The combination of Ce6,an acknowledged photosensitizer,and TPL,a natural anticancer agent,has been demonstrated as a useful strategy to reinforce the tumor growth suppression,as well as decrease the systemic side effe...The combination of Ce6,an acknowledged photosensitizer,and TPL,a natural anticancer agent,has been demonstrated as a useful strategy to reinforce the tumor growth suppression,as well as decrease the systemic side effects compared with their monotherapy.However,in view of the optimal chemo-photodynamic combination efficiency,there is still short of the feasible nanovehicle to steadily co-deliver Ce6 and TPL,and stimuli-responsively burst release drugs in tumor site.Herein,we described the synergistic antitumor performance of a pH-sensitive supramolecular nanosystem,mediated by the host–vip complexing betweenβ-CD and acid pH-responsive amphiphilic co-polymer mPEG-PBAE-mPEG,showing the shell–core structural micelles with the tightβ-CD layer coating.Both Ce6 and TPLwere facilely co-loaded into the spherical supramolecular NPs(TPL+Ce6/NPs)by one-step nanoprecipitation method,with an ideal particle size(156.0 nm),acid pH-responsive drug release profile,and enhanced cellular internalization capacity.In view of the combination benefit of photodynamic therapy and chemotherapy,as well as co-encapsulation in the fabricated pH-sensitive supramolecular NPs,TPL+Ce6/NPs exhibited significant efficacy to suppress cellular proliferation,boost ROS level,lower MMP,and promote cellular apoptosis in vitro.Particularly,fluorescence imaging revealed that TPL+Ce6/NPs preferentially accumulated in the tumor tissue area,with higher intensity than that of free Ce6.As expected,upon 650-nm laser irradiation,TPL+Ce6/NPs exhibited a cascade of amplified synergistic chemo-photodynamic therapeutic benefits to suppress tumor progression in both hepatoma H22 tumor-bearingmice and B16 tumor-bearingmice.More importantly,lower systemic toxicitywas found in the tumor-bearingmice treated with TPL+Ce6/NPs.Overall,the designed supramolecular TPL+Ce6/NPs provided a promising alternative approach for chemo-photodynamic therapy in tumor treatment.展开更多
Mix-dimensional van der Waals heterostructures(vdWHs)have inspired worldwide interests and efforts in the field of ad-vanced electronics and optoelectronics.The fundamental understanding of interfacial charge transfer...Mix-dimensional van der Waals heterostructures(vdWHs)have inspired worldwide interests and efforts in the field of ad-vanced electronics and optoelectronics.The fundamental understanding of interfacial charge transfer is of vital import-ance for guiding the design of functional optoelectronic applications.In this work,type-Ⅱ0D-2D CdSe/ZnS quantum dots/MoS_(2)vdWHs are designed to study the light-triggered interfacial charge behaviors and enhanced optoelectronic performances.From spectral measurements in both steady and transient states,the phenomena of suppressed photolu-minescence(PL)emissions,shifted Raman signals and changed PL lifetimes provide strong evidences of efficient charge transfer at the 0D-2D interface.A series of spectral evolutions of heterostructures with various QDs overlapping concentrations at different laser powers are analyzed in details,which clarifies the dynamic competition between exciton and trion during an efficient doping of 3.9×10^(13)cm^(−2).The enhanced photoresponses(1.57×10^(4)A·W^(-1))and detectivities(2.86×10^(11)Jones)in 0D/2D phototransistors further demonstrate that the light-induced charge transfer is still a feasible way to optimize the performance of optoelectronic devices.These results are expected to inspire the basic understand-ing of interfacial physics at 0D/2D interfaces,and shed the light on promoting the development of mixed-dimensional op-toelectronic devices in the near future.展开更多
This study aimed to explore the mediating roles of body dissatisfaction and self-esteem on the relationship between body mass index(BMI)and among female college students.Using a cross-sectional study design,669 Chines...This study aimed to explore the mediating roles of body dissatisfaction and self-esteem on the relationship between body mass index(BMI)and among female college students.Using a cross-sectional study design,669 Chinese female college students completed the Body Mass Index,the Body Image States Scale,the Self-Esteem Scale,and the Social Avoidance and Distress Scale.The results showed that body dissatisfaction partially mediated the relationship between BMI and social avoidance.Additionally,body dissatisfaction and self-esteem together formed a serial mediation pathway between BMI and social avoidance.In other words,BMI shows a direct association with social avoidance among female college students,as well as indirect associations through the simple mediation of body dissatisfaction and the serial mediation of body dissatisfaction and self-esteem.Findings suggest that increased body satisfaction and self-esteem can reduce social avoidance among female college students.展开更多
Doping can change the band structure of semiconductors,thereby affecting their electrical,optical,and magnetic properties.In this study,we describe the synthesis of two-dimensional(2D)Se-doped Cr_(2)S_(3)(Se-Cr_(2)S_(...Doping can change the band structure of semiconductors,thereby affecting their electrical,optical,and magnetic properties.In this study,we describe the synthesis of two-dimensional(2D)Se-doped Cr_(2)S_(3)(Se-Cr_(2)S_(3))nanosheets using the chemical vapor deposition method.In these semiconductor nanosheets,the Se doping concentration can be controlled by tuning the Se/S mass ratio in the precursor.At the doping concentrations of 10.05%and 2.05%,the room temperature conductivity and mobility were increased by nearly 4 and 2 orders of magnitude,respectively.In addition,the response time of an ultrathin Se-Cr_(2)S_(3)photodetector was 200 times shorter than that of an undoped Cr_(2)S_(3)nanosheet photodetector.4.07%-Se-Cr_(2)S_(3)nanosheets show ferrimagnetic behavior with a Curie temperature of~200 K,which is 80 K higher than that of undoped Cr_(2)S_(3)nanosheets.A density functional theory calculation indicated that the Se doping can induce the formation of intercalated Cr vacancies in SeCr_(2)S_(3)and enhance its metallic characteristics.Our results demonstrated that Se-Cr_(2)S_(3)has significant potential in future electronic,optoelectronic,and spintronic devices.展开更多
Substitutional doping of two-dimensional(2D)transition metal dichalcogenides(TMDs)has been recognized as a promising strategy to tune their optoelectronic properties for a wide array of applications.However,controllab...Substitutional doping of two-dimensional(2D)transition metal dichalcogenides(TMDs)has been recognized as a promising strategy to tune their optoelectronic properties for a wide array of applications.However,controllable doping of TMDs remains a challenging issue due to the natural doping of these materials.Here,we demonstrate the controllable growth of indium-doped p-type WS_(2) monolayers with various doping concentrations via chemical vapor deposition(CVD)of a host tungsten(W)source and indium(In)dopant.Scanning transmission electron microscopy confirmed that In atoms successfully substitute the W atoms in the WS_(2) lattice.Intriguingly,the photoluminescence of the doped sample experiences strong intensity modulation by the doping concentration,which first increases remarkably with an enhancement factor up to~35 and then decreases gradually when further increasing the doping concentration.Such a phenomenon is attributed to the progressive change of the exciton to trion ratio as well as the defect concentration in the doped samples.The assignment was further verified by the electric behavior of the fabricated In-doped WS_(2) field effect transistors,which changes regularly from n-type to bipolar and finally to p-type behavior with increasing doping concentration.The successful growth of p-type monolayer WS_(2) and the dual control of its optical and electrical properties by In doping may provide a promising method to engineer the opto-electronic properties of 2D materials.展开更多
基金supported by National Natural Science Foundation of China (No.81973662)Distinguished Young Scholar of Sichuan Provincial Science and Technology Department (No.2019JDJQ0049)111 Project (No.B18035)
文摘The combination of Ce6,an acknowledged photosensitizer,and TPL,a natural anticancer agent,has been demonstrated as a useful strategy to reinforce the tumor growth suppression,as well as decrease the systemic side effects compared with their monotherapy.However,in view of the optimal chemo-photodynamic combination efficiency,there is still short of the feasible nanovehicle to steadily co-deliver Ce6 and TPL,and stimuli-responsively burst release drugs in tumor site.Herein,we described the synergistic antitumor performance of a pH-sensitive supramolecular nanosystem,mediated by the host–vip complexing betweenβ-CD and acid pH-responsive amphiphilic co-polymer mPEG-PBAE-mPEG,showing the shell–core structural micelles with the tightβ-CD layer coating.Both Ce6 and TPLwere facilely co-loaded into the spherical supramolecular NPs(TPL+Ce6/NPs)by one-step nanoprecipitation method,with an ideal particle size(156.0 nm),acid pH-responsive drug release profile,and enhanced cellular internalization capacity.In view of the combination benefit of photodynamic therapy and chemotherapy,as well as co-encapsulation in the fabricated pH-sensitive supramolecular NPs,TPL+Ce6/NPs exhibited significant efficacy to suppress cellular proliferation,boost ROS level,lower MMP,and promote cellular apoptosis in vitro.Particularly,fluorescence imaging revealed that TPL+Ce6/NPs preferentially accumulated in the tumor tissue area,with higher intensity than that of free Ce6.As expected,upon 650-nm laser irradiation,TPL+Ce6/NPs exhibited a cascade of amplified synergistic chemo-photodynamic therapeutic benefits to suppress tumor progression in both hepatoma H22 tumor-bearingmice and B16 tumor-bearingmice.More importantly,lower systemic toxicitywas found in the tumor-bearingmice treated with TPL+Ce6/NPs.Overall,the designed supramolecular TPL+Ce6/NPs provided a promising alternative approach for chemo-photodynamic therapy in tumor treatment.
基金This work is supported by National Natural Science Foundation of China(No.92163135,11904098,51972105,U19A2090 and 62090035)Hunan Provincial Natural Science Foundation of China(No.2019JJ30004)+1 种基金Hunan International Innovation Cooperation Platform(No.2018WK4004)Key Program of Science and Technology Department of Hunan Province(Nos.2019XK2001,2020XK2001).
文摘Mix-dimensional van der Waals heterostructures(vdWHs)have inspired worldwide interests and efforts in the field of ad-vanced electronics and optoelectronics.The fundamental understanding of interfacial charge transfer is of vital import-ance for guiding the design of functional optoelectronic applications.In this work,type-Ⅱ0D-2D CdSe/ZnS quantum dots/MoS_(2)vdWHs are designed to study the light-triggered interfacial charge behaviors and enhanced optoelectronic performances.From spectral measurements in both steady and transient states,the phenomena of suppressed photolu-minescence(PL)emissions,shifted Raman signals and changed PL lifetimes provide strong evidences of efficient charge transfer at the 0D-2D interface.A series of spectral evolutions of heterostructures with various QDs overlapping concentrations at different laser powers are analyzed in details,which clarifies the dynamic competition between exciton and trion during an efficient doping of 3.9×10^(13)cm^(−2).The enhanced photoresponses(1.57×10^(4)A·W^(-1))and detectivities(2.86×10^(11)Jones)in 0D/2D phototransistors further demonstrate that the light-induced charge transfer is still a feasible way to optimize the performance of optoelectronic devices.These results are expected to inspire the basic understand-ing of interfacial physics at 0D/2D interfaces,and shed the light on promoting the development of mixed-dimensional op-toelectronic devices in the near future.
基金funding from the Key R&D Program(Soft Science Project)of Shandong Province,China(2024RKY0702)the Shandong Provincial Natural Science Foundation(ZR2022QC206)the Teaching Research and Teaching Reform Project of Shandong University of Political Science and Law:The Innovation and Practice of“Four-Level Orientation and Five-Dimensional Interaction”Strategy in Mental Health Education.
文摘This study aimed to explore the mediating roles of body dissatisfaction and self-esteem on the relationship between body mass index(BMI)and among female college students.Using a cross-sectional study design,669 Chinese female college students completed the Body Mass Index,the Body Image States Scale,the Self-Esteem Scale,and the Social Avoidance and Distress Scale.The results showed that body dissatisfaction partially mediated the relationship between BMI and social avoidance.Additionally,body dissatisfaction and self-esteem together formed a serial mediation pathway between BMI and social avoidance.In other words,BMI shows a direct association with social avoidance among female college students,as well as indirect associations through the simple mediation of body dissatisfaction and the serial mediation of body dissatisfaction and self-esteem.Findings suggest that increased body satisfaction and self-esteem can reduce social avoidance among female college students.
基金supported by the National Natural Science Foundation of China(Grant Nos.51872086,62174051,51991340,and 51991343)the Natural Science Foundation of Hunan Province(Grant No.2020JJ1001)+2 种基金the Hunan Province“Huxiang Talents”Project(Grant No.2021RC3038)the Double First-Class Initiative of Hunan University(Grant No.531109100004)the Shenzhen Basic Research Project(Grant No.JCYJ20210324142012035)。
文摘Doping can change the band structure of semiconductors,thereby affecting their electrical,optical,and magnetic properties.In this study,we describe the synthesis of two-dimensional(2D)Se-doped Cr_(2)S_(3)(Se-Cr_(2)S_(3))nanosheets using the chemical vapor deposition method.In these semiconductor nanosheets,the Se doping concentration can be controlled by tuning the Se/S mass ratio in the precursor.At the doping concentrations of 10.05%and 2.05%,the room temperature conductivity and mobility were increased by nearly 4 and 2 orders of magnitude,respectively.In addition,the response time of an ultrathin Se-Cr_(2)S_(3)photodetector was 200 times shorter than that of an undoped Cr_(2)S_(3)nanosheet photodetector.4.07%-Se-Cr_(2)S_(3)nanosheets show ferrimagnetic behavior with a Curie temperature of~200 K,which is 80 K higher than that of undoped Cr_(2)S_(3)nanosheets.A density functional theory calculation indicated that the Se doping can induce the formation of intercalated Cr vacancies in SeCr_(2)S_(3)and enhance its metallic characteristics.Our results demonstrated that Se-Cr_(2)S_(3)has significant potential in future electronic,optoelectronic,and spintronic devices.
基金financially supported by the National Natural Science Foundation of China (51525202, 61635001, 52072117 and 21703059)the Key Program of the Hunan Provincial Science and Technology Department (2019XK2001)the International Science and Technology Innovation Cooperation Base of Hunan Province (2018WK4004)
文摘Substitutional doping of two-dimensional(2D)transition metal dichalcogenides(TMDs)has been recognized as a promising strategy to tune their optoelectronic properties for a wide array of applications.However,controllable doping of TMDs remains a challenging issue due to the natural doping of these materials.Here,we demonstrate the controllable growth of indium-doped p-type WS_(2) monolayers with various doping concentrations via chemical vapor deposition(CVD)of a host tungsten(W)source and indium(In)dopant.Scanning transmission electron microscopy confirmed that In atoms successfully substitute the W atoms in the WS_(2) lattice.Intriguingly,the photoluminescence of the doped sample experiences strong intensity modulation by the doping concentration,which first increases remarkably with an enhancement factor up to~35 and then decreases gradually when further increasing the doping concentration.Such a phenomenon is attributed to the progressive change of the exciton to trion ratio as well as the defect concentration in the doped samples.The assignment was further verified by the electric behavior of the fabricated In-doped WS_(2) field effect transistors,which changes regularly from n-type to bipolar and finally to p-type behavior with increasing doping concentration.The successful growth of p-type monolayer WS_(2) and the dual control of its optical and electrical properties by In doping may provide a promising method to engineer the opto-electronic properties of 2D materials.
基金supported by the National Natural Science Foundation of China(62090035,U19A2090,61905071)the Key Program of the Hunan Provincial Science and Technology Department(2019XK2001,2020XK2001)+2 种基金the International Science and Technology Innovation Cooperation Base of Hunan Province(2018WK4004)the China Postdoctoral Science Foundation(2022TQ0100)the National Key Research and 288 Development Program of China(2022YFB3604701).
