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Spatiotemporally-controlled supramolecular hybrid nanoassembly enabling ferroptosis-augmented photodynamic immunotherapy of cancer
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作者 Yuequan Wang Congtian Wu +5 位作者 chengcheng feng Qin Chen Zhonggui He Shenwu Zhang Cong Luo Jin Sun 《Chinese Chemical Letters》 2025年第3期379-384,共6页
Photodynamic therapy(PDT)not only directly eradicates tumor cells but also boosts immunogenicity,promoting antigen presentation and immune cell infiltration.However,the robust antioxidant defense mechanisms within tum... Photodynamic therapy(PDT)not only directly eradicates tumor cells but also boosts immunogenicity,promoting antigen presentation and immune cell infiltration.However,the robust antioxidant defense mechanisms within tumor cells significantly weaken the efficacy of photodynamic immunotherapy.Herein,a supramolecular hybrid nanoassembly is constructed by exploring the synergistic effects of the photodynamic photosensitizer(pyropheophorbide a,PPa)and the ferroptosis inducer(erastin).The erastinmediated inhibition of system X_(c)−significantly downregulates glutathione(GSH)expression,amplifying intracellular oxidative stress,leading to pronounced cell apoptosis,and promoting the release of damageassociated molecular patterns(DAMPs).Additionally,the precise cooperation of PPa and erastin enhances ferroptosis efficiency,exacerbating the accumulation of lipid peroxides(LPOs).Ultimately,LPOs serve as a“find me”signal,while DMAPs act as an“eat me”signal,collectively promoting dendritic cell maturation,enhancing infiltration of the cytotoxic T lymphocytes,and eliciting a robust immune response.This study opens new horizons for enhancing tumor immunotherapy through simultaneous ferroptosis-PDT. 展开更多
关键词 SUPERMOLECULE Nanoasssembly Ferroptosis Photodynamic therapy IMMUNOTHERAPY
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Wettability-driven synergistic resistance of scale and oil on robust superamphiphobic coating 被引量:1
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作者 Yixuan Wang Jiexin Li +7 位作者 Zhihao Shang chengcheng feng Jianmin Gu Maosheng Ye Ran Zhao Danna Liu Jingxin Meng Shutao Wang 《Chinese Chemical Letters》 SCIE CAS CSCD 2024年第7期433-438,共6页
Disgusting deposits(e.g.,scale and crude oil)in daily life and industrial production are always serious problems,posing great threats to the safety and economic development.However,most of developed coatings can only ... Disgusting deposits(e.g.,scale and crude oil)in daily life and industrial production are always serious problems,posing great threats to the safety and economic development.However,most of developed coatings can only conquer one part of these deposits such as superhydrophobic coatings possess antiscaling capacity but would adhere crude oil.To integrate scale resistance with oil repellence,we herein report a robust superamphiphobic(SAB)coating simultaneously reducing pollution of scale and oil for extended period of time(two weeks with over 98%reduction).Compared with single role of superhydrophobic and amphiphilic surfaces,the SAB coating can not only inhibit interfacial nucleation of scale but also reduce the adhesion of formed scale and polluted oil.The durability of the SAB coating is evaluated via mechanical tests(sandpaper abrasion,tape stripping and sand falling)and chemical corrosion(corrosive liquid immersing),revealed by sustainable high contact angles and low contact angle hysteresis of water and oil.The universality of this strategy can be further confirmed by adding different particles like kaolin,Al_(2)O_(3),and SiO_(2),resisting multiple types of scale(i.e.,CaSO_(4),BaSO_(4)and MgCO_(3))and oil(i.e.,glycerol,glycol,and mineral oil).Therefore,this study provides an ideal avenue for resisting scale and oil,which may be used for conquering the complexity of application environments(e.g.,oil production and transportation). 展开更多
关键词 Superamphiphobic DURABILITY WETTABILITY ANTI-SCALING Oil repellence
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3D/4D additive-subtractive manufacturing of heterogeneous ceramics
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作者 Guo Liu Xinya Lu +17 位作者 Xiaofeng Zhang Yan Zhao Shenghui Yi Jingjun Xu Yuqi Zhan Jianan Yin chengcheng feng Zhifeng Zhou Peiyu Wang Zhou Chen Yunhu He Siyao Chen Pengchao Liu Jun Zuo Yu Dai Jian Wu Sida Liu Jian Lu 《Journal of Materials Science & Technology》 CSCD 2024年第34期210-221,共12页
The manufacturing of heterogeneous high-temperature material components is challenging for use in practical applications.Three-dimensional(3D)printing provides solutions to programmable constructing ceramic architectu... The manufacturing of heterogeneous high-temperature material components is challenging for use in practical applications.Three-dimensional(3D)printing provides solutions to programmable constructing ceramic architectures.However,the development of heterogeneous ceramics is limited by low flexibil-ity of heterogeneity,geometrical complexity,structural resolution,manufacturing efficiency,and mate-rial diversity.In this study,we demonstrated flexible and rapid approaches for fabricating complicated and precise heterogeneous ceramics by shape-changing(4D)or shape-keeping(3D)additive-subtractive manufacturing(ASM)methods.The shape-changing strategy for heterogeneous ceramics was achieved by global ceramization of heterogeneous precursors,while the shape-keeping strategy for heterogeneous ceramics was achieved by local receramization of homogeneous ceramics.Finite element analysis(FEA)simulations of the influence of the thermal shrinkage dominant in the shape-changing strategy on the shape deformation of heterogeneous ceramics could be valuable predictions of the experimental results.The 3D/4D ASM methods are generic for high-temperature materials and extendable to metallic and dia-mond materials. 展开更多
关键词 3D/4D printing Additive-subtractive manufacturing Heterogeneous ceramics Elastomer-derived ceramics Local receramization
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Whole-genome sequencing provides insights into the genetic diversity and domestication of bitter gourd(Momordica spp.) 被引量:11
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作者 Junjie Cui Yan Yang +21 位作者 Shaobo Luo Le Wang Rukui Huang Qingfang Wen Xiaoxia Han Nansheng Miao Jiaowen Cheng Ziji Liu Changyuan Zhang chengcheng feng Haisheng Zhu Jianwen Su Xinjian Wan Fang Hu Yu Niu Xiaoming Zheng Yulan Yang Dai Shan Zhensheng Dong Weiming He Narinder P.S.Dhillon Kailin Hu 《Horticulture Research》 SCIE 2020年第1期1758-1768,共11页
Bitter gourd(Momordica charantia)is a popular cultivated vegetable in Asian and African countries.To reveal the characteristics of the genomic structure,evolutionary trajectory,and genetic basis underlying the domesti... Bitter gourd(Momordica charantia)is a popular cultivated vegetable in Asian and African countries.To reveal the characteristics of the genomic structure,evolutionary trajectory,and genetic basis underlying the domestication of bitter gourd,we performed whole-genome sequencing of the cultivar Dali-11 and the wild small-fruited line TR and resequencing of 187 bitter gourd germplasms from 16 countries.The major gene clusters(Bi clusters)for the biosynthesis of cucurbitane triterpenoids,which confer a bitter taste,are highly conserved in cucumber,melon,and watermelon.Comparative analysis among cucurbit genomes revealed that the Bi cluster involved in cucurbitane triterpenoid biosynthesis is absent in bitter gourd.Phylogenetic analysis revealed that the TR group,including 21 bitter gourd germplasms,may belong to a new species or subspecies independent from M.charantia.Furthermore,we found that the remaining 166 M.charantia germplasms are geographically differentiated,and we identified 710,412,and 290 candidate domestication genes in the South Asia,Southeast Asia,and China populations,respectively.This study provides new insights into bitter gourd genetic diversity and domestication and will facilitate the future genomics-enabled improvement of bitter gourd. 展开更多
关键词 INSIGHT cluster WHOLE
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Changes of melatonin and its receptors in synchronizing turbot(Scophthalmus maximus)seasonal reproduction and maturation rhythm 被引量:1
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作者 Chunyan Zhao Shihong Xu +5 位作者 Yifan Liu chengcheng feng Yongshuang Xiao Yanfeng Wang Qinghua Liu Jun Li 《Acta Oceanologica Sinica》 SCIE CAS CSCD 2022年第1期84-98,共15页
In most fish,reproduction is seasonal or periodic under the suitable conditions.In turbot(Scophthalmus maximus)farms,one of the most economically important marine flatfish species,changes in daylength could cause chan... In most fish,reproduction is seasonal or periodic under the suitable conditions.In turbot(Scophthalmus maximus)farms,one of the most economically important marine flatfish species,changes in daylength could cause changes in the spawning time.In this study,to characterize the regulation of reproductive physiology following light signals,three melatonin receptors(Mtnr)investigated in turbot were named sm Mtnr1,sm Mtnr2,and sm Mtnr1 c.Distinct expression profiles demonstrated that Mtnr m RNAs were concentrated in the brain(as detected in the hypothalamus(Hy)and mesencephalon(Me)),gonad and eye.The most abundant Mtnr1 and Mtnr2 m RNA expression levels were detected in the central nervous system at the beginning of the breeding season,suggesting that Mtnr1 and Mtnr2 may play vital roles in the regulation of turbot gonadal development.In addition,the melatonin profiles gradually increased and reached to the highest level at the spawning stage,indicating that melatonin is a potent hormone in the regulation of fish oocyte growth and maturation.The results of this study suggested that melatonin is the primary factor that transduces the light signal and regulates the physiological functions of turbot seasonal reproduction.Moreover,the results of this study may establish a foundation for further research seeking to identify fish melatonin receptors involved in the gonadal development and gamete maturation. 展开更多
关键词 TURBOT brain MELATONIN melatonin receptors seasonal reproductive development
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A Case Study of a Regional Torrential Rain in North China Caused by Typhoon Damrey (2012) 被引量:1
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作者 Rui Xing Yuejia Zhu chengcheng feng 《Journal of Geoscience and Environment Protection》 2018年第5期220-227,共8页
By using the NCEP/GFS analysis data, CIMISS data, JMA and China’s Typhoon Networks, heavy rainstorm occurred in east of North China associated with Typhoon Damrey from August 3rd to 4th, 2012 was analyzed. Results sh... By using the NCEP/GFS analysis data, CIMISS data, JMA and China’s Typhoon Networks, heavy rainstorm occurred in east of North China associated with Typhoon Damrey from August 3rd to 4th, 2012 was analyzed. Results show during Damrey was going nearby Tianjin City and Hebei province of China, heavy rainstorm was observed in the cities of Qinhuangdao and Tangshan. The southerly jet stream from the southern side of the subtropical high and the periphery of Typhoon Saola is the conveyor belt for water vapor and energy, which enables Damrey to maintain for a long time and provide water vapor and heat conditions for rainfall in east of North China. The structure of Damrey caused a strong updraft in east of North China with a K-index greater than 35°C, which provided a favorable condition for the heavy rainstorm. The typhoon rainstorms in North China are the result of the interaction of the westerly, subtropical and tropical systems. In this heavy rain period, there was an obvious interaction between subtropical and tropical systems. This study has investigated the interaction between the northwestern Pacific typhoon and the North China heavy rainstorm, including the circulation characteristics of the typhoon and North China before and after the regional heavy rainstorm. Additionally, the climate background provides a reliable basis for the heavy rain forecast. 展开更多
关键词 TYPHOON Damrey RAINSTORM in NORTH China SYNOPTIC System Interaction
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Adaptability Evaluation and Annual Production Model of Chinese Vegetable Varieties in Burundi
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作者 Kaiqiang LIU chengcheng feng +3 位作者 Jiazuo LIANG Yuyi HUANG Guoqing GAO Rukui HUANG 《Asian Agricultural Research》 2020年第3期34-41,共8页
Burundi is one of the least developed countries identified by the United Nations.Vegetable is the main crop in Burundi,but the variety is relatively simple and the planting level is low.Making use of the rich vegetabl... Burundi is one of the least developed countries identified by the United Nations.Vegetable is the main crop in Burundi,but the variety is relatively simple and the planting level is low.Making use of the rich vegetable varieties and advanced cultivation techniques in China,the adaptability evaluation of new vegetable varieties in China was jointly carried out in Burundi to screen the vegetable varieties suitable for local cultivation.The purpose of this paper is to study the integration of high-yield cultivation techniques and annual production model to improve the level of vegetable cultivation in Burundi.From 2009 to 2015,our unit,together with the Burundian Fruit and Vegetable Promotion Center,carried out screening experiments on 144 vegetable varieties,such as tomato,balsam pear,chieh-qua,wax gourd,and cabbage.Through the methods of preliminary screening and experimental screening,the vegetable varieties suitable for planting in Burundi were selected,and the cultivation techniques of some main vegetable varieties were studied.The demonstration new varieties and new techniques were integrated to verify the high-yield cultivation techniques in the field.In 2009,18 varieties suitable for local planting were selected from 96 vegetable varieties.In 2010,40 vegetable varieties were selected for screening test,and 9 varieties suitable for planting in Burundi were selected.In 2011,27 vegetable varieties selected in 2009 and 2010 were further evaluated for adaptability,and 13 vegetable varieties with high yield,strong resistance and good marketability were selected.Among them,there were 5 melon vegetables,3 solanaceous fruit vegetables,1 legume vegetables and 4 leafy vegetables.The cultivation techniques of some vegetable varieties were studied from 2011 to 2012,and the key points of cultivation techniques of chieh-qua and other vegetable varieties were clarified.According to the ecological characteristics of two main vegetable producing areas(the plateau and plain areas of Burundi),six sets of annual production and cropping arrangement plans covering melons,leafy vegetables,solanaceous fruits,beans and other vegetables were put forward,and the annual production model of multiple cropping and three-dimensional cultivation was integrated.From 2014 to 2015,according to the previous test results and market demand,8 vegetable varieties were selected for Burundi to carry out screening experiments.4 varieties with good yield and adaptability were selected for two consecutive years in 2014 and 2015.The integrated demonstration and effect verification of some selected vegetable varieties and cultivation techniques were carried out from 2015 to 2016,and the comprehensive advantages such as field yield and economic benefit were obvious.In this study,the adaptability of Chinese vegetable varieties in Burundi was evaluated,and 17 vegetable varieties suitable for local production were selected,including 5 melon vegetables,5 solanaceous fruit vegetables,1 legume vegetables and 6 leafy vegetables.This paper studies the integrated cultivation techniques and annual production model with obvious advantages in yield and benefit,which plays an important role in improving the planting level and benefit of vegetables in Burundi. 展开更多
关键词 BURUNDI VEGETABLES Evaluation SCREENING VERIFICATION
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Comparative Study on Natural Selenium-enriching Ability of 7 Main Cultivars of Pueraria lobata
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作者 Kunpeng OU Yuanning YANG +4 位作者 Xueli WANG Risheng HUANG chengcheng feng Honghua HUANG Yan WANG 《Asian Agricultural Research》 2020年第8期45-48,共4页
[Objectives]To screen out the selenium-enriched Pueraria lobata varieties suitable for cultivation in Guangxi according to the natural selenium-enriching ability of 7 main cultivars.[Methods]Taking 7 main cultivars of... [Objectives]To screen out the selenium-enriched Pueraria lobata varieties suitable for cultivation in Guangxi according to the natural selenium-enriching ability of 7 main cultivars.[Methods]Taking 7 main cultivars of P.lobata in different places as experimental materials,field cultivation was carried out on the selenium-enriched yellow soil in Shanglin County,Nanning City of Guangxi,to study the difference in selenium-enriching ability of different main cultivars and the comparison of selenium content in different parts,as well as the transport mechanism.[Results]Under the condition of soil selenium content of 0.78 mg/kg,the selenium content of the root tubers of the 7 main cultivars all reached the selenium-enrichment standard.The selenium content of a single root tuber of Heping Variety in Teng County,Guangxi was the highest,at 0.061 mg/kg;Guifenge No.1 was the second at 0.055 mg/kg,and the total selenium accumulation per unit area was the largest.The ranking of selenium content in different parts of the same variety was:leaf>vine>head>root tuber.[Conclusions]Guifenge No.1 has the highest yield and the largest total selenium accumulation,so it is the most suitable natural selenium-enriched variety for cultivation. 展开更多
关键词 Pueraria lobata SELENIUM Enriching ability Comparison
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激光笔所致儿童黄斑损伤的OCT表现及预后观察 被引量:1
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作者 冯程程 高艳 +1 位作者 陈楠 万磊 《中华眼视光学与视觉科学杂志》 CAS CSCD 北大核心 2024年第3期186-192,共7页
目的:观察激光笔所致儿童黄斑损伤的临床表现,黄斑区光学相干断层扫描(OCT)图像特征及临床预后情况。方法:回顾性研究。连续性纳入2018年7月至2023年6月于山东第一医科大学附属青岛眼科医院眼底病科就诊,因激光笔照射后致视力下降,被诊... 目的:观察激光笔所致儿童黄斑损伤的临床表现,黄斑区光学相干断层扫描(OCT)图像特征及临床预后情况。方法:回顾性研究。连续性纳入2018年7月至2023年6月于山东第一医科大学附属青岛眼科医院眼底病科就诊,因激光笔照射后致视力下降,被诊断为黄斑光损伤的患儿9例(10眼),其中男8例、女1例,年龄5~12岁。采集初诊和随访时患者的最佳矫正视力和黄斑OCT扫描检查结果并进行分析。结果:9例患者中,绿色和红色激光笔致损伤分别有3例、4例,其余2例不详,照射时间为1~2 s。发病后就诊时间为1 d~36个月。初始视力为0.05~0.5。患儿随访时间为2~37个月,平均19个月。2例(病例1、2)患儿表现为黄斑出血,其中1例表现为内界膜下出血。3例(病例3、4、5)表现为黄斑中心凹处肌样体带、椭圆体带、嵌合体带断裂。3例(病例6、7、8)表现为黄斑裂孔,1例(病例9)表现为黄斑部脉络膜新生血管。多数患儿在末次随访视力得到明显改善,其中病例9预后欠佳。结论:激光笔照射导致患儿黄斑光损伤,可引起黄斑出血、黄斑裂孔、脉络膜新生血管以及特征性的中心凹处外层结构的断裂,视力预后与患儿损伤程度相关。 展开更多
关键词 激光 黄斑损伤 儿童 光学相干断层扫描
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Detection of radio-frequency interference signals from AMSR-E data over the United States with snow cover 被引量:5
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作者 chengcheng feng Xiaolei ZOU Juan ZHAO 《Frontiers of Earth Science》 CSCD 2016年第2期195-204,共10页
Radio Frequency Interference (RFI) causes severe contamination to passive and active microwave sensing observations and corresponding retrieval products. RFI signals should be detected and filtered before applying t... Radio Frequency Interference (RFI) causes severe contamination to passive and active microwave sensing observations and corresponding retrieval products. RFI signals should be detected and filtered before applying the microwave data to retrieval and data assimilation. It is difficult to detect RFI over land surfaces covered by snow because of the scattering effect of snow surface. The double principal component analysis (DPCA) method is adopted in this study, and its ability in identifying RFI signals in AMSR-E data over snow covered regions is investigated. Results show that the DPCA method can detect RFI signals effectively in spite of the impact of snow scattering, and the detected RFI signals persistent over time. Compared to other methods, such as PCA and normalized PCA, DPCA is more robust and suitable for operational application. 展开更多
关键词 Radio Frequency Interference (RFI) AMSR-E double principal component analysis (DPCA)
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