of SACs,meticulously dissecting their underlying principles,distinctive features,and versatile applications.Tailoring their operational paradigms to suit diverse application contexts,we elaborate on the operational mechanisms of SACs,accentuating their unparalleled catalytic efficacy and structural resilience.The review systematically delineates the design strategies for various SAC variations,encompassing prevalent materials alongside tactics to fortify their adaptability to environmental conditions and ensure enduring operational stability.Delving further,we scrutinized the potential domains,where SACs demonstrate breakthrough potential in biomedical targeted therapy,efficient energy electrocatalysis,and the deep degradation of pollutants by maximizing atomic utilization and controlling the coordination microenvironment.Conclusively,we deliberate on the challenges confronting SACs with regards to their catalytic prowess,proposing future trajectories and methodologies to amplify their ubiquitous deployment and further refine their efficacy in real-world applications.
文摘Tissue engineering focuses on repairing tissue and restoring tissue functions by employing three elements： scaffolds, cells and biochemical signals. In tissue engineering, bioactive material scaffolds have been used to cure tissue and organ defects with stem cell-based therapies being one of the best documented approaches. In the review, different biomaterials which are used in several methods to fabricate tissue engineering scaffolds were explained and show good properties （biocompatibility, biodegradability, and mechanical properties etc.） for cell migration and infiltration. Stem cell homing is a recruitment process for inducing the migration of the systemically transplanted cells, or host cells, to defect sites. The mechanisms and modes of stem cell homing-based tissue engineering can be divided into two types depending on the source of the stem cells： endogenous and exogenous. Exogenous stem cell-based bioactive scaffolds have the challenge of long-term culturing in vitro and for endogenous stem cells the biochemical signal homing recruitment mechanism is not clear yet. Although the stem cell homing-based bioactive scaffolds are attractive candidates for tissue defect therapies, based on in vitro studies and animal tests, there is still a long way before clinical application.
