The Red Soil Hilly Region in South China, where there is a high capacity of carbon(C), and the land use and vegetation cover change greatly, is an important ecological area in the world, and has an important impact on...The Red Soil Hilly Region in South China, where there is a high capacity of carbon(C), and the land use and vegetation cover change greatly, is an important ecological area in the world, and has an important impact on the global carbon cycle and the seasonal fluctuation of atmospheric CO_2. To better evaluate the effects of reclamation systems in orchards converted from grasslands on soil carbon sequestration, we investigated soil organic carbon(SOC) content and stable C isotope(δ^(13)C)composition in three nectarine orchards at Yuchi Experimental Station in South China. Compared with the sloping clean tillage orchard and terraced clean tillage orchard, SOC content in the terraced orchard with grass cover was increased by 14.90% to 38.49%, and 7.40% to 15.33%, respectively. During the 14 years after orchard establishment, the soil organic matter sources influenced both δ^(13)C distribution with depth and carbon replacement. SOC turnover of the upper soil layer in the terraced orchard with grass cover(a mean 63.05% of replacement in the 20 cm after 14 years) was 1.59 and 1.41 times larger than that of the sloping clean tillage orchard and terraced clean tillage orchard under subtropical conditions, respectively. The equilibrium value of soil organic carbon in the three treatments ranged from 16.067 to 25.608 g/kg under the experimental conditions. The equilibrium value of soil organic carbon in the surface layer under grass cover was 54.801 t/hm^2, and the carbon sequestration potential was 24.695 1 t/hm^2.展开更多
Ferroptosis induced by ferrous ions(Fe^(2+))and lipid peroxidation accumulation is a novel form of regulated cell death that has become a hot topic in tumor therapy research.Identifying small-molecule drugs that can i...Ferroptosis induced by ferrous ions(Fe^(2+))and lipid peroxidation accumulation is a novel form of regulated cell death that has become a hot topic in tumor therapy research.Identifying small-molecule drugs that can induce ferroptosis in tumor cells is a very attractive therapeutic strategy.Here,we screened a natural product,acevaltrate(ACE),which rapidly and strongly induces ferroptosis in colorectal cancer cells.ACE not only increases Fe^(2+)levels in colorectal cancer cells by targeting iron chaperones PCBP1/2 and reducing their expression but also disrupts the antioxidant system of colorectal cancer cells by targeting GPX4 and inhibiting its enzymatic activity,leading to its ubiquitin-mediated degradation.展开更多
To the Editor:Toxic epidermal necrosis(TEN)is a severe dermal-mucous reaction characterized by rashes,blisters,and a generalized laxity of the epidermis.[1]Blockade of the programmed cell death protein 1(PD-1)/program...To the Editor:Toxic epidermal necrosis(TEN)is a severe dermal-mucous reaction characterized by rashes,blisters,and a generalized laxity of the epidermis.[1]Blockade of the programmed cell death protein 1(PD-1)/programmed cell death 1 ligand 1(PD-L1)pathway could activate and proliferate auto-reactive CD8+T-cells,which is a crucial step in TEN.The efficacy of anti-CD19 chimeric antigen receptor-T(CAR-T)cells can be inhibited by activating the PD-1/PD-L1 pathway.[2]As a result,the combination of PD-1 blockade and CAR-T cell therapy would increase the functions of CAR-T cells.[3]This case report describes a patient with refractory diffuse large B-cell lymphoma(DLBCL)who had severe TEN after CAR-T cell therapy and PD-1 blockade.展开更多
To the Editor:The coronavirus disease 2019(COVID-19)pandemic has caused a significant global health crisis,led to staggering mortality rates,and imposed a substantial economic burden.[1]Pneumonia is the leading cause ...To the Editor:The coronavirus disease 2019(COVID-19)pandemic has caused a significant global health crisis,led to staggering mortality rates,and imposed a substantial economic burden.[1]Pneumonia is the leading cause of mortality in patients with COVID-19.During outbreak peaks,the surge in patients severely strained healthcare systems,highlighting the need for rapid and cost-effective screening methods.Although chest X-ray(CXR)is affordable and convenient,its low sensitivity limits its effectiveness for detecting lung abnormalities.Computed tomography(CT)is considered the gold standard for diagnosing pneumonia,including COVID-19 pneumonia,but it exposes patients to high doses of radiation(3-7 mSv)far exceeding the annual threshold of 1 mSv recommended by the World Health Organization.Even low-dose CT delivers an average effective dose of 1.6 mSv,adding to the patient’s radiation burden.展开更多
Natural killer/T cell lymphoma(NKTCL)is a malignant tumor originating from NK or T cells,characterized by its highly aggressive and heterogeneous nature.NKTCL is predominantly associated with Epstein-Barr virus infect...Natural killer/T cell lymphoma(NKTCL)is a malignant tumor originating from NK or T cells,characterized by its highly aggressive and heterogeneous nature.NKTCL is predominantly associated with Epstein-Barr virus infection,disproportionately affecting Asian and Latin American populations.Owing to the application of asparaginase and immunotherapy,clinical outcomes have improved significantly.However,for patients in whom first-line treatment fails,the prognosis is exceedingly poor.Overexpression of multidrug resistance genes,abnormal signaling pathways,epigenetic modifications and active Epstein-Barr virus infection may be responsible for resistance.This review summarized the mechanisms of resistance for NKTCL and proposed potential therapeutic approaches.展开更多
基金Supported by Science and Technology Program of Fujian Province(2017R1016-4)Natural Science Foundation of Fujian Province(2017J01072)
文摘The Red Soil Hilly Region in South China, where there is a high capacity of carbon(C), and the land use and vegetation cover change greatly, is an important ecological area in the world, and has an important impact on the global carbon cycle and the seasonal fluctuation of atmospheric CO_2. To better evaluate the effects of reclamation systems in orchards converted from grasslands on soil carbon sequestration, we investigated soil organic carbon(SOC) content and stable C isotope(δ^(13)C)composition in three nectarine orchards at Yuchi Experimental Station in South China. Compared with the sloping clean tillage orchard and terraced clean tillage orchard, SOC content in the terraced orchard with grass cover was increased by 14.90% to 38.49%, and 7.40% to 15.33%, respectively. During the 14 years after orchard establishment, the soil organic matter sources influenced both δ^(13)C distribution with depth and carbon replacement. SOC turnover of the upper soil layer in the terraced orchard with grass cover(a mean 63.05% of replacement in the 20 cm after 14 years) was 1.59 and 1.41 times larger than that of the sloping clean tillage orchard and terraced clean tillage orchard under subtropical conditions, respectively. The equilibrium value of soil organic carbon in the three treatments ranged from 16.067 to 25.608 g/kg under the experimental conditions. The equilibrium value of soil organic carbon in the surface layer under grass cover was 54.801 t/hm^2, and the carbon sequestration potential was 24.695 1 t/hm^2.
基金funded by the National Natural Science Foundation of China(No.82374086,82141203,82104459,82430116)National Key Research and Development Program of China(2022YFC3502000)+5 种基金hanghai Municipal Science and Technology Major Project(ZD2021CY001)Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(ZYYCXTDD-202004)Science and Technology Commission of Shanghai Municipality(20YF1458700)Organizational Key Research and Development Program of Shanghai University of Traditional Chinese Medicine(2023YZZ02)CAMS Innovation Fund for Medical Sciences(CIFMS)(2023-I2M-3-009)Key Project at Central Government Level:The Ability Establishment of Sustainable Use for Valuable Chinese Medicine Resources(2060302-2305-02)。
文摘Ferroptosis induced by ferrous ions(Fe^(2+))and lipid peroxidation accumulation is a novel form of regulated cell death that has become a hot topic in tumor therapy research.Identifying small-molecule drugs that can induce ferroptosis in tumor cells is a very attractive therapeutic strategy.Here,we screened a natural product,acevaltrate(ACE),which rapidly and strongly induces ferroptosis in colorectal cancer cells.ACE not only increases Fe^(2+)levels in colorectal cancer cells by targeting iron chaperones PCBP1/2 and reducing their expression but also disrupts the antioxidant system of colorectal cancer cells by targeting GPX4 and inhibiting its enzymatic activity,leading to its ubiquitin-mediated degradation.
基金supported by grants from the National Natural Science Foundation of China(Nos.81873450,82170181)Beijing Hospitals Authority Youth Programme(No.QML20200201)Beijing Natural Science Foundation(No.7222027)to Liang Wang.
文摘To the Editor:Toxic epidermal necrosis(TEN)is a severe dermal-mucous reaction characterized by rashes,blisters,and a generalized laxity of the epidermis.[1]Blockade of the programmed cell death protein 1(PD-1)/programmed cell death 1 ligand 1(PD-L1)pathway could activate and proliferate auto-reactive CD8+T-cells,which is a crucial step in TEN.The efficacy of anti-CD19 chimeric antigen receptor-T(CAR-T)cells can be inhibited by activating the PD-1/PD-L1 pathway.[2]As a result,the combination of PD-1 blockade and CAR-T cell therapy would increase the functions of CAR-T cells.[3]This case report describes a patient with refractory diffuse large B-cell lymphoma(DLBCL)who had severe TEN after CAR-T cell therapy and PD-1 blockade.
基金supported by the National Natural Science Foundation of China(No.82104771)Key Program of the National Natural Science Foundation of China(No.81930001)+2 种基金Shanghai Jiao Tong University Medical-Industrial Intersection Research Fund Project(No.YG2021QN94)Open Fund of Xuzhou Medical University(No.XXKF202119)Shanghai Sixth People’s Hospital Emergency Special Project for Combating COVID-19(No.ynxg202208)
文摘To the Editor:The coronavirus disease 2019(COVID-19)pandemic has caused a significant global health crisis,led to staggering mortality rates,and imposed a substantial economic burden.[1]Pneumonia is the leading cause of mortality in patients with COVID-19.During outbreak peaks,the surge in patients severely strained healthcare systems,highlighting the need for rapid and cost-effective screening methods.Although chest X-ray(CXR)is affordable and convenient,its low sensitivity limits its effectiveness for detecting lung abnormalities.Computed tomography(CT)is considered the gold standard for diagnosing pneumonia,including COVID-19 pneumonia,but it exposes patients to high doses of radiation(3-7 mSv)far exceeding the annual threshold of 1 mSv recommended by the World Health Organization.Even low-dose CT delivers an average effective dose of 1.6 mSv,adding to the patient’s radiation burden.
基金funded by Beijing Physician Scientist Training Project(No.BJPSTP-2024-01)to Liang Wang.
文摘Natural killer/T cell lymphoma(NKTCL)is a malignant tumor originating from NK or T cells,characterized by its highly aggressive and heterogeneous nature.NKTCL is predominantly associated with Epstein-Barr virus infection,disproportionately affecting Asian and Latin American populations.Owing to the application of asparaginase and immunotherapy,clinical outcomes have improved significantly.However,for patients in whom first-line treatment fails,the prognosis is exceedingly poor.Overexpression of multidrug resistance genes,abnormal signaling pathways,epigenetic modifications and active Epstein-Barr virus infection may be responsible for resistance.This review summarized the mechanisms of resistance for NKTCL and proposed potential therapeutic approaches.
