Protein arginine methyltransferase-6 participates in a range of biological functions,particularly RNA processing,transcription,chromatin remodeling,and endosomal trafficking.However,it remains unclear whether protein ...Protein arginine methyltransferase-6 participates in a range of biological functions,particularly RNA processing,transcription,chromatin remodeling,and endosomal trafficking.However,it remains unclear whether protein arginine methyl transferase-6 modifies neuropathic pain and,if so,what the mechanisms of this effect.In this study,protein arginine methyltransferase-6 expression levels and its effect on neuropathic pain were investigated in the spared nerve injury model,chronic constriction injury model and bone cancer pain model,using immunohistochemistry,western blotting,immunoprecipitation,and label-free proteomic analysis.The results showed that protein arginine methyltransferase-6 mostly co-localized withβ-tubulinⅢin the dorsal root ganglion,and that its expression decreased following spared nerve injury,chronic constriction injury and bone cancer pain.In addition,PRMT6 knockout(Prmt6~(-/-))mice exhibited pain hypersensitivity.Furthermore,the development of spared nerve injury-induced hypersensitivity to mechanical pain was attenuated by blocking the decrease in protein arginine methyltransferase-6 expression.Moreover,when protein arginine methyltransferase-6 expression was downregulated in the dorsal root ganglion in mice without spared nerve injury,increased levels of phosphorylated extracellular signal-regulated kinases were observed in the ipsilateral dorsal horn,and the response to mechanical stimuli was enhanced.Mechanistically,protein arginine methyltransferase-6 appeared to contribute to spared nerve injury-induced neuropathic pain by regulating the expression of heterogeneous nuclear ribonucleoprotein-F.Additionally,protein arginine methyltransfe rase-6-mediated modulation of hete rogeneous nuclear ribonucleoprotein-F expression required amino atids 319 to 388,but not classical H3R2 methylation.These findings indicated that protein arginine methyltransferase-6 is a potential therapeutic target fo r the treatment of peripheral neuro pathic pain.展开更多
The level of genetic variation within a breeding population affects the effectiveness of selection strategies for genetic improvement.The relationship between genetic variation level within Pinus tabuliformis breeding...The level of genetic variation within a breeding population affects the effectiveness of selection strategies for genetic improvement.The relationship between genetic variation level within Pinus tabuliformis breeding populations and selection strategies or selection effectiveness is not fully investigated.Here,we compared the selection effectiveness of combined and individual direct selection strategies using half-and full-sib families produced from advanced-generation P.tabuliformis seed orchard as our test populations.Our results revealed that,within half-sib families,average diameter at breast height(DBH),tree height,and volume growth of superior individuals selected by the direct selection strategy were higher by 7.72%,18.56%,and 31.01%,respectively,than those selected by the combined selection strategy.Furthermore,significant differences(P<0.01)were observed between the two strategies in terms of the expected genetic gains for average tree height and volume.In contrast,within full-sib families,the differences in tree average DBH,height,and volume between the two selection strategies were relatively minor with increase of 0.17%,2.73%,and 2.21%,respectively,and no significant differences were found in the average expected genetic gains for the studied traits.Half-sib families exhibited greater phenotypic and genetic variation,resulting in improved selection efficiency with the direct selection strategy but also introduced a level of inbreeding risk.Based on genetic distance estimates using molecular markers,our comparative seed orchard design analysis showed that the Improved Adaptive Genetic Programming Algorithm(IAPGA)reduced the average inbreeding coefficient by 14.36% and 14.73% compared to sequential and random designs,respectively.In conclusion,the combination of the direct selection strategy with IAPGA seed orchard design aimed at minimizing inbreeding offered an efficient approach for establishing advanced-generation P.tabuliformis seed orchards.展开更多
Wintersweet(Chimonanthus praecox),a well-known fragrant flowering shrub,is extensively planted for ornamental purpose and production of floral essential oil.Although the tepal color of wintersweet varieties exhibits t...Wintersweet(Chimonanthus praecox),a well-known fragrant flowering shrub,is extensively planted for ornamental purpose and production of floral essential oil.Although the tepal color of wintersweet varieties exhibits the most remarkable diversity,variations in the floral scent traits are also noticeable across different cultivars.In this study,the floral volatile organic compounds(VOCs)in three wintersweet cultivars,‘Yanlingsuxin’,‘Yuxiang’,and‘Hongyun’were detected via GC-MS coupled with OAV.The distinct floral aromas of the three cultivars were primarily attributed to benzyl alcohol(abundant in‘Yuxiang’),linalool(abundant in‘Yanlingsuxin’),(-)-γ-cadinene and eugenol(abundant in‘Hongyun’).Integrated analyses of metabolome and transcriptome showed that an R2R3-MYB transcription factor gene,CpODO1,potentially have a crucial regulatory function in controlling the production of multiple aroma compounds.Overexpression of CpODO1 can enhance the production of benzyl alcohol in transgenic tobacco flowers.Analysis of DAP-seq data,EMSA and dual-luciferase assay revealed that CpODO1 predominantly regulate the expression of CpCYP71,a cytochrome P450 gene encoding a key enzyme in the production of benzyl alcohol,and the transcriptional regulation of CpODO1 is driven by CpEOBII.The identification of polymorphisms in the MYB binding cis-motifs of CpCYP71 and CpODO1 promoters revealed the regulatory mechanism underlying the varied synthesis of benzyl alcohol in three wintersweet cultivars.This study provides new anchor points for floral scent quality improvement breeding of wintersweet,and the profusion of wintersweet germplasm can serve as a material basis for developing various aroma products.展开更多
Objective:Whether vortioxetine has a utility as an adjuvant drug in the treatment of bipolar depression remains controversial.This study aimed to validate the efficacy and safety of vortioxetine in bipolar depression....Objective:Whether vortioxetine has a utility as an adjuvant drug in the treatment of bipolar depression remains controversial.This study aimed to validate the efficacy and safety of vortioxetine in bipolar depression.Methods:Patients with bipolarⅡdepression were enrolled in this prospective,two-center,randomized,12-week pilot trial.The main indicator for assessing treatment effectiveness was a Montgomery-Asberg Depression Rating Scale(MADRS)of≥50%.All eligible patients initially received four weeks of lurasidone monotherapy.Patients who responded well continued to receive this kind of monotherapy.However,no-response patients were randomly assigned to either valproate or vortioxetine treatment for eight weeks.By comprehensively comparing the results of MADRS over a period of 4-12 weeks,a systematic analysis was conducted to determine whether vortioxetine could be used as an adjuvant drug for treating bipolar depression.Results:Thirty-seven patients responded to lurasidone monotherapy,and 60 patients were randomly assigned to the valproate or vortioxetine group for eight weeks.After two weeks of combined valproate or vortioxetine treatment,the MADRS score in the vortioxetine group was significantly lower than that in the valproate group.There was no difference in the MADRS scores between the two groups at 8 and 12 weeks.The incidence of side effects did not significantly differ between the valproate and vortioxetine groups.Importantly,three patients in the vortioxetine group appeared to switch to mania or hypomania.Conclusions:This study suggested that lurasidone combination with vortioxetine might have potential benefits to bipolar II depression in the early stage,while disease progression should be monitored closely for the risk of switching to mania.展开更多
The industrial Internet of Things(IoT)is a trend of factory development and a basic condition of intelligent factory.It is very important to ensure the security of data transmission in industrial IoT.Applying a new ch...The industrial Internet of Things(IoT)is a trend of factory development and a basic condition of intelligent factory.It is very important to ensure the security of data transmission in industrial IoT.Applying a new chaotic secure communication scheme to address the security problem of data transmission is the main contribution of this paper.The scheme is proposed and studied based on the synchronization of different-structure fractional-order chaotic systems with different order.The Lyapunov stability theory is used to prove the synchronization between the fractional-order drive system and the response system.The encryption and decryption process of the main data signals is implemented by using the n-shift encryption principle.We calculate and analyze the key space of the scheme.Numerical simulations are introduced to show the effectiveness of theoretical approach we proposed.展开更多
In this paper,the security problem for the multi-access edge computing(MEC)network is researched,and an intelligent immunity-based security defense system is proposed to identify the unauthorized mobile users and to p...In this paper,the security problem for the multi-access edge computing(MEC)network is researched,and an intelligent immunity-based security defense system is proposed to identify the unauthorized mobile users and to protect the security of whole system.In the proposed security defense system,the security is protected by the intelligent immunity through three functions,identification function,learning function,and regulation function,respectively.Meanwhile,a three process-based intelligent algorithm is proposed for the intelligent immunity system.Numerical simulations are given to prove the effeteness of the proposed approach.展开更多
Two amphiphilic TPE E/Z isomers with aggregation induced emission(AIE)property have been synthesized and characterized.The logarithmic fluorescent intensity of the two molecules was in positive relationship with logar...Two amphiphilic TPE E/Z isomers with aggregation induced emission(AIE)property have been synthesized and characterized.The logarithmic fluorescent intensity of the two molecules was in positive relationship with logarithmic viscosity of liquid.To note,the Z-TPE isomer exhibited more sensitivity in the viscosity of liquid sensing in comparison with the corresponding E-TPE counterpart(around 1.80 folds).Furthermore,two molecules could be used as fluorescent sensors for mechanical properties(viscosity and storage modulus)of hydrogel as well.In addition,two sensors displayed low cytotoxicity in normal tissue cell line(L929)within the concentration range of 2–10μmol/L.These results potentially promised their applications as fluorescent sensors for mechanical properties in the fields of biological and biomedical.展开更多
Dispersed computing can link all devices with computing capabilities on a global scale to form a fully decentralized network,which can make full use of idle computing resources.Realizing the overall resource allocatio...Dispersed computing can link all devices with computing capabilities on a global scale to form a fully decentralized network,which can make full use of idle computing resources.Realizing the overall resource allocation of the dispersed computing system is a significant challenge.In detail,by jointly managing the task requests of external users and the resource allocation of the internal system to achieve dynamic balance,the efficient and stable operation of the system can be guaranteed.In this paper,we first propose a task-resource joint management model,which quantifies the dynamic transformation relationship between the resources consumed by task requests and the resources occupied by the system in dispersed computing.Secondly,to avoid downtime caused by an overload of resources,we introduce intelligent control into the task-resource joint management model.The existence and stability of the positive periodic solution of the model can be obtained by theoretical analysis,which means that the stable operation of dispersed computing can be guaranteed through the intelligent feedback control strategy.Additionally,to improve the system utilization,the task-resource joint management model with bi-directional intelligent control is further explored.Setting control thresholds for the two resources not only reverse restrains the system resource overload,but also carries out positive incentive control when a large number of idle resources appear.The existence and stability of the positive periodic solution of the model are proved theoretically,that is,the model effectively avoids the two extreme cases and ensure the efficient and stable operation of the system.Finally,numerical simulation verifies the correctness and validity of the theoretical results.展开更多
Timbre,as one of the essential elements of sound,plays an important role in determining sound properties,whereas its manipulation has been remaining challenging for passive mechanical systems due to the intrinsic disp...Timbre,as one of the essential elements of sound,plays an important role in determining sound properties,whereas its manipulation has been remaining challenging for passive mechanical systems due to the intrinsic dispersion nature of resonances.Here,we present a meta-silencer supporting intensive mode density as well as highly tunable intrinsic loss and offering a fresh pathway for designable timbre in broadband.Strong global coupling is induced by intensive mode density and delicately modulated with the guidance of the theoretical model,which efficiently suppresses the resonance dispersion and provides desirable frequency-selective wave-manipulation capacity for timbre tuning.As proof-of-concept demonstrations for our design concepts,we propose three meta-silencers with the designing targets of high-efficiency broadband sound attenuation,efficiency-controlled sound attenuation and designable timbre,respectively.The proposed meta-silencers all operate in a broadband frequency range from 500 to 3200 Hz and feature deep-subwavelength sizes around 50 mm.Our work opens up a fundamental avenue to manipulate the timbre with passive resonances-controlled acoustic metamaterials and may inspire the development of novel multifunctional devices in noise-control engineering,impedance engineering,and architectural acoustics.展开更多
Cationic amphiphile aggregates exhibit superior antibacterial activity than monomers.However,the antimicrobial mechanism of aggregates has not been well understood because it is difficult to distinguish and monitor ag...Cationic amphiphile aggregates exhibit superior antibacterial activity than monomers.However,the antimicrobial mechanism of aggregates has not been well understood because it is difficult to distinguish and monitor aggregate and monomer in antimicrobial process.Herein,three bola-type cationic amphiphiles with aggregation-induced emission property have been developed to show distinguishable fluorescence in their monomer and aggregate.The hydrophilicity of monomer and the stability of aggregate are finely tuned by tailoring the linkers between two quaternary ammonium end groups and tetraphenylethylene skeleton.The sensitive fluorescence switching of monomer and aggregate achieves the quantitative monitoring of dynamic interaction of three amphiphiles with bacteria.The aggregates with cationic charges first attach to bacterial surface,and the monomers subsequently dissociate from aggregates to penetrate bacterial membrane.Further,our results reveal the vital role of stability of aggregates during antimicrobial process,shedding light on the rational design of high-efficient antimicrobials.展开更多
基金supported by the National Natural Science Foundation of China,Nos.82001178(to LW),81901129(to LH),82001175(to FX)Shanghai Sailing Program,No.20YF1439200(to LW)+1 种基金the Natural Science Foundation of Shanghai,China,No.23ZR1450800(to LH)and the Fundamental Research Funds for the Central Universities,No.YG2023LC15(to ZX)。
文摘Protein arginine methyltransferase-6 participates in a range of biological functions,particularly RNA processing,transcription,chromatin remodeling,and endosomal trafficking.However,it remains unclear whether protein arginine methyl transferase-6 modifies neuropathic pain and,if so,what the mechanisms of this effect.In this study,protein arginine methyltransferase-6 expression levels and its effect on neuropathic pain were investigated in the spared nerve injury model,chronic constriction injury model and bone cancer pain model,using immunohistochemistry,western blotting,immunoprecipitation,and label-free proteomic analysis.The results showed that protein arginine methyltransferase-6 mostly co-localized withβ-tubulinⅢin the dorsal root ganglion,and that its expression decreased following spared nerve injury,chronic constriction injury and bone cancer pain.In addition,PRMT6 knockout(Prmt6~(-/-))mice exhibited pain hypersensitivity.Furthermore,the development of spared nerve injury-induced hypersensitivity to mechanical pain was attenuated by blocking the decrease in protein arginine methyltransferase-6 expression.Moreover,when protein arginine methyltransferase-6 expression was downregulated in the dorsal root ganglion in mice without spared nerve injury,increased levels of phosphorylated extracellular signal-regulated kinases were observed in the ipsilateral dorsal horn,and the response to mechanical stimuli was enhanced.Mechanistically,protein arginine methyltransferase-6 appeared to contribute to spared nerve injury-induced neuropathic pain by regulating the expression of heterogeneous nuclear ribonucleoprotein-F.Additionally,protein arginine methyltransfe rase-6-mediated modulation of hete rogeneous nuclear ribonucleoprotein-F expression required amino atids 319 to 388,but not classical H3R2 methylation.These findings indicated that protein arginine methyltransferase-6 is a potential therapeutic target fo r the treatment of peripheral neuro pathic pain.
基金financially supported by the Biological BreedingNational Science and Technology Major Project(2023ZD0405806)the National Key R&D Program for the 14th Five-Year Plan in China(2022YFD2200304).
文摘The level of genetic variation within a breeding population affects the effectiveness of selection strategies for genetic improvement.The relationship between genetic variation level within Pinus tabuliformis breeding populations and selection strategies or selection effectiveness is not fully investigated.Here,we compared the selection effectiveness of combined and individual direct selection strategies using half-and full-sib families produced from advanced-generation P.tabuliformis seed orchard as our test populations.Our results revealed that,within half-sib families,average diameter at breast height(DBH),tree height,and volume growth of superior individuals selected by the direct selection strategy were higher by 7.72%,18.56%,and 31.01%,respectively,than those selected by the combined selection strategy.Furthermore,significant differences(P<0.01)were observed between the two strategies in terms of the expected genetic gains for average tree height and volume.In contrast,within full-sib families,the differences in tree average DBH,height,and volume between the two selection strategies were relatively minor with increase of 0.17%,2.73%,and 2.21%,respectively,and no significant differences were found in the average expected genetic gains for the studied traits.Half-sib families exhibited greater phenotypic and genetic variation,resulting in improved selection efficiency with the direct selection strategy but also introduced a level of inbreeding risk.Based on genetic distance estimates using molecular markers,our comparative seed orchard design analysis showed that the Improved Adaptive Genetic Programming Algorithm(IAPGA)reduced the average inbreeding coefficient by 14.36% and 14.73% compared to sequential and random designs,respectively.In conclusion,the combination of the direct selection strategy with IAPGA seed orchard design aimed at minimizing inbreeding offered an efficient approach for establishing advanced-generation P.tabuliformis seed orchards.
基金supported by the China National Natural Science Foundation(Grant No.32102417)Henan Key R&D Project,China(Grant No.221111110700)+1 种基金Henan Academy of Agricultural Sciences“Innovation and Utilization of Characteristic Flowers and Trees Germplasm”Team Project(Grant Nos.2023TD35 and2024TD26)Hunan Provincial Natural Science Foundation of China(Grant No.2024JJ6711),Natural Science Foundation of Guangxi(Grant No.2024JJB130300)。
文摘Wintersweet(Chimonanthus praecox),a well-known fragrant flowering shrub,is extensively planted for ornamental purpose and production of floral essential oil.Although the tepal color of wintersweet varieties exhibits the most remarkable diversity,variations in the floral scent traits are also noticeable across different cultivars.In this study,the floral volatile organic compounds(VOCs)in three wintersweet cultivars,‘Yanlingsuxin’,‘Yuxiang’,and‘Hongyun’were detected via GC-MS coupled with OAV.The distinct floral aromas of the three cultivars were primarily attributed to benzyl alcohol(abundant in‘Yuxiang’),linalool(abundant in‘Yanlingsuxin’),(-)-γ-cadinene and eugenol(abundant in‘Hongyun’).Integrated analyses of metabolome and transcriptome showed that an R2R3-MYB transcription factor gene,CpODO1,potentially have a crucial regulatory function in controlling the production of multiple aroma compounds.Overexpression of CpODO1 can enhance the production of benzyl alcohol in transgenic tobacco flowers.Analysis of DAP-seq data,EMSA and dual-luciferase assay revealed that CpODO1 predominantly regulate the expression of CpCYP71,a cytochrome P450 gene encoding a key enzyme in the production of benzyl alcohol,and the transcriptional regulation of CpODO1 is driven by CpEOBII.The identification of polymorphisms in the MYB binding cis-motifs of CpCYP71 and CpODO1 promoters revealed the regulatory mechanism underlying the varied synthesis of benzyl alcohol in three wintersweet cultivars.This study provides new anchor points for floral scent quality improvement breeding of wintersweet,and the profusion of wintersweet germplasm can serve as a material basis for developing various aroma products.
基金partially supported by the Construction Fund of Key Medical Disciplines of Hangzhou(No.OO2020491)the National Key Research and Development Program of China(No.2023YFC2506200)+4 种基金the Zhejiang Provincial Key Research and Development Program(No.2021C03107)the Research Project of Jinan Microecological Biomedicine Shandong Laboratory(No.JNL-2023001B)the Leading Talent of Scientific and Technological Innovation-“Ten Thousand Talents Program”of Zhejiang Province(No.2021R52016)the Innovation Team for Precision Diagnosis and Treatment of Major Brain Diseases(No.2020R01001)the Chinese Medical Education Association(No.2022KTZ004).
文摘Objective:Whether vortioxetine has a utility as an adjuvant drug in the treatment of bipolar depression remains controversial.This study aimed to validate the efficacy and safety of vortioxetine in bipolar depression.Methods:Patients with bipolarⅡdepression were enrolled in this prospective,two-center,randomized,12-week pilot trial.The main indicator for assessing treatment effectiveness was a Montgomery-Asberg Depression Rating Scale(MADRS)of≥50%.All eligible patients initially received four weeks of lurasidone monotherapy.Patients who responded well continued to receive this kind of monotherapy.However,no-response patients were randomly assigned to either valproate or vortioxetine treatment for eight weeks.By comprehensively comparing the results of MADRS over a period of 4-12 weeks,a systematic analysis was conducted to determine whether vortioxetine could be used as an adjuvant drug for treating bipolar depression.Results:Thirty-seven patients responded to lurasidone monotherapy,and 60 patients were randomly assigned to the valproate or vortioxetine group for eight weeks.After two weeks of combined valproate or vortioxetine treatment,the MADRS score in the vortioxetine group was significantly lower than that in the valproate group.There was no difference in the MADRS scores between the two groups at 8 and 12 weeks.The incidence of side effects did not significantly differ between the valproate and vortioxetine groups.Importantly,three patients in the vortioxetine group appeared to switch to mania or hypomania.Conclusions:This study suggested that lurasidone combination with vortioxetine might have potential benefits to bipolar II depression in the early stage,while disease progression should be monitored closely for the risk of switching to mania.
基金supported in part by the National Science Foundation Project of China (61931001, 61873026)the National Key R&D Program of China (2017YFC0820700)
文摘The industrial Internet of Things(IoT)is a trend of factory development and a basic condition of intelligent factory.It is very important to ensure the security of data transmission in industrial IoT.Applying a new chaotic secure communication scheme to address the security problem of data transmission is the main contribution of this paper.The scheme is proposed and studied based on the synchronization of different-structure fractional-order chaotic systems with different order.The Lyapunov stability theory is used to prove the synchronization between the fractional-order drive system and the response system.The encryption and decryption process of the main data signals is implemented by using the n-shift encryption principle.We calculate and analyze the key space of the scheme.Numerical simulations are introduced to show the effectiveness of theoretical approach we proposed.
基金This work was supported by National Natural Science Foundation of China(No.61971026)the Fundamental Research Funds for the Central Universities(No.FRF-TP-18-008A3).
文摘In this paper,the security problem for the multi-access edge computing(MEC)network is researched,and an intelligent immunity-based security defense system is proposed to identify the unauthorized mobile users and to protect the security of whole system.In the proposed security defense system,the security is protected by the intelligent immunity through three functions,identification function,learning function,and regulation function,respectively.Meanwhile,a three process-based intelligent algorithm is proposed for the intelligent immunity system.Numerical simulations are given to prove the effeteness of the proposed approach.
基金National Natural Science Foundation of China(Nos.21375116,21978251,22073080)Nature Science Foundation of Jiangsu Province(Nos.BK20190903,BK20190905)+2 种基金A Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions for financial supportThe open funds of the Ministry of Education Key Lab for Avian Preventive Medicine(No.YF202020)the Thousand Talents Plan for Young Professionals of China。
文摘Two amphiphilic TPE E/Z isomers with aggregation induced emission(AIE)property have been synthesized and characterized.The logarithmic fluorescent intensity of the two molecules was in positive relationship with logarithmic viscosity of liquid.To note,the Z-TPE isomer exhibited more sensitivity in the viscosity of liquid sensing in comparison with the corresponding E-TPE counterpart(around 1.80 folds).Furthermore,two molecules could be used as fluorescent sensors for mechanical properties(viscosity and storage modulus)of hydrogel as well.In addition,two sensors displayed low cytotoxicity in normal tissue cell line(L929)within the concentration range of 2–10μmol/L.These results potentially promised their applications as fluorescent sensors for mechanical properties in the fields of biological and biomedical.
基金supported in part by the National Science Foundation Project of P.R.China(No.61931001)the Scientific and Technological Innovation Foundation of Foshan,USTB(No.BK20AF003)。
文摘Dispersed computing can link all devices with computing capabilities on a global scale to form a fully decentralized network,which can make full use of idle computing resources.Realizing the overall resource allocation of the dispersed computing system is a significant challenge.In detail,by jointly managing the task requests of external users and the resource allocation of the internal system to achieve dynamic balance,the efficient and stable operation of the system can be guaranteed.In this paper,we first propose a task-resource joint management model,which quantifies the dynamic transformation relationship between the resources consumed by task requests and the resources occupied by the system in dispersed computing.Secondly,to avoid downtime caused by an overload of resources,we introduce intelligent control into the task-resource joint management model.The existence and stability of the positive periodic solution of the model can be obtained by theoretical analysis,which means that the stable operation of dispersed computing can be guaranteed through the intelligent feedback control strategy.Additionally,to improve the system utilization,the task-resource joint management model with bi-directional intelligent control is further explored.Setting control thresholds for the two resources not only reverse restrains the system resource overload,but also carries out positive incentive control when a large number of idle resources appear.The existence and stability of the positive periodic solution of the model are proved theoretically,that is,the model effectively avoids the two extreme cases and ensure the efficient and stable operation of the system.Finally,numerical simulation verifies the correctness and validity of the theoretical results.
文摘Timbre,as one of the essential elements of sound,plays an important role in determining sound properties,whereas its manipulation has been remaining challenging for passive mechanical systems due to the intrinsic dispersion nature of resonances.Here,we present a meta-silencer supporting intensive mode density as well as highly tunable intrinsic loss and offering a fresh pathway for designable timbre in broadband.Strong global coupling is induced by intensive mode density and delicately modulated with the guidance of the theoretical model,which efficiently suppresses the resonance dispersion and provides desirable frequency-selective wave-manipulation capacity for timbre tuning.As proof-of-concept demonstrations for our design concepts,we propose three meta-silencers with the designing targets of high-efficiency broadband sound attenuation,efficiency-controlled sound attenuation and designable timbre,respectively.The proposed meta-silencers all operate in a broadband frequency range from 500 to 3200 Hz and feature deep-subwavelength sizes around 50 mm.Our work opens up a fundamental avenue to manipulate the timbre with passive resonances-controlled acoustic metamaterials and may inspire the development of novel multifunctional devices in noise-control engineering,impedance engineering,and architectural acoustics.
基金National Natural Science Foundation of China,Grant/Award Number:22002137Natural Science Foundation of Jiangsu Province,Grant/Award Number:BK20200920+1 种基金Beijing Natural Science Foundation,Grant/Award Number:2212013Shenzhen Key Laboratory of Functional Aggregate Materials,Grant/Award Number:ZDSYS20211021111400001。
文摘Cationic amphiphile aggregates exhibit superior antibacterial activity than monomers.However,the antimicrobial mechanism of aggregates has not been well understood because it is difficult to distinguish and monitor aggregate and monomer in antimicrobial process.Herein,three bola-type cationic amphiphiles with aggregation-induced emission property have been developed to show distinguishable fluorescence in their monomer and aggregate.The hydrophilicity of monomer and the stability of aggregate are finely tuned by tailoring the linkers between two quaternary ammonium end groups and tetraphenylethylene skeleton.The sensitive fluorescence switching of monomer and aggregate achieves the quantitative monitoring of dynamic interaction of three amphiphiles with bacteria.The aggregates with cationic charges first attach to bacterial surface,and the monomers subsequently dissociate from aggregates to penetrate bacterial membrane.Further,our results reveal the vital role of stability of aggregates during antimicrobial process,shedding light on the rational design of high-efficient antimicrobials.
